CDC2-CDC28 Kinases
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Subject Areas on Research
- An oligonucleotide decoy for transcription factor E2F inhibits mesangial cell proliferation in vitro.
- Analysis of Cdc6 function in the assembly of mammalian prereplication complexes.
- Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts.
- Cell cycle. Checking two steps.
- Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells.
- Cyclin-binding motifs are essential for the function of p21CIP1.
- E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.
- Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation.
- Gene therapy with an E2F transcription factor decoy inhibits cell cycle progression in rat anti-Thy 1 glomerulonephritis.
- Human T-cell leukemia virus type 1 Tax activates cyclin-dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53-independent mechanism: Inhibition of cdk2.
- IFN-gamma induction of p21(WAF1) is required for cell cycle inhibition and suppression of apoptosis.
- IFNalpha induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells.
- IFNgamma inhibition of cell growth in glioblastomas correlates with increased levels of the cyclin dependent kinase inhibitor p21WAF1/CIP1.
- Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis.
- Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides.
- Loss of G(1)/S checkpoint in human immunodeficiency virus type 1-infected cells is associated with a lack of cyclin-dependent kinase inhibitor p21/Waf1.
- Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1.
- Overexpression of p21(waf1) in human T-cell lymphotropic virus type 1-infected cells and its association with cyclin A/cdk2.
- PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation.
- Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites.
- The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.
- Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines.
- When the checkpoints have gone: insights into Cdc25 functional activation.