14-3-3 Proteins
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Subject Areas on Research
- 14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
- 14-3-3 proteins are part of an abscisic acid-VIVIPAROUS1 (VP1) response complex in the Em promoter and interact with VP1 and EmBP1.
- A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2.
- A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25.
- A word of caution in the use of neuron-specific enolase expression in tumor diagnosis.
- Acute in vivo genetic rescue demonstrates that phosphorylation of RIM1alpha serine 413 is not required for mossy fiber long-term potentiation.
- Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family.
- Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation.
- High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer.
- Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3ζ via deacetylation of lysines within the 14-3-3ζ binding pocket.
- Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer.
- Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut8.
- LRRK2 activation in idiopathic Parkinson's disease.
- LRRK2 secretion in exosomes is regulated by 14-3-3.
- Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import.
- Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2.
- Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9.
- Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes.
- PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation.
- Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway.
- Platelet-derived growth factor (PDGF) regulates Slingshot phosphatase activity via Nox1-dependent auto-dephosphorylation of serine 834 in vascular smooth muscle cells.
- Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation.
- Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis.
- Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis.
- Role of 14-3-3-mediated p38 mitogen-activated protein kinase inhibition in cardiac myocyte survival.
- Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis.
- Signaling from the RNA sensor RIG-I is regulated by ufmylation.
- Stress and death: breaking up the c-Abl/14-3-3 complex in apoptosis.
- Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins.
- TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth.
- The bacterial effector HopM1 suppresses PAMP-triggered oxidative burst and stomatal immunity.
- The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.
- The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking.
- The roles of 14-3-3 proteins in signal transduction.
- When the checkpoints have gone: insights into Cdc25 functional activation.