Subject Areas on Research
- A rare example of lock-and-key RNA recognition.
- An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation.
- JMJD5 couples with CDK9 to release the paused RNA polymerase II.
- JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes.
- Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription.
- The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.