MAP Kinase Kinase Kinase 2

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  Subject Areas on Research

  • A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program. 
  • Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. 
  • Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation. 
  • Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling.