GTP-Binding Protein alpha Subunits, G12-G13
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Subject Areas on Research
- A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion.
- Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis.
- Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies.
- G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion.
- GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers.
- Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin.
- Gα-13 induces CXC motif chemokine ligand 5 expression in prostate cancer cells by transactivating NF-κB.
- Heterotrimeric G-alpha subunits Gpa11 and Gpa12 define a transduction pathway that control spore size and virulence in Mucor circinelloides.
- Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.
- Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells.
- MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells.
- N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias.
- Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility.
- Role of G12 proteins in oncogenesis and metastasis.
- Selective activation of human atrial Galpha12 and Galpha13 by Galphaq-coupled angiotensin and endothelin receptors.
- Selective uncoupling of G alpha 12 from Rho-mediated signaling.
- The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis.
- The GNA13-RhoA signaling axis suppresses expression of tumor protective Kallikreins.
- The emerging roles of Gα12/13 proteins on the hallmarks of cancer in solid tumors.
- The genetic landscape of mutations in Burkitt lymphoma.
- The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13.