Intracellular Signaling Peptides and Proteins
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Subject Areas on Research
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2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis.
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80K-H acts as a signaling bridge in intact living cells between PKCzeta and the GLUT4 translocation regulator Munc18c.
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A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo.
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A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans.
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A Genome-Wide Association Study Identifies Two Novel Susceptible Regions for Squamous Cell Carcinoma of the Head and Neck.
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A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP.
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A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size.
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A collection of cortical crescents: asymmetric protein localization in CNS precursor cells.
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A comprehensive mutation analysis of RP2 and RPGR in a North American cohort of families with X-linked retinitis pigmentosa.
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A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern.
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A genome-wide association study of corneal astigmatism: The CREAM Consortium.
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A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast.
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A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation.
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A pharmacodynamic study of rapamycin in men with intermediate- to high-risk localized prostate cancer.
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A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling.
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A single-gene cause in 29.5% of cases of steroid-resistant nephrotic syndrome.
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A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase.
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A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration.
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A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95.
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A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities.
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A20 modulates lipid metabolism and energy production to promote liver regeneration.
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A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation.
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A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis.
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A20 protects mice from D-galactosamine/lipopolysaccharide acute toxic lethal hepatitis.
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A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression.
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A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism.
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A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia.
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ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling.
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ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis.
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ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration.
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Aberrant processing of the WSC family and Mid2p cell surface sensors results in cell death of Saccharomyces cerevisiae O-mannosylation mutants.
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Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages.
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Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep.
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Acquisition of mitochondrial dysregulation and resistance to mitochondrial-mediated apoptosis after genotoxic insult in normal human fibroblasts: a possible model for early stage carcinogenesis.
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Actin is required for IFT regulation in Chlamydomonas reinhardtii.
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Activation of a nerve injury transcriptional signature in airway-innervating sensory neurons after lipopolysaccharide-induced lung inflammation.
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Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen.
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Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons.
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Adducin preferentially recruits spectrin to the fast growing ends of actin filaments in a complex requiring the MARCKS-related domain and a newly defined oligomerization domain.
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Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C.
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Adolescent intermittent alcohol exposure: persistence of structural and functional hippocampal abnormalities into adulthood.
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Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A.
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African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity.
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Alpha V integrin prolongs collagenase production through Jun activation binding protein 1.
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Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway.
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Alterations of the X-linked lymphoproliferative disease gene SH2D1A in common variable immunodeficiency syndrome.
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Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism.
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Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae.
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An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart.
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An essential role for c-FLIP in the efficient development of mature T lymphocytes.
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Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studies.
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Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis.
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Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.
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Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression.
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Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes.
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Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2.
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Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a Chinese population.
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Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity.
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Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases.
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Beta-arrestin-mediated signaling regulates protein synthesis.
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Blau syndrome and related genetic disorders causing childhood arthritis.
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Bridged peptide macrocycles as ligands for PDZ domain proteins.
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C8ORF37 Is Required for Photoreceptor Outer Segment Disc Morphogenesis by Maintaining Outer Segment Membrane Protein Homeostasis.
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CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension.
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CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation.
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CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation.
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CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis.
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CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation.
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COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness.
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Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death.
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Calcium-dependent gene regulation in myocyte hypertrophy and remodeling.
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Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling.
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Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis.
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Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of rapamycin.
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Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors.
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Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial Cells.
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Characterization of human Gadd45, a p53-regulated protein.
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Characterization of two labor-induced genes, DSCR1 and TCTE1L, in the pregnant ovine myometrium.
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Chemical waves in cell and developmental biology.
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Cholecystokinin.
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Chromosome rearrangements and aneuploidy in yeast strains lacking both Tel1p and Mec1p reflect deficiencies in two different mechanisms.
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Clinical and mutational spectrum of neurofibromatosis type 1-like syndrome.
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Coevolution of the major histocompatibility complex and the t-complex in the mouse. I. Generation and maintenance of high complementarity associations.
