JNK Mitogen-Activated Protein Kinases
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Subject Areas on Research
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A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase.
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Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism.
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Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer.
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Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors.
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Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degeneration.
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Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice.
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Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis.
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CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
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CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control.
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CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels.
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Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells.
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Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload.
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Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor.
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Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation.
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Co-opted JNK/SAPK signaling in Wnt/beta-catenin-induced tumorigenesis.
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Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine.
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Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System.
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Cross-talk between TGF-beta1 and IL-6 in human trabecular meshwork cells.
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Curcumin inhibits LPS-induced CCL2 expression via JNK pathway in C6 rat astrocytoma cells.
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Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior.
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Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo.
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Distinct gene expression profiles in adult mouse heart following targeted MAP kinase activation.
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Drosophila RhoA regulates the cytoskeleton and cell-cell adhesion in the developing epidermis.
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Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.
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Effect of ethanol on tumor necrosis factor signaling during liver regeneration.
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Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure.
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Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats.
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Flavanones structure-related inhibition on TPA-induced tumor promotion through suppression of extracellular signal-regulated protein kinases: involvement of prostaglandin E2 in anti-promotive process.
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Functional Toll-like receptor 4 mutations modulate the response to fibrinogen.
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G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion.
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Gene expression changes and signaling events associated with the direct antimelanoma effect of IFN-gamma.
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Genetic variants of JNK and p38α pathways and risk of non-small cell lung cancer in an Eastern Chinese population.
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Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production.
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Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.
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Hyperactivated JNK is a therapeutic target in pVHL-deficient renal cell carcinoma.
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Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy.
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Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase.
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Induction of ERK1/2 and histone H3 phosphorylation within the outer stripe of the outer medulla of the Eker rat by 2,3,5-tris-(glutathion-S-yl)hydroquinone.
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Induction of apoptosis in vascular smooth muscle cells by mechanical stretch.
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Induction of mitogenic signalling in the 1LN prostate cell line on exposure to submicromolar concentrations of cadmium+.
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JNK activation decreases PP2A regulatory subunit B56alpha expression and mRNA stability and increases AUF1 expression in cardiomyocytes.
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JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis.
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KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage.
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Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.
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MAP kinase and pain.
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Manipulating JNK signaling with (--)-zuonin A.
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Microparticles stimulate the synthesis of prostaglandin E(2) via induction of cyclooxygenase 2 and microsomal prostaglandin E synthase 1.
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Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.
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Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes.
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Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity.
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Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells.
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Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease.
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RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation.
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Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye.
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Regulation of Kupffer cell TNF gene expression during experimental acute pancreatitis: the role of p38-MAPK, ERK1/2, SAPK/JNK, and NF-kappaB.
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Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades.
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Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.
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Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): signaling to multidrug-efflux and hyperproliferation.
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Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model.
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Signal transduction. Three paths to stress relief.
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Stress and death: breaking up the c-Abl/14-3-3 complex in apoptosis.
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Stress-activated MAP kinases in cardiac remodeling and heart failure; new insights from transgenic studies.
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Suppression of the c-Jun N-terminal kinase pathway by 17beta-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction.
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Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells.
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TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death.
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Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects.
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Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination.
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The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer.
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The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation.
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The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway.
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The induction of HMGB1 release from RAW 264.7 cells by transfected DNA.
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The injured cochlea as a target for inflammatory processes, initiation of cell death pathways and application of related otoprotectives strategies.
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The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.
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The role of IFN-alpha and nitric oxide in the release of HMGB1 by RAW 264.7 cells stimulated with polyinosinic-polycytidylic acid or lipopolysaccharide.
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The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury.
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Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells.
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Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia.
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Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling.
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Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling.
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c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes.