Recombinases

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  Subject Areas on Research

  • A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. 
  • A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. 
  • A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. 
  • Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium. 
  • Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. 
  • Directed evolution of recombinase specificity by split gene reassembly. 
  • Structure-guided reprogramming of serine recombinase DNA sequence specificity. 
  • Synthesis of programmable integrases. 
  • Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies. 
  • Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase. 
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  Keywords of People

  • Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology