Adaptor Proteins, Signal Transducing
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Subject Areas on Research
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A 137-kb deletion within the Potocki-Shaffer syndrome interval on chromosome 11p11.2 associated with developmental delay and hypotonia.
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A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator.
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A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies.
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A loss-of-function RNA interference screen for molecular targets in cancer.
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A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC.
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A novel role of the WNT-dishevelled-GSK3β signaling cascade in the mouse nucleus accumbens in a social defeat model of depression.
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A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children's oncology group.
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A physical interaction network of dengue virus and human proteins.
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A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature.
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A role for MAPK in feedback inhibition of Tcrb recombination.
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A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation, and autoimmunity.
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A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins.
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A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation.
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ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis.
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AHI1 mutations cause both retinal dystrophy and renal cystic disease in Joubert syndrome.
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AT1 Angiotensin receptors-vascular and renal epithelial pathways for blood pressure regulation.
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ATM functions at the peroxisome to induce pexophagy in response to ROS.
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ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.
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Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.
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Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1.
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Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels.
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Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin.
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Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease.
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Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.
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Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor.
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Adaptor proteins in lymphocyte activation.
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Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy.
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Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.
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Allele separation facilitates interpretation of potential splicing alterations and genomic rearrangements.
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Alleles of the yeast Pms1 mismatch-repair gene that differentially affect recombination- and replication-related processes.
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Altered telomeres in tumors with ATRX and DAXX mutations.
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Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68.
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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.
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An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart.
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An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD.
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An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking.
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Analysis of BAG3 plasma concentrations in patients with acutely decompensated heart failure.
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Analysis of DNA mismatch repair proteins in human medulloblastoma.
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Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.
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Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.
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Apolipoprotein E and Alzheimer's disease: signal transduction mechanisms.
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Arrestins and protein ubiquitination.
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Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling.
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Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p.
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Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2.
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Association of CHFR promoter methylation with disease recurrence in locally advanced colon cancer.
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Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.
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Association of family history with cancer recurrence and survival among patients with stage III colon cancer.
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Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction.
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Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls.
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Aven-dependent activation of ATM following DNA damage.
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BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy.
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BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein.
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BIN1 is a novel MYC-interacting protein with features of a tumour suppressor.
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BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes.
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BMP-2 and TGFβ2 shared pathways regulate endocardial cell transformation.
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Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression.
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Bcl10 is not a target for frequent mutation in human carcinomas.
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Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin.
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Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.
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Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models.
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Biology of p62/sequestosome-1 in Age-Related Macular Degeneration (AMD).
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Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells.
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Blocking Dishevelled signaling in the noncanonical Wnt pathway in sea urchins disrupts endoderm formation and spiculogenesis, but not secondary mesoderm formation.
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CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
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CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation.
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CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.
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CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor.
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Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor.
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Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation.
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Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.
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Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling.
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Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p.
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Cell surface polarization during yeast mating.
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Cellular signaling by tyrosine phosphorylation in keloid and normal human dermal fibroblasts.
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Chapter Nine - Cellular Roles of Beta-Arrestins as Substrates and Adaptors of Ubiquitination and Deubiquitination.
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Characterization of a new family of protein kinases from Arabidopsis containing phosphoinositide 3/4-kinase and ubiquitin-like domains.
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Charting the landscape of tandem BRCT domain-mediated protein interactions.
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Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA.
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Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line.
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Clinical and functional findings in choroideremia due to complete deletion of the CHM gene.
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Clinicopathologic significance of DNA mismatch repair protein defects and endometrial cancer in women 40years of age and younger.
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Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor.
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Combined aerobic exercise and enzyme replacement therapy rejuvenates the mitochondrial-lysosomal axis and alleviates autophagic blockage in Pompe disease.
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Common variants at 19p13 are associated with susceptibility to ovarian cancer.
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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
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Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans.
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Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function.
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Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1.
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Consensus nomenclature for the human ArfGAP domain-containing proteins.
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Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2.
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Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix α0.
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Convergent evolution of escape from hepaciviral antagonism in primates.
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Conversion of diploidy to haploidy.
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Cutting Edge: Localization of linker for activation of T cells to lipid rafts is not essential in T cell activation and development.
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Cutting Edge: c-Maf Is Required for Regulatory T Cells To Adopt RORγt+ and Follicular Phenotypes.
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Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells.
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Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity.
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Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS.
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DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.
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DNA chain length dependence of formation and dynamics of hMutSalpha.hMutLalpha.heteroduplex complexes.