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Coevolution of the major histocompatibility complex and the t-complex in the mouse. II. Modification of response to sharing of histocompatibility antigens.
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Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells.
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Common variation in Nemo-like kinase is associated with risk of ovarian cancer.
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Comparative phenotypic and CARD15 mutational analysis among African American, Hispanic, and White children with Crohn's disease.
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Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function.
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Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model.
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Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi.
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Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1.
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Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix α0.
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Conversion of protein phosphatase 1 catalytic subunit to a Mn(2+)-dependent enzyme impairs its regulation by inhibitor 1.
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Cordon-bleu is a conserved gene involved in neural tube formation.
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Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting.
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Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer.
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Definition of a functional single nucleotide polymorphism in the cell migration inhibitory gene MIIP that affects the risk of breast cancer.
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Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae.
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Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis.
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Design, synthesis, and evaluation of linear and cyclic peptide ligands for PDZ10 of the multi-PDZ domain protein MUPP1.
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Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans.
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Differential requirement for the SAP-Fyn interaction during NK T cell development and function.
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Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme.
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Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice.
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Distinctive regulatory and metabolic properties of glycogen-targeting subunits of protein phosphatase-1 (PTG, GL, GM/RGl) expressed in hepatocytes.
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Divergence of protein kinase A catalytic subunits in Cryptococcus neoformans and Cryptococcus gattii illustrates evolutionary reconfiguration of a signaling cascade.
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Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth.
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Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation.
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Dual kinase-mediated regulation of PITK by CaMKII and GSK3.
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Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy.
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Dynamic regulation of the translation initiation helicase complex by mitogenic signal transduction to eukaryotic translation initiation factor 4G.
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Dynamics of Delta/Notch signaling on endomesoderm segregation in the sea urchin embryo.
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Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells.
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Effect of aspirin response signature gene expression on preterm birth and preeclampsia among women with lupus: a pilot study.
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Elevated intraocular pressure induces Rho GTPase mediated contractile signaling in the trabecular meshwork.
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Endoglin deficiency impairs stroke recovery.
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Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC.
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Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development.
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Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation.
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Enhanced sensitivity to cytochrome c-induced apoptosis mediated by PHAPI in breast cancer cells.
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Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.
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Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95.
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Evidence for involvement of GNB1L in autism.
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Evidence that Par-4 participates in the pathogenesis of HIV encephalitis.
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Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations.
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Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus.
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Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis.
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Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma.
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Expression of PSD-95/SAP90 is critical for N-methyl-D-aspartate receptor-mediated thermal hyperalgesia in the spinal cord.
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Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts.
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Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow.
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Expression of genes and proteins of the pax-six-eya-dach network in the metamorphic sea urchin: Insights into development of the enigmatic echinoderm body plan and sensory structures.
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Expression of the candidate tumor suppressor gene hSRBC is frequently lost in primary lung cancers with and without DNA methylation.
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Factors affecting Sertoli cell function in the testis.
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Failure to replicate effect of Kibra on human memory in two large cohorts of European origin.
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FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes.
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From man to fish: What can Zebrafish tell us about ApoL1 nephropathy?
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From promiscuity to precision: protein phosphatases get a makeover.
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Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.
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Functional polymorphisms of JWA gene are associated with risk of bladder cancer.
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Functional repeats (TGYCC)n in the p53-inducible gene 3 (PIG3) promoter and susceptibility to squamous cell carcinoma of the head and neck.
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G Protein-regulated inducer of neurite outgrowth (GRIN) modulates Sprouty protein repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation.
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GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors.
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GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.
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Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy.
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Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP.
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Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function.
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Genetic variants of JNK and p38α pathways and risk of non-small cell lung cancer in an Eastern Chinese population.
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Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
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Genome-Wide Association Meta-Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci.
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Genome-Wide Association Study Links Receptor Tyrosine Kinase Inhibitor Sprouty 2 to Thrombocytopenia after Coronary Artery Bypass Surgery.
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Genome-wide association of pericardial fat identifies a unique locus for ectopic fat.
