Proteasome Endopeptidase Complex

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  Subject Areas on Research

  • A bacterial virulence protein suppresses host innate immunity to cause plant disease. 
  • A kiss of death--proteasome-mediated membrane fusion and programmed cell death in plant defense against bacterial infection. 
  • A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. 
  • Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. 
  • Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway. 
  • Activity dependent localization of synaptic NMDA receptors in spinal neurons. 
  • Acute decreases in proteasome pathway activity after inhalation of fresh diesel exhaust or secondary organic aerosol. 
  • Age-Dependent Effects of Immunoproteasome Deficiency on Mouse Adenovirus Type 1 Pathogenesis. 
  • Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein. 
  • Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling. 
  • Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains. 
  • C-Raf antagonizes apoptosis induced by IFN-alpha in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A. 
  • CD1d degradation in Chlamydia trachomatis-infected epithelial cells is the result of both cellular and chlamydial proteasomal activity. 
  • CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef. 
  • Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. 
  • Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearance. 
  • Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor. 
  • Contribution of proteasome-catalyzed peptide cis-splicing to viral targeting by CD8+ T cells in HIV-1 infection. 
  • Control of cellular GADD34 levels by the 26S proteasome. 
  • Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. 
  • Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model. 
  • Cytoprotective effects of proteasome beta5 subunit overexpression in lens epithelial cells. 
  • DNA adducts of decarbamoyl mitomycin C efficiently kill cells without wild-type p53 resulting from proteasome-mediated degradation of checkpoint protein 1. 
  • Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway. 
  • Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy. 
  • Discovery of novel non-covalent inhibitors selective to the β5-subunit of the human 20S proteasome. 
  • Distribution of proteasomes and of the five proteolytic activities in rat tissues. 
  • Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. 
  • E2-induced degradation of uterine insulin receptor substrate-2: requirement for an IGF-I-stimulated, proteasome-dependent pathway. 
  • ERK-dependent proteasome degradation of Txnip regulates thioredoxin oxidoreductase activity. 
  • Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factors. 
  • Effects of donor age on proteasome activity and senescence in trabecular meshwork cells. 
  • Effects of ligand binding on the mechanical properties of ankyrin repeat protein gankyrin. 
  • Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts. 
  • Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression. 
  • Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D. 
  • Exogenous Hsp70 delays senescence and improves cognitive function in aging mice. 
  • F-actin homeostasis through transcriptional regulation and proteasome-mediated proteolysis. 
  • FBW2 targets GCMa to the ubiquitin-proteasome degradation system. 
  • FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis 
  • Finale: the last minutes of Smads. 
  • Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. 
  • Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos. 
  • Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment. 
  • HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. 
  • HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells. 
  • Homoserine toxicity in Saccharomyces cerevisiae and Candida albicans homoserine kinase (thr1Delta) mutants. 
  • Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. 
  • Imaging molecular pathways: reporter genes. 
  • Immunoproteasome down-modulation enhances the ability of dendritic cells to stimulate antitumor immunity. 
  • Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut8. 
  • Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration. 
  • Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma. 
  • Inhibitory effect of b-AP15 on the 20S proteasome. 
  • Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. 
  • Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3. 
  • Interferon-dependent immunoproteasome activity during mouse adenovirus type 1 infection. 
  • Interleukin-3-induced activation of the JAK/STAT pathway is prolonged by proteasome inhibitors. 
  • LMP2 expression and proteasome activity in NOD mice. 
  • LMP2 expression and proteasome activity in NOD mice. 
  • Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. 
  • Mechanical unfolding of an ankyrin repeat protein. 
  • Melanoma immunotherapy using mature DCs expressing the constitutive proteasome. 
  • Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis. 
  • Methed-up FOXOs can't in-Akt-ivate. 
  • Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint. 
  • Molecular pathophysiology of Parkinson's disease. 
  • Multiple cell-type-specific elements regulate Myc protein stability. 
  • Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. 
  • Novel therapies for pancreatic adenocarcinoma. 
  • Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. 
  • Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. 
  • Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells. 
  • Pan-PIM kinase inhibitors enhance Lenalidomide's anti-myeloma activity via cereblon-IKZF1/3 cascade. 
  • Pathogen virulence factors as molecular probes of basic plant cellular functions. 
  • Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer. 
  • Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90. 
  • Potentially functional genetic variants of VAV2 and PSMA4 in the immune-activation pathway and non-small cell lung cancer survival. 
  • Potentially functional variants of ERAP1, PSMF1 and NCF2 in the MHC-I-related pathway predict non-small cell lung cancer survival. 
  • Premature translational termination products are rapidly degraded substrates for MHC class I presentation. 
  • Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphoma. 
  • Prevention of brefeldin A-induced resistance to teniposide by the proteasome inhibitor MG-132: involvement of NF-kappaB activation in drug resistance. 
  • Probing Proteostatic Stress in Degenerating Photoreceptors Using Two Complementary In Vivo Reporters of Proteasomal Activity. 
  • Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor. 
  • Proteasome inhibition by chronic oxidative stress in human trabecular meshwork cells. 
  • Proteasome inhibition with bortezomib induces cell death in GBM stem-like cells and temozolomide-resistant glioma cell lines, but stimulates GBM stem-like cells' VEGF production and angiogenesis. 
  • Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration. 
  • Proteasome regulators: activators and inhibitors. 
  • Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer. 
  • Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity. 
  • Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains. 
  • Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane. 
  • Reaper is regulated by IAP-mediated ubiquitination. 
  • Recruiting substrates to cullin 4-dependent ubiquitin ligases by DDB1. 
  • Regulation of P311 expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system. 
  • Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome. 
  • Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. 
  • Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes. 
  • Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. 
  • Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. 
  • Reproductive cytotoxicity is predicted by magnetic resonance microscopy and confirmed by ubiquitin-proteasome immunohistochemistry in a theophylline-induced model of rat testicular and epididymal toxicity. 
  • Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity. 
  • Reversible protein phosphorylation regulates circadian rhythms. 
  • Routine single particle CryoEM sample and grid characterization by tomography. 
  • Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae. 
  • SRCP1 Conveys Resistance to Polyglutamine Aggregation. 
  • Selective Autophagy of BES1 Mediated by DSK2 Balances Plant Growth and Survival. 
  • Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy. 
  • Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. 
  • Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling. 
  • Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives. 
  • Synthesis and proteasome inhibition of lithocholic acid derivatives. 
  • Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions. 
  • Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease. 
  • Targeting the Leukemia Antigen PR1 with Immunotherapy for the Treatment of Multiple Myeloma. 
  • The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes. 
  • The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing. 
  • The anaphase-promoting complex/cyclosome is required for anaphase progression in multinucleated Ashbya gossypii cells. 
  • The bacterial effector HopM1 suppresses PAMP-triggered oxidative burst and stomatal immunity. 
  • The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. 
  • The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome. 
  • The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis. 
  • The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes. 
  • The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome. 
  • The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis. 
  • The protein hSnm1B is stabilized when bound to the telomere-binding protein TRF2. 
  • The role of proteolytic cellular systems in trabecular meshwork homeostasis. 
  • Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors. 
  • USP5 Is Dispensable for Monoubiquitin Maintenance in Drosophila. 
  • Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23. 
  • Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2). 
  • Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. 
  • VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. 
  • XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis. 
  • beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. 
  • c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells. 
  • {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. 
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  Keywords of People

  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology