Proto-Oncogene Proteins B-raf

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  Subject Areas on Research

  • A Multivariate Computational Method to Analyze High-Content RNAi Screening Data. 
  • A combined molecular-pathologic score improves risk stratification of thyroid papillary microcarcinoma. 
  • A phase II study of capecitabine, oxaliplatin, bevacizumab and cetuximab in the treatment of metastatic colorectal cancer. 
  • Adjuvant vemurafenib in resected, BRAFV600 mutation-positive melanoma (BRIM8): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial. 
  • Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. 
  • Association of k-ras, b-raf, and p53 status with the treatment effect of bevacizumab. 
  • Avoiding Severe Toxicity From Combined BRAF Inhibitor and Radiation Treatment: Consensus Guidelines from the Eastern Cooperative Oncology Group (ECOG). 
  • BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth. 
  • BRAF V600E expression in Langerhans cell histiocytosis: clinical and immunohistochemical study on 25 pulmonary and 54 extrapulmonary cases. 
  • BRAF V600E mutation independently predicts central compartment lymph node metastasis in patients with papillary thyroid cancer. 
  • BRAF in melanoma: current strategies and future directions. 
  • BRAF polymorphisms and the risk of ovarian cancer of low malignant potential. 
  • BRAFV600E mutation in papillary thyroid microcarcinoma: a genotype-phenotype correlation. 
  • Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms. 
  • Bevacizumab, irinotecan, temozolomide, tyrosine kinase inhibition, and MEK inhibition are effective against pleomorphic xanthoastrocytoma regardless of V600E status. 
  • Both BRAF V600E mutation and older age (≥ 65 years) are associated with recurrent papillary thyroid cancer. 
  • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. 
  • Can binimetinib, encorafenib and masitinib be more efficacious than currently available mutation-based targeted therapies for melanoma treatment? 
  • Clinical correlates of NRAS and BRAF mutations in primary human melanoma. 
  • Clinical significance and prognostic relevance of KRAS, BRAF, PI3K and TP53 genetic mutation analysis for resectable and unresectable colorectal liver metastases: A systematic review of the current evidence. 
  • Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profiles. 
  • Colon cancer, version 3.2014. 
  • Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial. 
  • Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer. 
  • Copper Chelation Inhibits BRAFV600E-Driven Melanomagenesis and Counters Resistance to BRAFV600E and MEK1/2 Inhibitors. 
  • Copper is required for oncogenic BRAF signalling and tumorigenesis. 
  • Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease. 
  • Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors. 
  • Dangerous liaisons: flirtations between oncogenic BRAF and GRP78 in drug-resistant melanomas. 
  • Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism. 
  • Detection of Circulating BRAF(V600E) in Patients with Papillary Thyroid Carcinoma. 
  • Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors. 
  • Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup. 
  • Elution profile analysis of SDS-induced subcomplexes by quantitative mass spectrometry. 
  • Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades. 
  • Estimating Survival in Melanoma Patients With Brain Metastases: An Update of the Graded Prognostic Assessment for Melanoma Using Molecular Markers (Melanoma-molGPA). 
  • Evaluation of KRAS mutations, angiogenic biomarkers, and DCE-MRI in patients with advanced non-small-cell lung cancer receiving sorafenib. 
  • Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. 
  • Exposure to flame retardant chemicals and occurrence and severity of papillary thyroid cancer: A case-control study. 
  • Final analysis of a randomised trial comparing pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory advanced melanoma. 
  • Gene expression markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance). 
  • Genetic convergence of rare lymphomas. 
  • Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis. 
  • Hairy Cell Leukemia, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology. 
  • Histological and molecular evaluation of patient-derived colorectal cancer explants. 
  • Hobnail variant of papillary thyroid carcinoma: an institutional case series and molecular profile. 
  • Identification of recurrent USP48 and BRAF mutations in Cushing's disease. 
  • Initial testing (stage 1) of AZD6244 (ARRY-142886) by the Pediatric Preclinical Testing Program. 
  • KIT mutations and CD117 overexpression are markers of better progression-free survival in vulvar melanomas. 
  • LGR5 is associated with tumor aggressiveness in papillary thyroid cancer. 
  • Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence. 
  • Melanoma brain metastasis: overview of current management and emerging targeted therapies. 
  • MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma. 
  • Mitogen-activated protein kinase (MAPK) hyperactivation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells. 
  • Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis. 
  • Molecular profile and copy number analysis of sporadic colorectal cancer in Taiwan. 
  • Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults. 
  • Mutation location on the RAS oncogene affects pathologic features and survival after resection of colorectal liver metastases. 
  • Mutations of the BRAF gene in human cancer. 
  • Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. 
  • Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma. 
  • Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract. 
  • Optimizing surgical treatment of papillary thyroid carcinoma associated with BRAF mutation. 
  • Papillary thyroid cancer. 
  • Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial. 
  • Ral activation promotes melanomagenesis. 
  • Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma. 
  • Sorafenib, a multikinase inhibitor, enhances the response of melanoma to regional chemotherapy. 
  • Suspicious ultrasound characteristics predict BRAF V600E-positive papillary thyroid carcinoma. 
  • Tall cell variant of papillary thyroid microcarcinoma: clinicopathologic features with BRAF(V600E) mutational analysis. 
  • Targeting BRAF in metastatic colorectal cancer: Maximizing molecular approaches. 
  • The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. 
  • The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. 
  • The Prognostic Value of BRAF, C-KIT, and NRAS Mutations in Melanoma Patients With Brain Metastases. 
  • The limitations of imaging response criteria. 
  • Tumor genotype determines phenotype and disease-related outcomes in thyroid cancer: a study of 1510 patients. 
  • Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. 
  • mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • McCall, Shannon Jones, Associate Professor of Pathology, Pathology
  • Pang, Herbert, Adjunct Assistant Professor in the Department of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics