JNK Mitogen-Activated Protein Kinases
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Subject Areas on Research
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2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression.
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A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase.
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Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism.
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Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer.
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Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors.
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Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degeneration.
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Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice.
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Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis.
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CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
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CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control.
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CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels.
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Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload.
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Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation.
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Cross-talk between TGF-beta1 and IL-6 in human trabecular meshwork cells.
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Curcumin inhibits LPS-induced CCL2 expression via JNK pathway in C6 rat astrocytoma cells.
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Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior.
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Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo.
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Drosophila RhoA regulates the cytoskeleton and cell-cell adhesion in the developing epidermis.
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Effect of ethanol on tumor necrosis factor signaling during liver regeneration.
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Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats.
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Functional Toll-like receptor 4 mutations modulate the response to fibrinogen.
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G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion.
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Gene expression changes and signaling events associated with the direct antimelanoma effect of IFN-gamma.
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Genetic variants of JNK and p38α pathways and risk of non-small cell lung cancer in an Eastern Chinese population.
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Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production.
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Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.
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Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy.
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Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase.
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Induction of ERK1/2 and histone H3 phosphorylation within the outer stripe of the outer medulla of the Eker rat by 2,3,5-tris-(glutathion-S-yl)hydroquinone.
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Induction of mitogenic signalling in the 1LN prostate cell line on exposure to submicromolar concentrations of cadmium+.
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Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease.
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JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis.
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KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage.
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MAP kinase and pain.
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Manipulating JNK signaling with (--)-zuonin A.
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Microparticles stimulate the synthesis of prostaglandin E(2) via induction of cyclooxygenase 2 and microsomal prostaglandin E synthase 1.
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Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts.
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Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells.
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Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease.
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RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation.
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Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye.
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Regulation of Kupffer cell TNF gene expression during experimental acute pancreatitis: the role of p38-MAPK, ERK1/2, SAPK/JNK, and NF-kappaB.
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Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades.
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Requirement of TGF-beta receptor-dependent activation of c-Jun N-terminal kinases (JNKs)/stress-activated protein kinases (Sapks) for TGF-beta up-regulation of the urokinase-type plasminogen activator receptor.
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Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): signaling to multidrug-efflux and hyperproliferation.
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Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model.
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Signal transduction. Three paths to stress relief.
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Staurosporine-induced apoptosis in cardiomyocytes: A potential role of caspase-3.
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Stress and death: breaking up the c-Abl/14-3-3 complex in apoptosis.
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Suppression of the c-Jun N-terminal kinase pathway by 17beta-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction.
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TL1, a novel tumor necrosis factor-like cytokine, induces apoptosis in endothelial cells. Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) and caspase-3-like protease.
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TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death.
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The c-Jun transcription factor--bipotential mediator of neuronal death, survival and regeneration.
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The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway.
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The induction of HMGB1 release from RAW 264.7 cells by transfected DNA.
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The injured cochlea as a target for inflammatory processes, initiation of cell death pathways and application of related otoprotectives strategies.
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The role of IFN-alpha and nitric oxide in the release of HMGB1 by RAW 264.7 cells stimulated with polyinosinic-polycytidylic acid or lipopolysaccharide.
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Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells.
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Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia.
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Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.
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Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling.
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