Epigenesis, Genetic

• 

  Subject Areas on Research

  • 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. 
  • 5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain. 
  • ^* CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory Environments. 
  • A DNA methylation biomarker of alcohol consumption. 
  • A Randomized Phase II Trial of Epigenetic Priming with Guadecitabine and Carboplatin in Platinum-resistant, Recurrent Ovarian Cancer. 
  • A genetic memory initiates the epigenetic loop necessary to preserve centromere position. 
  • A longitudinal study of epigenetic variation in twins. 
  • A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance. 
  • A non-canonical RNAi pathway controls virulence and genome stability in Mucorales. 
  • A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line. 
  • A three-generation approach in biodemography is based on the developmental profiles and the epigenetics of female gametes. 
  • A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex. 
  • ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer. 
  • ASO Visual Abstract: Machine Learning-Based Epigenetic Classifiers for Axillary Staging of Patients with ER-Positive Early-Stage Breast Cancer. 
  • Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution. 
  • Accelerated epigenetic aging in newborns with Down syndrome. 
  • Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic-Epigenetic Cross-Talk. 
  • Age-associated epigenetic change in chimpanzees and humans. 
  • Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration. 
  • Age-related variations in the methylome associated with gene expression in human monocytes and T cells. 
  • Amenable epigenetic traits of dental pulp stem cells underlie high capability of xeno-free episomal reprogramming. 
  • An epigenetic biomarker of aging for lifespan and healthspan. 
  • An epigenetic mechanism links socioeconomic status to changes in depression-related brain function in high-risk adolescents. 
  • An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior. 
  • An epigenetic pathway in rice connects genetic variation to anaerobic germination and seedling establishment. 
  • An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci. 
  • An overview of naturally occurring histone deacetylase inhibitors. 
  • Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood. 
  • Analysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation. 
  • Antifungal drug resistance evoked via RNAi-dependent epimutations. 
  • Antisense oligonucleotides targeting mutant Ataxin-7 restore visual function in a mouse model of spinocerebellar ataxia type 7. 
  • Are epigenetic changes in the intrauterine environment related to newborn neurobehavior? 
  • Assessing the co-variability of DNA methylation across peripheral cells and tissues: Implications for the interpretation of findings in epigenetic epidemiology. 
  • Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis. 
  • Association between sleep disordered breathing and epigenetic age acceleration: Evidence from the Multi-Ethnic Study of Atherosclerosis. 
  • Association of Neighborhood Disadvantage in Childhood With DNA Methylation in Young Adulthood. 
  • Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. 
  • Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children. 
  • Associations between oxytocin receptor gene (OXTR) methylation, plasma oxytocin, and attachment across adulthood. 
  • BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells. 
  • Bacterial infection remodels the DNA methylation landscape of human dendritic cells. 
  • Bayesian genome- and epigenome-wide association studies with gene level dependence. 
  • Behavioral epigenetics and the developmental origins of child mental health disorders. 
  • Beyond genotype: serotonin transporter epigenetic modification predicts human brain function. 
  • Bimodal quantitative relationships between histone modifications for X-linked and autosomal loci. 
  • Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children. 
  • Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. 
  • Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis. 
  • Body mass index associated with genome-wide methylation in breast tissue. 
  • Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes. 
  • Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides. 
  • Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer. 
  • CBX2 is required to stabilize the testis pathway by repressing Wnt signaling. 
  • CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements. 
  • CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells. 
  • COPD: balancing oxidants and antioxidants. 
  • Cadmium exposure and the epigenome: Exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs. 
  • Caenorhabditis elegans as an emerging model system in environmental epigenetics. 
  • Can we identify meaningful epigenetic effects on human brain function and related risk for mental illness? 
  • Can we observe epigenetic effects on human brain function? 
  • Cancer susceptibility: epigenetic manifestation of environmental exposures. 
  • Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. 
  • Cell surface GRP78 signaling: An emerging role as a transcriptional modulator in cancer. 
  • Cell-type-dependent histone demethylase specificity promotes meiotic chromosome condensation in Arabidopsis. 
  • Changes in Neuroimmune and Neuronal Death Markers after Adolescent Alcohol Exposure in Rats are Reversed by Donepezil. 
  • Chromatin Remodeling of Colorectal Cancer Liver Metastasis is Mediated by an HGF-PU.1-DPP4 Axis. 
  • Chromatin and DNA replication. 
  • Chromatin architecture reorganization during stem cell differentiation. 
  • Clinical-pathological correlations of BAV and the attendant thoracic aortopathies. Part 2: Pluridisciplinary perspective on their genetic and molecular origins. 
  • Clipping of arginine-methylated histone tails by JMJD5 and JMJD7. 
  • Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. 
  • Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium. 
  • Cohort profile: Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study. 
  • Common non-epigenetic drugs as epigenetic modulators. 
  • Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. 
  • Comparative analysis of metazoan chromatin organization. 
  • Comparative analysis reveals distinctive epigenetic features of the human cerebellum. 
  • Comparative cellular analysis of motor cortex in human, marmoset and mouse. 
  • Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. 
  • Complete genomic and epigenetic maps of human centromeres. 
  • Comprehensive functional genomic resource and integrative model for the human brain. 
  • Computational analysis reveals a correlation of exon-skipping events with splicing, transcription and epigenetic factors. 
  • Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors. 
  • Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer. 
  • Core and region-enriched networks of behaviorally regulated genes and the singing genome. 
  • DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation. 
  • DNA Methylation in Babies Born to Nonsmoking Mothers Exposed to Secondhand Smoke during Pregnancy: An Epigenome-Wide Association Study. 
  • DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. 
  • DNA epigenetic signature predictive of benefit from neoadjuvant chemotherapy in oesophageal adenocarcinoma: results from the MRC OE02 trial. 
  • DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies. 
  • DNA methylation and miRNA expression profiling in childhood B-cell acute lymphoblastic leukemia. 
  • DNA methylation in epigenetic control of gene expression. 
  • DNA methylation of NR3c1 in infancy: Associations between maternal caregiving and infant sex. 
  • DNA methylation of imprinted gene control regions in the regression of low-grade cervical lesions. 
  • DNA methylation of individual repetitive elements in hepatitis C virus infection-induced hepatocellular carcinoma. 
  • DNA methylation profiles are associated with complex regional pain syndrome after traumatic injury. 
  • DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan. 
  • DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitis. 
  • Decoding the language of epigenetics during neural development is key for understanding development as well as developmental neurotoxicity. 
  • Decrease in the lgl tumor suppressor dose in Drosophila increases survival and longevity in stress conditions. 
  • Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription. 
  • Deletion or epigenetic silencing of AJAP1 on 1p36 in glioblastoma. 
  • Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo. 
  • Development of germ cells in the mouse. 
  • Developmental programming of brain and behavior by perinatal diet: focus on inflammatory mechanisms. 
  • Dicentric chromosomes: unique models to study centromere function and inactivation. 
  • Dietary Methionine in T Cell Biology and Autoimmune Disease. 
  • Differential DNA methylation patterns in human Schlemm's canal endothelial cells with glaucoma. 
  • Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape. 
  • Differential Gene Expression and DNA Methylation in the Risk of Depression in LOAD Patients. 
  • Direct evidence for (G)O6···H2-N4(C)+ hydrogen bonding in transient G(syn)-C+ and G(syn)-m5C+ Hoogsteen base pairs in duplex DNA from cytosine amino nitrogen off-resonance R1ρ relaxation dispersion measurements. 
  • Disparities in Cervical Cancer Incidence and Mortality: Can Epigenetics Contribute to Eliminating Disparities? 
  • Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes. 
  • Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion. 
  • Does evolutionary theory need a rethink? 
  • Donepezil Reverses Dendritic Spine Morphology Adaptations and Fmr1 Epigenetic Modifications in Hippocampus of Adult Rats After Adolescent Alcohol Exposure. 
  • Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer. 
  • Drug-Resistant Epimutants Exhibit Organ-Specific Stability and Induction during Murine Infections Caused by the Human Fungal Pathogen Mucor circinelloides. 
  • DunedinPACE, a DNA methylation biomarker of the pace of aging. 
  • Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. 
  • Dysregulated metabolism contributes to oncogenesis. 
  • Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome. 
  • Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart. 
  • Early adversities accelerate epigenetic aging into adulthood: a 10-year, within-subject analysis. 
  • Early de novo DNA methylation and prolonged demethylation in the muscle lineage. 
  • Early-life prevention of non-communicable diseases. 
  • Editing the epigenome: technologies for programmable transcription and epigenetic modulation. 
  • Elevations of inflammatory proteins in neonatal blood are associated with obesity and overweight among 2-year-old children born extremely premature. 
  • Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies. 
  • Enchondromatosis and Growth Plate Development. 
  • Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. 
  • Epigenetic Clocks. 
  • Epigenetic Programming by Maternal Behavior in the Human Infant. 
  • Epigenetic Regulation of Fanconi Anemia Genes Implicates PRMT5 Blockage as a Strategy for Tumor Chemosensitization. 
  • Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia. 
  • Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition. 
  • Epigenetic Signatures Predict Pathologic Nodal Stage in Breast Cancer Patients with Estrogen Receptor-Positive, Clinically Node-Positive Disease. 
  • Epigenetic Signatures of Cigarette Smoking. 
  • Epigenetic Silencing of Recombinant Adeno-associated Virus Genomes by NP220 and the HUSH Complex. 
  • Epigenetic Switch-Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer. 
  • Epigenetic activation of unintegrated HIV-1 genomes by gut-associated short chain fatty acids and its implications for HIV infection. 
  • Epigenetic ageing of the prefrontal cortex and cerebellum in humans and chimpanzees. 
  • Epigenetic alterations in cytochrome P450 oxidoreductase (Por) in sperm of rats exposed to tetrahydrocannabinol (THC). 
  • Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. 
  • Epigenetic and epitranscriptomic regulation of viral replication. 
  • Epigenetic assimilation in the aging human brain. 
  • Epigenetic basis for the development of depression in children. 
  • Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity. 
  • Epigenetic control of intestinal barrier function and inflammation in zebrafish. 
  • Epigenetic deregulation in pediatric acute lymphoblastic leukemia. 
  • Epigenetic dynamics of centromeres and neocentromeres in Cryptococcus deuterogattii. 
  • Epigenetic dysregulation of Oxtr in Tet1-deficient mice has implications for neuropsychiatric disorders. 
  • Epigenetic dysregulation of SHANK3 in brain tissues from individuals with autism spectrum disorders. 
  • Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. 
  • Epigenetic markers in rectal cancer. 
  • Epigenetic mechanisms of drug resistance in fungi. 
  • Epigenetic mechanisms underlying diet-sourced compounds in the prevention and treatment of gastrointestinal cancer. 
  • Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. 
  • Epigenetic regulation of AXL and risk of childhood asthma symptoms. 
  • Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells. 
  • Epigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replication. 
  • Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis. 
  • Epigenetic regulation of Newborns' imprinted genes related to gestational growth: patterning by parental race/ethnicity and maternal socioeconomic status. 
  • Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells. 
  • Epigenetic regulation of male fate commitment from an initially bipotential system. 
  • Epigenetic regulator BMI1 promotes alveolar rhabdomyosarcoma proliferation and constitutes a novel therapeutic target. 
  • Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency. 
  • Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182. 
  • Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer. 
  • Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. 
  • Epigenetic variation in OPRM1 gene in opioid-exposed mother-infant dyads. 
  • Epigenetics and autism spectrum disorder: A report of an autism case with mutation in H1 linker histone HIST1H1E and literature review. 
  • Epigenetics and cancer metabolism. 
  • Epigenetics and the regulation of stress vulnerability and resilience. 
  • Epigenetics and the transition from acute to chronic pain. 
  • Epigenetics as a new avenue for the role of inbreeding depression in evolutionary ecology. 
  • Epigenetics in brain function. 
  • Epigenetics in dilated cardiomyopathy. 
  • Epigenetics of chronic pain after thoracic surgery. 
  • Epigenome-wide Association Study Analysis of Calorie Restriction in Humans, CALERIETM Trial Analysis. 
  • Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults. 
  • Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci. 
  • Epigenome-wide association study of metabolic syndrome in African-American adults. 
  • Epigenome-wide meta-analysis of DNA methylation and childhood asthma. 
  • Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR. 
  • Epigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotency. 
  • Epigenomic links from metabolism-methionine and chromatin architecture. 
  • Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture. 
  • Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis. 
  • Epigenomics of centromere assembly and function. 
  • Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication. 
  • Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort. 
  • Establishing a generalized polyepigenetic biomarker for tobacco smoking. 
  • Establishing the epigenetic status of the Prader-Willi/Angelman imprinting center in the gametes and embryo. 
  • Estrogen-mediated epigenetic repression of large chromosomal regions through DNA looping. 
  • Evaluating DNA methylation age on the Illumina MethylationEPIC Bead Chip. 
  • Exaggerated CpH methylation in the autism-affected brain. 
  • Expanding the diversity of DNA base modifications with N⁶-methyldeoxyadenosine. 
  • Flow-Dependent Epigenetic DNA Methylation in Endothelial Gene Expression and Atherosclerosis. 
  • Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis 
  • Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST). 
  • Folic acid throughout pregnancy: too much? 
  • Food-Grade TiO₂ Particles Generate Intracellular Superoxide and Alter Epigenetic Modifiers in Human Lung Cells. 
  • Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer. 
  • From induction to conduction: how intrinsic transcriptional priming of extrinsic neuronal connectivity shapes neuronal identity. 
  • G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program. 
  • GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium. 
  • Genetic Association Between Epigenetic Aging-Acceleration and the Progression of Mild Cognitive Impairment to Alzheimer's Disease. 
  • Genetic and epigenetic engines of diversity in pathogenic microbes. 
  • Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma. 
  • Genetic assimilation and accommodation: Models and mechanisms. 
  • Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates. 
  • Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression. 
  • Genome organization and three kinds of heritable changes: general description and stochastic factors (a review). 
  • Genome-scale screen for DNA methylation-based detection markers for ovarian cancer. 
  • Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types. 
  • Genome-wide chromatin state transitions associated with developmental and environmental cues. 
  • Genome-wide identification of autosomal genes with allelic imbalance of chromatin state. 
  • Genome-wide quantification of the effects of DNA methylation on human gene regulation. 
  • Genomic and Epigenetic Foundations of Neocentromere Formation. 
  • Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. 
  • Genomic complexity is associated with epigenetic regulator mutations and poor prognosis in diffuse large B-cell lymphoma. 
  • Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment. 
  • Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research. 
  • Global gene expression and chromatin accessibility of the peripheral nervous system in animal models of persistent pain. 
  • Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding. 
  • Growth-Phase-Specific Modulation of Cell Morphology and Gene Expression by an Archaeal Histone Protein. 
  • HIV-1 Proviral Transcription and Latency in the New Era. 
  • Harnessing epigenetic variability for crop improvement: current status and future prospects. 
  • High social status males experience accelerated epigenetic aging in wild baboons. 
  • High-Resolution Mapping of Chromatin Conformation in Cardiac Myocytes Reveals Structural Remodeling of the Epigenome in Heart Failure. 
  • Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements. 
  • Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer. 
  • Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism. 
  • Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3. 
  • Histone modifications and chromatin organization in prostate cancer. 
  • Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing. 
  • Hypoexpression and epigenetic regulation of candidate tumor suppressor gene CADM-2 in human prostate cancer. 
  • Identical twins carry a persistent epigenetic signature of early genome programming. 
  • Identification and characterization of a functional zebrafish smrt corepressor (ncor2). 
  • Identification of a novel epigenetic regulatory region within the pluripotency associated microRNA cluster, EEmiRC. 
  • Identification of functional elements and regulatory circuits by Drosophila modENCODE. 
  • Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus. 
  • Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies. 
  • In-utero epigenetic factors are associated with early-onset myopia in young children. 
  • Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy. 
  • Inactivation of the tumor suppressor genes causing the hereditary syndromes predisposing to head and neck cancer via promoter hypermethylation in sporadic head and neck cancers. 
  • Incorporating epigenetic mechanisms to advance fetal programming theories. 
  • Influence of threonine metabolism on S-adenosylmethionine and histone methylation. 
  • Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas. 
  • Integrating genetic and epigenetic factors in chronic myeloid leukemia risk assessment: toward gene expression-based biomarkers. 
  • Integration of the Salmonella Typhimurium Methylome and Transcriptome Reveals That DNA Methylation and Transcriptional Regulation Are Largely Decoupled under Virulence-Related Conditions. 
  • Integrative functional genomic analysis of human brain development and neuropsychiatric risks. 
  • Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism. 
  • Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. 
  • Intergenic and genic sequence lengths have opposite relationships with respect to gene expression. 
  • Interplay between SCARECROW, GA and LIKE HETEROCHROMATIN PROTEIN 1 in ground tissue patterning in the Arabidopsis root. 
  • Intracellular Generation of Superoxide by TiO₂ Nanoparticles Decreases Histone Deacetylase 9 (HDAC9), an Epigenetic Modifier. 
  • Introduction to the Special Section on Epigenetics. 
  • Is epigenetic inheritance a counterexample to the central dogma? 
  • K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking. 
  • Landscape of stimulation-responsive chromatin across diverse human immune cells. 
  • Leaf chlorosis in Arabidopsis thaliana hybrids is associated with transgenerational decline and imbalanced ribosome number. 
  • Lifetime marijuana use and epigenetic age acceleration: A 17-year prospective examination. 
  • Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca. 
  • Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function. 
  • Long Noncoding RNAs in Atherosclerosis and Vascular Injury: Pathobiology, Biomarkers, and Targets for Therapy. 
  • Long noncoding RNA MIR4435-2HG enhances metabolic function of myeloid dendritic cells from HIV-1 elite controllers. 
  • MATCHER: manifold alignment reveals correspondence between single cell transcriptome and epigenome dynamics. 
  • Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation. 
  • Machine Learning-Based Epigenetic Classifiers for Axillary Staging of Patients with ER-Positive Early-Stage Breast Cancer. 
  • Male obesity impacts DNA methylation reprogramming in sperm. 
  • Mapping and characterization of structural variation in 17,795 human genomes. 
  • Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. 
  • Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study. 
  • Mechanotransduction Mechanisms for Intraventricular Diastolic Vortex Forces and Myocardial Deformations: Part 2. 
  • Mechanotransduction mechanisms for intraventricular diastolic vortex forces and myocardial deformations: part 1. 
  • Menstrual cyclic change of metastin/GPR54 in endometrium. 
  • Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight. 
  • Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation. 
  • Metabolic Signaling Drives IFN-γ. 
  • Metabolic decisions in development and disease-a Keystone Symposia report. 
  • Metabolic interactions with cancer epigenetics. 
  • Metabolic regulation of epigenetic remodeling in immune cells. 
  • Methionine metabolism in health and cancer: a nexus of diet and precision medicine. 
  • Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development. 
  • Methylation markers of malignant potential in meningiomas. 
  • Methylation subtypes and large-scale epigenetic alterations in gastric cancer. 
  • Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. 
  • Methylomics of gene expression in human monocytes. 
  • Modeling folate, one-carbon metabolism, and DNA methylation. 
  • Models of epigenetic age capture patterns of DNA methylation in glioma associated with molecular subtype, survival, and recurrence. 
  • Modulation of tissue repair by regeneration enhancer elements. 
  • Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma. 
  • Molecular biology of head and neck cancer: risks and pathways. 
  • Molecular hallmarks of endogenous chromatin complexes containing master regulators of hematopoiesis. 
  • Monocyte miRNAs Are Associated With Type 2 Diabetes. 
  • Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. 
  • Myogenic Progenitor Cell Lineage Specification by CRISPR/Cas9-Based Transcriptional Activators. 
  • NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling. 
  • NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition. 
  • Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders. 
  • New agents and regimens for diffuse large B cell lymphoma. 
  • New genetic loci link adipose and insulin biology to body fat distribution. 
  • Noncoding RNAs: biology and applications-a Keystone Symposia report. 
  • Nongenetic inheritance and multigenerational plasticity in the nematode C. elegans. 
  • Novel insights into the genetics and epigenetics of MALT lymphoma unveiled by next generation sequencing analyses. 
  • Novel roles of apoptotic caspases in tumor repopulation, epigenetic reprogramming, carcinogenesis, and beyond. 
  • Nutrients and the microenvironment to feed a T cell army. 
  • One-carbon metabolism and epigenetics: understanding the specificity. 
  • Opposing Epigenetic Signatures in Human Sperm by Intake of Fast Food Versus Healthy Food. 
  • Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors. 
  • Optical High Content Nanoscopy of Epigenetic Marks Decodes Phenotypic Divergence in Stem Cells. 
  • Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring. 
  • Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort. 
  • Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism. 
  • Perinatal risk factors in the development of aggression and violence. 
  • Pharmacodynamic study of disulfiram in men with non-metastatic recurrent prostate cancer. 
  • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. 
  • Phase separation of chromatin and small RNA pathways in plants. 
  • Potential therapeutic effect of epigenetic therapy on treatment-induced neuroendocrine prostate cancer. 
  • Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer. 
  • Proteomic dissection of LPS-inducible, PHF8-dependent secretome reveals novel roles of PHF8 in TLR4-induced acute inflammation and T cell proliferation. 
  • Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis. 
  • RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence. 
  • Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells. 
  • Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma. 
  • Resource base influences genome-wide DNA methylation levels in wild baboons (Papio cynocephalus). 
  • Reversal of Epigenetic Silencing Allows Robust HIV-1 Replication in the Absence of Integrase Function. 
  • Ribosome stalling and SGS3 phase separation prime the epigenetic silencing of transposons. 
  • Role of SIRT1 and Progesterone Resistance in Normal and Abnormal Endometrium. 
  • Screening Regulatory Element Function with CRISPR/Cas9-based Epigenome Editing. 
  • Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes. 
  • Serine, glycine and one-carbon units: cancer metabolism in full circle. 
  • Sex determination without sex chromosomes. 
  • Sex-specific fitness effects of unpredictable early life conditions are associated with DNA methylation in the avian glucocorticoid receptor. 
  • Sexual fidelity trade-offs promote regulatory variation in the prairie vole brain. 
  • Shaping Chromatin States in Prostate Cancer by Pioneer Transcription Factors. 
  • Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection. 
  • Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. 
  • Snacking frequency and dietary intake in toddlers and preschool children. 
  • SnapShot: Origins of DNA replication. 
  • Sparrows and supergenes: Ecological epigenetics in action. 
  • Sperm DNA methylation altered by THC and nicotine: Vulnerability of neurodevelopmental genes with bivalent chromatin. 
  • Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling. 
  • Structural and functional dynamics of human centromeric chromatin. 
  • Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells. 
  • Systemic acquired resistance: turning local infection into global defense. 
  • T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation. 
  • T cell stemness and dysfunction in tumors are triggered by a common mechanism. 
  • Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells. 
  • Targeted Exome Sequencing of the Cancer Genome in Patients with Very High-risk Bladder Cancer. 
  • Targeting Isocitrate Dehydrogenase Mutations in Cancer: Emerging Evidence and Diverging Strategies. 
  • Targeting the epigenome in ovarian cancer. 
  • Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome. 
  • The BLUEPRINT Data Analysis Portal. 
  • The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. 
  • The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery. 
  • The Molecular Taxonomy of Primary Prostate Cancer. 
  • The Nuclear Pore Complex in Cell Type-Specific Chromatin Structure and Gene Regulation. 
  • The PsychENCODE project. 
  • The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming. 
  • The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis. 
  • The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study. 
  • The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality. 
  • The association between neuraxial anesthesia and the development of childhood asthma - a secondary analysis of the newborn epigenetics study cohort. 
  • The association of accelerated epigenetic age with all-cause mortality in cardiac catheterization patients as mediated by vascular and cardiometabolic outcomes. 
  • The diverse culinary habits of microglia. 
  • The dynamic epitranscriptome: N6-methyladenosine and gene expression control. 
  • The epigenetics of adaptation: focusing on epigenetic stability as an evolving trait. 
  • The evolving metabolic landscape of chromatin biology and epigenetics. 
  • The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis. 
  • The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. 
  • The human imprintome: regulatory mechanisms, methods of ascertainment, and roles in disease susceptibility. 
  • The impact of cellular metabolism on chromatin dynamics and epigenetics. 
  • The integrated genomic and epigenomic landscape of brainstem glioma. 
  • The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans. 
  • The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. 
  • The negative side of retinoic acid receptors. 
  • The role of EVI1 in myeloid malignancies. 
  • The role of epigenetics in the endothelial cell shear stress response and atherosclerosis 
  • The role of the extracellular matrix protein TGFBI in cancer. 
  • The unique DEK oncoprotein in women's health: A potential novel biomarker. 
  • Therapeutic targets for neuroblastomas. 
  • Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription. 
  • Transcriptome and epigenome landscape of human cortical development modeled in organoids. 
  • Transgenerational Effects of Early Life Starvation on Growth, Reproduction, and Stress Resistance in Caenorhabditis elegans. 
  • Transgenerational Effects of Extended Dauer Diapause on Starvation Survival and Gene Expression Plasticity in Caenorhabditis elegans . 
  • Transgenic mice for in vivo epigenome editing with CRISPR-based systems. 
  • Traumatic stress and accelerated DNA methylation age: A meta-analysis. 
  • Uncoupling of genomic and epigenetic signals in the maintenance and inheritance of heterochromatin domains in fission yeast. 
  • Unique cell-type-specific patterns of DNA methylation in the root meristem. 
  • Unmodern Synthesis: Developmental Hierarchies and the Origin of Phenotypes. 
  • Up-regulation of SNCA gene expression: implications to synucleinopathies. 
  • Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma. 
  • Vertebrate sex determination: evolutionary plasticity of a fundamental switch. 
  • Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity. 
  • Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers. 
  • Whole-genome comparison of Leu3 binding in vitro and in vivo reveals the importance of nucleosome occupancy in target site selection. 
  • Whole-genome fingerprint of the DNA methylome during human B cell differentiation. 
  • Wnt activation promotes memory T cell polyfunctionality via epigenetic regulator PRMT1. 
  • Yin yang 1 modulates taxane response in epithelial ovarian cancer. 
  • lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer. 
• 

  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Ciofani, Maria, Associate Professor of Immunology, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Sullivan, Beth Ann, Professor of Molecular Genetics and Microbiology, Duke Science & Society
  • Yan, Hai, Adjunct Professor of Pathology, Pathology