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Genomic correlates of variability in immune response to an oral cholera vaccine.
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Germline mutations in PPFIBP2 are associated with lethal prostate cancer.
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Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania.
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Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.
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Growth factor modulation of p53-mediated growth arrest versus apoptosis.
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Gαs proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-αvβ3 and CD44-CD44 interactions.
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Hepatitis C virus directly acting antivirals: current developments with NS3/4A HCV serine protease inhibitors.
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Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells.
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High rates of "unselected" aneuploidy and chromosome rearrangements in tel1 mec1 haploid yeast strains.
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Hippocampal infusions of MARCKS peptides impair memory of rats on the radial-arm maze.
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How do halogen substituents contribute to protein-binding interactions? A thermodynamic study of peptide ligands with diverse aryl halides.
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Human RPE expression of cell survival factors.
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Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse.
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Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice.
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Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma.
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Hypervirulent group A Streptococcus emergence in an acaspular background is associated with marked remodeling of the bacterial cell surface.
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IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation.
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Identification and functional characterization of JWA polymorphisms and their association with risk of gastric cancer and esophageal squamous cell carcinoma in a Chinese population.
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Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking.
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Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity.
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Identification of driver genes in hepatocellular carcinoma by exome sequencing.
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Identification of neural transcription factors required for the differentiation of three neuronal subtypes in the sea urchin embryo.
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Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes.
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Identification of prohibitin and prohibiton as novel factors binding to the p53 induced gene 3 (PIG3) promoter (TGYCC)(15) motif.
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Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease.
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Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct.
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Identification of yeast mutants with altered telomere structure.
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Immunological approach to the study of hormone action: regulation of the phosphorylation state of protein phosphatase inhibitor-1 by hormones.
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Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation.
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Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles.
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Indian hedgehog as a progesterone-responsive factor mediating epithelial-mesenchymal interactions in the mouse uterus.
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Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase.
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Inhibition of Rho-kinase induces alphaB-crystallin expression in lens epithelial cells.
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Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules.
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Inhibition of native and recombinant nicotinic acetylcholine receptors by the myristoylated alanine-rich C kinase substrate peptide.
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Inhibition of the dopamine D1 receptor signaling by PSD-95.
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Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis.
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Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma.
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Insulin and diabetes cause reciprocal changes in the association of eIF-4E and PHAS-I in rat skeletal muscle.
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Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.
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Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation.
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Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae.
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Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.
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Investigation of known genetic risk factors for primary open angle glaucoma in two populations of African ancestry.
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Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression.
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Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22.
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Involvement of the checkpoint protein Mec1p in silencing of gene expression at telomeres in Saccharomyces cerevisiae.
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Jaffe-Campanacci syndrome, revisited: detailed clinical and molecular analyses determine whether patients have neurofibromatosis type 1, coincidental manifestations, or a distinct disorder.
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Joint effects of single nucleotide polymorphisms in P53BP1 and p53 on breast cancer risk in a Chinese population.
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KAP-1 promotes resection of broken DNA ends not protected by γ-H2AX and 53BP1 in G₁-phase lymphocytes.
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KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis.
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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
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LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.
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Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts.
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Light-driven translocation of signaling proteins in vertebrate photoreceptors.
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Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells.
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Low prevalence of NPHS2 mutations in African American children with steroid-resistant nephrotic syndrome.
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Lymphocytic vasculitis involving the central nervous system occurs in patients with X-linked lymphoproliferative disease in the absence of Epstein-Barr virus infection.
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Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells.
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MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.
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Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions.
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Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves.
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Membrane association of the myristoylated alanine-rich C kinase substrate (MARCKS) protein appears to involve myristate-dependent binding in the absence of a myristoyl protein receptor.
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Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9.
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Methodologies for the characterization, identification and quantification of S-nitrosylated proteins.
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Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis.
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Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease.
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Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis.
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Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
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Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.
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Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop.
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Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.
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Molecular basis of T cell inactivation by CTLA-4.
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Molecular characterization of the tumor-suppressive function of nischarin in breast cancer.
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Molecular cloning of protein phosphatase inhibitor-1 and its expression in rat and rabbit tissues.
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Molecular determinants of nuclear protein phosphatase-1 regulation by NIPP-1.
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Molecular pathophysiology of Parkinson's disease.
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Monitoring neural activity with bioluminescence during natural behavior.
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Multiple domains of MCIP1 contribute to inhibition of calcineurin activity.
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Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.
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Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor.
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Mutational analysis of NPHS2 and WT1 in frequently relapsing and steroid-dependent nephrotic syndrome.
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Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients.
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Mutations in RPGR and RP2 account for 15% of males with simplex retinal degenerative disease.
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Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo.
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N-(4-hydroxyphenyl)retinamide (4-HPR) modulates GADD45 expression in radiosensitive bladder cancer cell lines.
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NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway.
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NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia.
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Neonatal co-infection with helicobacter species markedly accelerates the development of inflammation-associated colonic neoplasia in IL-10(-/-) mice.
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Nephrotic syndrome in the first year of life: two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2).
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Neural and hormonal regulation of pancreatic secretion.
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Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy.
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Neurofibromatosis Type 1 and tumorigenesis: molecular mechanisms and therapeutic implications.
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Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy.
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Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia.
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Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism.
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Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice.
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Notch/Delta expression in the developing mouse lung.
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Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation.
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Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway.
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Nucleotide sequence, expression, and chromosomal mapping of Mrp and mapping of five related sequences.
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Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation.
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PAK kinases Ste20 and Pak1 govern cell polarity at different stages of mating in Cryptococcus neoformans.
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PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis.
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PHAS-I as a link between mitogen-activated protein kinase and translation initiation.
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PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K.
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PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation.
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PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors.
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PTEN as an effector in the signaling of antimigratory G protein-coupled receptor.
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Pediatric narcolepsy.
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Peptide array X-linking (PAX): a new peptide-protein identification approach.
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Phenotypic characterization of murine models of cerebral cavernous malformations.
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Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes.
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Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility.
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Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.
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Phosphorylation of the translational regulator, PHAS-I, by protein kinase CK2.
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Physiologic importance of protein phosphatase inhibitors.
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Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease.
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Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck.
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Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population.
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Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium.
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Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis.
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Primary structure and domain organization of human alpha and beta adducin.
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Proteasome inhibitor attenuates skeletal muscle reperfusion injury by blocking the pathway of nuclear factor-kappaB activation.
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Protein (serine and threonine) phosphate phosphatases.
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Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post-Lung Transplant Primary Graft Dysfunction Risk.
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Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase.
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Protein phosphatase regulation by endogenous inhibitors.
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Protein serine/threonine phosphatases: life, death, and sleeping.
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Purification and characterization of a 60-kDa protein from oat, formerly known as a TCP1-related chaperone.
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RAP2 mediates mechanoresponses of the Hippo pathway.
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ROCK1 phosphorylates and activates zipper-interacting protein kinase.
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RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro.
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Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis.
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Recent advances in pancreatic endocrine and exocrine secretion.
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Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Galphai family.
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Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.
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Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes.
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Regulation of mast cell survival and function by tuberous sclerosis complex 1.
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Regulation of mitotic chromosome cohesion by Haspin and Aurora B.
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Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility.
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Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses.
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Regulation of nuclear Prointerleukin-16 and p27(Kip1) in primary human T lymphocytes.
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Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase.
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Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2.
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Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.
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Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO.
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Rho A/Rho kinase: human umbilical artery mRNA expression in normal and pre eclamptic pregnancies and functional role in isoprostane-induced vasoconstriction.
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Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma.
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Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
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Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration.
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Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells.
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Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae.
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Rovalpituzumab tesirine, a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: a first-in-human, first-in-class, open-label, phase 1 study.
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SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling.
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Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity.
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Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma.
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Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival.
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Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha.
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Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
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Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.
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Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation.
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Single-walled carbon nanotubes increase pandemic influenza A H1N1 virus infectivity of lung epithelial cells.
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Six1 and Six1 cofactor expression is altered during early skeletal muscle overload in mice.
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Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism.
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Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45.
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Sonic hedgehog is required for cardiac outflow tract and neural crest cell development.
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Specific podocin mutations correlate with age of onset in steroid-resistant nephrotic syndrome.
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Sprinter: a novel transmembrane protein required for Wg secretion and signaling.
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Stall encodes an ADAMTS metalloprotease and interacts genetically with Delta in Drosophila ovarian follicle formation.
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Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems.
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Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells.
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Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance.
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Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.
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TD-19, an erlotinib derivative, induces epidermal growth factor receptor wild-type nonsmall-cell lung cancer apoptosis through CIP2A-mediated pathway.
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TOLLIP, MUC5B, and the Response to N-Acetylcysteine among Individuals with Idiopathic Pulmonary Fibrosis.
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Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function.
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Targeting A20 decreases glioma stem cell survival and tumor growth.
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Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease.
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Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function.
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Targeting the Wnt-Regulatory Protein CTNNBIP1 by microRNA-214 Enhances the Stemness and Self-Renewal of Cancer Stem-Like Cells in Lung Adenocarcinomas.
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The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification.
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The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae.
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The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and influences Trichoplusia ni herbivory.
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The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis.
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The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.
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The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains.
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The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.
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The G72/G30 gene complex and cognitive abnormalities in schizophrenia.
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The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast.
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The SABRE gene is required for normal cell expansion in Arabidopsis.
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The Saccharomyces cerevisiae suppressor of choline sensitivity (SCS2) gene is a multicopy Suppressor of mec1 telomeric silencing defects.
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The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein.
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The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome.
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The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms.
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The integrin-linked kinase regulates cell morphology and motility in a rho-associated kinase-dependent manner.
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The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly.
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The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells.
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The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint.
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The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus.
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The modulation of MSC integrin expression by RGD presentation.
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The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter.
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The p53-dependent gamma-ray response of GADD45.
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The production and characterization of murine monoclonal antibodies to human Gadd45 raised against a recombinant protein.
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The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle.
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The role of modulatory calcineurin-interacting proteins in calcineurin signaling.
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Thromboxane binding and signal transduction in rat glomerular mesangial cells.
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Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling.
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Tissue interactions pattern the mesenchyme of the embryonic mouse lung.
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Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli.
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Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia.
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UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity.
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Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system.
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Update in podocyte biology: putting one's best foot forward.
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Urinary-cell mRNA profile and acute cellular rejection in kidney allografts.
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Variant genotypes of CDKN1A and CDKN1B are associated with an increased risk of breast cancer in Chinese women.
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Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.
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WASP-interacting protein is important for actin filament elongation and prompt pseudopod formation in response to a dynamic chemoattractant gradient.
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WLS retrograde transport to the endoplasmic reticulum during Wnt secretion.
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WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification.
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Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants.
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Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism.
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X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses.
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XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype.
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Zonisamide prevents olanzapine-associated hyperphagia, weight gain, and elevated blood glucose in rats.
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beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors.
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mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.
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neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions.
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p27Kip1 in stage III colon cancer: implications for outcome following adjuvant chemotherapy in cancer and leukemia group B protocol 89803.
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p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
-
Ciofani, Maria,
Associate Professor of Immunology,
Immunology
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Gunn, Michael Dee,
Professor of Medicine,
Immunology
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Hogan, Brigid L. M.,
George Barth Geller Distinguished Professor for Research in Molecular Biology,
Cell Biology
-
Krangel, Michael S.,
George Barth Geller Distinguished Professor of Immunology,
Immunology
-
Liu, Yutao,
Adjunct Assistant Professor in the Department of Medicine,
Medicine, Medical Genetics
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McDonnell, Donald Patrick,
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine,
Duke Innovation & Entrepreneurship
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
-
Soderling, Scott Haydn,
George Barth Geller Distinguished Professor of Molecular Biology,
Cell Biology