Microarray Analysis

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  Subject Areas on Research

  • A 137-kb deletion within the Potocki-Shaffer syndrome interval on chromosome 11p11.2 associated with developmental delay and hypotonia. 
  • A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. 
  • A low-cost, scalable, current-sensing digital headstage for high channel count μECoG. 
  • A multispecies-based taxonomic microarray reveals interspecies hybridization and introgression in Saccharomyces cerevisiae. 
  • A novel array chip to monitor in situ composite degradation using electrochemical impedance spectroscopy. 
  • A pathobiological role of the insulin receptor in chronic lymphocytic leukemia. 
  • A pilot genome-wide association study shows genomic variants enriched in the non-tumor cells of patients with well-differentiated neuroendocrine tumors of the ileum. 
  • A sea of standards for omics data: sink or swim? 
  • Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. 
  • Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo. 
  • Afforestation alters the composition of functional genes in soil and biogeochemical processes in South American grasslands. 
  • Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury. 
  • An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina. 
  • An individualized predictor of health and disease using paired reference and target samples. 
  • Angle-dependent resonance of localized and propagating surface plasmons in microhole arrays for enhanced biosensing. 
  • Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. 
  • Array comparative genomic hybridisation (aCGH) analysis of premenopausal breast cancers from a nuclear fallout area and matched cases from Western New York. 
  • Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events. 
  • Assessing transcription factor motif drift from noisy decoy sequences. 
  • Association of RB/p16-pathway perturbations with DCIS recurrence: dependence on tumor versus tissue microenvironment. 
  • Bayesian semiparametric regression models for evaluating pathway effects on continuous and binary clinical outcomes. 
  • Cellular arrays for large-scale analysis of transcription factor activity. 
  • Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells. 
  • Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal. 
  • Cholangiocarcinoma: Correlation between Molecular Profiling and Imaging Phenotypes. 
  • Chromosomal microarray analysis in clinical evaluation of neurodevelopmental disorders-reporting a novel deletion of SETDB1 and illustration of counseling challenge. 
  • Clinical efficacy and immune regulation with peanut oral immunotherapy. 
  • Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems. 
  • Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis. 
  • Confirmation of TBK1 duplication in normal tension glaucoma. 
  • Convergent differential regulation of parvalbumin in the brains of vocal learners. 
  • Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer. 
  • Coordination of replication and transcription along a Drosophila chromosome. 
  • Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization. 
  • Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma. 
  • Cryptococcus neoformans gene expression during murine macrophage infection. 
  • Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model. 
  • Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolism. 
  • Detection and reporting of homozygosity associated with consanguinity in the clinical laboratory. 
  • Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients. 
  • Developmental exposure to organophosphates triggers transcriptional changes in genes associated with Parkinson's disease in vitro and in vivo. 
  • Differential evolution of peripheral cytokine levels in symptomatic and asymptomatic responses to experimental influenza virus challenge. 
  • Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain. 
  • Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. 
  • Droplet Size-Aware High-Level Synthesis for Micro-Electrode-Dot-Array Digital Microfluidic Biochips. 
  • Droplet Size-Aware and Error-Correcting Sample Preparation Using Micro-Electrode-Dot-Array Digital Microfluidic Biochips. 
  • ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration. 
  • Effects of Temperature on the Meiotic Recombination Landscape of the Yeast Saccharomyces cerevisiae. 
  • Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. 
  • Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-beta-synthase mutant mouse. 
  • Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci. 
  • Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epithelium.[corrected]. 
  • Gene Expression Profiling in the Hibernating Primate, Cheirogaleus Medius. 
  • Gene Signature of the Human Pancreatic ε Cell. 
  • Gene expression of the endolymphatic sac. 
  • Gene expression profile in human trabecular meshwork from patients with primary open-angle glaucoma. 
  • Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. 
  • Genome rearrangements caused by interstitial telomeric sequences in yeast. 
  • Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. 
  • Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae. 
  • Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. 
  • Genomic loss of miR-486 regulates tumor progression and the OLFM4 antiapoptotic factor in gastric cancer. 
  • Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival. 
  • HIV-1 Infection Primes Macrophages Through STAT Signaling to Promote Enhanced Inflammation and Viral Replication. 
  • Heterogeneity within the PF-EPN-B ependymoma subgroup. 
  • High rates of "unselected" aneuploidy and chromosome rearrangements in tel1 mec1 haploid yeast strains. 
  • High resolution analysis of genomic aberrations by metaphase and array comparative genomic hybridization identifies candidate tumour genes in lung cancer cell lines. 
  • Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm. 
  • IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver. 
  • Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome. 
  • Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. 
  • Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression. 
  • Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments. 
  • Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel. 
  • Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress. 
  • Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy. 
  • Isolation and characterization of microRNAs of human mature erythrocytes. 
  • Literature Lab: a method of automated literature interrogation to infer biology from microarray analysis. 
  • Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. 
  • Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma. 
  • MChip, a low density microarray, differentiates among seasonal human H1N1, North American swine H1N1, and the 2009 pandemic H1N1. 
  • Meeting report: high-throughput technologies for in vivo imaging agents. 
  • Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development. 
  • MicroRNA expression profiling using microarrays. 
  • Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE. 
  • Microarray-based comparison of three amplification methods for nanogram amounts of total RNA. 
  • Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers. 
  • Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis. 
  • Mild fetal ventriculomegaly: diagnosis, evaluation, and management. 
  • Model-based analysis of multiple electrode array stimulation for epiretinal visual prostheses. 
  • Molecular markers for incidence, prognosis, and response to therapy. 
  • Molecular staging of epithelial maturation using secretory cell-specific genes as markers. 
  • Mouse models of cancers: opportunities to address heterogeneity of human cancer and evaluate therapeutic strategies. 
  • NPAS1 regulates branching morphogenesis in embryonic lung. 
  • Nature and distribution of large sequence polymorphisms in Saccharomyces cerevisiae. 
  • Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice. 
  • Oxidatively modified proteins as plasma biomarkers in breast cancer. 
  • Polyreactivity and autoreactivity among HIV-1 antibodies. 
  • Prediction of autism by translation and immune/inflammation coexpressed genes in toddlers from pediatric community practices. 
  • Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia. 
  • Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. 
  • Randomized, Double-Blind, Placebo-Controlled Trial of the Effect of Vitamin D3 on the Interferon Signature in Patients With Systemic Lupus Erythematosus. 
  • Sample size considerations of prediction-validation methods in high-dimensional data for survival outcomes. 
  • Short-lag spatial coherence imaging on matrix arrays, part 1: Beamforming methods and simulation studies. 
  • Short-lag spatial coherence imaging on matrix arrays, part II: Phantom and in vivo experiments. 
  • Simultaneous detection of major drug resistance mutations in the protease and reverse transcriptase genes for HIV-1 subtype C by use of a multiplex allele-specific assay. 
  • Stem Cell Surface Marker Expression Defines Late Stages of Reprogramming to Pluripotency in Human Fibroblasts. 
  • Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia. 
  • Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad. 
  • The end game of chemical genetics: target identification. 
  • The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences. 
  • The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. 
  • The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo. 
  • Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome. 
  • Transcriptome changes affecting Hedgehog and cytokine signalling in the umbilical cord: implications for disease risk. 
  • Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. 
  • Unsupervised Bayesian linear unmixing of gene expression microarrays. 
  • Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates. 
  • Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors. 
  • Whole-animal chemical screen identifies colistin as a new immunomodulator that targets conserved pathways. 
  • Whole-genome positive selection and habitat-driven evolution in a shallow and a deep-sea urchin. 
  • miRNA expression in diffuse large B-cell lymphoma treated with chemoimmunotherapy. 
  • permGPU: Using graphics processing units in RNA microarray association studies. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Bowes Rickman, Catherine, Professor of Ophthalmology, Cell Biology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
  • Liton, Paloma Borrajo, Associate Professor in Ophthalmology, Pathology
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Pang, Herbert, Adjunct Assistant Professor in the Department of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Reddy, Timothy E, Associate Professor of Biostatistics & Bioinformatics, Molecular Genetics and Microbiology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology
  • Tenenbaum, Jessica Dale, Assistant Professor of Biostatistics & Bioinformatics, Duke Science & Society