Macromolecular Substances
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Subject Areas on Research
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A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol.
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A Sephadex dialysis method of determining small molecule-macromolecule binding constants.
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A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1.
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A conserved region in alpha-macroglobulins participates in binding to the mammalian alpha-macroglobulin receptor.
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A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation.
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A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production.
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A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.
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A kinetic study of the subunit dissociation and reassembly of rabbit muscle phosphofructokinase.
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A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs.
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A new function for adducin. Calcium/calmodulin-regulated capping of the barbed ends of actin filaments.
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A new purification procedure for bovine milk xanthine oxidase: effect of proteolysis on the subunit structure.
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A new view of convective-diffusive transport processes in the arterial intima.
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A six-armed oligomer isolated from cell surface fibronectin preparations.
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A source of bias in the analysis of single channel data: assessing the apparent interaction between channel proteins.
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A study of the binding of thiamine diphosphate and thiochrome diphosphate to the pyruvate dehydrogenase multienzyme complex.
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A surface of Escherichia coli sigma 70 required for promoter function and antitermination by phage lambda Q protein.
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A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor.
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A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast.
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A unique placental lactogen receptor: implications for fetal growth.
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Actin and myosin function in acanthamoeba.
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Actin dynamics: the arp2/3 complex branches out.
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Activated conformers of Escherichia coli sulfite reductase heme protein subunit.
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Activation of human plasminogen by urokinase. Partial characterization of a pre-activation peptide.
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Activation of phenylalanine hydroxylase by phenylalanine.
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Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons.
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Adenovirus-mediated expression of the catalytic subunit of glucose-6-phosphatase in INS-1 cells. Effects on glucose cycling, glucose usage, and insulin secretion.
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Adhesin presentation in bacteria requires molecular chaperones and ushers.
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Affinity chromatography of H+-translocating adenosine triphosphatase isolated by chloroform extraction of Rhodospirillum rubrum chromatophores. Modification of binding affinity by divalent cations and activating anions.
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Aggregation of rabbit muscle phosphofructokinase.
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Alkaline low spin form of sulfite reductase hemeprotein subunit.
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Allosteric interactions in non-alpha chains isolated from normal human hemoglobin, fetal hemoglobin, and hemoglobin Abruzzo (beta143 (H21) His replaced by Arg).
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Alpha 2-macroglobulin is a binding protein for basic fibroblast growth factor.
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Alpha-adducin dissociates from F-actin and spectrin during platelet activation.
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Alpha-crystallin, a molecular chaperone, forms a stable complex with carbonic anhydrase upon heat denaturation.
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Altered ultrastructural morphology of self-aggregated low density lipoproteins: coalescence of lipid domains forming droplets and vesicles.
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Amanitin-resistant RNA polymerase II mutations are in the enzyme's largest subunit.
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Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase.
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Amphitrite ornata erythrocruorin. II. Molecular controls of function.
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Amyloidogenic and anti-amyloidogenic properties of recombinant transthyretin variants.
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An NMR study of the rates of single-molecule exchange in a cylindrical host capsule.
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An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles.
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An equilibrium binding study of the interaction of aspartate transcarbamylase with cytidine 5'-triphosphate and adenosine 5'-triphosphate.
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An equilibrium binding study of the interaction of fructose 6-phosphate and fructose 1,6-bisphosphate with rabbit muscle phosphofructokinase.
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Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan.
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Analysis of the effect of three different allosteric ligands on oxygen binding by hemocyanin of the shrimp, Penaeus setiferus.
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Analysis of the gene encoding the largest subunit of RNA polymerase II in Drosophila.
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Analysis of the role of E2A-encoded proteins in insulin gene transcription.
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Ankyrin and spectrin associate with voltage-dependent sodium channels in brain.
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Anti-inflammatory effects of pentoxifylline in claudication.
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Anti-sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens.
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Application of singular value decomposition to the analysis of time-resolved macromolecular x-ray data.
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Assay of G-protein beta gamma-subunit complex by catalytic support of ADP-ribosylation of Go alpha.
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Assembly and calcium-induced cooperativity of Limulus IV hemocyanin: a model system for analysis of structure-function relationships in the absence of subunit heterogeneity.
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Assembly of a chemically synthesized peptide of Escherichia coli type 1 fimbriae into fimbria-like antigenic structures.
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Assembly of microtubules from preformed, ring-shaped protofilaments and 6-S tubulin.
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Assembly of pure tubulin in the absence of free GTP: effect of magnesium, glycerol, ATP, and the nonhydrolyzable GTP analogues.
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Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16.
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Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor.
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Automated image acquisition and processing using a new generation of 4K x 4K CCD cameras for cryo electron microscopic studies of macromolecular assemblies.
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Automated systematic evaluation of cryo-EM specimens with SmartScope.
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Available space and extracellular transport of macromolecules: effects of pore size and connectedness.
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Available volume fraction of macromolecules in the extravascular space of a fibrosarcoma: implications for drug delivery.
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Avidin-biotin interactions at vesicle surfaces: adsorption and binding, cross-bridge formation, and lateral interactions.
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Bacterial cell division protein FtsZ assembles into protofilament sheets and minirings, structural homologs of tubulin polymers.
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Beam image-shift accelerated data acquisition for near-atomic resolution single-particle cryo-electron tomography.
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Beta-Arrestins: new roles in regulating heptahelical receptors' functions.
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Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.
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Binding and endocytosis of alpha 2-macroglobulin-plasmin complexes.
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Binding stoichiometry and structural mapping of the epsilon polypeptide of chloroplast coupling factor 1.
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Biochemical characterization of the adrenergic receptors: affinity labeling, purification, and reconstitution studies.
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Brain adducin: a protein kinase C substrate that may mediate site-directed assembly at the spectrin-actin junction.
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Brain ankyrin. A membrane-associated protein with binding sites for spectrin, tubulin, and the cytoplasmic domain of the erythrocyte anion channel.
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Brain spectrin. Isolation of subunits and formation of hybrids with erythrocyte spectrin subunits.
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CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
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Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit.
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Calcium control of muscle phosphorylase kinase through the combined action of calmodulin and troponin.
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Calcium/calmodulin inhibits direct binding of spectrin to synaptosomal membranes.
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Calmodulin as an integral subunit of phosphorylase kinase from rabbit skeletal muscle.
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Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X-receptors.
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Characterization of CD8(-) HLA class I/epitope tetrameric complexes binding T cells.
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Characterization of a Ca2+-calmodulin-stimulated cyclic GMP phosphodiesterase from bovine brain.
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Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies.
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Characterization of a partial cDNA for lysyl hydroxylase from human skin fibroblasts; lysyl hydroxylase mRNAs are regulated differently by minoxidil derivatives and hydralazine.
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Characterization of acetylcholine receptor isolated from Torpedo californica electroplax through the use of an easily removable detergent, beta-D-octylglucopyranoside.
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Characterization of alpha 2-macroglobulin-plasmin complexes: complete subunit cleavage alters receptor recognition in vivo and in vitro.
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Characterization of fragment E from fibrinogen and cross-linked fibrin.
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Characterization of human alpha 2-macroglobulin monomers obtained by reduction with dithiothreitol.
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Characterization of microtubule-associated protein MAP1B: phosphorylation state, light chains, and binding to microtubules.
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Characterization of murine peritoneal macrophage receptors for fibrin(ogen) degradation products.
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Characterization of myosin heavy chain by cyanogen bromide peptide maps.
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Characterization of three-subunit chloroplast coupling factor.
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Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically 13C- and 15N-Labeled DNA.
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Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
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Charge transfer in dynamical biosystems, or the treachery of (static) images.
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Chemical cross-linking studies of chloroplast coupling factor 1.
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Chemical modification and fluorescence studies of chloroplast coupling factor.
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Chemoattractant receptors on phagocytic cells.
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Chloroplast coupling factor 1: dependence of rotational correlation time on polypeptide composition.
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Clathrin-coated vesicle assembly polypeptides: physical properties and reconstitution studies with brain membranes.
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Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65.
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Co-operative interactions between troponin-tropomyosin units extend the length of the thin filament in skeletal muscle.
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Co-operativity in protein-protein association. The structure and stability of the actin filament.
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Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate.
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Colocalization of band 3 with ankyrin and spectrin at the basal membrane of intercalated cells in the rat kidney.
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Competition in oxygen-linked anion binding to normal and variant human hemoglobins.
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Complete purification of dog renal renin.
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Computational studies of small carbon and iron-carbon systems relevant to carbon nanotube growth.
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Conformation and protease binding activity of binary and ternary human alpha 2-macroglobulin-protease complexes.
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Conformational kinetics reveals affinities of protein conformational states.
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Contribution of macromolecules to brain 1 H MR spectra: Experts' consensus recommendations.
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Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit.
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Cooperation among multiple transcription factors is required for access to minimal T-cell receptor alpha-enhancer chromatin in vivo.
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Coping with polypharmacology by computational medicinal chemistry.
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Counting on natural products for drug design.
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Cross-linked fibrinogen dimers demonstrate a feature of the molecular packing in fibrin fibers.
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Cross-linking of fibrin by fibrin=stabilizing factor.
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Crossover interference on nucleolus organizing region-bearing chromosomes in Arabidopsis.
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Cryo-electron microscopy--a primer for the non-microscopist.
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Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue.
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Crystallization of a complex of cro repressor with a 17 base-pair operator.
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Crystallization of succinylated concanavalin A bound to a synthetic bivalent ligand and preliminary structural analysis.
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Crystallization of the bifunctional biotin operon repressor.
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Cytochrome oxidase: structural insights from electron microscopy and from secondary structure prediction.
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Cytosolic delivery of macromolecules. 3. Synthesis and characterization of acid-sensitive bis-detergents.
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Cytosolic delivery of macromolecules. II. Mechanistic studies with pH-sensitive morpholine lipids.
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Cytosolic delivery of macromolecules: I. Synthesis and characterization of pH-sensitive acyloxyalkylimidazoles.
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DNA and RNA topoisomerase activities of Top3β are promoted by mediator protein Tudor domain-containing protein 3.
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Deep UV nano-microstructuring of substrates for surface plasmon resonance imaging.
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Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia.
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Definition of the critical cellular components which distinguish between hormone and antihormone activated progesterone receptor.
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Degradation of von Willebrand factor in patients with acquired clinical conditions in which there is heightened proteolysis.
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Describing patterns of protein tertiary structure.
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Desmoplakin I and desmoplakin II. Purification and characterization.
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Determinants of PF4/heparin immunogenicity.
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Development of human protein reference database as an initial platform for approaching systems biology in humans.
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Differences in the regulation of messenger RNA for housekeeping and specialized-cell ferritin. A comparison of three distinct ferritin complementary DNAs, the corresponding subunits, and identification of the first processed in amphibia.
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Different dimerization activities of alpha and beta thyroid hormone receptor isoforms.
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Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication.
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Differential expression of gamma-aminobutyric acidA receptor subunits.
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Direct localization of monoclonal antibody-binding sites on Acanthamoeba myosin-II and inhibition of filament formation by antibodies that bind to specific sites on the myosin-II tail.
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Distinct combinations of NF-kappa B subunits determine the specificity of transcriptional activation.
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Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells.
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Drosophila spectrin. II. Conserved features of the alpha-subunit are revealed by analysis of cDNA clones and fusion proteins.
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Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation.
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Drosophilia spectrin. I. Characterization of the purified protein.
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Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo.
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Editorial overview: Nucleic acids and their protein complexes: Progress in nucleic acid structural biology: new technologies and discoveries.
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Effect of fluid shear stress on the permeability of the arterial endothelium.
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Effect of heme and non-heme ligands on subunit dissociation of normal and carboxypeptidase-digested hemoglobin. Gel filtration and flash photolysis studies.
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Effect of oxygen and allosteric effects on structural stability of oligomeric hemocyanins of the arthropod, Limulus polyphemus, and the mollusc, Helix pomatia.
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Effect of pH and anions on functional properties of hemoglobin from Lemur fulvus fulvus.
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Effect of tissue transglutaminase on the solubility of proteins containing expanded polyglutamine repeats.
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Effects of diethyldithiocarbamate and nine other nucleophiles on the intersubunit protein cross-linking and inactivation of purified human alpha 2-macroglobulin by cis-diamminedichloroplatinum(II).
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Effects of maternal nicotine injections on brain development in the rat: ornithine decarboxylase activity, nucleic acids and proteins in discrete brain regions.
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Electron microscope study of native and crosslinked rabbit muscle phosphofructokinase.
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Electron microscopy of human factor VIII/Von Willebrand glycoprotein: effect of reducing reagents on structure and function.
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Electron microscopy studies of alpha 2-macroglobulin subunit association after limited reduction with dithiothreitol.
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Electron paramagnetic resonance and optical spectroscopic evidence for interaction between siroheme and Fe4S4 prosthetic groups in Escherichia coli sulfite reductase hemoprotein subunit.
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Emergent mechanical properties of self-assembled polymeric capsules.
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Engineered chimeric streptavidin tetramers as novel tools for bioseparations and drug delivery.
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Engineered leucine zippers show that hemiphosphorylated CREB complexes are transcriptionally active.
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Epitope mapping of the von Willebrand factor subunit distinguishes fragments present in normal and type IIA von Willebrand disease from those generated by plasmin.
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Evidence for two cellular pathways of renin secretion by the mouse submandibular gland.
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Evidence of a role for heterotrimeric GTP-binding proteins in endosome fusion.
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Expanded polyglutamine stretches form an 'aggresome'.
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Exploitation of intracellular pH gradients in the cellular delivery of macromolecules.
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Expression and localization of components of the histone deacetylases multiprotein repressory complexes in the mouse preimplantation embryo.
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Fabrication of gold nanowires by electric-field-induced scanning probe lithography and in situ chemical development.
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Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations.
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Fibronectin molecule visualized in electron microscopy: a long, thin, flexible strand.
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Flory theorem for structurally asymmetric mixtures
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Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium.
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Force measurements of the alpha5beta1 integrin-fibronectin interaction.
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Functional analysis of a type IIB von Willebrand disease missense mutation: increased binding of large von Willebrand factor multimers to platelets.
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Functional and structural properties of Murex fulvescens hemocyanin: isolation of two different subunits required for reassociation of a molluscan hemocyanin.
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Functional consequences of ligand-linked dissociation in hemoglobin from the sea cucumber Molpadia arenicola.
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Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein.
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Functional equivalence of monomeric (shark) and dimeric (bovine) cytochrome c oxidase.
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Functional properties of hemoglobin Pôrto Alegre (alpha2A beta2 9Ser leads to Cys) and the reactivity of its extra cysteinyl residue.
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Functional studies on crosslinked bovine cytochrome c oxidase.
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Functionalized few-walled carbon nanotubes for mechanical reinforcement of polymeric composites.
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Functionalized graphene sheets for polymer nanocomposites.
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G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha.
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G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
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G protein gamma subunits contain a 20-carbon isoprenoid.
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G protein involvement in receptor-effector coupling.
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G proteins control diverse pathways of transmembrane signaling.
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G proteins. The subunit story thickens.
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G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.
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Generation of high curvature membranes mediated by direct endophilin bilayer interactions.
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Glucocorticoids regulate the development of intracellular signaling: enhanced forebrain adenylate cyclase catalytic subunit activity after fetal dexamethasone exposure.
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Gradated assembly of multiple proteins into supramolecular nanomaterials.
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Gz, a guanine nucleotide-binding protein with unique biochemical properties.
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HIV-1 infection of human T lymphocytes results in enhanced alpha 5 beta 1 integrin expression.
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HLA-A2 mutants immunoselected in vitro. Definition of residues contributing to an HLA-A2-specific serological determinant.
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HMW-2, the Sertoli cell cytoplasmic dynein from rat testis, is a dimer composed of nearly identical subunits.
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Hemocyanins in spiders, XIII. Kinetics of oxygen dissociation from individual subunits of Eurypelma and Cupiennius hemocyanin.
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Hemoglobin of the electric Atlantic torpedo, Torpedo nobiliana: a cooperative hemoglobin without Bohr effects.
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Hemoglobins of the tadpole of the bullfrog, Rana catesbeiana. pH dependence of ligand binding and subunit dissociation equilibria and kinetics.
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Hemoglobins of two terebellid polychaetes: Enoplobranchus sanguineus and Amphitrite ornata.
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High level expression of mammalian protein farnesyltransferase in a baculovirus system. The purified protein contains zinc.
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High-level synthesis of biologically active reovirus protein sigma 1 in a mammalian expression vector system.
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High-resolution structure determination using high-throughput electron cryo-tomography.
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Highly selective water channel activity measured by voltage clamp: analysis of planar lipid bilayers reconstituted with purified AqpZ.
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Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.
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Human Factor XIII from plasma and platelets. Molecular weights, subunit structures, proteolytic activation, and cross-linking of fibrinogen and fibrin.
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Human G(alpha q): cDNA and tissue distribution.
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Human T cell receptor-gamma and -delta chain pairing analyzed by transfection of a T cell receptor-delta negative mutant cell line.
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Human erythrocyte clathrin and clathrin-uncoating protein.
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Human erythrocyte spectrin: phosphorylation in intact cells and purification of the 32P-labeled protein in a non-aggregated state.
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Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.
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Human substance P receptor expressed in Chinese hamster ovary cells directly activates G(alpha q/11), G(alpha s), G(alpha o).
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Huntington's-chorea fibroblasts. Cellular protein glycosylation.
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Identification of "embryonin" as bovine alpha 2-macroglobulin.
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Identification of a new family of protein phosphatase 2A regulatory subunits.
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Identification of a novel stage of ribosome/nascent chain association with the endoplasmic reticulum membrane.
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Identification of amino acid residues involved in structural and ubiquinone-binding functions of subunit IV of the cytochrome bc1 complex from Rhodobacter sphaeroides.
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Identification of functional regions on the tail of Acanthamoeba myosin-II using recombinant fusion proteins. I. High resolution epitope mapping and characterization of monoclonal antibody binding sites.
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Identification of monomeric alpha-macroglobulin proteinase inhibitors in birds, reptiles, amphibians and mammals, and purification and characterization of a monomeric alpha-macroglobulin proteinase inhibitor from the American bullfrog Rana catesbeiana.
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Identification of the iron-sulfur center of spinach ferredoxin-nitrite reductase as a tetranuclear center, and preliminary EPR studies of mechanism.
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Identification of the spectrin subunit and domains required for formation of spectrin/adducin/actin complexes.
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Identifying the macromolecular targets of de novo-designed chemical entities through self-organizing map consensus.
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Immune (gamma) interferon production by a murine T cell lymphoma: requirements for macromolecular synthesis and lack of relationship with cell cycle.
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Immunoglobulin-like PapD chaperone caps and uncaps interactive surfaces of nascently translocated pilus subunits.
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Immunological correlates between the multiple hemocyanin subunits of Limulus polyphemus and Techypleus tridentatus.
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Immunological correspondence between arthropod hemocyanin subunits. II. Xiphosuran (Limulus) and spider (Eurypelma, Cupiennius) hemocyanin.
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Immunological studies of RNA polymerase II using antibodies to subunits of Drosophila and wheat germ enzyme.
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Improved excitation pulse bandwidths using shaped pulses, with application to heteronuclear half filters in macromolecular NMR.
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In vitro analysis of the human antiporcine T-cell repertoire.
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In vitro processing of recombinant G protein gamma subunits. Requirements for assembly of an active beta gamma complex.
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In vitro proteolysis of a large subunit of Drosophila melanogaster RNA polymerase B.
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In vitro synthesis of type IV procollagen.
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In vitro transcriptional studies of the roles of the thyroid hormone (T3) response elements and minimal promoters in T3-stimulated gene transcription.
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In vivo catabolism of heparin cofactor II and its complex with thrombin: evidence for a common receptor-mediated clearance pathway for three serine proteinase inhibitors.
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In vivo metabolism of inter-alpha-trypsin inhibitor and its proteinase complexes: evidence for proteinase transfer to alpha 2-macroglobulin and alpha 1-proteinase inhibitor.
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Incorporation of ribonucleoside 5'-(alpha-P-borano)triphosphates into a 20-mer RNA by T7 RNA polymerase.
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Influence of allosteric ligands on the activity and aggregation of rabbit muscle phosphofructokinase.
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Instability of myelin tubes under dehydration: deswelling of layered cylindrical structures.
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Interaction of reduced nicotinamide adenine dinucleotide with beef heart s-malate dehydrogenase.
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Interactions of nicotinamide adenine dinucleotides with varied states and forms of hemoglobin.
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Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.
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Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22.
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Ion channel behavior of amphotericin B in sterol-free and cholesterol- or ergosterol-containing supported phosphatidylcholine bilayer model membranes investigated by electrochemistry and spectroscopy.
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Isolation of an ankyrin-band 3 oligomer from human erythrocyte membranes.
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Isolation of polypeptide chains with heme from the extracellular hemoglobin of Amphitrite ornata (Polychaeta, Annelida).
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Isolation of the domain containing the molybdenum, iron-sulfur I, and iron-sulfur II centers of chicken liver xanthine dehydrogenase.
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Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator.
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Keyhole limpet hemocyanin: structural and functional characterization of two different subunits and multimers.
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L-selectin binds to P-selectin glycoprotein ligand-1 on leukocytes: interactions between the lectin, epidermal growth factor, and consensus repeat domains of the selectins determine ligand binding specificity.
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Lateral packing of protofibrils in fibrin fibers and fibrinogen polymers.
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Leucine periodicity of U2 small nuclear ribonucleoprotein particle (snRNP) A' protein is implicated in snRNP assembly via protein-protein interactions.
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Life as a moving fluid: fate of cytoplasmic macromolecules in dynamic fungal syncytia.
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Ligand binding, conformational change and plasma elimination of human, mouse and rat alpha-macroglobulin proteinase inhibitors.
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Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts.
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Lipid specificity of beta-hydroxybutyrate dehydrogenase activation.
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Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase.
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Localization of functionally important epitopes within the second C-type domain of coagulation factor V using recombinant chimeras.
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Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood.
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MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation.
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MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes.
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Macromolecular assembly of the transition state regulator AbrB in its unbound and complexed states probed by microelectrospray ionization mass spectrometry.
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Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix.
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Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit.
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Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements.
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Mapping the domain structure of human erythrocyte adducin.
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Mechanically interlocked calix[4]arene dimers display reversible bond breakage under force.
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Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system.
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Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex.
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Mechanisms of beta-adrenergic receptor desensitization and resensitization.
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Mechanisms of protein prenylation and role in G protein function.
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Metabolic impact of adenovirus-mediated overexpression of the glucose-6-phosphatase catalytic subunit in hepatocytes.
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Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome.
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Microtubule structure at 18 A resolution.
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Microtubule-associated protein 2, a microtubule-associated protein from brain, is immunologically related to the alpha subunit of erythrocyte spectrin.
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Model of alpha 2-macroglobulin structure and function.
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MolProbity: all-atom contacts and structure validation for proteins and nucleic acids.
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Molecular analysis of alcohol dehydrogenase electromorphs in wild type and transformed Drosophila melanogaster.
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Molecular and regulatory properties of adrenergic receptors.
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Molecular cloning of a novel human GTP-binding protein and its potential role in chemoattractant stimulus-response coupling.
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Morphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates.
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Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium.
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Mutant zeta-crystallin from guinea-pig hereditary cataracts has altered structural and enzymatic properties.
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Myosin from human erythrocytes.
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Myosins exist as homodimers of heavy chains: demonstration with specific antibody purified by nematode mutant myosin affinity chromatography.
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Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins.
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Nanomaterials as possible contaminants: the fullerene example.
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Nearest neighbor analysis for brain synapsin I. Evidence from in vitro reassociation assays for association with membrane protein(s) and the Mr = 68,000 neurofilament subunit.
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Negatively stained vinblastine aggregates.
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New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system.
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New tools in MolProbity validation: CaBLAM for CryoEM backbone, UnDowser to rethink "waters," and NGL Viewer to recapture online 3D graphics.
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Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go.
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Nitric oxide binding to human ferrihemoglobins cross-linked between either alpha or beta subunits.
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Nonproteolytic incorporation of protein ligands into human alpha 2-macroglobulin: implications for the binding mechanism of alpha 2-macroglobulin.
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Not just another hole in the wall: understanding intercellular protein trafficking.
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Novel strategy for diameter-selective separation and functionalization of single-wall carbon nanotubes.
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Nucleation of microtubule assembly. Experimental kinetics, computer fitting of models, and observations on tubulin rings.
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Observation of plasmon propagation, redirection, and fan-out in silver nanowires.
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One-dimensional crystals of (Na+ + K+)-ATPase dimers.
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One-pot synthesis of CdTe nanocrystals and shape control of luminescent CdTe-cystine nanocomposites.
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Oxidative dissociation of human alpha 2-macroglobulin tetramers into dysfunctional dimers.
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PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells.
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Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex.
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Phosphorylation of hen progesterone receptor by cAMP dependent protein kinase.
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Physical and chemical properties of rabbit muscle phosphofructokinase cross-linked with dimethyl suberimidate.
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Placental lactogen receptors in maternal sheep liver: effects of fasting and refeeding.
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Polymeric hemoglobins of the house mouse (Mus musculus L.): isolation of cysteinyl peptides.
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Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system.
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Posttranscriptional generation of macromolecular complexes.
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Prenylation and G protein signaling.
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Pretreatment of amphiphilic comb polymer surfaces dramatically affects protein adsorption
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Primary structure and domain organization of human alpha and beta adducin.
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Primary structure of hemoglobins from trout (Salmo irideus).partial determination of amino acid sequence of HB trout IV.
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Probing the domain structure of FtsZ by random truncation and insertion of GFP.
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Probing the oligomeric structure of an enzyme by electrospray ionization time-of-flight mass spectrometry.
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Protein (serine and threonine) phosphate phosphatases.
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Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
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Protein-Protein Docking Benchmark 2.0: an update.
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Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3.
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Proton NMR of Escherichia coli sulfite reductase: the unligated hemeprotein subunit.
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Purification and characterization of a "half-molecule" alpha 2-macroglobulin from the southern grass frog: absence of binding to the mammalian alpha 2-macroglobulin receptor.
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Purification and characterization of frog alpha-macroglobulin: receptor recognition of an amphibian glycoprotein.
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Purification and characterization of human alpha 2-macroglobulin conformational variants by non-ideal high performance size-exclusion chromatography.
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Purification and characterization of one-chain and two-chain renins from mouse submandibular gland.
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Purification and properties of a multifunctional calcium/calmodulin-dependent protein kinase from rat pancreas.
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Purification and properties of sulfite oxidase from chicken liver. Presence of molybdenum in sulfite oxidase from diverse sources.
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Purification and some properties of the Glu- and Lys-human plasmin heavy chains.
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Purification of brain analogs of red blood cell membrane skeletal proteins: ankyrin, protein 4.1 (synapsin), spectrin, and spectrin subunits.
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Purification of the three nuclear RNA polymerases from Neurospora crassa.
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Purified lac permease and cytochrome o oxidase are functional as monomers.
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Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA.
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Quasielastic light scattering by biopolymers. Conformation of chromatin multimers.
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RNA contributions to the form and function of biomolecular condensates.
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RNA polymerase from sporulating Bacillus subtilis. Purification and properties of a modified form of the enzyme containing two sporulation polypeptides.
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RNA subunit of mitochondrial RNA-processing enzyme is induced by contractile activity in striated muscle.
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Rapid identification of protein phosphatase 1-binding proteins by mixed peptide sequencing and data base searching. Characterization of a novel holoenzymic form of protein phosphatase 1.
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Reaction mechanism of human DNA repair excision nuclease.
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Reaction of human alpha 2-macroglobulin half-molecules with plasmin as a probe of protease binding site structure.
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Recent developments in phasing and structure refinement for macromolecular crystallography.
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Receptor biophysics and biochemistry. Enzymes.
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Reconstitution of functional membrane-bound acetylcholine receptor from isolated Torpedo californica receptor protein and electroplax lipids.
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Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. IV. The Escherichia coli hemoflavoprotein: subunit structure and dissociation into hemoprotein and flavoprotein components.
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Regions of the 110-kDa regulatory subunit M110 required for regulation of myosin-light-chain-phosphatase activity in smooth muscle.
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Regulation of G protein-coupled receptor signaling by scaffold proteins.
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Regulation of expression of transcobalamin II receptor in the rat.
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Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone.
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Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase.
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Relaxation spectra of aspartate transcarbamylase. I. Interaction of 5-bromocytidine triphosphate with native enzyme and regulatory subunit.
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Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with an adenosine 5'-triphosphate analog.
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Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with cytidine 5'-triphosphate.
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Relaxation spectrometry of biological systems.
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Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 1. Siroheme vibrational modes.
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Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.
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Results and interpretation of a fitting challenge for MR spectroscopy set up by the MRS study group of ISMRM.
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Revealing the Macromolecular Targets of Fragment-Like Natural Products.
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Revealing the macromolecular targets of complex natural products.
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Role of autophosphorylation in regulating calmodulin-dependent protein kinases.
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Role of water in short-range repulsive and attractive interactions between macromolecules and bilayers.
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Roles of v-erbA homodimers and heterodimers in mediating dominant negative activity by v-erbA.
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Room temperature purification of few-walled carbon nanotubes with high yield.
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Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro.
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Scaling behavior of nanopatterned polymer brushes.
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Schematic drawings of protein structures.
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Scientific benchmarks for guiding macromolecular energy function improvement.
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Secreted extracellular domains of macrophage scavenger receptors form elongated trimers which specifically bind crocidolite asbestos.
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Self-association and oxygen-binding characteristics of the isolated subunits of Limulus polyphemus hemocyanin.
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Septin ring assembly involves cycles of GTP loading and hydrolysis by Cdc42p.
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Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain.
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Sequencing of laminin B chain cDNAs reveals C-terminal regions of coiled-coil alpha-helix.
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Sialic acid prevents loss of large von Willebrand factor multimers by protecting against amino-terminal proteolytic cleavage.
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Sialyl-dimeric Lewis-X antigen expressed on mucin-like glycoproteins in colorectal cancer metastases.
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Similarity of three-dimensional structure between the immunoglobulin domain and the copper, zinc superoxide dismutase subunit.
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Site-specific effects of compression on macromolecular diffusion in articular cartilage.
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Sites of interaction between rod G-protein alpha-subunit and cGMP-phosphodiesterase gamma-subunit. Implications for the phosphodiesterase activation mechanism.
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Size-controlled electrochemical synthesis and properties of SnO2 nanotubes.
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Specificity and regulation of a synaptic vesicle docking complex.
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Spectroscopic evidence for anthracenedione antineoplastic agent self-association and complex formation with flavin nucleotides.
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Spot hemoglobin. Studies on the Root effect hemoglobin of a marine teleost.
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Stability of oxidized Escherichia coli thioredoxin and its dependence on protonation of the aspartic acid residue in the 26 position.
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Steering electrons on moving pathways.
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Stimulation of cartilage macromolecule synthesis by adenosine 3',5'-monophosphate.
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Structural analysis of the purine repressor, an Escherichia coli DNA-binding protein.
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Structural and functional analysis of the spontaneous re-formation of the thiol ester bond in human alpha 2-macroglobulin, rat alpha 1-inhibitor-3 and chemically modified derivatives.
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Structural and functional properties of cytochrome c oxidases isolated from sharks.
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Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR.
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Structural basis for the root effect in haemoglobin.
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Structural biology of plasmid segregation proteins.
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Structural comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain.
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Structural organization of chloroplast coupling factor.
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Structural properties of an active form of rabbit muscle phosphofructokinase.
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Structural studies on Neurospora RNA polymerases and associated proteins.
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Structural transitions accompanying the activation of peptide binding to the endoplasmic reticulum Hsp90 chaperone GRP94.
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Structure and activities of Escherichia coli DNA gyrase.
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Structure and evolution of prokaryotic and eukaryotic RNA polymerases: a model.
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Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength.
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Structure of human platelet membrane glycoproteins IIb and IIIa as determined by electron microscopy.
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Structure of macromolecular aggregates. I. Aggregation-induced conformational changes in polypeptides.
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Structure of oxidative- and photo-phosphorylation coupling factor complexes.
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Structure of the fibrin protofibril.
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Structure, function, and assembly in the hemocyanin system of the scorpion, Androctonus australis.
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Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein.
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Studies of the regulatory mechanism of Ca2+/calmodulin-dependent protein kinase II. Mutation of threonine 286 to alanine and aspartate.
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Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants.
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Studying and polishing the PDB's macromolecules.
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Substructure of human von Willebrand factor. Proteolysis by V8 and characterization of two functional domains.
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Subunit IV of cytochrome bc1 complex from Rhodobacter sphaeroides. Localization of regions essential for interaction with the three-subunit core complex.
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Subunit composition of high molecular weight oligomer: Limulus polyphemus hemocyanin.
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Subunit composition of plasma von Willebrand factor in patients with the myeloproliferative syndrome.
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Subunit structure and oxygen binding by hemocyanin of the isopod Ligia exotica.
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Subunit structure of fragment D from fibrinogen and cross-linked fibrin.
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Summary of Wenner-Gren international symposium receptor-receptor interactions among heptaspanning membrane receptors: from structure to function.
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Supramolecular nanomimetics: replication of micelles, viruses, and other naturally occurring nanoscale objects.
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Surface-stress-induced phase transformation in metal nanowires.
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Synaptically targeted narp plays an essential role in the aggregation of AMPA receptors at excitatory synapses in cultured spinal neurons.
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Synthesis and optical properties of silver nanobars and nanorice.
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Synthesis of Double-walled Carbon Nanotubes Using Iron Disilicide as Catalyst
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Synthesis of high-density, large-diameter, and aligned single-walled carbon nanotubes by multiple-cycle growth methods.
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Synthesis of oxidation-resistant cupronickel nanowires for transparent conducting nanowire networks.
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Synthetic biomimetic hydrogels incorporated with ephrin-A1 for therapeutic angiogenesis.
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T2 relaxation times of macromolecules and metabolites in the human brain at 9.4 T.
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T7-induced DNA polymerase. Characterization of associated exonuclease activities and resolution into biologically active subunits.
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Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis.
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Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase.
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Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor.
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The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo.
-
The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit.
-
The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits.
-
The absorption of oleic acid from emulsion and micellar solution.
-
The anatomy and taxonomy of protein structure.
-
The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.
-
The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.
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The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.
-
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress.
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The effect of nanowire length and diameter on the properties of transparent, conducting nanowire films
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The effect of plasmin on the subunit structure of human fibrin.
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The effect of plasmin on the subunit structure of human fibrinogen.
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The effect of zinc and other divalent cations on the structure and function of human alpha 2-macroglobulin.
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The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis.
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The glucocorticoid hormone signal transduction pathway in mice homozygous for chromosomal deletions causing failure of cell type-specific inducible gene expression.
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The hemoglobin system of the primitive fish, Amia calva: isolation and functional characterization of the individual hemoglobin components.
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The human keratin genes and their differential expression.
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The kinetics of microtubule assembly. Evidence for a two-stage nucleation mechanism.
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The membrane skeleton of human erythrocytes and its implications for more complex cells.
-
The membrane-binding domain of ankyrin contains four independently folded subdomains, each comprised of six ankyrin repeats.
-
The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.
-
The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase.
-
The role of calmodulin in the structure and regulation of phosphorylase kinase from rabbit skeletal muscle.
-
The role of subunit entropy in cooperative assembly. Nucleation of microtubules and other two-dimensional polymers.
-
The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation.
-
The spectrin-actin junction of erythrocyte membrane skeletons.
-
The straight and curved conformation of FtsZ protofilaments-evidence for rapid exchange of GTP into the curved protofilament.
-
The structure and assembly of microtubules.
-
The structure and function of pyruvate kinase.
-
The temperature-dependent reaction between alpha 2-macroglobulin and streptokinase-plasmin(ogen) complex.
-
The type I and type II bovine scavenger receptors expressed in Chinese hamster ovary cells are trimeric proteins with collagenous triple helical domains comprising noncovalently associated monomers and Cys83-disulfide-linked dimers.
-
The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene.
-
Thermodynamic effects of reduction of the active-site disulfide of Escherichia coli thioredoxin explored by differential scanning calorimetry.
-
Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5, and beta-4 subunits of neuronal nicotinic acetylcholine receptors. Preferential transcription of the alpha-3 and beta-4 genes by immature CD4+8+ thymocytes and evidence for response to nicotine in thymocytes.
-
Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells.
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Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes.
-
Transvascular drug delivery in solid tumors.
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Treatment of acute graft-versus-host disease with humanized anti-Tac: an antibody that binds to the interleukin-2 receptor.
-
Triiodothyronine (T3) differentially affects T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor heterodimer binding to DNA.
-
Tubulin rings: curved filaments with limited flexibility and two modes of association.
-
Two crystal forms of bovine superoxide dismutase.
-
Two forms of the T-cell receptor gamma protein found on peripheral blood cytotoxic T lymphocytes.
-
Two steps in Maf1-dependent repression of transcription by RNA polymerase III.
-
Use of monoclonal antibodies to probe subunit- and polymer-specific epitopes of 987P fimbriae of Escherichia coli.
-
Use of okadaic acid to inhibit protein phosphatases in intact cells.
-
Variation of molecular alignment as a means of resolving orientational ambiguities in protein structures from dipolar couplings.
-
ZDOCK and RDOCK performance in CAPRI rounds 3, 4, and 5.
-
cAMP receptor and G-protein interactions control development in Dictyostelium.
-
cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I.
-
pH-dependent conformational change of gastric mucin leads to sol-gel transition.
-
Keywords of People
-
-
Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
-
Erickson, Harold Paul,
James B. Duke Distinguished Professor Emeritus,
Cell Biology
-
Ferreira, Paulo Alexandre,
Associate Professor in Ophthalmology,
Pathology
-
Gall, Ken,
Professor in the Department of Mechanical Engineering and Materials Science,
Thomas Lord Department of Mechanical Engineering and Materials Science
-
Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
-
Krangel, Michael S.,
George Barth Geller Distinguished Professor of Immunology,
Integrative Immunobiology
-
Sullivan, Daniel Carl,
Professor Emeritus of Radiology,
Radiology