Ubiquitin-Protein Ligase Complexes

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  Subject Areas on Research

  • A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest. 
  • CRL4Mahj E3 ubiquitin ligase promotes neural stem cell reactivation. 
  • Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6. 
  • Emi2-mediated inhibition of E2-substrate ubiquitin transfer by the anaphase-promoting complex/cyclosome through a D-box-independent mechanism. 
  • Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase. 
  • Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions. 
  • Limited functional redundancy and oscillation of cyclins in multinucleated Ashbya gossypii fungal cells. 
  • Not-so-pseudo a substrate: Acm1-mediated inhibition of the APC. 
  • Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. 
  • Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1. 
  • Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae. 
  • SCF E3-mediated autoubiquitination negatively regulates activity of Cdc34 E2 but plays a nonessential role in the catalytic cycle in vitro and in vivo. 
  • Stalling in mitosis and releasing the apoptotic brake. 
  • Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. 
  • The anaphase-promoting complex/cyclosome is required for anaphase progression in multinucleated Ashbya gossypii cells. 
  • The cell-cycle transcriptional network generates and transmits a pulse of transcription once each cell cycle. 
  • Ubiquitylation of p53 by the APC/C inhibitor Trim39. 
  • Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors. 
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  Keywords of People

  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology