Tumor Burden

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  Subject Areas on Research

  • (18)F-Fluorothymidine PET-CT for resected malignant gliomas before radiotherapy: tumor extent according to proliferative activity compared with MRI. 
  • 3'-Deoxy-3'-[F-18]fluorothymidine positron emission tomography in patients with recurrent glioblastoma multiforme: comparison with Gd-DTPA enhanced magnetic resonance imaging. 
  • A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer. 
  • A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice. 
  • A novel method for volumetric MRI response assessment of enhancing brain tumors. 
  • A novel, reproducible, and objective method for volumetric magnetic resonance imaging assessment of enhancing glioblastoma. 
  • A promising approach for treatment of tumor-induced bone diseases: utilizing bisphosphonate derivatives of nucleoside antimetabolites. 
  • A signature of epithelial-mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype. 
  • ACR appropriateness criteria on external beam radiation therapy treatment planning for clinically localized prostate cancer expert panel on radiation oncology--prostate. 
  • Accelerating volumetric cine MRI (VC-MRI) using undersampling for real-time 3D target localization/tracking in radiation therapy: a feasibility study. 
  • Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. 
  • Actual 10-Year Survivors After Resection of Hepatocellular Carcinoma. 
  • Actual 10-year survival following hepatectomy for hepatocellular carcinoma. 
  • Adaptive replanning strategies accounting for shrinkage in head and neck IMRT. 
  • Adaptive stereotactic body radiation therapy planning for lung cancer. 
  • Addition of bevacizumab to standard radiation therapy and daily temozolomide is associated with minimal toxicity in newly diagnosed glioblastoma multiforme. 
  • Adjunct endovascular interventions in carotid body tumors. 
  • Adrenal Imaging Features Predict Malignancy Better than Tumor Size. 
  • African-American men with low-grade prostate cancer have higher tumor burdens: results from the Duke Prostate Center. 
  • Agreement among RTOG sarcoma radiation oncologists in contouring suspicious peritumoral edema for preoperative radiation therapy of soft tissue sarcoma of the extremity. 
  • American Society of Radiation Oncology recommendations for documenting intensity-modulated radiation therapy treatments. 
  • An effective preoperative three-dimensional radiotherapy target volume for extremity soft tissue sarcoma and the effect of margin width on local control. 
  • Anatomic tumor location influences the success of contemporary limb-sparing surgery and radiation among adults with soft tissue sarcomas of the extremities. 
  • Angiotensin receptor signaling and prostate tumor growth in mice. 
  • Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia. 
  • Anti-tumor activity of a novel monoclonal antibody, NPC-1C, optimized for recognition of tumor antigen MUC5AC variant in preclinical models. 
  • Apparatus-dependent dosimetric differences in spine stereotactic body radiotherapy. 
  • Applying Criteria of Active Surveillance to Low-Risk Papillary Thyroid Cancer Over a Decade: How Many Surgeries and Complications Can Be Avoided? 
  • Assessment of Treatment Response With Diffusion-Weighted MRI and Dynamic Contrast-Enhanced MRI in Patients With Early-Stage Breast Cancer Treated With Single-Dose Preoperative Radiotherapy: Initial Results. 
  • Assessment of circulating tumor cells (CTCs) in prostate cancer patients with low-volume tumors. 
  • Associations Between Prostate Volume and Oncologic Outcomes in Men Undergoing Focal Cryoablation of the Prostate. 
  • Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor. 
  • Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease. 
  • Benchmark Credentialing Results for NRG-BR001: The First National Cancer Institute-Sponsored Trial of Stereotactic Body Radiation Therapy for Multiple Metastases. 
  • Biopsy accuracy in identifying unilateral prostate cancer depends on prostate weight. 
  • Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. 
  • Challenges in the clinical application of advanced technologies to reduce radiation-associated normal tissue injury. 
  • Changes in oligosaccharide chains of autoantibodies to GRP78 expressed during progression of malignant melanoma stimulate melanoma cell growth and survival. 
  • Characterization of Small (< 4 cm) Focal Renal Lesions: Diagnostic Accuracy of Spectral Analysis Using Single-Phase Contrast-Enhanced Dual-Energy CT. 
  • Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface. 
  • Chemotherapy-related amenorrhea after adjuvant paclitaxel-trastuzumab (APT trial). 
  • Clinical end points and response criteria in mycosis fungoides and Sézary syndrome: a consensus statement of the International Society for Cutaneous Lymphomas, the United States Cutaneous Lymphoma Consortium, and the Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer. 
  • Clinical practice guidance for radiotherapy planning after induction chemotherapy in locoregionally advanced head-and-neck cancer. 
  • Clinical predictors of renal mass pathological features. 
  • Clinicopathological Features and Prognosis of Mixed-Type T1a Gastric Cancer Based on Lauren's Classification. 
  • Colorectal cancer with potentially resectable hepatic metastases: optimizing treatment. 
  • Combined ablation and resection (CARe) as an effective parenchymal sparing treatment for extensive colorectal liver metastases. 
  • Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent. 
  • Computer-extracted MR imaging features are associated with survival in glioblastoma patients. 
  • Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer. 
  • Concurrent stereotactic radiosurgery and bevacizumab in recurrent malignant gliomas: a prospective trial. 
  • Cone-beam CT localization of internal target volumes for stereotactic body radiotherapy of lung lesions. 
  • Cost Implications of an Evidence-Based Approach to Radiation Treatment After Lumpectomy for Early-Stage Breast Cancer. 
  • Cryoablation for Small Renal Masses: Selection Criteria, Complications, and Functional and Oncologic Results. 
  • Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia. 
  • Data analysis: evaluation of nanoscale contrast agent enhanced CT scan to differentiate between benign and malignant lung cancer in mouse model. 
  • Defining the optimal planning target volume in image-guided stereotactic radiosurgery of brain metastases: results of a randomized trial. 
  • Development of RTOG consensus guidelines for the definition of the clinical target volume for postoperative conformal radiation therapy for prostate cancer. 
  • Development of enhanced ethanol ablation as an alternative to surgery in treatment of superficial solid tumors. 
  • Diaphragmatic hernia after hepatic resection: case series at a single Western institution. 
  • Differential platelet levels affect response to taxane-based therapy in ovarian cancer. 
  • Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells. 
  • Does larger tumor volume explain the higher prostate specific antigen levels in black men with prostate cancer--Results from the SEARCH database. 
  • Dose as a function of lung volume and planned treatment volume in helical tomotherapy intensity-modulated radiation therapy-based stereotactic body radiation therapy for small lung tumors. 
  • Dosimetric effect of intrafraction motion and residual setup error for hypofractionated prostate intensity-modulated radiotherapy with online cone beam computed tomography image guidance. 
  • Dosimetric quantifiers for low-dose-rate prostate brachytherapy: is V(100) superior to D(90)? 
  • Dosimetric verification of lung cancer treatment using the CBCTs estimated from limited-angle on-board projections. 
  • Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study. 
  • Dual-energy micro-computed tomography imaging of radiation-induced vascular changes in primary mouse sarcomas. 
  • ELF3 is a repressor of androgen receptor action in prostate cancer cells. 
  • Effect of machine learning methods on predicting NSCLC overall survival time based on Radiomics analysis. 
  • Effect of pazopanib on tumor microenvironment and liposome delivery. 
  • Effects of Cancer Stage and Treatment Differences on Racial Disparities in Survival From Colon Cancer: A United States Population-Based Study. 
  • Effects of iron depletion on CALM-AF10 leukemias. 
  • Evaluating the validity of model for end-stage liver disease exception points for hepatocellular carcinoma patients with multiple nodules <2 cm. 
  • Evaluation of hepatocellular carcinoma size using two-dimensional and volumetric analysis: effect on liver transplantation eligibility. 
  • Evaluation of the accuracy of a 3D surface imaging system for patient setup in head and neck cancer radiotherapy. 
  • Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study. 
  • Evidence for Feedback Regulation Following Cholesterol Lowering Therapy in a Prostate Cancer Xenograft Model. 
  • Exploring the Margin Recipe for Online Adaptive Radiation Therapy for Intermediate-Risk Prostate Cancer: An Intrafractional Seminal Vesicles Motion Analysis. 
  • FOLFIRINOX Induction Therapy for Stage 3 Pancreatic Adenocarcinoma. 
  • FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate. 
  • Factors predicting prostatic biopsy Gleason sum under grading. 
  • Fibrosarcoma-like lipomatous neoplasm: a reappraisal of so-called spindle cell liposarcoma defining a unique lipomatous tumor unrelated to other liposarcomas. 
  • Fish oil slows prostate cancer xenograft growth relative to other dietary fats and is associated with decreased mitochondrial and insulin pathway gene expression. 
  • Functional Implications of Renal Tumor Enucleation Relative to Standard Partial Nephrectomy. 
  • Genetic And Morphological Evaluation (GAME) score for patients with colorectal liver metastases. 
  • Genetic variants at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer. 
  • Global search for chromosomal abnormalities in infiltrating ductal carcinoma of the breast using array-comparative genomic hybridization. 
  • Gut barrier dysfunction in the Apc(Min/+) mouse model of colon cancer cachexia. 
  • Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth. 
  • Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer. 
  • Hepatic tumors: region-of-interest versus volumetric analysis for quantification of attenuation at CT. 
  • Image acquisition optimization of a limited-angle intrafraction verification (LIVE) system for lung radiotherapy. 
  • Imaging primary lung cancers in mice to study radiation biology. 
  • Impact of T status and N status on perioperative outcomes after thoracoscopic lobectomy for lung cancer. 
  • Impact of collimator leaf width and treatment technique on stereotactic radiosurgery and radiotherapy plans for intra- and extracranial lesions. 
  • Impact of consolidation radiation therapy in stage III-IV diffuse large B-cell lymphoma with negative post-chemotherapy radiologic imaging. 
  • In Reply to O'Sullivan et al. 
  • Initial testing (stage 1) of sunitinib by the pediatric preclinical testing program. 
  • Initial testing of the replication competent Seneca Valley virus (NTX-010) by the pediatric preclinical testing program. 
  • Intraoperative mapping during repeat awake craniotomy reveals the functional plasticity of adult cortex. 
  • Laparoscopic partial nephrectomy for tumors 7cm and above. Perioperative outcomes. 
  • Low-carbohydrate diets and prostate cancer: how low is "low enough"? 
  • Management of hepatocellular adenoma: comparison of resection, embolization and observation. 
  • Mechanical Signaling and Extracellular Matrix in Uterine Fibroids. 
  • Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma. 
  • Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: induction of potent anti-residual tumour immunity. 
  • Modeling pathologic response of esophageal cancer to chemoradiation therapy using spatial-temporal 18F-FDG PET features, clinical parameters, and demographics. 
  • Modulation of pancreatic cancer chemoresistance by inhibition of TAK1. 
  • Neoadjuvant Systemic Therapy for Breast Cancer: Factors Influencing Surgeons' Referrals. 
  • Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. 
  • Notch promotes radioresistance of glioma stem cells. 
  • Notch3 pathway alterations in ovarian cancer. 
  • Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer. 
  • Pancreatic mucinous cystic neoplasm size using CT volumetry, spherical and ellipsoid formulas: validation study. 
  • Pancreatic neuroendocrine tumors with involved surgical margins: prognostic factors and the role of adjuvant radiotherapy. 
  • Parenchymal-Sparing Versus Anatomic Liver Resection for Colorectal Liver Metastases: a Systematic Review. 
  • Pathologic and molecular features correlate with long-term outcome after adjuvant therapy of resected primary GI stromal tumor: the ACOSOG Z9001 trial. 
  • Pathologic grade and tumor size are associated with recurrence-free survival in patients with duodenal neuroendocrine tumors. 
  • Percent tumor involvement and risk of biochemical progression after radical prostatectomy. 
  • Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth. 
  • Perineural and intraneural invasion in posttherapy pancreaticoduodenectomy specimens predicts poor prognosis in patients with pancreatic ductal adenocarcinoma. 
  • Persistent pulmonary subsolid nodules with solid portions of 5 mm or smaller: Their natural course and predictors of interval growth. 
  • Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas. 
  • Phase III study of pasireotide long-acting release in patients with metastatic neuroendocrine tumors and carcinoid symptoms refractory to available somatostatin analogues. 
  • Pregnancy-related fibroid reduction. 
  • Preoperative imaging for resectable periampullary cancer: clinicopathologic implications of reported radiographic findings. 
  • Preoperative single fraction partial breast radiotherapy for early-stage breast cancer. 
  • Primary tumour standardised uptake value is prognostic in nonsmall cell lung cancer: a multivariate pooled analysis of individual data. 
  • Prognostic value of midtreatment FDG-PET in oropharyngeal cancer. 
  • Progression Patterns in the Remnant Pancreas after Resection of Non-Invasive or Micro-Invasive Intraductal Papillary Mucinous Neoplasms (IPMN). 
  • Qualifiers of atypia in the cytologic diagnosis of thyroid nodules are associated with different Afirma gene expression classifier results and clinical outcomes. 
  • Quantification and minimization of uncertainties of internal target volume for stereotactic body radiation therapy of lung cancer. 
  • RAS mutations in thyroid FNA specimens are highly predictive of predominantly low-risk follicular-pattern cancers. 
  • RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer. 
  • RTOG sarcoma radiation oncologists reach consensus on gross tumor volume and clinical target volume on computed tomographic images for preoperative radiotherapy of primary soft tissue sarcoma of extremity in Radiation Therapy Oncology Group studies. 
  • Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study. 
  • Racial variation in adjuvant chemotherapy initiation among breast cancer patients receiving oncotype DX testing. 
  • Radiogenomics of lower-grade glioma: algorithmically-assessed tumor shape is associated with tumor genomic subtypes and patient outcomes in a multi-institutional study with The Cancer Genome Atlas data. 
  • Rare codons capacitate Kras-driven de novo tumorigenesis. 
  • Recurrence and Survival After Resection of Small Intraductal Papillary Mucinous Neoplasm-associated Carcinomas (≤20-mm Invasive Component): A Multi-institutional Analysis. 
  • Reduced Core Targeted (RCT) biopsy: Combining multiparametric magnetic resonance imaging - transrectal ultrasound fusion targeted biopsy with laterally-directed sextant biopsies - An alternative template for prostate fusion biopsy. 
  • Reduction in Tumor Volume by Cone Beam Computed Tomography Predicts Overall Survival in Non-Small Cell Lung Cancer Treated With Chemoradiation Therapy. 
  • Reproducibility of tumor motion probability distribution function in stereotactic body radiation therapy of lung cancer. 
  • Resection and survival. 
  • Resection of large hepatocellular carcinoma (≥10 cm): a unique western perspective. 
  • Role of YAP1 as a Marker of Sensitivity to Dual AKT and P70S6K Inhibition in Ovarian and Uterine Malignancies. 
  • Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma. 
  • Significant Reduction of Late Toxicities in Patients With Extremity Sarcoma Treated With Image-Guided Radiation Therapy to a Reduced Target Volume: Results of Radiation Therapy Oncology Group RTOG-0630 Trial. 
  • Size of sentinel node tumor deposits and extent of axillary lymph node involvement: which breast cancer patients may benefit from less aggressive axillary dissections? 
  • Solid pseudopapillary neoplasm of the pancreas: clinicopathologic and survival analyses of 64 cases from a single institution. 
  • Sorafenib, a multikinase inhibitor, enhances the response of melanoma to regional chemotherapy. 
  • Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the pediatric preclinical testing program. 
  • Stereotactic body radiotherapy for lesions of the spine and paraspinal regions. 
  • Systemic anti-tumour effects of local thermally sensitive liposome therapy. 
  • Targeting eNOS in pancreatic cancer. 
  • Targeting stem cell behavior in desmoid tumors (aggressive fibromatosis) by inhibiting hedgehog signaling. 
  • Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program. 
  • The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. 
  • The PREVAIL Study: Primary Outcomes by Site and Extent of Baseline Disease for Enzalutamide-treated Men with Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer. 
  • The immunocytokine NHS-IL12 as a potential cancer therapeutic. 
  • The impact of tumor size on the association of the extent of lymph node resection and survival in clinical stage I non-small cell lung cancer. 
  • The influence of diabetes severity on receipt of guideline-concordant treatment for breast cancer. 
  • The oligometastatic state - separating truth from wishful thinking. 
  • The role of seminal vesicle motion in target margin assessment for online image-guided radiotherapy for prostate cancer. 
  • The small abnormal parathyroid gland is increasingly common and heralds operative complexity. 
  • Therapeutic targeting of erbB3 with MM-121/SAR256212 enhances antitumor activity of paclitaxel against erbB2-overexpressing breast cancer. 
  • Thermal dose fractionation affects tumour physiological response. 
  • Triphasic contrast enhanced CT simulation with bolus tracking for pancreas SBRT target delineation. 
  • Tumor volume changes on 1.5 tesla endorectal MRI during neoadjuvant androgen suppression therapy for higher-risk prostate cancer and recurrence in men treated using radiation therapy results of the phase II CALGB 9682 study. 
  • Understanding the pathological features of focality, grade and tumour volume of early-stage prostate cancer as a foundation for parenchyma-sparing prostate cancer therapies: active surveillance and focal targeted therapy. 
  • Use of bioluminescence imaging to detect enhanced hepatic and systemic tumor growth following partial hepatectomy in mice. 
  • Uveal melanoma treated with iodine-125 episcleral plaque: an analysis of dose on disease control and visual outcomes. 
  • Validating a prognostic scoring system for postmastectomy locoregional recurrence in breast cancer. 
  • Variation in the definition of clinical target volumes for pelvic nodal conformal radiation therapy for prostate cancer. 
  • Variation in the gross tumor volume and clinical target volume for preoperative radiotherapy of primary large high-grade soft tissue sarcoma of the extremity among RTOG sarcoma radiation oncologists. 
  • Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression. 
  • Vascular inflow control during hemi-hepatectomy: a comparison between intrahepatic pedicle ligation and extrahepatic vascular ligation. 
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  Keywords of People

  • Badea, Cristian Tudorel, Professor in Radiology, Biomedical Engineering
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Craciunescu, Oana, Associate Professor of Radiation Oncology, Radiation Oncology
  • Hoang, Jenny K., Associate Professor of Radiology, Radiology, Neuroradiology
  • Johnson, G. Allan, Charles E. Putman University Professor of Radiology, Physics
  • McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Duke Innovation & Entrepreneurship
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
  • Yoo, Sua, Associate Professor of Radiation Oncology, Radiation Oncology