MAP Kinase Kinase 2

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  Subject Areas on Research

  • A randomized phase II study of the MEK1/MEK2 inhibitor trametinib (GSK1120212) compared with docetaxel in KRAS-mutant advanced non-small-cell lung cancer (NSCLC)†. 
  • Inhibition of p38 MAPK alpha/beta reduces ischemic injury and does not block protective effects of preconditioning. 
  • MEK inhibitors, novel anti-adhesive molecules, reduce sickle red blood cell adhesion in vitro and in vivo, and vasoocclusion in vivo. 
  • MEK1/2 inhibitors reverse acute vascular occlusion in mouse models of sickle cell disease. 
  • Negative regulation of mTOR activation by diacylglycerol kinases.