Mitogen-Activated Protein Kinase 3
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Subject Areas on Research
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(Pro)renin receptor is expressed in human retinal pigment epithelium and participates in extracellular matrix remodeling.
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5-Oxo-eicosatetraenoate is a broadly active, eosinophil-selective stimulus for human granulocytes.
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A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation.
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A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.
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Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors.
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Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis.
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Angiotensin II-stimulated signaling through G proteins and beta-arrestin.
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Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands.
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Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms.
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Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression.
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Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
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Beta-arrestin-mediated signaling regulates protein synthesis.
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Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.
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Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms.
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Bi-directional migration of lens epithelial cells in a physiological electrical field.
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Bone Marrow Mesenchymal Stem Cell Transplantation Increases GAP-43 Expression via ERK1/2 and PI3K/Akt Pathways in Intracerebral Hemorrhage.
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Bradykinin receptor subtype 1 expression and function in prostate cancer.
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Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model.
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Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2.
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Constrained selected reaction monitoring: quantification of selected post-translational modifications and protein isoforms.
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Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades.
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Copper is required for oncogenic BRAF signalling and tumorigenesis.
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Cutting edge: TGF-beta-induced expression of Foxp3 in T cells is mediated through inactivation of ERK.
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Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference.
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Dexamethasone suppresses DU145 cell proliferation and cell cycle through inhibition of the extracellular signal-regulated kinase 1/2 pathway and cyclin D1 expression.
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Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas.
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Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor.
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Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.
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Dynamic regulation of the translation initiation helicase complex by mitogenic signal transduction to eukaryotic translation initiation factor 4G.
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Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells.
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Electric fields and MAP kinase signaling can regulate early wound healing in lens epithelium.
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Electron transport complex I is required for CD8+ T cell function.
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Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway.
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Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium.
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Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression.
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Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium.
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Estrogen-induced mitogenesis of MCF-7 cells does not require the induction of mitogen-activated protein kinase activity.
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Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration.
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Factor Xa induces tissue factor expression in endothelial cells by P44/42 MAPK and NF-κB-dependent pathways.
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Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases.
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Functional Toll-like receptor 4 mutations modulate the response to fibrinogen.
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Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling.
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G Protein and β-arrestin signaling bias at the ghrelin receptor.
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G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning.
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G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases.
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GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation.
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HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor.
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Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.
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Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model.
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Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis.
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Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN.
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Insufficient luteinizing hormone-induced intracellular signaling disrupts ovulation in preovulatory follicles lacking estrogen receptor-{beta}.
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Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2.
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Interleukin-1beta mediates human airway epithelial cell migration via NF-kappaB.
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Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function.
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Lysophosphatidic acid receptor signaling in mammalian retinal pigment epithelial cells.
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MEK inhibitors, novel anti-adhesive molecules, reduce sickle red blood cell adhesion in vitro and in vivo, and vasoocclusion in vivo.
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MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer.
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MEKK3 is essential for lymphopenia-induced T cell proliferation and survival.
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Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells.
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Mitogen-activated protein kinases 3 and 6 are required for full priming of stress responses in Arabidopsis thaliana.
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Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis.
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Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.
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Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases.
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Pollutant particles produce vasoconstriction and enhance MAPK signaling via angiotensin type I receptor.
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Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway.
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.
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Regulation of Kupffer cell TNF gene expression during experimental acute pancreatitis: the role of p38-MAPK, ERK1/2, SAPK/JNK, and NF-kappaB.
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Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades.
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Regulation of mitogen-activated protein kinase pathways by catecholamine receptors.
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Role of the heat shock protein 90 in immune response stimulation by bacterial DNA and synthetic oligonucleotides.
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Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.
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Selenium's effects on MMP-2 and TIMP-1 secretion by human trabecular meshwork cells.
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Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis.
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Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2.
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Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis.
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Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta.
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The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner.
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The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.
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The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway.
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The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.
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Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.
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Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1.
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Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights.
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Visualizing G protein-coupled receptor signalsomes using confocal immunofluorescence microscopy.
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ZAP-70-dependent and -independent activation of Erk in Jurkat T cells. Differences in signaling induced by H2o2 and Cd3 cross-linking.
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ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors.
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beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.
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beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.
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beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
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p38 mitogen-activated protein kinase regulates growth factor-induced mitogenesis of rat pulmonary myofibroblasts.
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Keywords of People