S-Phase Kinase-Associated Proteins

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  Subject Areas on Research

  • CTLA-4-Mediated inhibition of early events of T cell proliferation. 
  • Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1. 
  • FBW2 targets GCMa to the ubiquitin-proteasome degradation system. 
  • Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. 
  • Immunologic targeting of FOXP3 in inflammatory breast cancer cells. 
  • Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27(Kip1) accumulation. 
  • Skp2 regulates Myc protein stability and activity. 
  • Stability of plant immune-receptor resistance proteins is controlled by SKP1-CULLIN1-F-box (SCF)-mediated protein degradation. 
  • The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 Ligase SKP2.