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DOK2 inhibits EGFR-mutated lung adenocarcinoma.
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Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation.
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Developmental regulation of p66Shc is altered by bronchopulmonary dysplasia in baboons and humans.
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Differences between AGAP1, ASAP1 and Arf GAP1 in substrate recognition: interaction with the N-terminus of Arf1.
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Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells.
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Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas.
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Differential expression of receptor tyrosine kinases and Shc in fetal and adult rat fibroblasts: toward defining scarless versus scarring fibroblast phenotypes.
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Dimer-specific immunoprecipitation of active caspase-2 identifies TRAF proteins as novel activators.
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Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha.
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Disabled homolog 2 controls macrophage phenotypic polarization and adipose tissue inflammation.
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Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.
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Dishevelled-3 activates p65 to upregulate p120-catenin transcription via a p38-dependent pathway in non-small cell lung cancer.
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Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss.
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Disruption of the Ang II type 1 receptor promotes longevity in mice.
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Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu.
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Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.
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Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.
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Dosage changes of a segment at 17p13.1 lead to intellectual disability and microcephaly as a result of complex genetic interaction of multiple genes.
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Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin.
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Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.
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Dysregulated activation of fetal liver programme in acute liver failure.
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E1-like activating enzyme Atg7 is preferentially sequestered into p62 aggregates via its interaction with LC3-I.
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Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis.
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Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
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Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC.
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Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC.
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Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis.
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Eps15 homology domain-NPF motif interactions regulate clathrin coat assembly during synaptic vesicle recycling.
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Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95.
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Erbin suppresses the MAP kinase pathway.
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Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine.
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Essential role of LAT in T cell development.
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Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer.
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Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways.
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Evolution and development of the mammalian dentition: insights from the marsupial Monodelphis domestica.
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Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways.
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Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes.
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Expression cloning of protein targets for 3-phosphorylated phosphoinositides.
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Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction.
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Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.
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Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination.
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Fluorescence resonance energy transfer analysis of cell surface receptor interactions and signaling using spectral variants of the green fluorescent protein.
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Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse.
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Frequency of mutations in mismatch repair genes in a population-based study of women with ovarian cancer.
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Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.
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Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity.
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G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
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G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases.
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GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation.
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GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin.
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GIT2-A keystone in ageing and age-related disease.
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GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.
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Generation of high curvature membranes mediated by direct endophilin bilayer interactions.
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Genetic Drivers of Kidney Defects in the DiGeorge Syndrome.
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Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians.
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Genetic analysis of a family with hereditary glomuvenous malformations.
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Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance.
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Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk.
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Genetic regulation of pristane-induced oil granuloma responses.
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Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival.
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Genetic variations of mTORC1 genes and risk of gastric cancer in an Eastern Chinese population.
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Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
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Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
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Genome-wide association study of sepsis in extremely premature infants.
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Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.
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Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer.
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Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation.
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Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis.
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Heat shock protein 70-binding protein 1 is highly expressed in high-grade gliomas, interacts with multiple heat shock protein 70 family members, and specifically binds brain tumor cell surfaces.
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Hedgehog regulates yes-associated protein 1 in regenerating mouse liver.
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Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.
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High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6.
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Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf.
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IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.
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Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling.
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Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells.
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Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation.
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Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation.
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Identification of cis-suppression of human disease mutations by comparative genomics.
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Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.
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In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast.
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Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation.
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Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.
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Initial testing (stage 1) of SGI-1776, a PIM1 kinase inhibitor, by the pediatric preclinical testing program.
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Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target.
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Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes.
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Integrated pathway and epistasis analysis reveals interactive effect of genetic variants at TERF1 and AFAP1L2 loci on melanoma risk.
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Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting.
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Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif.
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Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.
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Intercellular growth factor signaling and the development of mouse tracheal submucosal glands.
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Involvement of linker for activation of T cells in the costimulatory signaling pathways.
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Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled.
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Isolation and characterization of effector-loop mutants of CDC42 in yeast.
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Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast.
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Kinetic mechanism of RGS9-1 potentiation by R9AP.
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Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development.
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LAB: a new membrane-associated adaptor molecule in B cell activation.
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LAT is essential for Fc(epsilon)RI-mediated mast cell activation.
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LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
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LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.
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LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.
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LAT-mediated signaling in CD4+CD25+ regulatory T cell development.
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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
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LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.
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LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.
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Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts.
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Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages.
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Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding.
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Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditions.
