Extracellular Signal-Regulated MAP Kinases
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Subject Areas on Research
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A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP.
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A phase II study of sorafenib in malignant mesothelioma: results of Cancer and Leukemia Group B 30307.
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ACE-inhibition increases podocyte number in experimental glomerular disease independent of proliferation.
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Accelerated Marfan syndrome model recapitulates established signaling pathways.
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Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif).
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Activation of decidual invariant natural killer T cells promotes lipopolysaccharide-induced preterm birth.
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Activation of extracellular signal-regulated kinase (ERK) in G2 phase delays mitotic entry through p21CIP1.
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Activation of extracellular signal-regulated kinase in the anterior cingulate cortex contributes to the induction and expression of affective pain.
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Ad-IRF-1 induces apoptosis in esophageal adenocarcinoma.
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Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.
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Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients.
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An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.
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An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.
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An essential role for c-FLIP in the efficient development of mature T lymphocytes.
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Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia.
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Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis.
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Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7.
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Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.
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Beta-arrestin-mediated signaling in the heart.
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Beta-arrestins and cell signaling.
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Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration.
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Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells.
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Capillary isoelectric-focusing immunoassays to study dynamic oncoprotein phosphorylation and drug response to targeted therapies in non-small cell lung cancer.
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Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy.
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Cigarette smoke-related hydroquinone induces filamentous actin reorganization and heat shock protein 27 phosphorylation through p38 and extracellular signal-regulated kinase 1/2 in retinal pigment epithelium: implications for age-related macular degeneration.
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Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling.
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Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes.
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Control of osteoblast regeneration by a train of Erk activity waves.
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DOK2 inhibits EGFR-mutated lung adenocarcinoma.
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Derlin-1 is overexpressed in non-small cell lung cancer and promotes cancer cell invasion via EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9.
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Deubiquitinases and their emerging roles in β-arrestin-mediated signaling.
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Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses.
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Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.
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Different effects of opioid and cannabinoid receptor agonists on C-fiber-induced extracellular signal-regulated kinase activation in dorsal horn neurons in normal and spinal nerve-ligated rats.
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Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion.
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Distinct gene expression profiles in adult mouse heart following targeted MAP kinase activation.
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Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease.
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Dopamine and α-synuclein dysfunction in Smad3 null mice.
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EGFR-Dependent IL8 Production by Airway Epithelial Cells After Exposure to the Food Flavoring Chemical 2,3-Butanedione.
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ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model.
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ERK-dependent proteasome degradation of Txnip regulates thioredoxin oxidoreductase activity.
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Effect of vitamin E on tamoxifen-treated breast cancer cells.
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Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling.
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Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia.
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Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.
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Erythropoietin inhibits apoptosis in breast cancer cells via an Akt-dependent pathway without modulating in vivo chemosensitivity.
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Estrogen receptor beta protects against in vivo injury in RPE cells.
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Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha.
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Extracellular signal-regulated kinase regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport requires TAP-NxT1 binding and the AU-rich element.
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FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis [corrected] and regulate gastrulation during sea urchin development.
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Fgf8 is required for anterior heart field development.
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Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone.
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Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury.
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G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor.
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GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst.
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Gαq and hyper-phosphorylated ERK expression in Sturge-Weber syndrome leptomeningeal blood vessel endothelial cells.
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HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells.
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Helicobacter pylori stimulates gastric epithelial cell MMP-1 secretion via CagA-dependent and -independent ERK activation.
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Human Erbb2-induced Erk activity robustly stimulates cycling and functional remodeling of rat and human cardiomyocytes.
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Human neural progenitors express functional lysophospholipid receptors that regulate cell growth and morphology.
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Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells.
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Increased expression of Nox1 in neointimal smooth muscle cells promotes activation of matrix metalloproteinase-9.
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Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP.
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Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor.
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Influence of actin cytoskeletal integrity on matrix metalloproteinase-2 activation in cultured human trabecular meshwork cells.
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Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy.
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Integrative genomic approaches identify IKBKE as a breast cancer oncogene.
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Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.
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Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen.
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Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia.
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Loss of Nuclear Localized Parathyroid Hormone-Related Protein in Primary Breast Cancer Predicts Poor Clinical Outcome and Correlates with Suppressed Stat5 Signaling.
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Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.
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Lysophosphatidic acid stimulates cell growth by different mechanisms in SKOV-3 and Caov-3 ovarian cancer cells: distinct roles for Gi- and Rho-dependent pathways.
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MAP kinase and pain.
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Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent.
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Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation.
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Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling.
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Modulation of ATP-induced calcium signaling by progesterone in T47D-Y breast cancer cells.
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Morphogenetic signals from chondrocytes promote chondrogenic and osteogenic differentiation of mesenchymal stem cells.
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Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma.
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NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment.
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NF-κB- and AP-1-mediated DNA looping regulates osteopontin transcription in endotoxin-stimulated murine macrophages.
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Negative regulation of mTOR activation by diacylglycerol kinases.
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Neuregulin-induced expression of the acetylcholine receptor requires endocytosis of ErbB receptors.
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Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer.
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Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors.
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Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.
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Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration.
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Ontogeny of the eotaxins in human lung.
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PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of FcγRI.
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Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord.
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Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104).
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Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.
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Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization.
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Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.
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Photoreceptor synapses degenerate early in experimental choroidal neovascularization.
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Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease.
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Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells.
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Profiling Hsp90 differential expression and the molecular effects of the Hsp90 inhibitor IPI-504 in high-grade glioma models.
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RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation.
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Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes.
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Regulation of RasGRP1 function in T cell development and activation by its unique tail domain.
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Regulation of endothelial cell activation and angiogenesis by injectable peptide nanofibers.
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Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.
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Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.
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Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.
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Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model.
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Sorafenib, a multikinase inhibitor, enhances the response of melanoma to regional chemotherapy.
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TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.
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Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity.
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The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.
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The chemopreventive agent myoinositol inhibits Akt and extracellular signal-regulated kinase in bronchial lesions from heavy smokers.
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The dopamine metabolite 3-methoxytyramine is a neuromodulator.
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The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway.
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The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells.
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The monomeric receptor binding domain of tetrameric α2-macroglobulin binds to cell surface GRP78 triggering equivalent activation of signaling cascades.
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The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome.
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The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation.
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Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation.
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Understanding the mechanism of bias signaling of the insulin-like growth factor 1 receptor: Effects of LL37 and HASF.
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Up-regulation of proline-rich tyrosine kinase 2 in non-small cell lung cancer.
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Urinary-type plasminogen activator receptor/alpha 3 beta 1 integrin signaling, altered gene expression, and oral tumor progression.
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Vertical Inhibition of the RAF-MEK-ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in H/NRASQ61X
Mutant Rhabdomyosarcoma.
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Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase.
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Whole-brain activity mapping onto a zebrafish brain atlas.
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XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells.
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beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling.
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beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.
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{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation.
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β-Arrestin-Biased Allosteric Modulator Potentiates Carvedilol-Stimulated β Adrenergic Receptor Cardioprotection.
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β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X.
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Keywords of People