Chimerism

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  Subject Areas on Research

  • Allogeneic hematopoietic stem-cell transplantation for leukocyte adhesion deficiency. 
  • Apoptotic Donor Cells in Transplantation. 
  • CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model. 
  • Challenges in the pursuit of immune tolerance. 
  • Comparison of outcomes of hematopoietic stem cell transplantation without chemotherapy conditioning by using matched sibling and unrelated donors for treatment of severe combined immunodeficiency. 
  • Contemporary Strategies and Barriers to Transplantation Tolerance. 
  • Do We Need Full Donor Chimerism? How Alloreactive Cell Therapies without Substantial Engraftment Might Treat Hematologic Cancers. 
  • Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy. 
  • Durable Chimerism and Long-Term Survival after Unrelated Umbilical Cord Blood Transplantation for Pediatric Hemophagocytic Lymphohistiocytosis: A Single-Center Experience. 
  • Epstein-Barr-associated leiomyomatosis and T-cell chimerism after haploidentical bone marrow transplantation for severe combined immunodeficiency disease. 
  • Evidence for kidney rejection after combined bone marrow and renal transplantation despite ongoing whole-blood chimerism in rhesus macaques. 
  • Extranodal lymphoid microstructures in inflamed muscle and disease severity of new-onset juvenile dermatomyositis. 
  • Hematopoietic Stem Cell Transplantation in ADA2 Deficiency: Early Restoration of ADA2 Enzyme Activity and Disease Relapse upon Drop of Donor Chimerism. 
  • In vivo engineering of bone tissues with hematopoietic functions and mixed chimerism. 
  • Is tolerance induction the answer to adolescent non-adherence? 
  • Low-dose total-body irradiation and alemtuzumab-based reduced-intensity conditioning regimen results in durable engraftment and correction of clinical disease among children with chronic granulomatous disease. 
  • Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. 
  • Maternal microchimerism in Hirschsprung's disease. 
  • No evidence for maternal-fetal microchimerism in infantile hemangioma: a molecular genetic investigation. 
  • Standardizing Definitions of Hematopoietic Recovery, Graft Rejection, Graft Failure, Poor Graft Function, and Donor Chimerism in Allogeneic Hematopoietic Cell Transplantation: A Report on Behalf of the American Society for Transplantation and Cellular Therapy. 
  • The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation. 
  • The fetal allograft revisited: does the study of an ancient invertebrate species shed light on the role of natural killer cells at the maternal-fetal interface? 
  • Translational impact of NIH-funded nonhuman primate research in transplantation. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
  • Chen, Jun, Professor of Medicine, Duke Cancer Institute
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology