MAP Kinase Kinase 2

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  Subject Areas on Research

  • Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer. 
  • MEK inhibitors, novel anti-adhesive molecules, reduce sickle red blood cell adhesion in vitro and in vivo, and vasoocclusion in vivo. 
  • MEK1/2 inhibitors reverse acute vascular occlusion in mouse models of sickle cell disease. 
  • Negative regulation of mTOR activation by diacylglycerol kinases.