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Linking angiotensin II to nuclear factor-κ light chain enhancer of activated B cells-induced cardiovascular damage: bad CARMAs.
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Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes.
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Localisation of receptor interacting protein 140 (RIP140) within 100 kb of D21S13 on 21q11, a gene-poor region of the human genome.
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Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system.
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Loss-of-Function RNAi Screen to Identify Necrosis-Signaling Molecules.
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Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells.
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MAVS Coordination of Antiviral Innate Immunity.
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MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition.
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MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.
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MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch.
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Mammalian Scribble forms a tight complex with the betaPIX exchange factor.
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Maternal genotype and gestational diabetes.
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Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.
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Methods to Visualize MAVS Subcellular Localization.
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Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development.
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Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours.
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Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis.
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Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus.
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Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity.
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Molecular editing of cellular responses by the high-affinity receptor for IgE.
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Molecular genetics of autosomal-dominant axonal Charcot-Marie-Tooth disease.
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Molecular profile and copy number analysis of sporadic colorectal cancer in Taiwan.
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Muir-Torre syndrome.
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Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity.
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Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
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Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation.
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Mutation analysis in nephronophthisis using a combined approach of homozygosity mapping, CEL I endonuclease cleavage, and direct sequencing.
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Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy.
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Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination.
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Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS.
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Negative regulation of T cell activation and autoimmunity by the transmembrane adaptor protein LAB.
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Negative regulation of TCR signaling by linker for activation of X cells via phosphotyrosine-dependent and -independent mechanisms.
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Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo.
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Novel Genetic Triggers and Genotype-Phenotype Correlations in Patients With Left Ventricular Noncompaction.
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Novel PMS1 alleles preferentially affect the repair of primer strand loops during DNA replication.
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Novel compound heterozygous variants in CECR1 gene associated with childhood onset polyarteritis nodosa and deficiency of ADA2.
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Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis.
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Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway.
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Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.
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Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages.
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Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells.
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Overexpression of CRKL correlates with poor prognosis and cell proliferation in non-small cell lung cancer.
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PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation.
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PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP.
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Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells.
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Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.
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Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.
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Phosphorylation of c-Abl by protein kinase Pak2 regulates differential binding of ABI2 and CRK.
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Physical and genetic mapping of the CMT4A locus and exclusion of PMP-2 as the defect in CMT4A.
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Polarity establishment requires localized activation of Cdc42.
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Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population.
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Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL.
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Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction.
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Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506.
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Precision Medicine for Heart Failure: Lessons From Oncology.
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Probing the role of PPARγ in the regulation of late-onset Alzheimer's disease-associated genes.
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Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase.
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Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo.
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Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.
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RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses.
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RAP2 mediates mechanoresponses of the Hippo pathway.
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RNA-Seq and ChIP-Seq reveal SQSTM1/p62 as a key mediator of JunB suppression of NF-κB-dependent inflammation.
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RPGRIP1L mutations are mainly associated with the cerebello-renal phenotype of Joubert syndrome-related disorders.
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Rabphilin-3A: a multifunctional regulator of synaptic vesicle traffic.
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Rapamycin antagonizes cyclosporin A- and tacrolimus (FK506)-mediated augmentation of linker for activation of T cell expression in T cells.
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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
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Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway.
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Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
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Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway.
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Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.
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Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems.
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Recurrent CNVs and SNVs at the NPHP1 locus contribute pathogenic alleles to Bardet-Biedl syndrome.
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Reduced expression of hMLH1 and hGTBP/hMSH6: a risk factor for head and neck cancer.
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Reduced expression of hMSH2 and hMLH1 and risk of prostate cancer: a case-control study.
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Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt.
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Reduced expression of mismatch repair genes measured by multiplex reverse transcription-polymerase chain reaction in human gliomas.
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Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes.
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Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase.
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Regulation of cell-cell adhesion by Abi/Diaphanous complexes.
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Regulation of hematopoietic cell development and activation by adapter proteins.
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Regulation of lymphocyte development and activation by the LAT family of adapter proteins.
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Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79.
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Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export.
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Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.
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Removal of frameshift intermediates by mismatch repair proteins in Saccharomyces cerevisiae.
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Requirement for Abl kinases in T cell receptor signaling.
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Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells.
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Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.
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Retinoic acid regulates sex-specific timing of meiotic initiation in mice.
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Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling.
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Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae.
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Role of LAT in the granule-mediated cytotoxicity of CD8 T cells.
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Role of Toll-like receptor-driven innate immunity in thoracic organ transplantation.
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Role of YAP1 as a Marker of Sensitivity to Dual AKT and P70S6K Inhibition in Ovarian and Uterine Malignancies.
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Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases.
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Role of mismatch repair in the fidelity of RAD51- and RAD59-dependent recombination in Saccharomyces cerevisiae.
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Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma.
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Roles of Alternative RNA Splicing of the Bif-1 Gene by SRRM4 During the Development of Treatment-induced Neuroendocrine Prostate Cancer.
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Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease.
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Scaffold-mediated symmetry breaking by Cdc42p.
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Screen and identification of proteins interacting with ADAM19 cytoplasmic tail.
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Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
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Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB.
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Severe sirolimus-related inflammatory state anemia in an HIV+ liver transplant patient with calcineurin inhibitor renal insufficiency: a case report.
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Signaling by wingless in Drosophila.
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Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation.
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Single Nucleotide Polymorphisms in CBLB, a Regulator of T-Cell Response, Predict Radiation Pneumonitis and Outcomes After Definitive Radiotherapy for Non-Small-Cell Lung Cancer.
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Singularity in polarization: rewiring yeast cells to make two buds.
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Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling.
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Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability.
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Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy.
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Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing.
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Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis.
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Studies on the adapter molecule LAT.
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Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification.
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Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex.
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Systematic morphological profiling of human gene and allele function via Cell Painting.
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T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10.
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TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk.
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TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors.
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TRPC6 and FSGS: the latest TRP channelopathy.
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TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum.
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Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function.
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Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma.
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The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia.
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The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory.
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The Bardet-Biedl syndrome-related protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the mTOR complex.
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The Bin1 gene localizes to human chromosome 2q14 by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization.
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The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.
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The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing.
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The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo.
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The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs.
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The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity.
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The NPHP1 gene deletion associated with juvenile nephronophthisis is present in a subset of individuals with Joubert syndrome.
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The TOR signal transduction cascade controls cellular differentiation in response to nutrients.
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The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1.
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The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation.
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The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling.
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The beta sliding clamp binds to multiple sites within MutL and MutS.
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The dishevelled protein is modified by wingless signaling in Drosophila.
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The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage.
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The extracellular matrix protein agrin promotes heart regeneration in mice.
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The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome.
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The importance of LAT in the activation, homeostasis, and regulatory function of T cells.
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The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation.
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The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity.
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The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB.
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The influence of AHI1 variants on the diagnosis and treatment outcome in schizophrenia.
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The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2.
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The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells.
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The prosurvival protein BAG3: a new participant in vascular homeostasis.
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The requirement of linker for activation of T cells in the primary and memory responses of CD8 T cells.
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The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9.
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The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.
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The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation.
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The role of membrane-associated adaptors in T cell receptor signalling.
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The role of the LAT-PLC-gamma1 interaction in T regulatory cell function.
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The type III TGFbeta receptor regulates directional migration: new tricks for an old dog.
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The type III TGFβ receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells.
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Three synchronous primary carcinomas in a patient with HNPCC associated with a novel germline mutation in MLH1: Case report.
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Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli.
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Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.
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Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements.
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Transethnic genome-wide scan identifies novel Alzheimer's disease loci.
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Transmembrane adaptor proteins: organizers of immunoreceptor signalling.
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Two distinct genes encode small isoproteolipids affecting plasma membrane H(+)-ATPase activity of Saccharomyces cerevisiae.
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Uncertainty in the utility of immunohistochemistry in mismatch repair protein expression in epithelial ovarian cancer.
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Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.
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Validation of an oligo-gene signature for the prognostic stratification of ductal carcinoma in situ (DCIS).
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Vein graft neointimal hyperplasia is exacerbated by tumor necrosis factor receptor-1 signaling in graft-intrinsic cells.
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Whole exome sequencing identifies a mutation for a novel form of corneal intraepithelial dyskeratosis.
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Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2.
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[GIPC: a new target for therapy in pancreatic adenocarcinoma?]
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beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.
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beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.
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dishevelled and armadillo act in the wingless signalling pathway in Drosophila.
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mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination.
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β-Arrestin and dishevelled coordinate biased signaling.
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β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
-
Lew, Daniel Julio,
James B. Duke Professor of Pharmacology and Cancer Biology,
Cell Biology
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Moorman, Patricia Gripka,
Professor in Family Medicine and Community Health,
Duke Cancer Institute
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Yan, Hai,
Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine,
Pathology