CDC2-CDC28 Kinases

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  Subject Areas on Research

  • A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex. 
  • An oligonucleotide decoy for transcription factor E2F inhibits mesangial cell proliferation in vitro. 
  • Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. 
  • Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts. 
  • Cell cycle. Checking two steps. 
  • Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells. 
  • Cyclin-binding motifs are essential for the function of p21CIP1. 
  • E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. 
  • Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation. 
  • Gene therapy with an E2F transcription factor decoy inhibits cell cycle progression in rat anti-Thy 1 glomerulonephritis. 
  • Human T-cell leukemia virus type 1 Tax activates cyclin-dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53-independent mechanism: Inhibition of cdk2. 
  • IFN-gamma induction of p21(WAF1) is required for cell cycle inhibition and suppression of apoptosis. 
  • IFNalpha induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells. 
  • IFNgamma inhibition of cell growth in glioblastomas correlates with increased levels of the cyclin dependent kinase inhibitor p21WAF1/CIP1. 
  • Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis. 
  • Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. 
  • Loss of G(1)/S checkpoint in human immunodeficiency virus type 1-infected cells is associated with a lack of cyclin-dependent kinase inhibitor p21/Waf1. 
  • Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. 
  • Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1. 
  • Overexpression of p21(waf1) in human T-cell lymphotropic virus type 1-infected cells and its association with cyclin A/cdk2. 
  • PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation. 
  • Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites. 
  • The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. 
  • Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. 
  • When the checkpoints have gone: insights into Cdc25 functional activation.