Cytokinesis

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  Subject Areas on Research

  • A Wor1-Like Transcription Factor Is Essential for Virulence of Cryptococcus neoformans. 
  • Analysis of Rho-GTPase Activity During Budding Yeast Cytokinesis. 
  • Cell-cycle control of cell polarity in yeast. 
  • Characterization of Plasmodium liver stage inhibition by halofuginone. 
  • Chemical waves in cell and developmental biology. 
  • Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi. 
  • Cytokinesis breaks dicentric chromosomes preferentially at pericentromeric regions and telomere fusions. 
  • Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation. 
  • Distinct roles of Rho1, Cdc42, and Cyk3 in septum formation and abscission during yeast cytokinesis. 
  • Error-prone polyploid mitosis during normal Drosophila development. 
  • Evidence that a septin diffusion barrier is dispensable for cytokinesis in budding yeast. 
  • Fission yeast Cyk3p is a transglutaminase-like protein that participates in cytokinesis and cell morphogenesis. 
  • FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one. 
  • HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells. 
  • Human ASPM participates in spindle organisation, spindle orientation and cytokinesis. 
  • Inhibition of Cdc42 during mitotic exit is required for cytokinesis. 
  • Liposome division by a simple bacterial division machinery. 
  • MKKS/BBS6, a divergent chaperonin-like protein linked to the obesity disorder Bardet-Biedl syndrome, is a novel centrosomal component required for cytokinesis. 
  • Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells. 
  • Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check. 
  • Morphogenesis and the cell cycle. 
  • Ras1 acts through duplicated Cdc42 and Rac proteins to regulate morphogenesis and pathogenesis in the human fungal pathogen Cryptococcus neoformans. 
  • Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. 
  • Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae. 
  • Role of the Hof1-Cyk3 interaction in cleavage-furrow ingression and primary-septum formation during yeast cytokinesis. 
  • The C2 domain protein Cts1 functions in the calcineurin signaling circuit during high-temperature stress responses in Cryptococcus neoformans. 
  • The Cryptococcus neoformans Rho-GDP dissociation inhibitor mediates intracellular survival and virulence. 
  • Timely Endocytosis of Cytokinetic Enzymes Prevents Premature Spindle Breakage during Mitotic Exit. 
  • Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster. 
  • Two CDC42 paralogues modulate Cryptococcus neoformans thermotolerance and morphogenesis under host physiological conditions. 
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  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Biomedical Engineering
  • Lew, Daniel Julio, James B. Duke Distinguished Professor of Pharmacology and Cancer Biology, Cell Biology