Embryonic Development

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  Subject Areas on Research

  • A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein. 
  • A genomic regulatory network for development. 
  • A high-throughput histoarray for quantitative molecular profiling of multiple, uniformly oriented medaka (Oryzias latipes) embryos. 
  • A non-canonical Raf function is required for dorsal-ventral patterning during Drosophila embryogenesis. 
  • AHR2-Mediated transcriptomic responses underlying the synergistic cardiac developmental toxicity of PAHs. 
  • Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish. 
  • Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish. 
  • Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids. 
  • An interview with Dr Blanche Capel. 
  • An invertebrate model of the developmental neurotoxicity of insecticides: effects of chlorpyrifos and dieldrin in sea urchin embryos and larvae. 
  • Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. 
  • Apoptotic force and tissue dynamics during Drosophila embryogenesis. 
  • Aryl phosphate esters within a major PentaBDE replacement product induce cardiotoxicity in developing zebrafish embryos: potential role of the aryl hydrocarbon receptor. 
  • Aurora-A kinase is essential for bipolar spindle formation and early development. 
  • Automated annotation of gene expression image sequences via non-parametric factor analysis and conditional random fields. 
  • Autonomous Boolean modelling of developmental gene regulatory networks. 
  • BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. 
  • Bayesian modeling of embryonic growth using latent variables. 
  • Biased precursor ingression underlies the center-to-pole pattern of male sex determination in mouse. 
  • Bone morphogenetic proteins in development. 
  • Bone morphogenetic proteins: multifunctional regulators of vertebrate development. 
  • CDK-Regulated Phase Separation Seeded by Histone Genes Ensures Precise Growth and Function of Histone Locus Bodies. 
  • CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. 
  • CYP1B1 knockdown does not alter synergistic developmental toxicity of polycyclic aromatic hydrocarbons in zebrafish (Danio rerio). 
  • Caenorhabditis elegans cog-1 locus encodes GTX/Nkx6.1 homeodomain proteins and regulates multiple aspects of reproductive system development. 
  • Calcium- and polyphosphate-containing acidocalcisomes in chicken egg yolk. 
  • Cell cycle control during early embryogenesis. 
  • Cell ingression and apical shape oscillations during dorsal closure in Drosophila. 
  • Cell-surface co-receptors: emerging roles in signaling and human disease. 
  • Characterizing sources of variability in zebrafish embryo screening protocols. 
  • Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination. 
  • Comments about Joint Modeling of Cluster Size and Binary and Continuous Subunit-Specific Outcomes. 
  • Commitment along the dorsoventral axis of the sea urchin embryo is altered in response to NiCl2. 
  • Comparative embryology without a microscope: using genomic approaches to understand the evolution of development. 
  • Complete canthi removal reveals that forces from the amnioserosa alone are sufficient to drive dorsal closure in Drosophila. 
  • Compound- and mixture-specific differences in resistance to polycyclic aromatic hydrocarbons and PCB-126 among Fundulus heteroclitus subpopulations throughout the Elizabeth River estuary (Virginia, USA). 
  • Conserved and divergent expression dynamics during early patterning of the telencephalon in mouse and chick embryos. 
  • Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity. 
  • Cullin-5 mutants reveal collective sensing of the nucleocytoplasmic ratio in Drosophila embryogenesis. 
  • Cumulus cell pappalysin-1, luteinizing hormone/choriogonadotropin receptor, amphiregulin and hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 mRNA levels associate with oocyte developmental competence and embryo outcomes. 
  • Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism. 
  • Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. 
  • Deployment of extracellular matrix proteins in sea urchin embryogenesis. 
  • Developing pressures: fluid forces driving morphogenesis. 
  • Developmental Exposure to Low Concentrations of Organophosphate Flame Retardants Causes Life-Long Behavioral Alterations in Zebrafish. 
  • Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. 
  • Developmental exposure to a complex PAH mixture causes persistent behavioral effects in naive Fundulus heteroclitus (killifish) but not in a population of PAH-adapted killifish. 
  • Developmental exposure to low concentrations of two brominated flame retardants, BDE-47 and BDE-99, causes life-long behavioral alterations in zebrafish. 
  • Developmental exposure to organophosphate flame retardants causes behavioral effects in larval and adult zebrafish. 
  • Developmental exposure to organophosphate flame retardants elicits overt toxicity and alters behavior in early life stage zebrafish (Danio rerio). 
  • Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish. 
  • Differential developmental toxicity of naphthoic acid isomers in medaka (Oryzias latipes) embryos. 
  • Diphenyl Phosphate-Induced Toxicity During Embryonic Development. 
  • Does shaking alter the time of hatching in incubated medaka (Oryzias latipes) embryos? 
  • Drosophila Ctr1A functions as a copper transporter essential for development. 
  • Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions. 
  • Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene. 
  • Effect-directed analysis of Elizabeth River porewater: developmental toxicity in zebrafish (Danio rerio). 
  • Effects of single and combined exposures to benzo(a)pyrene and 3,3'4,4'5-pentachlorobiphenyl on EROD activity and development in Fundulus heteroclitus. 
  • Embryo toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the wood duck (Aix sponsa). 
  • Emergent properties during dorsal closure in Drosophila morphogenesis. 
  • Establishing the epigenetic status of the Prader-Willi/Angelman imprinting center in the gametes and embryo. 
  • Evolution and development of the mammalian dentition: insights from the marsupial Monodelphis domestica. 
  • Exposure of developing chicks to perfluorooctanoic acid induces defects in prehatch and early posthatch development. 
  • Expression of fgf23 and αklotho in developing embryonic tissues and adult kidney of the zebrafish, Danio rerio. 
  • Forces for morphogenesis investigated with laser microsurgery and quantitative modeling. 
  • Frizzled 1/2/7 signaling directs beta catenin nuclearization and initiates endoderm specification in macromeres during sea urchin morphogenesis 
  • Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development. 
  • Functional complementation between FADD and RIP1 in embryos and lymphocytes. 
  • Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. 
  • Gene expression throughout a vertebrate's embryogenesis. 
  • Genomic and physiological responses to strong selective pressure during late organogenesis: few gene expression changes found despite striking morphological differences. 
  • Genomic structure and embryonic expression of estrogen receptor beta a (ERbetaa) in zebrafish (Danio rerio). 
  • Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos. 
  • Glutathione transferase pi class 2 (GSTp2) protects against the cardiac deformities caused by exposure to PAHs but not PCB-126 in zebrafish embryos. 
  • Halogenated carbazoles induce cardiotoxicity in developing zebrafish (Danio rerio) embryos. 
  • High-resolution magnetic resonance histology of the embryonic and neonatal mouse: a 4D atlas and morphologic database. 
  • Identifying Genetic Players in Cell Sheet Morphogenesis Using a Drosophila Deficiency Screen for Genes on Chromosome 2R Involved in Dorsal Closure. 
  • Identifying Key Genetic Regions for Cell Sheet Morphogenesis on Chromosome 2L Using a Drosophila Deficiency Screen in Dorsal Closure. 
  • Immediate and long-term consequences of vascular toxicity during zebrafish development. 
  • Influence of water hardening of the chorion on cadmium accumulation in medaka (Oryzias latipes) eggs. 
  • Interneurons from embryonic development to cell-based therapy. 
  • Intravital imaging of mouse embryos. 
  • JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis. 
  • Later life swimming performance and persistent heart damage following subteratogenic PAH mixture exposure in the Atlantic killifish (Fundulus heteroclitus). 
  • Loss of the cytoskeletal protein Pdlim7 predisposes mice to heart defects and hemostatic dysfunction. 
  • Magnetic resonance microscopy defines ethanol-induced brain abnormalities in prenatal mice: effects of acute insult on gestational day 8. 
  • Mathematical models of dorsal closure. 
  • Measuring time during early embryonic development. 
  • Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation. 
  • Metabolic changes in Japanese medaka (Oryzias latipes) during embryogenesis and hypoxia as determined by in vivo 31P NMR. 
  • Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development. 
  • Mitochondrial response and resilience to anthropogenic chemicals during embryonic development. 
  • Mitotic waves in the early embryogenesis of Drosophila: Bistability traded for speed. 
  • Molecular mechanisms of development of the human fetal female reproductive tract. 
  • Molecular morphogens. Upside-down ideas vindicated. 
  • Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. 
  • Multi‑organ assessment via a 9.4‑Tesla MRS evaluation of metabolites during the embryonic development of cleft palate induced by dexamethasone. 
  • NTP-CERHR expert panel report on the reproductive and developmental toxicity of hydroxyurea. 
  • Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response. 
  • Neurotoxicity of FireMaster 550® in zebrafish (Danio rerio): Chronic developmental and acute adolescent exposures. 
  • New insights into human female reproductive tract development. 
  • Nonadditive effects of PAHs on Early Vertebrate Development: mechanisms and implications for risk assessment. 
  • Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo. 
  • Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior. 
  • Physiology, Development, and Disease Modeling in the Drosophila Excretory System. 
  • Posttranslational control of Cdc25 degradation terminates Drosophila's early cell-cycle program. 
  • Progesterone Increases Mitochondria Membrane Potential in Non-human Primate Oocytes and Embryos. 
  • Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. 
  • Quantifying dorsal closure in three dimensions. 
  • RIP3: a molecular switch for necrosis and inflammation. 
  • Rbm8a haploinsufficiency disrupts embryonic cortical development resulting in microcephaly. 
  • Rearing conditions differentially affect the locomotor behavior of larval zebrafish, but not their response to valproate-induced developmental neurotoxicity. 
  • Regulation of early adipose commitment by Zfp521. 
  • Remodeling Tissue Interfaces and the Thermodynamics of Zipping during Dorsal Closure in Drosophila. 
  • Roles of bone morphogenetic protein signaling and its antagonism in holoprosencephaly. 
  • STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo. 
  • SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development. 
  • Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity. 
  • Sea urchin embryonic development provides a model for evaluating therapies against beta-amyloid toxicity. 
  • Sea urchin embryos and larvae as biosensors for neurotoxicants. 
  • Selenomethionine exposure affects chondrogenic differentiation and bone formation in Japanese medaka (Oryzias latipes). 
  • Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in Drosophila Embryos. 
  • Silver exposure in developing zebrafish (Danio rerio): persistent effects on larval behavior and survival. 
  • Silver nanocolloids disrupt medaka embryogenesis through vital gene expressions. 
  • Silver nanoparticles alter zebrafish development and larval behavior: distinct roles for particle size, coating and composition. 
  • Smad5 induces ventral fates in Xenopus embryo. 
  • Sprinter: a novel transmembrane protein required for Wg secretion and signaling. 
  • Stage sensitivity of medaka (Oryzias latipes) eggs and embryos to permethrin. 
  • Systems biology of robustness and homeostatic mechanisms. 
  • Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice. 
  • Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad. 
  • The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms. 
  • The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis. 
  • The Snail repressor is required for PMC ingression in the sea urchin embryo. 
  • The Wnt/JNK signaling target gene alcam is required for embryonic kidney development. 
  • The channel kinase, TRPM7, is required for early embryonic development. 
  • The effects of model polysiloxane and fouling-release coatings on embryonic development of a sea urchin (Arbacia punctulata) and a fish (Oryzias latipes). 
  • The genome of the sea urchin Stongylocentrotus purpuratus 
  • The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks. 
  • The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation. 
  • The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity. 
  • The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine. 
  • The tardigrade Hypsibius dujardini, a new model for studying the evolution of development. 
  • The vacuole within: how cellular organization dictates notochord function. 
  • The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish. 
  • Tissue self-organization underlies morphogenesis of the notochord. 
  • Triphenyl phosphate-induced developmental toxicity in zebrafish: potential role of the retinoic acid receptor. 
  • Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster. 
  • Twist is an integrator of SHH, FGF, and BMP signaling. 
  • Unlocking mechanisms of development through advances in tools. 
  • Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. 
  • WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. 
  • Waves in Embryonic Development. 
  • Waves of Cdk1 Activity in S Phase Synchronize the Cell Cycle in Drosophila Embryos. 
  • When developmental pathways diverge. 
  • Whole Mount In Situ Hybridization in Murine Tissues. 
  • Zebrafish Posterior Lateral Line primordium migration requires interactions between a superficial sheath of motile cells and the skin. 
  • alphaSU2, an epithelial integrin that binds laminin in the sea urchin embryo. 
  • dbl-1/TGF-β and daf-12/NHR Signaling Mediate Cell-Nonautonomous Effects of daf-16/FOXO on Starvation-Induced Developmental Arrest 
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  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology