HCT116 Cells
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Subject Areas on Research
- A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR.
- A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.
- A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization.
- A novel conditionally replicating "armed" adenovirus selectively targeting gastrointestinal tumors with aberrant wnt signaling.
- A novel functional DEC1 promoter polymorphism -249T>C reduces risk of squamous cell carcinoma of the head and neck.
- A simplified synthesis of the hypoxia imaging agent 2-(2-Nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-[(18)F]pentafluoropropyl)-acetamide ([18F]EF5).
- Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis.
- Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.
- Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.
- Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression.
- Chemical Inhibitors of a Selective SWI/SNF Function Synergize with ATR Inhibition in Cancer Cell Killing.
- Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.
- Cytoprotective effects of IAPs revealed by a small molecule antagonist.
- Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate.
- DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions.
- Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death.
- Distinct effects of endosomal escape and inhibition of endosomal trafficking on gene delivery via electrotransfection.
- Efficient and specific gene knockdown by small interfering RNAs produced in bacteria.
- Expression level is a key determinant of E2F1-mediated cell fate.
- Genomic variation within alpha satellite DNA influences centromere location on human chromosomes with metastable epialleles.
- Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models.
- HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
- Heat induces gene amplification in cancer cells.
- High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet.
- Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C.
- Intestinal inflammation requires FOXO3 and prostaglandin E2-dependent lipogenesis and elevated lipid droplets.
- Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel Targets.
- Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication.
- Mesenchymal stem cells support growth and organization of host-liver colorectal-tumor organoids and possibly resistance to chemotherapy.
- Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line.
- Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width.
- Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells.
- Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy.
- Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo.
- Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation.
- Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.
- Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.
- Precision cancer immunotherapy: optimizing dendritic cell-based strategies to induce tumor antigen-specific T-cell responses against individual patient tumors.
- Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.
- Rare codons regulate KRas oncogenesis.
- Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis.
- Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis.
- Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism.
- Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism.
- Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress.
- The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.
- Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery.
- WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration.
- ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation.
- hBub1 negatively regulates p53 mediated early cell death upon mitotic checkpoint activation.
- miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β.
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Keywords of People
- McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
- Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology