PPAR alpha
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Subject Areas on Research
- A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals.
- A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression.
- Alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice.
- CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice.
- Fenofibrate rapidly decreases hepatic lipid and glycogen storage in neonatal mice with glycogen storage disease type Ia.
- Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk.
- Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels.
- MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism.
- Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation.
- Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors.
- Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet.
- Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.
- Overcompensation of CoA Trapping by Di(2-ethylhexyl) Phthalate (DEHP) Metabolites in Livers of Wistar Rats.
- Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.
- Pharmacological activation of PPARbeta/delta stimulates utrophin A expression in skeletal muscle fibers and restores sarcolemmal integrity in mature mdx mice.
- SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα.
- Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise.
- The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination.