Multiprotein Complexes

• 

  Subject Areas on Research

  • A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway. 
  • A conserved retromer-independent function for RAB-6.2 in C. elegans epidermis integrity. 
  • A geometric arrangement algorithm for structure determination of symmetric protein homo-oligomers from NOEs and RDCs. 
  • A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation. 
  • A phase II trial of temsirolimus in men with castration-resistant metastatic prostate cancer. 
  • A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. 
  • AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. 
  • ATM functions at the peroxisome to induce pexophagy in response to ROS. 
  • ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. 
  • Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. 
  • Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. 
  • Allosteric modulation of nucleoporin assemblies by intrinsically disordered regions. 
  • An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1. 
  • An expanded role of the tumor suppressor TSC1 in T cell tolerance. 
  • Analysis of the Rab GTPase Interactome in Dendritic Cells Reveals Anti-microbial Functions of the Rab32 Complex in Bacterial Containment. 
  • Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. 
  • Asymmetric cell divisions promote stratification and differentiation of mammalian skin. 
  • Autophagic activity dictates the cellular response to oncogenic RAS. 
  • Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. 
  • BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. 
  • BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation. 
  • Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. 
  • Bi-modal regulation of a formin by srGAP2. 
  • Branched-Chain Aminotransferases Control TORC1 Signaling in Saccharomyces cerevisiae. 
  • Characterization of the CaMKKβ-AMPK signaling complex. 
  • Charting the landscape of tandem BRCT domain-mediated protein interactions. 
  • Condensin and cohesin display different arm conformations with characteristic hinge angles. 
  • Cooperation among multiple transcription factors is required for access to minimal T-cell receptor alpha-enhancer chromatin in vivo. 
  • Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA. 
  • Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex. 
  • Crystallization of a Complex Between MYC and Jas Motif. 
  • De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex. 
  • Differential susceptibility of yeast S and M phase CDK complexes to inhibitory tyrosine phosphorylation. 
  • Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. 
  • Domain unfolding plays a role in superfibronectin formation. 
  • Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin. 
  • Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells. 
  • Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae. 
  • Epigenetic Silencing of Recombinant Adeno-associated Virus Genomes by NP220 and the HUSH Complex. 
  • Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages. 
  • Everolimus tablets for patients with subependymal giant cell astrocytoma. 
  • Expression and localization of components of the histone deacetylases multiprotein repressory complexes in the mouse preimplantation embryo. 
  • Flexible stereospecific interactions and composition within nucleoprotein complexes assembled on the TCR alpha gene enhancer. 
  • Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. 
  • FtsZ Protofilament Curvature Is the Opposite of Tubulin Rings. 
  • GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling. 
  • Genetic variations of mTORC1 genes and risk of gastric cancer in an Eastern Chinese population. 
  • Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-beta signaling at the bipotent erythro-megakaryocytic progenitor stage. 
  • Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly. 
  • Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. 
  • Identification and activity of the functional complex between hnRNPL and the pseudoexfoliation syndrome-associated lncRNA, LOXL1-AS1. 
  • Identification and characterization of a functional zebrafish smrt corepressor (ncor2). 
  • Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. 
  • In vitro assembly and GTP hydrolysis by bacterial tubulins BtubA and BtubB. 
  • Investigating the SecY plug movement at the SecYEG translocation channel. 
  • Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1. 
  • KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance. 
  • Lateral density of receptor arrays in the membrane plane influences sensitivity of the E. coli chemotaxis response. 
  • Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function. 
  • Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization. 
  • Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. 
  • Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis. 
  • Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK. 
  • Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies. 
  • Myocilin, a component of a membrane-associated protein complex driven by a homologous Q-SNARE domain. 
  • Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. 
  • Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation. 
  • Nox2 Inhibition Regulates Stress Response and Mitigates Skeletal Muscle Fiber Atrophy during Simulated Microgravity. 
  • NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions. 
  • Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations. 
  • PolyQ-dependent RNA-protein assemblies control symmetry breaking. 
  • Polymorphisms in mTORC1 genes modulate risk of esophageal squamous cell carcinoma in eastern Chinese populations. 
  • Primate-specific melanoma antigen-A11 regulates isoform-specific human progesterone receptor-B transactivation. 
  • Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test. 
  • Protein-protein docking: overview and performance analysis. 
  • RNA contributions to the form and function of biomolecular condensates. 
  • Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation. 
  • Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells. 
  • Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin. 
  • Regulation of T-cell survival and mitochondrial homeostasis by TSC1. 
  • Regulation of mast cell survival and function by tuberous sclerosis complex 1. 
  • RelB/p50 complexes regulate cytokine-induced YKL-40 expression. 
  • STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo. 
  • Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease. 
  • Salicylic acid activates DNA damage responses to potentiate plant immunity. 
  • Sparsely-sampled, high-resolution 4-D omit spectra for detection and assignment of intermolecular NOEs of protein complexes. 
  • Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte. 
  • Structural and mechanical study of a self-assembling protein nanotube. 
  • Structural and transcriptional analyses of a purine nucleotide-binding protein from Pyrococcus furiosus: a component of a novel, membrane-bound multiprotein complex unique to this hyperthermophilic archaeon. 
  • Structure of a four-way bridged ParB-DNA complex provides insight into P1 segrosome assembly. 
  • Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia. 
  • Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis. 
  • T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex. 
  • TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation. 
  • Targeted inhibition of phosphoinositide 3-kinase activity as a novel strategy to normalize beta-adrenergic receptor function in heart failure. 
  • Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle. 
  • The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. 
  • The Chlamydia type III secretion system C-ring engages a chaperone-effector protein complex. 
  • The ELF4-ELF3-LUX complex links the circadian clock to diurnal control of hypocotyl growth. 
  • The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. 
  • The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. 
  • The coiled coils of cohesin are conserved in animals, but not in yeast. 
  • The crystal structure of the RsbN-σBldN complex from Streptomyces venezuelae defines a new structural class of anti-σ factor. 
  • The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. 
  • The monomeric receptor binding domain of tetrameric α2-macroglobulin binds to cell surface GRP78 triggering equivalent activation of signaling cascades. 
  • The role of tuberous sclerosis complex 1 in regulating innate immunity. 
  • The state of the septin cytoskeleton from assembly to function. 
  • The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors. 
  • Tissue factor around dermal vessels has bound factor VII in the absence of injury. 
  • Transcription factor-dependent nuclear localization of a transcriptional repressor in jasmonate hormone signaling. 
  • Tumor suppressor TSC1 is critical for T-cell anergy. 
  • Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex. 
  • Two distinct signalling cascades target the NF-kappaB regulatory factor c-IAP1 for degradation. 
  • Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex. 
  • Vesicular Trafficking Systems Impact TORC1-Controlled Transcriptional Programs in Saccharomyces cerevisiae. 
  • WAVE signalling: from biochemistry to biology. 
  • ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers. 
  • ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline. 
  • iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions. 
  • mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. 
  • mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. 
  • mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation. 
  • mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination. 
  • mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice. 
  • mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development. 
  • α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide. 
• 

  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Halabi, Susan, Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology