Receptors, G-Protein-Coupled

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  Subject Areas on Research

  • A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. 
  • A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion. 
  • A beta-arrestin 2 signaling complex mediates lithium action on behavior. 
  • A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors. 
  • A brief history of G-protein coupled receptors (Nobel Lecture). 
  • A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling. 
  • A humanized mouse model to study mast cells mediated cutaneous adverse drug reactions. 
  • A protocol for heterologous expression and functional assay for mouse pheromone receptors. 
  • A role for G(z) in pancreatic islet beta-cell biology. 
  • A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor. 
  • A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion. 
  • A single phenylalanine residue in β-arrestin2 critically regulates its binding to G protein-coupled receptors. 
  • A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. 
  • A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities. 
  • Acidosis activation of the proton-sensing GPR4 receptor stimulates vascular endothelial cell inflammatory responses revealed by transcriptome analysis. 
  • Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice. 
  • Activation of a nerve injury transcriptional signature in airway-innervating sensory neurons after lipopolysaccharide-induced lung inflammation. 
  • Activation state of the M3 muscarinic acetylcholine receptor modulates mammalian odorant receptor signaling. 
  • Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. 
  • Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner. 
  • Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature. 
  • Age increases expression and receptor-mediated activation of G alpha i in human atria. 
  • Agonists of G-Protein-Coupled Odorant Receptors Are Predicted from Chemical Features. 
  • Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin. 
  • Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management. 
  • An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. 
  • An interview with Professor Robert J. Lefkowitz, M.D. Interview by Vicki Glaser. 
  • An interview with Robert J. Lefkowitz. 
  • Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells. 
  • Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression. 
  • Angiotensin 1-7 reduces mortality and rupture of intracranial aneurysms in mice. 
  • Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. 
  • Arrestins and protein ubiquitination. 
  • Arrestins come of age: a personal historical perspective. 
  • Association of AGTR1 with 18-month treatment outcome in late-life depression. 
  • Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands. 
  • Autocrine stimulation of mas oncogene leads to altered growth control. 
  • Beta-Arrestins and Receptor Signaling in the Vascular Endothelium. 
  • Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. 
  • Beta-arrestin-biased ligands at seven-transmembrane receptors. 
  • Beta-arrestin-mediated localization of smoothened to the primary cilium. 
  • Beta-arrestins: multifunctional cellular mediators. 
  • Beyond desensitization: physiological relevance of arrestin-dependent signaling. 
  • Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery. 
  • Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery. 
  • Biased agonists of the chemokine receptor CXCR3 differentially signal through Gαi:β-arrestin complexes. 
  • Biased signalling: from simple switches to allosteric microprocessors. 
  • Bitter Taste Receptors and Chronic Otitis Media. 
  • Cardiac GPCRs: GPCR signaling in healthy and failing hearts. 
  • Chapter One - Ubiquitination and Deubiquitination of G Protein-Coupled Receptors. 
  • Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages. 
  • Chemoattractant receptors activate distinct pathways for chemotaxis and secretion. Role of G-protein usage. 
  • Co-expression of nAChRs and molecules of the bitter taste transduction pathway by epithelial cells of intrapulmonary airways. 
  • Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions. 
  • Community guidelines for GPCR ligand bias: IUPHAR review 32. 
  • Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor. 
  • Conformational Basis of G Protein-Coupled Receptor Signaling Versatility. 
  • Connecting virulence pathways to cell-cycle progression in the fungal pathogen Cryptococcus neoformans. 
  • Conserved Residues Control Activation of Mammalian G Protein-Coupled Odorant Receptors. 
  • Conserved anti-inflammatory effects and sensing of butyrate in zebrafish. 
  • Constitutive desensitization: a new paradigm for g protein-coupled receptor regulation. 
  • Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network. 
  • Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies. 
  • Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs. 
  • Cross-desensitization among receptors for platelet activating factor and peptide chemoattractants. Evidence for independent regulatory pathways. 
  • Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. 
  • Dawn of a New RAMPage. 
  • Desensitization of G protein-coupled receptors and neuronal functions. 
  • Design, synthesis and biological evaluation of GPR55 agonists. 
  • Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones. 
  • Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity. 
  • Detection of β-Arrestin-Mediated G Protein-Coupled Receptor Ubiquitination Using BRET. 
  • Development of a membrane-anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain. 
  • Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. 
  • Differential regulation of formyl peptide and platelet-activating factor receptors. Role of phospholipase Cbeta3 phosphorylation by protein kinase A. 
  • Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras. 
  • Directionality of wingless protein transport influences epidermal patterning in the Drosophila embryo. 
  • Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. 
  • Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics. 
  • Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity. 
  • Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors. 
  • Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. 
  • Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. 
  • Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy. 
  • Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice. 
  • Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. 
  • Editorial overview: Respiratory: GPCR signaling and the lung. 
  • Elucidating structural and molecular mechanisms of β-arrestin-biased agonism at GPCRs via MS-based proteomics. 
  • Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. 
  • Epilepsy and all that jazz. 
  • Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. 
  • Expression of the blue-light receptor cryptochrome in the human retina. 
  • FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. 
  • Fidelity in planar cell polarity signalling. 
  • Functional analysis of a mammalian odorant receptor subfamily. 
  • Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. 
  • Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. 
  • Functional selectivity in adrenergic and angiotensin signaling systems. 
  • G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands. 
  • G Protein-Coupled Receptor Signaling Through β-Arrestin-Dependent Mechanisms. 
  • G Protein-coupled Receptor Biased Agonism. 
  • G alpha(q)-coupled receptors in human atrium function through protein kinase C epsilon and delta. 
  • G protein-coupled estrogen receptor (GPER) expression in normal and abnormal endometrium. 
  • G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes. 
  • G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. 
  • G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. 
  • G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. 
  • G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor. 
  • G protein-coupled receptor signaling: transducers and effectors. 
  • G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. 
  • G-Protein-Coupled Receptors in Heart Disease. 
  • G-protein-coupled receptors as signaling targets for antiplatelet therapy. 
  • G-protein-coupled receptors signaling pathways in new antiplatelet drug development. 
  • GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells. 
  • GPCR desensitization: Acute and prolonged phases. 
  • GPCR signaling: conformational activation of arrestins. 
  • GPCR systems pharmacology: a different perspective on the development of biased therapeutics. 
  • GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling. 
  • GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision. 
  • GPCRs and arrestins in airways: implications for asthma. 
  • GPER1 is required to protect fetal health from maternal inflammation. 
  • GPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure. 
  • GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. 
  • GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain. 
  • GPR54 is a target for suppression of metastasis in endometrial cancer. 
  • GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. 
  • GWAS Identifies New Loci for Painful Temporomandibular Disorder: Hispanic Community Health Study/Study of Latinos. 
  • Galpha subunit Gpa2 recruits kelch repeat subunits that inhibit receptor-G protein coupling during cAMP-induced dimorphic transitions in Saccharomyces cerevisiae. 
  • Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant-induced bronchodilation. 
  • Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. 
  • Genome-Wide Association Meta-Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci. 
  • Genome-wide association meta-analyses to identify common genetic variants associated with hallux valgus in Caucasian and African Americans. 
  • Genomic signatures of G-protein-coupled receptor expansions reveal functional transitions in the evolution of cephalopod signal transduction. 
  • Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). 
  • Glucocorticoid hedgehog agonists in neurogenesis. 
  • Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans. 
  • Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility. 
  • Gut hormone pharmacology of a novel GPR119 agonist (GSK1292263), metformin, and sitagliptin in type 2 diabetes mellitus: results from two randomized studies. 
  • Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway. 
  • Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth. 
  • Hedgehog signaling in human medullary thyroid carcinoma: a novel signaling pathway. 
  • Hedgehog signaling requires motile cilia in the sea urchin. 
  • Hedgehog-GLI signaling inhibition suppresses tumor growth in squamous lung cancer. 
  • Heptahelical terpsichory. Who calls the tune? 
  • Historical review: a brief history and personal retrospective of seven-transmembrane receptors. 
  • Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions. 
  • Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling. 
  • Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine. 
  • Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. 
  • Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. 
  • In vivo electroporation and non-protein based screening assays to identify antibodies against native protein conformations. 
  • In vivo identification of eugenol-responsive and muscone-responsive mouse odorant receptors. 
  • Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6. 
  • Inflammation and Infection in Pain and the Role of GPR37. 
  • Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness. 
  • International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached? 
  • Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee. 
  • Introduction to the series on novel aspects of cardiovascular G-protein-coupled receptor signaling. 
  • Invasion of human vascular endothelial cells by Actinobacillus actinomycetemcomitans via the receptor for platelet-activating factor. 
  • Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma. 
  • JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma. 
  • LGR5 in Barrett's Esophagus and its Utility in Predicting Patients at Increased Risk of Advanced Neoplasia. 
