Adaptor Proteins, Signal Transducing
-
Subject Areas on Research
-
A 137-kb deletion within the Potocki-Shaffer syndrome interval on chromosome 11p11.2 associated with developmental delay and hypotonia.
-
A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies.
-
A loss-of-function RNA interference screen for molecular targets in cancer.
-
A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC.
-
A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children's oncology group.
-
A physical interaction network of dengue virus and human proteins.
-
A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature.
-
A role for MAPK in feedback inhibition of Tcrb recombination.
-
A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation, and autoimmunity.
-
A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation.
-
ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis.
-
AHI1 mutations cause both retinal dystrophy and renal cystic disease in Joubert syndrome.
-
AT1 Angiotensin receptors-vascular and renal epithelial pathways for blood pressure regulation.
-
ATM functions at the peroxisome to induce pexophagy in response to ROS.
-
ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.
-
Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.
-
Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1.
-
Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels.
-
Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin.
-
Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease.
-
Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.
-
Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor.
-
Adaptor proteins in lymphocyte activation.
-
Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy.
-
Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.
-
Allele separation facilitates interpretation of potential splicing alterations and genomic rearrangements.
-
Alleles of the yeast Pms1 mismatch-repair gene that differentially affect recombination- and replication-related processes.
-
Altered telomeres in tumors with ATRX and DAXX mutations.
-
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.
-
An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart.
-
An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD.
-
An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking.
-
Analysis of BAG3 plasma concentrations in patients with acutely decompensated heart failure.
-
Analysis of DNA mismatch repair proteins in human medulloblastoma.
-
Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.
-
Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.
-
Apolipoprotein E and Alzheimer's disease: signal transduction mechanisms.
-
Arrestins and protein ubiquitination.
-
Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling.
-
Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p.
-
Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2.
-
Association of CHFR promoter methylation with disease recurrence in locally advanced colon cancer.
-
Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.
-
Association of family history with cancer recurrence and survival among patients with stage III colon cancer.
-
Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction.
-
Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls.
-
Aven-dependent activation of ATM following DNA damage.
-
BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy.
-
BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein.
-
BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes.
-
BMP-2 and TGFβ2 shared pathways regulate endocardial cell transformation.
-
Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression.
-
Bcl10 is not a target for frequent mutation in human carcinomas.
-
Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin.
-
Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.
-
Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models.
-
Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells.
-
Blocking Dishevelled signaling in the noncanonical Wnt pathway in sea urchins disrupts endoderm formation and spiculogenesis, but not secondary mesoderm formation.
-
CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
-
CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation.
-
CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.
-
CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor.
-
Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor.
-
Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation.
-
Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.
-
Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling.
-
Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p.
-
Cell surface polarization during yeast mating.
-
Cellular signaling by tyrosine phosphorylation in keloid and normal human dermal fibroblasts.
-
Chapter Nine - Cellular Roles of Beta-Arrestins as Substrates and Adaptors of Ubiquitination and Deubiquitination.
-
Characterization of a new family of protein kinases from Arabidopsis containing phosphoinositide 3/4-kinase and ubiquitin-like domains.
-
Charting the landscape of tandem BRCT domain-mediated protein interactions.
-
Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA.
-
Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line.
-
Clinical and functional findings in choroideremia due to complete deletion of the CHM gene.
-
Clinicopathologic significance of DNA mismatch repair protein defects and endometrial cancer in women 40years of age and younger.
-
Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor.
-
Combined aerobic exercise and enzyme replacement therapy rejuvenates the mitochondrial-lysosomal axis and alleviates autophagic blockage in Pompe disease.
-
Common variants at 19p13 are associated with susceptibility to ovarian cancer.
-
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
-
Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans.
-
Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function.
-
Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1.
-
Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2.
-
Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix α0.
-
Convergent evolution of escape from hepaciviral antagonism in primates.
-
Conversion of diploidy to haploidy.
-
Cutting Edge: Localization of linker for activation of T cells to lipid rafts is not essential in T cell activation and development.
-
Cutting Edge: c-Maf Is Required for Regulatory T Cells To Adopt RORγt+ and Follicular Phenotypes.
-
Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells.
-
Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity.
-
Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS.
-
DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.
-
DNA chain length dependence of formation and dynamics of hMutSalpha.hMutLalpha.heteroduplex complexes.
-
DOK2 inhibits EGFR-mutated lung adenocarcinoma.
-
Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation.
-
Developmental regulation of p66Shc is altered by bronchopulmonary dysplasia in baboons and humans.
-
Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells.
-
Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas.
-
Differential expression of receptor tyrosine kinases and Shc in fetal and adult rat fibroblasts: toward defining scarless versus scarring fibroblast phenotypes.
-
Dimer-specific immunoprecipitation of active caspase-2 identifies TRAF proteins as novel activators.
-
Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha.
-
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.
-
Dishevelled-3 activates p65 to upregulate p120-catenin transcription via a p38-dependent pathway in non-small cell lung cancer.
-
Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss.
-
Disruption of the Ang II type 1 receptor promotes longevity in mice.
-
Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu.
-
Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.
-
Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.
-
Dosage changes of a segment at 17p13.1 lead to intellectual disability and microcephaly as a result of complex genetic interaction of multiple genes.
-
Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin.
-
Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.
-
Dysregulated activation of fetal liver programme in acute liver failure.
-
E1-like activating enzyme Atg7 is preferentially sequestered into p62 aggregates via its interaction with LC3-I.
-
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis.
-
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
-
Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC.
-
Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC.
-
Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis.
-
Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95.
-
Erbin suppresses the MAP kinase pathway.
-
Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine.
-
Essential role of LAT in T cell development.
-
Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer.
-
Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways.
-
Evolution and development of the mammalian dentition: insights from the marsupial Monodelphis domestica.
-
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways.
-
Expression cloning of protein targets for 3-phosphorylated phosphoinositides.
-
Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction.
-
Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.
-
Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination.
-
Fluorescence resonance energy transfer analysis of cell surface receptor interactions and signaling using spectral variants of the green fluorescent protein.
-
Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse.
-
Frequency of mutations in mismatch repair genes in a population-based study of women with ovarian cancer.
-
Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.
-
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
-
G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases.
-
GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation.
-
GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.
-
Generation of high curvature membranes mediated by direct endophilin bilayer interactions.
-
Genetic Drivers of Kidney Defects in the DiGeorge Syndrome.
-
Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians.
-
Genetic analysis of a family with hereditary glomuvenous malformations.
-
Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance.
-
Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk.
-
Genetic regulation of pristane-induced oil granuloma responses.
-
Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival.
-
Genetic variations of mTORC1 genes and risk of gastric cancer in an Eastern Chinese population.
-
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
-
Genome-wide association study of sepsis in extremely premature infants.
-
Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.
-
Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer.
-
Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation.
-
Heat shock protein 70-binding protein 1 is highly expressed in high-grade gliomas, interacts with multiple heat shock protein 70 family members, and specifically binds brain tumor cell surfaces.
-
Hedgehog regulates yes-associated protein 1 in regenerating mouse liver.
-
Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.
-
High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6.
-
Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf.
-
IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.
-
Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling.
-
Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells.
-
Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation.
-
Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation.
-
Identification of cis-suppression of human disease mutations by comparative genomics.
-
Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.
-
In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast.
-
Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation.
-
Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.
-
Initial testing (stage 1) of SGI-1776, a PIM1 kinase inhibitor, by the pediatric preclinical testing program.
-
Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target.
-
Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes.
-
Integrated pathway and epistasis analysis reveals interactive effect of genetic variants at TERF1 and AFAP1L2 loci on melanoma risk.
-
Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif.
-
Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.
-
Intercellular growth factor signaling and the development of mouse tracheal submucosal glands.
-
Involvement of linker for activation of T cells in the costimulatory signaling pathways.
-
Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled.
-
Isolation and characterization of effector-loop mutants of CDC42 in yeast.
-
Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast.
-
Kinetic mechanism of RGS9-1 potentiation by R9AP.
-
Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development.
-
LAB: a new membrane-associated adaptor molecule in B cell activation.
-
LAT is essential for Fc(epsilon)RI-mediated mast cell activation.
-
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
-
LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.
-
LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.
-
LAT-mediated signaling in CD4+CD25+ regulatory T cell development.
-
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
-
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.
-
LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.
-
Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts.
-
Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages.
-
Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding.
-
Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditions.
-
Linking angiotensin II to nuclear factor-κ light chain enhancer of activated B cells-induced cardiovascular damage: bad CARMAs.
-
Localisation of receptor interacting protein 140 (RIP140) within 100 kb of D21S13 on 21q11, a gene-poor region of the human genome.
