Citrobacter rodentium

• 

  Subject Areas on Research

  • Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium. 
  • The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis. 
  • The apolipoprotein E-mimetic peptide COG112 inhibits the inflammatory response to Citrobacter rodentium in colonic epithelial cells by preventing NF-kappaB activation. 
  • mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium. 
  • miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis.