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Subject Areas on Research
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A biophysical model of the cortex-basal ganglia-thalamus network in the 6-OHDA lesioned rat model of Parkinson's disease.
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A method to estimate the spatial extent of activation in thalamic deep brain stimulation.
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A model predicting optimal parameters for deep brain stimulation in essential tremor.
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Acute readmission following deep brain stimulation surgery for Parkinson's disease: A nationwide analysis.
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Amplitude- and frequency-dependent changes in neuronal regularity parallel changes in tremor With thalamic deep brain stimulation.
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Analysis of deep brain stimulation electrode characteristics for neural recording.
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Analysis of the time course of the effect of subthalamic nucleus stimulation upon hand function in Parkinson's patients.
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Anatomical variability predicts individual differences in transcranial electric stimulation motor threshold.
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Antidromic propagation of action potentials in branched axons: implications for the mechanisms of action of deep brain stimulation.
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Automated Deep Brain Stimulation Programming for Tremor.
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Automatic localization of the subthalamic nucleus on patient-specific clinical MRI by incorporating 7 T MRI and machine learning: Application in deep brain stimulation.
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Before and after the veterans affairs cooperative program 468 study: Deep brain stimulator target selection for treatment of Parkinson's disease.
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Benefits and risks of unilateral and bilateral ventral intermediate nucleus deep brain stimulation for axial essential tremor symptoms.
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Brain stimulation in neurology and psychiatry: perspectives on an evolving field.
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Brain stimulation in neuropsychiatry.
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Characterization of pallidocortical motor network in Parkinson's disease through complex network analysis.
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Characterizing effects of subthalamic nucleus deep brain stimulation on methamphetamine-induced circling behavior in hemi-Parkinsonian rats.
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Chronic spinal cord electrical stimulation protects against 6-hydroxydopamine lesions.
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Clinical response to varying the stimulus parameters in deep brain stimulation for essential tremor.
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Closed-loop control of deep brain stimulation: a simulation study.
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Comparison of Bilateral vs. Staged Unilateral Deep Brain Stimulation (DBS) in Parkinson's Disease in Patients Under 70 Years of Age.
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Comparison of Deep Brain Stimulation Lead Targeting Accuracy and Procedure Duration between 1.5- and 3-Tesla Interventional Magnetic Resonance Imaging Systems: An Initial 12-Month Experience.
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Computer-based model of epidural motor cortex stimulation: effects of electrode position and geometry on activation of cortical neurons.
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Continuous deep brain stimulation of the subthalamic nucleus may not modulate beta bursts in patients with Parkinson's disease.
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Correlation of diffusion tensor tractography and intraoperative macrostimulation during deep brain stimulation for Parkinson disease.
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Cortical stimulation in conscious rats controls joint inflammation.
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Creating and parameterizing patient-specific deep brain stimulation pathway-activation models using the hyperdirect pathway as an example.
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Current density distributions, field distributions and impedance analysis of segmented deep brain stimulation electrodes.
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Deep brain stimulation alleviates parkinsonian bradykinesia by regularizing pallidal activity.
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Deep brain stimulation and ablation for obsessive compulsive disorder: evolution of contemporary indications, targets and techniques.
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Deep brain stimulation as a mode of treatment of early onset pantothenate kinase-associated neurodegeneration.
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Deep brain stimulation for Parkinson disease in elderly individuals—reply.
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Deep brain stimulation of the subthalamic nucleus reestablishes neuronal information transmission in the 6-OHDA rat model of parkinsonism.
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Deep brain stimulation reduces neuronal entropy in the MPTP-primate model of Parkinson's disease.
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Deep brain stimulation shape and surface characteristics: electrical and mechanical design goals.
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Deep brain stimulation that abolishes Parkinsonian activity in basal ganglia improves thalamic relay fidelity in a computational circuit.
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Design and in vivo evaluation of more efficient and selective deep brain stimulation electrodes.
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Disrupting abnormal electrical activity with deep brain stimulation: is epilepsy the next frontier?
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Effect of advancing age on outcomes of deep brain stimulation for Parkinson disease.
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Effective deep brain stimulation suppresses low-frequency network oscillations in the basal ganglia by regularizing neural firing patterns.
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Effects of ramped-frequency thalamic deep brain stimulation on tremor and activity of modeled neurons.
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Electroconvulsive therapy in the presence of deep brain stimulation implants: electric field effects.
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Evaluation of high-perimeter electrode designs for deep brain stimulation.
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Factors related to extended hospital stays following deep brain stimulation for Parkinson's disease.
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Failure to suppress low-frequency neuronal oscillatory activity underlies the reduced effectiveness of random patterns of deep brain stimulation.
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Feasibility of using ultra-high field (7 T) MRI for clinical surgical targeting.
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Frequency-Specific Optogenetic Deep Brain Stimulation of Subthalamic Nucleus Improves Parkinsonian Motor Behaviors.
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Frequency-dependent antidromic activation in thalamocortical relay neurons: effects of synaptic inputs.
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Frequency-dependent, transient effects of subthalamic nucleus deep brain stimulation on methamphetamine-induced circling and neuronal activity in the hemiparkinsonian rat.
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Gustatory and reward brain circuits in the control of food intake.
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High efficiency electrodes for deep brain stimulation.
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How does deep brain stimulation work?
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Impact of advancing age on post-operative complications of deep brain stimulation surgery for essential tremor.
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Impedance characteristics of deep brain stimulation electrodes in vitro and in vivo.
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Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease.
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Influences of interpolation error, electrode geometry, and the electrode-tissue interface on models of electric fields produced by deep brain stimulation.
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Instrumentation to record evoked potentials for closed-loop control of deep brain stimulation.
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Intractable Blepharospasm Treated with Bilateral Pallidal Deep Brain Stimulation.
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Investigation of deep brain stimulation mechanisms during implantable pulse generator replacement surgery.
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Measurement of evoked potentials during thalamic deep brain stimulation.
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Mechanisms of deep brain stimulation in movement disorders as revealed by changes in stimulus frequency.
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Microelectrode Recordings Validate the Clinical Visualization of Subthalamic-Nucleus Based on 7T Magnetic Resonance Imaging and Machine Learning for Deep Brain Stimulation Surgery.
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Modeling deep brain stimulation: point source approximation versus realistic representation of the electrode.
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Motor cortex stimulation and neuropathic facial pain.
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Myoclonus and tremor response to thalamic deep brain stimulation parameters in a patient with inherited myoclonus-dystonia syndrome.
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Neural origin of evoked potentials during thalamic deep brain stimulation.
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Neuropsychologic effects of neuromodulation techniques for treatment-resistant depression: a review.
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Neuropsychological function before and after subcallosal cingulate deep brain stimulation in patients with treatment-resistant depression.
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Neurosurgical Device-Related Infections.
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Optimized temporal pattern of brain stimulation designed by computational evolution.
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Patient Experience with Rechargeable Implantable Pulse Generator Deep Brain Stimulation for Movement Disorders.
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Patient-specific anatomical model for deep brain stimulation based on 7 Tesla MRI.
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Patterned low-frequency deep brain stimulation induces motor deficits and modulates cortex-basal ganglia neural activity in healthy rats.
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Postmortem diffusion MRI of the human brainstem and thalamus for deep brain stimulator electrode localization.
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Precision non-implantable neuromodulation therapies: a perspective for the depressed brain.
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Pulse-to-pulse changes in the frequency of deep brain stimulation affect tremor and modeled neuronal activity.
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Recording evoked potentials during deep brain stimulation: development and validation of instrumentation to suppress the stimulus artefact.
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Relative contributions of local cell and passing fiber activation and silencing to changes in thalamic fidelity during deep brain stimulation and lesioning: a computational modeling study.
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Safety considerations for deep brain stimulation: review and analysis.
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Sensory percepts induced by microwire array and DBS microstimulation in human sensory thalamus.
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Separating hope from hype: some ethical implications of the development of deep brain stimulation in psychiatric research and treatment.
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Short pauses in thalamic deep brain stimulation promote tremor and neuronal bursting.
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Smart neuromodulation in movement disorders.
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Somatic treatments for mood disorders.
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Speech motor program maintenance, but not switching, is enhanced by left-hemispheric deep brain stimulation in Parkinson's disease.
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Stimulation Efficiency With Decaying Exponential Waveforms in a Wirelessly Powered Switched-Capacitor Discharge Stimulation System.
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Stimulus features underlying reduced tremor suppression with temporally patterned deep brain stimulation.
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Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial.
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Subcortical neuronal ensembles: an analysis of motor task association, tremor, oscillations, and synchrony in human patients.
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Surgical Treatment of Parkinson Disease.
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Temporal excitation properties of paresthesias evoked by thalamic microstimulation.
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Temporo-parietal junction stimulation in the treatment of depersonalization disorder.
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The Emerging Role of Biomarkers in Adaptive Modulation of Clinical Brain Stimulation.
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The appropriate use of neurostimulation: stimulation of the intracranial and extracranial space and head for chronic pain. Neuromodulation Appropriateness Consensus Committee.
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The ethics of research on deep brain stimulation for depression: decisional capacity and therapeutic misconception.
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Transcranial magnetic stimulation in the presence of deep brain stimulation implants: Induced electrode currents.
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Tremor reduction and modeled neural activity during cycling thalamic deep brain stimulation.
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Tremor varies as a function of the temporal regularity of deep brain stimulation.
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Unified thalamic model generates multiple distinct oscillations with state-dependent entrainment by stimulation.
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When they go low, we go high.
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Keywords of People
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Clyde, Merlise,
Professor of Statistical Science,
Statistical Science
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McClintock, Shawn Michael,
Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences,
Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology
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Nicolelis, Miguel Angelo L.,
Duke School of Medicine Professor in Neuroscience,
Psychology and Neuroscience
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Turner, Dennis Alan,
Professor of Neurosurgery,
Biomedical Engineering