VDJ Recombinases
-
Subject Areas on Research
- A functional analysis of the spacer of V(D)J recombination signal sequences.
- A role for histone acetylation in the developmental regulation of VDJ recombination.
- A role for secondary V(D)J recombination in oncogenic chromosomal translocations?
- An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus.
- Developmental regulation of VDJ recombination by the core fragment of the T cell receptor alpha enhancer.
- Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T-cell receptor alpha/delta locus.
- Enhancer control of local accessibility to V(D)J recombinase.
- Flanking nuclear matrix attachment regions synergize with the T cell receptor delta enhancer to promote V(D)J recombination.
- Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB.
- Germline transcription: a key regulator of accessibility and recombination.
- Immunoglobulin gene hypermutation in germinal centers is independent of the RAG-1 V(D)J recombinase.
- Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element.
- Mechanics of T cell receptor gene rearrangement.
- Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells.
- Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization.
- Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination.
- Regulation of V(D)J recombination by E-protein transcription factors.
- Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility.
- Targeted inhibition of V(D)J recombination by a histone methyltransferase.
- The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development.
- The Ties that Bind (the Igh Locus).
- Turning T-cell receptor beta recombination on and off: more questions than answers.
- V(D)J recombinase activity in a subset of germinal center B lymphocytes.
- V(D)J recombinase-mediated processing of coding junctions at cryptic recombination signal sequences in peripheral T cells during human development.
-
Keywords of People
- Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
- Zhong, Xiaoping, Professor of Pediatrics, Integrative Immunobiology