JNK Mitogen-Activated Protein Kinases
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Subject Areas on Research
- A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase.
- Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism.
- Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer.
- Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors.
- Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degeneration.
- Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice.
- Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis.
- CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
- CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control.
- CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels.
- Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload.
- Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation.
- Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System.
- Cross-talk between TGF-beta1 and IL-6 in human trabecular meshwork cells.
- Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior.
- Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo.
- Drosophila RhoA regulates the cytoskeleton and cell-cell adhesion in the developing epidermis.
- Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.
- Effect of ethanol on tumor necrosis factor signaling during liver regeneration.
- Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats.
- Flavanones structure-related inhibition on TPA-induced tumor promotion through suppression of extracellular signal-regulated protein kinases: involvement of prostaglandin E2 in anti-promotive process.
- Functional Toll-like receptor 4 mutations modulate the response to fibrinogen.
- G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion.
- Gene expression changes and signaling events associated with the direct antimelanoma effect of IFN-gamma.
- Genetic variants of JNK and p38α pathways and risk of non-small cell lung cancer in an Eastern Chinese population.
- Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.
- Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy.
- Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase.
- Induction of ERK1/2 and histone H3 phosphorylation within the outer stripe of the outer medulla of the Eker rat by 2,3,5-tris-(glutathion-S-yl)hydroquinone.
- Induction of mitogenic signalling in the 1LN prostate cell line on exposure to submicromolar concentrations of cadmium+.
- JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis.
- KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage.
- Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.
- MAP kinase and pain.
- Manipulating JNK signaling with (--)-zuonin A.
- Microparticles stimulate the synthesis of prostaglandin E(2) via induction of cyclooxygenase 2 and microsomal prostaglandin E synthase 1.
- Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.
- Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes.
- Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity.
- Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells.
- Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease.
- RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation.
- Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye.
- Regulation of Kupffer cell TNF gene expression during experimental acute pancreatitis: the role of p38-MAPK, ERK1/2, SAPK/JNK, and NF-kappaB.
- Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades.
- Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.
- Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): signaling to multidrug-efflux and hyperproliferation.
- Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model.
- Signal transduction. Three paths to stress relief.
- Stress and death: breaking up the c-Abl/14-3-3 complex in apoptosis.
- Suppression of the c-Jun N-terminal kinase pathway by 17beta-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction.
- TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death.
- The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer.
- The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation.
- The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway.
- The induction of HMGB1 release from RAW 264.7 cells by transfected DNA.
- The injured cochlea as a target for inflammatory processes, initiation of cell death pathways and application of related otoprotectives strategies.
- The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.
- The role of IFN-alpha and nitric oxide in the release of HMGB1 by RAW 264.7 cells stimulated with polyinosinic-polycytidylic acid or lipopolysaccharide.
- The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury.
- Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells.
- Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia.
- Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling.
- Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling.
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Keywords of People
- Liton, Paloma Borrajo, Associate Professor in Ophthalmology, Pathology