-
Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system.
-
Loss-of-Function RNAi Screen to Identify Necrosis-Signaling Molecules.
-
Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells.
-
MAVS Coordination of Antiviral Innate Immunity.
-
MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition.
-
MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.
-
MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch.
-
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.
-
Methods to Visualize MAVS Subcellular Localization.
-
Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development.
-
Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours.
-
Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis.
-
Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus.
-
Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity.
-
Molecular editing of cellular responses by the high-affinity receptor for IgE.
-
Molecular genetics of autosomal-dominant axonal Charcot-Marie-Tooth disease.
-
Molecular profile and copy number analysis of sporadic colorectal cancer in Taiwan.
-
Muir-Torre syndrome.
-
Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity.
-
Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
-
Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation.
-
Mutation analysis in nephronophthisis using a combined approach of homozygosity mapping, CEL I endonuclease cleavage, and direct sequencing.
-
Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy.
-
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination.
-
Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS.
-
Negative regulation of T cell activation and autoimmunity by the transmembrane adaptor protein LAB.
-
Negative regulation of TCR signaling by linker for activation of X cells via phosphotyrosine-dependent and -independent mechanisms.
-
Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo.
-
Novel Genetic Triggers and Genotype-Phenotype Correlations in Patients With Left Ventricular Noncompaction.
-
Novel PMS1 alleles preferentially affect the repair of primer strand loops during DNA replication.
-
Novel compound heterozygous variants in CECR1 gene associated with childhood onset polyarteritis nodosa and deficiency of ADA2.
-
Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis.
-
Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway.
-
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.
-
Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages.
-
Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells.
-
Overexpression of CRKL correlates with poor prognosis and cell proliferation in non-small cell lung cancer.
-
PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation.
-
PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP.
-
Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells.
-
Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.
-
Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.
-
Phosphorylation of c-Abl by protein kinase Pak2 regulates differential binding of ABI2 and CRK.
-
Physical and genetic mapping of the CMT4A locus and exclusion of PMP-2 as the defect in CMT4A.
-
Polarity establishment requires localized activation of Cdc42.
-
Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population.
-
Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL.
-
Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction.
-
Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506.
-
Precision Medicine for Heart Failure: Lessons From Oncology.
-
Probing the role of PPARγ in the regulation of late-onset Alzheimer's disease-associated genes.
-
Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase.
-
Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo.
-
Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.
-
RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses.
-
RAP2 mediates mechanoresponses of the Hippo pathway.
-
RNA-Seq and ChIP-Seq reveal SQSTM1/p62 as a key mediator of JunB suppression of NF-κB-dependent inflammation.
-
RPGRIP1L mutations are mainly associated with the cerebello-renal phenotype of Joubert syndrome-related disorders.
-
Rapamycin antagonizes cyclosporin A- and tacrolimus (FK506)-mediated augmentation of linker for activation of T cell expression in T cells.
-
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
-
Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway.
-
Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
-
Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway.
-
Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.
-
Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems.
-
Recurrent CNVs and SNVs at the NPHP1 locus contribute pathogenic alleles to Bardet-Biedl syndrome.
-
Reduced expression of hMLH1 and hGTBP/hMSH6: a risk factor for head and neck cancer.
-
Reduced expression of hMSH2 and hMLH1 and risk of prostate cancer: a case-control study.
-
Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt.
-
Reduced expression of mismatch repair genes measured by multiplex reverse transcription-polymerase chain reaction in human gliomas.
-
Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes.
-
Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase.
-
Regulation of cell-cell adhesion by Abi/Diaphanous complexes.
-
Regulation of hematopoietic cell development and activation by adapter proteins.
-
Regulation of lymphocyte development and activation by the LAT family of adapter proteins.
-
Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79.
-
Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export.
-
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.
-
Removal of frameshift intermediates by mismatch repair proteins in Saccharomyces cerevisiae.
-
Requirement for Abl kinases in T cell receptor signaling.
-
Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells.
-
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.
-
Retinoic acid regulates sex-specific timing of meiotic initiation in mice.
-
Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling.
-
Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae.
-
Role of LAT in the granule-mediated cytotoxicity of CD8 T cells.
-
Role of Toll-like receptor-driven innate immunity in thoracic organ transplantation.
-
Role of YAP1 as a Marker of Sensitivity to Dual AKT and P70S6K Inhibition in Ovarian and Uterine Malignancies.
-
Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases.
-
Role of mismatch repair in the fidelity of RAD51- and RAD59-dependent recombination in Saccharomyces cerevisiae.
-
Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma.
-
Roles of Alternative RNA Splicing of the Bif-1 Gene by SRRM4 During the Development of Treatment-induced Neuroendocrine Prostate Cancer.
-
Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease.
-
Scaffold-mediated symmetry breaking by Cdc42p.
-
Screen and identification of proteins interacting with ADAM19 cytoplasmic tail.
-
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
-
Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB.
-
Signaling by wingless in Drosophila.
-
Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation.
-
Single Nucleotide Polymorphisms in CBLB, a Regulator of T-Cell Response, Predict Radiation Pneumonitis and Outcomes After Definitive Radiotherapy for Non-Small-Cell Lung Cancer.
-
Singularity in polarization: rewiring yeast cells to make two buds.
-
Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling.
-
Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability.
-
Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy.
-
Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis.
-
Studies on the adapter molecule LAT.
-
Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex.
-
T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10.
-
TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk.
-
TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors.
-
TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum.
-
Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function.
-
Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma.
-
The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia.
-
The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory.
-
The Bardet-Biedl syndrome-related protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the mTOR complex.
-
The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.
-
The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing.
-
The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs.
-
The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity.
-
The NPHP1 gene deletion associated with juvenile nephronophthisis is present in a subset of individuals with Joubert syndrome.
-
The TOR signal transduction cascade controls cellular differentiation in response to nutrients.
-
The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1.
-
The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation.
-
The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling.
-
The beta sliding clamp binds to multiple sites within MutL and MutS.
-
The dishevelled protein is modified by wingless signaling in Drosophila.
-
The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage.
-
The extracellular matrix protein agrin promotes heart regeneration in mice.
-
The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome.
-
The importance of LAT in the activation, homeostasis, and regulatory function of T cells.
-
The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation.
-
The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity.
-
The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB.
-
The influence of AHI1 variants on the diagnosis and treatment outcome in schizophrenia.
-
The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2.
-
The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells.
-
The prosurvival protein BAG3: a new participant in vascular homeostasis.
-
The requirement of linker for activation of T cells in the primary and memory responses of CD8 T cells.
-
The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9.
-
The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.
-
The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation.
-
The role of membrane-associated adaptors in T cell receptor signalling.
-
The role of the LAT-PLC-gamma1 interaction in T regulatory cell function.
-
The type III TGFbeta receptor regulates directional migration: new tricks for an old dog.
-
The type III TGFβ receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells.
-
Three synchronous primary carcinomas in a patient with HNPCC associated with a novel germline mutation in MLH1: Case report.
-
Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli.
-
Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.
-
Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements.
-
Transethnic genome-wide scan identifies novel Alzheimer's disease loci.
-
Transmembrane adaptor proteins: organizers of immunoreceptor signalling.
-
Two distinct genes encode small isoproteolipids affecting plasma membrane H(+)-ATPase activity of Saccharomyces cerevisiae.
-
Uncertainty in the utility of immunohistochemistry in mismatch repair protein expression in epithelial ovarian cancer.
-
Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.
-
Validation of an oligo-gene signature for the prognostic stratification of ductal carcinoma in situ (DCIS).
-
Vein graft neointimal hyperplasia is exacerbated by tumor necrosis factor receptor-1 signaling in graft-intrinsic cells.
-
Whole exome sequencing identifies a mutation for a novel form of corneal intraepithelial dyskeratosis.
-
[GIPC: a new target for therapy in pancreatic adenocarcinoma?]
-
beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.
-
beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.
-
dishevelled and armadillo act in the wingless signalling pathway in Drosophila.
-
mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination.
-
β-Arrestin and dishevelled coordinate biased signaling.
-
β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury.
-
Keywords of People
-
Berchuck, Andrew,
James M. Ingram Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
-
Lew, Daniel Julio,
James B. Duke Professor of Pharmacology and Cancer Biology,
Cell Biology
-
McLendon, Roger Edwin,
Professor of Pathology,
Pathology
-
Moorman, Patricia Gripka,
Professor in Family Medicine and Community Health,
Duke Cancer Institute
-
Yan, Hai,
Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine,
Pathology