Mitogen-Activated Protein Kinase 9

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  Subject Areas on Research

  • A role for cFLIP in B cell proliferation and stress MAPK regulation. 
  • Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells. 
  • Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP. 
  • JNK1 is required to preserve cardiac function in the early response to pressure overload. 
  • Manipulating JNK signaling with (--)-zuonin A. 
  • Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. 
  • The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition. 
  • The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia. 
  • The role of tuberous sclerosis complex 1 in regulating innate immunity. 
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  Keywords of People

  • Zhong, Xiaoping, Professor of Pediatrics, Integrative Immunobiology