Electron Transport Complex I

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  Subject Areas on Research

  • Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. 
  • Electron transport complex I is required for CD8+ T cell function. 
  • Evidence for Compartmentalized Axonal Mitochondrial Biogenesis: Mitochondrial DNA Replication Increases in Distal Axons As an Early Response to Parkinson's Disease-Relevant Stress. 
  • Gene up-regulation in heart during mammalian hibernation. 
  • Human, Tissue-Engineered, Skeletal Muscle Myobundles to Measure Oxygen Uptake and Assess Mitochondrial Toxicity. 
  • Identifying single S-nitrosothiol sites with cardioprotection. 
  • Immunology. Outwitted by viral RNAs. 
  • Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [18F]FAZA PET In Vivo. 
  • Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease. 
  • Mitochondrial polymorphism A10398G and Haplogroup I are associated with Fuchs' endothelial corneal dystrophy. 
  • Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone. 
  • Mutational hotspots in the mitochondrial genome of lung cancer. 
  • Photoreceptors in a mouse model of Leigh syndrome are capable of normal light-evoked signaling. 
  • Progressive optic atrophy in a retinal ganglion cell-specific mouse model of complex I deficiency. 
  • Role of mitochondrial DNA damage and dysfunction in veterans with Gulf War Illness. 
  • The biological foundation of the genetic association of TOMM40 with late-onset Alzheimer's disease.