Cell Size

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  Subject Areas on Research

  • A noisy linear map underlies oscillations in cell size and gene expression in bacteria. 
  • A novel human cancer culture model for the study of prostate cancer. 
  • A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy. 
  • A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. 
  • A specific domain of Gialpha required for the transactivation of Gialpha by tubulin is implicated in the organization of cellular microtubules. 
  • A systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response. 
  • APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases. 
  • Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. 
  • Activation of excitatory amino acid receptors in the rat hippocampal slice increases intracellular Cl- and cell volume. 
  • Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells. 
  • Adverse neurodevelopmental effects of dexamethasone modeled in PC12 cells: identifying the critical stages and concentration thresholds for the targeting of cell acquisition, differentiation and viability. 
  • Aging impairs axonal sprouting response of dentate granule cells following target loss and partial deafferentation. 
  • Alpha-adducin dissociates from F-actin and spectrin during platelet activation. 
  • Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors. 
  • An auxin gradient and maximum in the Arabidopsis root apex shown by high-resolution cell-specific analysis of IAA distribution and synthesis. 
  • Ankyrin-B directs membrane tethering of periaxin and is required for maintenance of lens fiber cell hexagonal shape and mechanics. 
  • Antidromic propagation of action potentials in branched axons: implications for the mechanisms of action of deep brain stimulation. 
  • Apoptosis is the mode of cell death caused by carcinogenic chromium. 
  • Available volume fraction of macromolecules in the extravascular space of a fibrosarcoma: implications for drug delivery. 
  • B cells from patients with chronic GVHD are activated and primed for survival via BAFF-mediated pathways. 
  • Bacterial Growth Inhibition Screen (BGIS) identifies a loss-of-function mutant of the DEK oncogene, indicating DNA modulating activities of DEK in chromatin. 
  • Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1: possible role in volume regulation and osmotaxis. 
  • Calcineurin signaling and muscle remodeling. 
  • Calcium-dependent gene regulation in myocyte hypertrophy and remodeling. 
  • Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. 
  • Cell and extracellular matrix growth theory and its implications for tumorigenesis. 
  • Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae. 
  • Cell number and distribution in human and rat airways. 
  • Cell size and communication: role in structural and electrical development and remodeling of the heart. 
  • Cellular and molecular alterations in the beta adrenergic system with cardiomyopathy induced by tachycardia. 
  • Changes in blubber distribution and morphology associated with starvation in the harbor porpoise (Phocoena phocoena): evidence for regional differences in blubber structure and function. 
  • Characterization of a sudden expansion flow chamber to study the response of endothelium to flow recirculation. 
  • Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood. 
  • Chlorpyrifos interferes with cell development in rat brain regions. 
  • Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. 
  • Combined acetaldehyde and nicotine exposure depresses cardiac contraction in ventricular myocytes: prevention by folic acid. 
  • Common actions of adenosine receptor agonists in modulating human trabecular meshwork cell transport. 
  • Conditions that promote primary human skeletal myoblast culture and muscle differentiation in vitro. 
  • Contribution of superficial layer neurons to premotor bursts in the superior colliculus. 
  • Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration. 
  • Cultivation in rotating bioreactors promotes maintenance of cardiac myocyte electrophysiology and molecular properties. 
  • Cultured porcine trabecular meshwork cells display altered lysosomal function when subjected to chronic oxidative stress. 
  • Cytoskeletal actin gates a Cl- channel in neocortical astrocytes. 
  • Cytoskeletal dependence of adenosine triphosphate release by human trabecular meshwork cells. 
  • Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice. 
  • Deencryption of cellular tissue factor is independent of its cytoplasmic domain. 
  • Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass. 
  • Delineation of the signaling pathways involved in glucocorticoid-induced and spontaneous apoptosis of rat thymocytes. 
  • Dendrites of classes of hippocampal neurons differ in structural complexity and branching patterns. 
  • Dietary prenatal choline supplementation alters postnatal hippocampal structure and function. 
  • Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells. 
  • Distinct cell-specific expression patterns of early and late gibberellin biosynthetic genes during Arabidopsis seed germination. 
  • Do genetic make-up and growth manipulation affect tomato fruit size by cell number, or cell size and DNA endoreduplication? 
  • Does prenatal nicotine exposure sensitize the brain to nicotine-induced neurotoxicity in adolescence? 
  • Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. 
  • Dynamic adhesion of umbilical cord blood endothelial progenitor cells under laminar shear stress. 
  • EJ-Ras inhibits phospholipase C gamma 1 but not actin polymerization induced by platelet-derived growth factor-BB via phosphatidylinositol 3-kinase. 
  • Effect of streptavidin-biotin on endothelial vasoregulation and leukocyte adhesion. 
  • Effects of cardiotonic steroids on trabecular meshwork cells: search for mediator of ouabain-enhanced outflow facility. 
  • Electrophysiological effects of remodeling cardiac gap junctions and cell size: experimental and model studies of normal cardiac growth. 
  • Estrogen regulation of aquaporins in the mouse uterus: potential roles in uterine water movement. 
  • Evidence for the role of cell stiffness in modulation of volume-regulated anion channels. 
  • Exercise alters the regulation of myocardial Na(+)/H(+) exchanger-1 activity. 
  • Exposure to environmental tobacco smoke during pregnancy in rats yields less effect on indices of brain cell number and size than does postnatal exposure. 
  • Expression of aquaporin-1 in human trabecular meshwork cells: role in resting cell volume. 
  • Extent of Cell Confinement in Microtracks Affects Speed and Results in Differential Matrix Strains. 
  • Fast modulation of prefrontal cortex activity by basal forebrain noncholinergic neuronal ensembles. 
  • Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy. 
  • Fibronectin-mediated hepatocyte shape change reprograms cytochrome P450 2C11 gene expression via an integrin-signaled induction of ribonuclease activity. 
  • Fine-needle aspiration in non-Hodgkin lymphoma: evaluation of cell size by cytomorphology and flow cytometry. 
  • Function of microglia in organotypic slice cultures. 
  • Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. 
  • Generation of high curvature membranes mediated by direct endophilin bilayer interactions. 
  • Glucocorticoid-induced thymocyte apoptosis: protease-dependent activation of cell shrinkage and DNA degradation. 
  • Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. 
  • Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells. 
  • Homogeneity of intrinsic properties of sexually dimorphic vocal motoneurons in male and female zebra finches. 
  • Hydrogen peroxide induces microvilli on human retinal pigment epithelial cells in culture. 
  • Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4. 
  • IL-7 enhances the survival and maintains the size of naive T cells. 
  • Impaired volume regulation is the mechanism of excitotoxic sensitization to complement. 
  • Improving interstitial transport of macromolecules through reduction in cell volume fraction in tumor tissues. 
  • In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. 
  • Increased interstitial loading reduces the effect of microstructural variations in cardiac tissue. 
  • Interneurons of the dentate-hilus border of the rat dentate gyrus: morphological and electrophysiological heterogeneity. 
  • Intrinsic myocyte dysfunction and tyrosine kinase pathway activation underlie the impaired wall thickening of adjacent regions during postinfarct left ventricular remodeling. 
  • Isolation and purification of canine adipose microvascular endothelial cells. 
  • Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. 
  • Label-free, high-throughput measurements of dynamic changes in cell nuclei using angle-resolved low coherence interferometry. 
  • Lack of annexin 1 results in an increase in corticotroph number in male but not female mice. 
  • Lasting effects of developmental dexamethasone treatment on neural cell number and size, synaptic activity, and cell signaling: critical periods of vulnerability, dose-effect relationships, regional targets, and sex selectivity. 
  • Lovastatin-induced cytoskeletal reorganization in lens epithelial cells: role of Rho GTPases. 
  • Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. 
  • Microtubule disruption leads to cellular contraction in human trabecular meshwork cells. 
  • Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. 
  • Modulation of podocyte phenotype in collapsing glomerulopathies. 
  • Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: regionally selective alterations in neurons and glia. 
  • Morphometric and electrical properties of reconstructed hippocampal CA3 neurons recorded in vivo. 
  • Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila. 
  • Myocardial volume and organization are changed by failure of addition of secondary heart field myocardium to the cardiac outflow tract. 
  • Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkey. 
  • Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems. 
  • Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family. 
  • Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases. 
  • Nonlinear osmotic properties of the cell nucleus. 
  • Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. 
  • Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis. 
  • Optical imaging of hippocampal neurons with a chloride-sensitive dye: early effects of in vitro ischemia. 
  • Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease. 
  • Paget's disease of the breast masquerading as squamous cell carcinoma on cytology: a case report. 
  • Potassium is a critical regulator of apoptotic enzymes in vitro and in vivo. 
  • Prenatal choline supplementation increases NGF levels in the hippocampus and frontal cortex of young and adult rats. 
  • Prenatal nicotine exposure evokes alterations of cell structure in hippocampus and somatosensory cortex. 
  • Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth. 
  • Quantitative and morphological analysis of dentate granule cells with recurrent basal dendrites from normal and epileptic rats. 
  • RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro. 
  • Reciprocal connections between the zona incerta and the pretectum and superior colliculus of the cat. 
  • Red blood cell distribution width and 1-year mortality in acute heart failure. 
  • Region-Specific Differences in Morphometric Features and Synaptic Colocalization of Astrocytes During Development. 
  • Regulation of glial size by eicosapentaenoic acid through a novel Golgi apparatus mechanism. 
  • Regulatory Roles of Anoctamin-6 in Human Trabecular Meshwork Cells. 
  • Relationship between 3T3 cell spreading and the strength of adhesion on glass and silane surfaces. 
  • Response of zonal chondrocytes to extracellular matrix-hydrogels. 
  • Role of aquaporin-1 in trabecular meshwork cell homeostasis during mechanical strain. 
  • Role of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growth. 
  • Role of platelet-activating factor in Chinese hamster ovary cell responses to cholera toxin. 
  • Root development in Arabidopsis: four mutants with dramatically altered root morphogenesis. 
  • SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. 
  • Separation of two phenotypically similar cell types via a single common marker in microfluidic channels. 
  • Shortening of the calycal process actin cytoskeleton is correlated with myoid elongation in teleost rods. 
  • Size and ionic currents of unexcitable cells coupled to cardiomyocytes distinctly modulate cardiac action potential shape and pacemaking activity in micropatterned cell pairs. 
  • Spindle-cell lesions of the liver: diagnosis by fine-needle aspiration biopsy. 
  • Sporangiospore size dimorphism is linked to virulence of Mucor circinelloides. 
  • Structural mechanisms to produce differential dendritic gains. 
  • Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs. 
  • Synaptic plasticity in morphologically identified CA1 stratum radiatum interneurons and giant projection cells. 
  • Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance. 
  • Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion. 
  • The conserved phosphoinositide 3-kinase pathway determines heart size in mice. 
  • The control of body size in insects. 
  • The effects of molecular noise and size control on variability in the budding yeast cell cycle. 
  • The evolution of embryonic patterning mechanisms in animals. 
  • The pattern of expression of the voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models. 
  • The role of NAD(P)H:quinone oxidoreductase in mitomycin C- and porfiromycin-resistant HCT 116 human colon-cancer cells. 
  • The role of protein kinase C in laminin-mediated neurite outgrowth. 
  • The role of protein kinase C in modulation of aqueous humor outflow facility. 
  • The transcriptional response of the islet to pregnancy in mice. 
  • Transgenic ω-3 PUFA enrichment alters morphology and gene expression profile in adipose tissue of obese mice: Potential role for protectins. 
  • Volume changes induced by osmotic stress in freshly isolated rat hippocampal neurons. 
  • Water movement during apoptosis: a role for aquaporins in the apoptotic volume decrease (AVD). 
  • p38 Mitogen-activated protein kinase regulates chamber-specific perinatal growth in heart. 
  • ΔN-TRPV1: A Molecular Co-detector of Body Temperature and Osmotic Stress. 
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  Keywords of People

  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Wax, Adam P., Professor of Biomedical Engineering, Biomedical Engineering
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology