MAP Kinase Kinase 1
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Subject Areas on Research
- A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development.
- A novel role for copper in Ras/mitogen-activated protein kinase signaling.
- A randomized phase II study of the MEK1/MEK2 inhibitor trametinib (GSK1120212) compared with docetaxel in KRAS-mutant advanced non-small-cell lung cancer (NSCLC)†.
- Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor.
- An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis.
- Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
- Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease.
- Factor Xa induces tissue factor expression in endothelial cells by P44/42 MAPK and NF-κB-dependent pathways.
- Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases.
- Gene expression changes and signaling events associated with the direct antimelanoma effect of IFN-gamma.
- Ligation of the alpha2M* signaling receptor regulates synthesis of cytosolic phospholipase A2.
- MEK inhibitors, novel anti-adhesive molecules, reduce sickle red blood cell adhesion in vitro and in vivo, and vasoocclusion in vivo.
- MEK1/2 inhibitors reverse acute vascular occlusion in mouse models of sickle cell disease.
- Negative regulation of mTOR activation by diacylglycerol kinases.
- Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity.
- Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression.
- Regulation of the Saccharomyces cerevisiae Slt2 kinase pathway by the stress-inducible Sdp1 dual specificity phosphatase.