Deep Brain Stimulation

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  Subject Areas on Research

  • A biophysical model of the cortex-basal ganglia-thalamus network in the 6-OHDA lesioned rat model of Parkinson's disease. 
  • A method to estimate the spatial extent of activation in thalamic deep brain stimulation. 
  • A model predicting optimal parameters for deep brain stimulation in essential tremor. 
  • Amplitude- and frequency-dependent changes in neuronal regularity parallel changes in tremor With thalamic deep brain stimulation. 
  • Analysis of deep brain stimulation electrode characteristics for neural recording. 
  • Analysis of the time course of the effect of subthalamic nucleus stimulation upon hand function in Parkinson's patients. 
  • Anatomical variability predicts individual differences in transcranial electric stimulation motor threshold. 
  • Antidromic propagation of action potentials in branched axons: implications for the mechanisms of action of deep brain stimulation. 
  • Automated Deep Brain Stimulation Programming for Tremor. 
  • Available and emerging treatments for Parkinson's disease: a review. 
  • Before and after the veterans affairs cooperative program 468 study: Deep brain stimulator target selection for treatment of Parkinson's disease. 
  • Brain stimulation in neurology and psychiatry: perspectives on an evolving field. 
  • Brain stimulation in neuropsychiatry. 
  • Characterizing effects of subthalamic nucleus deep brain stimulation on methamphetamine-induced circling behavior in hemi-Parkinsonian rats. 
  • Chronic spinal cord electrical stimulation protects against 6-hydroxydopamine lesions. 
  • Clinical response to varying the stimulus parameters in deep brain stimulation for essential tremor. 
  • Closed-loop control of deep brain stimulation: a simulation study. 
  • Comparison of Bilateral vs. Staged Unilateral Deep Brain Stimulation (DBS) in Parkinson's Disease in Patients Under 70 Years of Age. 
  • Comparison of Deep Brain Stimulation Lead Targeting Accuracy and Procedure Duration between 1.5- and 3-Tesla Interventional Magnetic Resonance Imaging Systems: An Initial 12-Month Experience. 
  • Computer-based model of epidural motor cortex stimulation: effects of electrode position and geometry on activation of cortical neurons. 
  • Correlation of diffusion tensor tractography and intraoperative macrostimulation during deep brain stimulation for Parkinson disease. 
  • Creating and parameterizing patient-specific deep brain stimulation pathway-activation models using the hyperdirect pathway as an example. 
  • Current density distributions, field distributions and impedance analysis of segmented deep brain stimulation electrodes. 
  • Deep brain stimulation alleviates parkinsonian bradykinesia by regularizing pallidal activity. 
  • Deep brain stimulation and ablation for obsessive compulsive disorder: evolution of contemporary indications, targets and techniques. 
  • Deep brain stimulation as a mode of treatment of early onset pantothenate kinase-associated neurodegeneration. 
  • Deep brain stimulation for Parkinson disease in elderly individuals—reply. 
  • Deep brain stimulation of the subthalamic nucleus reestablishes neuronal information transmission in the 6-OHDA rat model of parkinsonism. 
  • Deep brain stimulation reduces neuronal entropy in the MPTP-primate model of Parkinson's disease. 
  • Deep brain stimulation shape and surface characteristics: electrical and mechanical design goals. 
  • Deep brain stimulation that abolishes Parkinsonian activity in basal ganglia improves thalamic relay fidelity in a computational circuit. 
  • Design and in vivo evaluation of more efficient and selective deep brain stimulation electrodes. 
  • Disrupting abnormal electrical activity with deep brain stimulation: is epilepsy the next frontier? 
  • Effect of advancing age on outcomes of deep brain stimulation for Parkinson disease. 
  • Effective deep brain stimulation suppresses low-frequency network oscillations in the basal ganglia by regularizing neural firing patterns. 
  • Electroconvulsive therapy in the presence of deep brain stimulation implants: electric field effects. 
  • Evaluation of high-perimeter electrode designs for deep brain stimulation. 
  • Factors related to extended hospital stays following deep brain stimulation for Parkinson's disease. 
  • Failure to suppress low-frequency neuronal oscillatory activity underlies the reduced effectiveness of random patterns of deep brain stimulation. 
  • Feasibility of using ultra-high field (7 T) MRI for clinical surgical targeting. 
  • Frequency-dependent, transient effects of subthalamic nucleus deep brain stimulation on methamphetamine-induced circling and neuronal activity in the hemiparkinsonian rat. 
  • Gustatory and reward brain circuits in the control of food intake. 
  • High efficiency electrodes for deep brain stimulation. 
  • How does deep brain stimulation work? 
  • Impact of advancing age on post-operative complications of deep brain stimulation surgery for essential tremor. 
  • Impedance characteristics of deep brain stimulation electrodes in vitro and in vivo. 
  • Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease. 
  • Impulsive and compulsive behaviors in Parkinson's disease. 
  • Influences of interpolation error, electrode geometry, and the electrode-tissue interface on models of electric fields produced by deep brain stimulation. 
  • Instrumentation to record evoked potentials for closed-loop control of deep brain stimulation. 
  • Intractable Blepharospasm Treated with Bilateral Pallidal Deep Brain Stimulation. 
  • Investigation of deep brain stimulation mechanisms during implantable pulse generator replacement surgery. 
  • Measurement of evoked potentials during thalamic deep brain stimulation. 
  • Mechanisms of deep brain stimulation in movement disorders as revealed by changes in stimulus frequency. 
  • Modeling deep brain stimulation: point source approximation versus realistic representation of the electrode. 
  • Motor cortex stimulation and neuropathic facial pain. 
  • Myoclonus and tremor response to thalamic deep brain stimulation parameters in a patient with inherited myoclonus-dystonia syndrome. 
  • Neural origin of evoked potentials during thalamic deep brain stimulation. 
  • Neuropsychologic effects of neuromodulation techniques for treatment-resistant depression: a review. 
  • Neuropsychological function before and after subcallosal cingulate deep brain stimulation in patients with treatment-resistant depression. 
  • Neurosurgical Device-Related Infections. 
  • Optimized temporal pattern of brain stimulation designed by computational evolution. 
  • Patient-specific anatomical model for deep brain stimulation based on 7 Tesla MRI. 
  • Patterned low-frequency deep brain stimulation induces motor deficits and modulates cortex-basal ganglia neural activity in healthy rats. 
  • Postmortem diffusion MRI of the human brainstem and thalamus for deep brain stimulator electrode localization. 
  • Potential utility of optogenetics in the study of depression. 
  • Pulse-to-pulse changes in the frequency of deep brain stimulation affect tremor and modeled neuronal activity. 
  • Recording evoked potentials during deep brain stimulation: development and validation of instrumentation to suppress the stimulus artefact. 
  • Relative contributions of local cell and passing fiber activation and silencing to changes in thalamic fidelity during deep brain stimulation and lesioning: a computational modeling study. 
  • Safety considerations for deep brain stimulation: review and analysis. 
  • Sensory percepts induced by microwire array and DBS microstimulation in human sensory thalamus. 
  • Separating hope from hype: some ethical implications of the development of deep brain stimulation in psychiatric research and treatment. 
  • Short pauses in thalamic deep brain stimulation promote tremor and neuronal bursting. 
  • Somatic treatments for mood disorders. 
  • Speech motor program maintenance, but not switching, is enhanced by left-hemispheric deep brain stimulation in Parkinson's disease. 
  • Stimulation Efficiency With Decaying Exponential Waveforms in a Wirelessly Powered Switched-Capacitor Discharge Stimulation System. 
  • Stimulus features underlying reduced tremor suppression with temporally patterned deep brain stimulation. 
  • Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial. 
  • Subcortical neuronal ensembles: an analysis of motor task association, tremor, oscillations, and synchrony in human patients. 
  • Susceptibility-enhanced 3-Tesla T1-weighted spoiled gradient echo of the midbrain nuclei for guidance of deep brain stimulation implantation. 
  • Temporal excitation properties of paresthesias evoked by thalamic microstimulation. 
  • Temporo-parietal junction stimulation in the treatment of depersonalization disorder. 
  • The appropriate use of neurostimulation: stimulation of the intracranial and extracranial space and head for chronic pain. Neuromodulation Appropriateness Consensus Committee. 
  • The ethics of research on deep brain stimulation for depression: decisional capacity and therapeutic misconception. 
  • Transcranial magnetic stimulation in the presence of deep brain stimulation implants: Induced electrode currents. 
  • Tremor reduction and modeled neural activity during cycling thalamic deep brain stimulation. 
  • Tremor varies as a function of the temporal regularity of deep brain stimulation. 
  • Unified thalamic model generates multiple distinct oscillations with state-dependent entrainment by stimulation. 
  • When they go low, we go high. 
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  Keywords of People

  • Chen, Nan-kuei, Adjunct Associate Professor in the Department of Radiology, Radiology
  • Clyde, Merlise, Professor of Statistical Science, Statistical Science
  • McClintock, Shawn Michael, Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology
  • Nicolelis, Miguel Angelo L., Duke School of Medicine Professor in Neuroscience, Psychology and Neuroscience
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering
  • Watson, Glenn, Postdoctoral Associate, Psychology and Neuroscience