Epigenesis, Genetic

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  Subject Areas on Research

  • * CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory Environments. 
  • 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. 
  • 5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain. 
  • 5-Hydroxymethylcytosine alterations in the human postmortem brains of autism spectrum disorder. 
  • A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division. 
  • A longitudinal study of epigenetic variation in twins. 
  • A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line. 
  • A three-generation approach in biodemography is based on the developmental profiles and the epigenetics of female gametes. 
  • ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer. 
  • Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration. 
  • Amenable epigenetic traits of dental pulp stem cells underlie high capability of xeno-free episomal reprogramming. 
  • An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse. 
  • An epigenetic mechanism links socioeconomic status to changes in depression-related brain function in high-risk adolescents. 
  • An overview of naturally occurring histone deacetylase inhibitors. 
  • Analysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation. 
  • Antifungal drug resistance evoked via RNAi-dependent epimutations. 
  • Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model. 
  • Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. 
  • BATF Modulates the Th2 Locus Control Region and Regulates CD4+ T Cell Fate during Antihelminth Immunity. 
  • Bacterial infection remodels the DNA methylation landscape of human dendritic cells. 
  • Bayesian genome- and epigenome-wide association studies with gene level dependence. 
  • Beyond genotype: serotonin transporter epigenetic modification predicts human brain function. 
  • Bimodal quantitative relationships between histone modifications for X-linked and autosomal loci. 
  • Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children. 
  • Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children. 
  • Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. 
  • Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides. 
  • Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer. 
  • CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements. 
  • COPD: balancing oxidants and antioxidants. 
  • Cadmium exposure and the epigenome: Exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs. 
  • Caenorhabditis elegans as an emerging model system in environmental epigenetics. 
  • Can we identify meaningful epigenetic effects on human brain function and related risk for mental illness? 
  • Can we observe epigenetic effects on human brain function? 
  • Cancer susceptibility: epigenetic manifestation of environmental exposures. 
  • Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. 
  • Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine. 
  • Chromatin and DNA replication. 
  • Chromatin architecture reorganization during stem cell differentiation. 
  • Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. 
  • Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium. 
  • Cohort profile: Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study. 
  • Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. 
  • Comparative analysis of metazoan chromatin organization. 
  • Comprehensive functional genomic resource and integrative model for the human brain. 
  • Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer. 
  • Core and region-enriched networks of behaviorally regulated genes and the singing genome. 
  • DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. 
  • DNA methylation age is associated with mortality in a longitudinal Danish twin study. 
  • DNA methylation of imprinted gene control regions in the regression of low-grade cervical lesions. 
  • Decrease in the lgl tumor suppressor dose in Drosophila increases survival and longevity in stress conditions. 
  • Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription. 
  • Deletion or epigenetic silencing of AJAP1 on 1p36 in glioblastoma. 
  • Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo. 
  • Diagnostic and prognostic utility of a DNA hypermethylated gene signature in prostate cancer. 
  • Dicentric chromosomes: unique models to study centromere function and inactivation. 
  • Dietary and commercialized fructose: Sweet or sour? 
  • Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape. 
  • Disparities in Cervical Cancer Incidence and Mortality: Can Epigenetics Contribute to Eliminating Disparities? 
  • Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes. 
  • Does evolutionary theory need a rethink? 
  • Double epigenetic modulation of high-dose chemotherapy with azacitidine and vorinostat for patients with refractory or poor-risk relapsed lymphoma. 
  • Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer. 
  • Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. 
  • Dysregulated metabolism contributes to oncogenesis. 
  • Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome. 
  • Early-life prevention of non-communicable diseases. 
  • Editing the epigenome: technologies for programmable transcription and epigenetic modulation. 
  • Editorial Perspective: Psychological stress and epigenetic aging - what can we learn and how can we prevent? 
  • Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia. 
  • Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. 
  • Epigenetic assimilation in the aging human brain. 
  • Epigenetic control of intestinal barrier function and inflammation in zebrafish. 
  • Epigenetic deregulation in pediatric acute lymphoblastic leukemia. 
  • Epigenetic dysregulation of SHANK3 in brain tissues from individuals with autism spectrum disorders. 
  • Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. 
  • Epigenetic markers in rectal cancer. 
  • Epigenetic programming by stress and glucocorticoids along the human lifespan. 
  • Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. 
  • Epigenetic regulation of AXL and risk of childhood asthma symptoms. 
  • Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells. 
  • Epigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replication. 
  • Epigenetic regulation of Newborns' imprinted genes related to gestational growth: patterning by parental race/ethnicity and maternal socioeconomic status. 
  • Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells. 
  • Epigenetic regulation of male fate commitment from an initially bipotential system. 
  • Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182. 
  • Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer. 
  • Epigenetics and cancer metabolism. 
  • Epigenetics and human disease. 
  • Epigenetics and the regulation of stress vulnerability and resilience. 
  • Epigenetics and the transition from acute to chronic pain. 
  • Epigenetics in brain function. 
  • Epigenetics of chronic pain after thoracic surgery. 
  • Epigenome-wide association study of metabolic syndrome in African-American adults. 
  • Epigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotency. 
  • Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis. 
  • Epigenomics of centromere assembly and function. 
  • Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication. 
  • Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort. 
  • Exaggerated CpH methylation in the autism-affected brain. 
  • Expanding the diversity of DNA base modifications with N⁶-methyldeoxyadenosine. 
  • Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST). 
  • Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer. 
  • Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications. 
  • Genetic and epigenetic engines of diversity in pathogenic microbes. 
  • Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma. 
  • Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates. 
  • Genome organization and three kinds of heritable changes: general description and stochastic factors (a review). 
  • Genome-scale screen for DNA methylation-based detection markers for ovarian cancer. 
  • Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types. 
  • Genome-wide chromatin state transitions associated with developmental and environmental cues. 
  • Genome-wide identification of autosomal genes with allelic imbalance of chromatin state. 
  • Genome-wide quantification of the effects of DNA methylation on human gene regulation. 
  • Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding. 
  • Growth-Phase-Specific Modulation of Cell Morphology and Gene Expression by an Archaeal Histone Protein. 
  • Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements. 
  • Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer. 
  • Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism. 
  • Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3. 
  • Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing. 
  • Hypoexpression and epigenetic regulation of candidate tumor suppressor gene CADM-2 in human prostate cancer. 
  • Identification and characterization of a functional zebrafish smrt corepressor (ncor2). 
  • Identification of a novel epigenetic regulatory region within the pluripotency associated microRNA cluster, EEmiRC. 
  • Identification of functional elements and regulatory circuits by Drosophila modENCODE. 
  • Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus. 
  • Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies. 
  • Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy. 
  • Inactivation of the tumor suppressor genes causing the hereditary syndromes predisposing to head and neck cancer via promoter hypermethylation in sporadic head and neck cancers. 
  • Influence of threonine metabolism on S-adenosylmethionine and histone methylation. 
  • Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy. 
  • Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas. 
  • Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism. 
  • Intergenic and genic sequence lengths have opposite relationships with respect to gene expression. 
  • Interplay between SCARECROW, GA and LIKE HETEROCHROMATIN PROTEIN 1 in ground tissue patterning in the Arabidopsis root. 
  • Is epigenetic inheritance a counterexample to the central dogma? 
  • K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking. 
  • Life stress, glucocorticoid signaling, and the aging epigenome: Implications for aging-related diseases. 
  • Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling. 
  • Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca. 
  • Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function. 
  • MATCHER: manifold alignment reveals correspondence between single cell transcriptome and epigenome dynamics. 
  • Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation. 
  • Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. 
  • Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. 
  • Menstrual cyclic change of metastin/GPR54 in endometrium. 
  • Metabolic Signaling Drives IFN-γ. 
  • Metabolic interactions with cancer epigenetics. 
  • Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development. 
  • Methylation subtypes and large-scale epigenetic alterations in gastric cancer. 
  • Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. 
  • Modeling folate, one-carbon metabolism, and DNA methylation. 
  • Modulation of tissue repair by regeneration enhancer elements. 
  • Molecular biology of head and neck cancer: risks and pathways. 
  • Monogenic mouse models of autism spectrum disorders: Common mechanisms and missing links. 
  • NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition. 
  • Novel roles of apoptotic caspases in tumor repopulation, epigenetic reprogramming, carcinogenesis, and beyond. 
  • Nutrients and the microenvironment to feed a T cell army. 
  • One-carbon metabolism and epigenetics: understanding the specificity. 
  • Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors. 
  • Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort. 
  • Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism. 
  • Perinatal risk factors in the development of aggression and violence. 
  • Pharmacodynamic study of disulfiram in men with non-metastatic recurrent prostate cancer. 
  • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. 
  • Resource base influences genome-wide DNA methylation levels in wild baboons (Papio cynocephalus). 
  • Screening Regulatory Element Function with CRISPR/Cas9-based Epigenome Editing. 
  • Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes. 
  • Serine, glycine and one-carbon units: cancer metabolism in full circle. 
  • Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. 
  • SnapShot: Origins of DNA replication. 
  • Structural and functional dynamics of human centromeric chromatin. 
  • Systemic acquired resistance: turning local infection into global defense. 
  • T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation. 
  • TNF-α induces phenotypic modulation in cerebral vascular smooth muscle cells: implications for cerebral aneurysm pathology. 
  • Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells. 
  • Targeted Exome Sequencing of the Cancer Genome in Patients with Very High-risk Bladder Cancer. 
  • Targeting the epigenome in ovarian cancer. 
  • Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome. 
  • The BLUEPRINT Data Analysis Portal. 
  • The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. 
  • The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery. 
  • The Molecular Taxonomy of Primary Prostate Cancer. 
  • The PsychENCODE project. 
  • The biological effects of childhood trauma. 
  • The dynamic epitranscriptome: N6-methyladenosine and gene expression control. 
  • The epigenetics of adaptation: focusing on epigenetic stability as an evolving trait. 
  • The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. 
  • The human imprintome: regulatory mechanisms, methods of ascertainment, and roles in disease susceptibility. 
  • The impact of cellular metabolism on chromatin dynamics and epigenetics. 
  • The performance of BRCA1 immunohistochemistry for detecting germline, somatic, and epigenetic BRCA1 loss in high-grade serous ovarian cancer. 
  • The role of EVI1 in myeloid malignancies. 
  • Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription. 
  • Toward molecular understanding of polar overdominance at the ovine callipyge locus. 
  • Transcriptome and epigenome landscape of human cortical development modeled in organoids. 
  • Transgenerational Effects of Early Life Starvation on Growth, Reproduction, and Stress Resistance in Caenorhabditis elegans. 
  • Transgenerational Effects of Extended Dauer Diapause on Starvation Survival and Gene Expression Plasticity in Caenorhabditis elegans. 
  • Traumatic stress and accelerated DNA methylation age: A meta-analysis. 
  • Uncoupling of genomic and epigenetic signals in the maintenance and inheritance of heterochromatin domains in fission yeast. 
  • Unique cell-type-specific patterns of DNA methylation in the root meristem. 
  • Unmodern Synthesis: Developmental Hierarchies and the Origin of Phenotypes. 
  • Up-regulation of SNCA gene expression: implications to synucleinopathies. 
  • Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma. 
  • Vertebrate sex determination: evolutionary plasticity of a fundamental switch. 
  • Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers. 
  • Whole-genome comparison of Leu3 binding in vitro and in vivo reveals the importance of nucleosome occupancy in target site selection. 
  • Whole-genome fingerprint of the DNA methylome during human B cell differentiation. 
  • Yin yang 1 modulates taxane response in epithelial ovarian cancer. 
  • lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Ciofani, Maria, Assistant Professor of Immunology, Immunology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Sullivan, Beth Ann, Associate Professor of Molecular Genetics and Microbiology, Duke Science & Society
  • Yan, Hai, Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology