MAP Kinase Kinase 4
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Subject Areas on Research
- A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR.
- A functional variant (-1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity.
- A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.
- A tumor-associated splice-isoform of MAP2K7 drives dedifferentiation in MBNL1-low cancers via JNK activation.
- Activation of JNK pathway in persistent pain.
- Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
- Bone morphogenetic protein 4 mediates myocardial ischemic injury through JNK-dependent signaling pathway.
- CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control.
- Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases.
- Hyperactivated JNK is a therapeutic target in pVHL-deficient renal cell carcinoma.
- Induction of ERK1/2 and histone H3 phosphorylation within the outer stripe of the outer medulla of the Eker rat by 2,3,5-tris-(glutathion-S-yl)hydroquinone.
- Induction of apoptosis in vascular smooth muscle cells by mechanical stretch.
- Induction of mitogenic signalling in the 1LN prostate cell line on exposure to submicromolar concentrations of cadmium+.
- Interleukin-1beta mediates human airway epithelial cell migration via NF-kappaB.
- Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.
- Manipulating JNK signaling with (--)-zuonin A.
- Merkel cell polyomavirus small tumour antigen activates the p38 MAPK pathway to enhance cellular motility.
- Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity.
- Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity.
- Regulation of the metastasis suppressor gene MKK4 in ovarian cancer.
- Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase.
- Signal transduction. Three paths to stress relief.
- Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1.
- Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells.
- The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta.
- Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis.
- Whole-genome analysis informs breast cancer response to aromatase inhibition.
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Keywords of People
- Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology