Myosin-Light-Chain Phosphatase

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  Subject Areas on Research

  • Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase. 
  • Elevated intraocular pressure induces Rho GTPase mediated contractile signaling in the trabecular meshwork. 
  • Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. 
  • Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent. 
  • Molecular cloning and functional expression of a recombinant 72.5 kDa fragment of the 110 kDa regulatory subunit of smooth muscle protein phosphatase 1M. 
  • Ontogenesis of myosin light chain phosphorylation in guinea pig tracheal smooth muscle. 
  • Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase. 
  • Purification and characterization of the mammalian myosin light chain phosphatase holoenzyme. The differential effects of the holoenzyme and its subunits on smooth muscle. 
  • ROCK1 phosphorylates and activates zipper-interacting protein kinase. 
  • Regions of the 110-kDa regulatory subunit M110 required for regulation of myosin-light-chain-phosphatase activity in smooth muscle. 
  • Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase. 
  • Smooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition. 
  • Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides. 
  • Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling. 
  • Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy. 
  • The role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction. 
  • ZIP kinase, a key regulator of myosin protein phosphatase 1. 
  • β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration. 
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  Keywords of People

  • Kiehart, Daniel P., Professor of Biology, Duke Science & Society