  • LGR5 is associated with tumor aggressiveness in papillary thyroid cancer. 
  • Large candidate gene association study reveals genetic risk factors and therapeutic targets for fibromyalgia. 
  • Lasting effects of developmental dexamethasone treatment on neural cell number and size, synaptic activity, and cell signaling: critical periods of vulnerability, dose-effect relationships, regional targets, and sex selectivity. 
  • Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions. 
  • Localization and characterization of secretin binding sites expressed by rat bile duct epithelium. 
  • Location bias contributes to functionally selective responses of biased CXCR3 agonists. 
  • Loss of biased signaling at a G protein-coupled receptor in overexpressed systems. 
  • Lysophosphatidic acid receptor signaling in mammalian retinal pigment epithelial cells. 
  • MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection. 
  • Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi. 
  • Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9. 
  • Mas oncogene receptor coupling and peptide specificity in Balb 3T3 and vascular smooth muscle cells. 
  • Menstrual cyclic change of metastin/GPR54 in endometrium. 
  • Mice lacking proSAAS display alterations in emotion, consummatory behavior and circadian entrainment. 
  • MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3. 
  • Modeling of bias for the analysis of receptor signaling in biochemical systems. 
  • Molecular evolutionary characterization of a V1R subfamily unique to strepsirrhine primates. 
  • Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors. 
  • Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases. 
  • Morphine side effects in beta-arrestin 2 knockout mice. 
  • Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. 
  • Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy. 
  • Nanobodies as Probes and Modulators of Cardiovascular G Protein-Coupled Receptors. 
  • Neuronal expression of bitter taste receptors and downstream signaling molecules in the rat brainstem. 
  • Neutrophils self-limit swarming to contain bacterial growth in vivo. 
  • New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. 
  • New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms? 
  • New perspectives regarding β(2) -adrenoceptor ligands in the treatment of asthma. 
  • New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors. 
  • Niacin in cardiovascular prevention: mechanisms, efficacy, and safety. 
  • Non-equivalent roles of Drosophila Frizzled and Dfrizzled2 in embryonic wingless signal transduction. 
  • Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors. 
  • Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium. 
  • Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. 
  • Oncogenic role of the frizzled-7/beta-catenin pathway in hepatocellular carcinoma. 
  • Optical coding of mammalian cells using semiconductor quantum dots. 
  • Ovarian epithelium regeneration by Lgr5(+) cells. 
  • PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia. 
  • PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation. 
  • Papillary Glioneuronal Tumor With a Novel GPR37L1-PRKCA Fusion. 
  • Patched-one or smoothened gene mutations are infrequent in chondrosarcoma. 
  • Pathophysiology and pharmacology of G protein-coupled receptors in the heart. 
  • Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex. 
  • Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor. 
  • Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression. 
  • Phosphorylation analysis of G protein-coupled receptor by mass spectrometry: identification of a phosphorylation site in V2 vasopressin receptor. 
  • Potential arms race in the coevolution of primates and angiosperms: brazzein sweet proteins and gorilla taste receptors. 
  • Prevention of Barrett esophagus and esophageal adenocarcinoma by smoothened inhibitor in a rat model of gastroesophageal reflux disease. 
  • Primary infection by a human immunodeficiency virus with atypical coreceptor tropism. 
  • Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor. 
  • Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin. 
  • Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling. 
  • Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. 
  • Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins. 
  • RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses. 
  • Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function. 
  • Recent developments in biased agonism. 
  • Receptor-transporting protein 1 short (RTP1S) mediates translocation and activation of odorant receptors by acting through multiple steps. 
  • Receptors for bitter and sweet taste. 
  • Recovery and expression of messenger RNA from postmortem human brain tissue. 
  • Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye. 
  • Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1. 
  • Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation. 
  • Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies. 
  • Regulator of G-protein signaling (RGS) proteins in cancer biology. 
  • Relationship between the G protein signaling and homologous desensitization of G protein-coupled receptors. 
  • Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. 
  • Renal actions of RGS2 control blood pressure. 
  • Resonating to the music of ubiquitination. 
  • Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases. 
  • Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility. 
  • Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses. 
  • Role of phospholipase Cbeta3 phosphorylation in the desensitization of cellular responses to platelet-activating factor. 
  • Role of platelet activating factor in the intestinal epithelial secretory and Chinese hamster ovary cell cytoskeletal responses to cholera toxin. 
  • Role of platelet-activating factor in Chinese hamster ovary cell responses to cholera toxin. 
  • Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. 
  • S-Nitrosylation of β-Arrestins Biases Receptor Signaling and Confers Ligand Independence. 
  • Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity. 
  • Secretin receptors in a new preparation of plasma membranes from intrahepatic biliary epithelium. 
  • Sequence coevolution and structure stabilization modulate olfactory receptor expression. 
  • Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity. 
  • Seven transmembrane receptors: a brief personal retrospective. 
  • Seven transmembrane receptors: something old, something new. 
  • Seven-transmembrane receptor signaling through beta-arrestin. 
  • Seven-transmembrane receptors and ubiquitination. 
  • Should we B-leavin' now? 
  • Signaling at the endosome: cryo-EM structure of a GPCR-G protein-beta-arrestin megacomplex. 
  • Single cell transcriptome analysis of mouse carotid body glomus cells. 
  • Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling. 
  • Single-round selection yields a unique retroviral envelope utilizing GPR172A as its host receptor. 
  • Smoothened inhibition leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells. 
  • Smoothened is a master regulator of adult liver repair. 
  • Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. 
  • Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase. 
  • SnapShot: β-Arrestin Functions. 
  • Sonic Hedgehog-induced proliferation requires specific Gα inhibitory proteins. 
  • Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling. 
  • Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function. 
  • Split luciferase complementation assay for the analysis of G protein-coupled receptor ligand response in Saccharomyces cerevisiae. 
  • Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray technology. 
  • Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion. 
  • Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex. 
  • Structure, function and pharmacology of human itch GPCRs. 
  • Structure-Function Relationships of Olfactory and Taste Receptors. 
  • T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. 
  • Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage. 
  • Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss. 
  • Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. 
  • Taste perception: how sweet it is (to be transcribed by you). 
  • Taste perception: how to make a gourmet mouse. 
  • Teaching old receptors new tricks: biasing seven-transmembrane receptors. 
  • The Aminoalkylindole BML-190 Negatively Regulates Chitosan Synthesis via the Cyclic AMP/Protein Kinase A1 Pathway in Cryptococcus neoformans. 
  • The Escherichia coli subtilase cytotoxin A subunit specifically cleaves cell-surface GRP78 protein and abolishes COOH-terminal-dependent signaling. 
  • The G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures. 
  • The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells. 
  • The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner. 
  • The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. 
  • The GPCR-β-arrestin complex allosterically activates C-Raf by binding its amino terminus. 
  • The LOV domain family: photoresponsive signaling modules coupled to diverse output domains. 
  • The N-terminal region of RTP1S plays important roles in dimer formation and odorant receptor-trafficking. 
  • The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases. 
  • The brain hypocretins and their receptors: mediators of allostatic arousal. 
  • The capsaicin receptor participates in artificial sweetener aversion. 
  • The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon. 
  • The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. 
  • The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels. 
  • The neural mechanisms of gustation: a distributed processing code. 
  • The neuroscience of sugars in taste, gut-reward, feeding circuits, and obesity. 
  • The primary cilium as a Hedgehog signal transduction machine. 
  • The stem cell-expressed receptor Lgr5 possesses canonical and functionally active molecular determinants critical to β-arrestin-2 recruitment. 
  • The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation. 
  • The variable loop 3 in the envelope glycoprotein is critical for the atypical coreceptor usage of an HIV-1 strain. 
  • The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors. 
  • Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation. 
  • Trafficking of G protein-coupled receptors. 
  • Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts. 
  • Transduction of receptor signals by beta-arrestins. 
  • Transient receptor potential (TRP) channels and taste sensation. 
  • Visualization of arrestin recruitment by a G-protein-coupled receptor. 
  • Visualizing G protein-coupled receptor signalsomes using confocal immunofluorescence microscopy. 
  • Visualizing receptor endocytosis and trafficking. 
  • WLS retrograde transport to the endoplasmic reticulum during Wnt secretion. 
  • WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. 
  • What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling. 
  • When 7 transmembrane receptors are not G protein-coupled receptors. 
  • Wnt proteins synergize to activate β-catenin signaling. 
  • Wnt signaling: an embarrassment of receptors. 
  • YJ5 as an immunohistochemical marker of osteogenic lineage. 
  • beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. 
  • beta-arrestins: traffic cops of cell signaling. 
  • {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. 
  • Β-arrestin: a signaling molecule and potential therapeutic target for heart failure. 
  • β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors. 
  • β-Arrestin-mediated receptor trafficking and signal transduction. 
  • β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology