Receptor, Adenosine A2A

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  Subject Areas on Research

  • A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. 
  • Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients. 
  • Genetic deletion of A2A adenosine receptors in the striatum selectively impairs habit formation 
  • Phase Ia/b, Open-Label, Multicenter Study of AZD4635 (an Adenosine A2A Receptor Antagonist) as Monotherapy or Combined with Durvalumab, in Patients with Solid Tumors. 
  • Requirements for T lymphocyte migration in explanted lymph nodes.