Cell Proliferation

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  Subject Areas on Research

  • 'Chimeric' grafts assembled from multiple allodisparate donors enjoy enhanced transplant survival. 
  • 18F-EF5 PET imaging as an early response biomarker for the hypoxia-activated prodrug SN30000 combined with radiation treatment in a non-small cell lung cancer xenograft model. 
  • 27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6-JAK-STAT3 Signaling in Prostate Cancer Cells. 
  • 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. 
  • A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors. 
  • A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect. 
  • A Genetic Cardiomyocyte Ablation Model for the Study of Heart Regeneration in Zebrafish. 
  • A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma. 
  • A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation. 
  • A Therapeutic Antibody for Cancer, Derived from Single Human B Cells. 
  • A bioactive titanium foam scaffold for bone repair. 
  • A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion. 
  • A comparison of antiangiogenic therapies for the prevention of liver metastases. 
  • A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation. 
  • A critical role for the autophagy gene Atg5 in T cell survival and proliferation. 
  • A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. 
  • A cytokine cocktail directly modulates the phenotype of DC-enriched anti-tumor T cells to convey potent anti-tumor activities in a murine model. 
  • A dual role for ErbB2 signaling in cardiac trabeculation. 
  • A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders. 
  • A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling. 
  • A high-throughput histoarray for quantitative molecular profiling of multiple, uniformly oriented medaka (Oryzias latipes) embryos. 
  • A joint analysis of metabolomics and genetics of breast cancer. 
  • A loss-of-function RNA interference screen for molecular targets in cancer. 
  • A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer. 
  • A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells. 
  • A novel bioluminescence orthotopic mouse model for advanced lung cancer. 
  • A novel conditionally replicating "armed" adenovirus selectively targeting gastrointestinal tumors with aberrant wnt signaling. 
  • A novel fibrotic disorder associated with increased dermal fibroblast proliferation and downregulation of genes of the microfibrillar network. 
  • A novel ribosomopathy caused by dysfunction of RPL10 disrupts neurodevelopment and causes X-linked microcephaly in humans. 
  • A novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycle. 
  • A role for Pin1 in mammalian germ cell development and spermatogenesis. 
  • A role for cFLIP in B cell proliferation and stress MAPK regulation. 
  • A small-molecule antagonist of the hedgehog signaling pathway. 
  • A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells. 
  • A switch in the control of growth of the wing imaginal disks of Manduca sexta. 
  • A system for the direct co-culture of endothelium on smooth muscle cells. 
  • A20 modulates lipid metabolism and energy production to promote liver regeneration. 
  • A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism. 
  • ABCB5 is a limbal stem cell gene required for corneal development and repair. 
  • ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. 
  • ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis. 
  • ADAM12: a genetic modifier of preclinical peripheral arterial disease. 
  • AKT Hyperactivation and the Potential of AKT-Targeted Therapy in Diffuse Large B-Cell Lymphoma. 
  • ATM deficiency promotes progression of CRPC by enhancing Warburg effect. 
  • ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation. 
  • Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells. 
  • Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors. 
  • Aberrant methylation and loss of CADM2 tumor suppressor expression is associated with human renal cell carcinoma tumor progression. 
  • Abi3bp regulates cardiac progenitor cell proliferation and differentiation. 
  • Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling. 
  • Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. 
  • Abundance and Localization of Progesterone Receptor Isoforms in Endometrium in Women With and Without Endometriosis and in Peritoneal and Ovarian Endometriotic Implants. 
  • Abundant copy-number loss of CYCLOPS and STOP genes in gastric adenocarcinoma. 
  • Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks. 
  • Accurate identification of proliferative index in melanocytic neoplasms with Melan-A/Ki-67 double stain. 
  • Acoustic separation of circulating tumor cells. 
  • Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses. 
  • Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells. 
  • Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation. 
  • Activation of RalA is critical for Ras-induced tumorigenesis of human cells. 
  • Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer. 
  • Activation of the PKB/Akt pathway in histological benign prostatic tissue adjacent to the primary malignant lesions. 
  • Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism. 
  • Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response. 
  • Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice. 
  • Acute graft-versus-host disease: are we close to bringing the bench to the bedside? 
  • Adipose stem cell crosstalk with chemo-residual breast cancer cells: implications for tumor recurrence. 
  • Advances in the biology and genetics of the podocytopathies: implications for diagnosis and therapy. 
  • Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells. 
  • Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats. 
  • Akt is required for Stat5 activation and mammary differentiation. 
  • Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer. 
  • Altered phenotypic gene expression of 10T1/2 mesenchymal cells in nonuniformly stretched PEGDA hydrogels. 
  • Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal Cancer. 
  • Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression. 
  • Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells. 
  • Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors. 
  • Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. 
  • Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase. 
  • An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells. 
  • An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis. 
  • An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis. 
  • An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. 
  • An animal model of MYC-driven medulloblastoma. 
  • An early study on the mechanisms that allow tissue-engineered vascular grafts to resist intimal hyperplasia. 
  • An engineered vascular endothelial growth factor-activating transcription factor induces therapeutic angiogenesis in ApoE knockout mice with hindlimb ischemia. 
  • An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo. 
  • An integrative approach identified genes associated with drug response in gastric cancer. 
  • An oxidized extracellular oxidation-reduction state increases Nox1 expression and proliferation in vascular smooth muscle cells via epidermal growth factor receptor activation. 
  • Analysis of Epstein-Barr virus-regulated host gene expression changes through primary B-cell outgrowth reveals delayed kinetics of latent membrane protein 1-mediated NF-κB activation. 
  • Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion. 
  • Analysis of renal cell transformation following exposure to trichloroethene in vivo and its metabolite S-(dichlorovinyl)-L-cysteine in vitro. 
  • Analysis of the immune responses in chimpanzees infected with HIV type 1 isolates. 
  • Anchorage-independent cell growth signature identifies tumors with metastatic potential. 
  • Androgen and estrogen treatment, alone or in combination, differentially influences bone maturation and hypothalamic mechanisms that time puberty in the male rhesus monkey (Macaca mulatta). 
  • Androgen receptor antagonism drives cytochrome P450 17A1 inhibitor efficacy in prostate cancer. 
  • Androgen receptor with short polyglutamine tract preferably enhances Wnt/β-catenin-mediated prostatic tumorigenesis. 
  • Androgens promote prostate cancer cell growth through induction of autophagy. 
  • Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch. 
  • Angiogenesis-like activity of endothelial cells co-cultured with VEGF-producing smooth muscle cells. 
  • Angiotensin-II mediates nonmuscle myosin II activation and expression and contributes to human keloid disease progression. 
  • Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia. 
  • Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma. 
  • Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor. 
  • Antiangiogenic treatment with the three thrombospondin-1 type 1 repeats recombinant protein in an orthotopic human pancreatic cancer model. 
  • Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model. 
  • Anticancer therapeutic potential of Mn porphyrin/ascorbate system. 
  • Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. 
  • Antiproliferative effects of interferon alpha on hepatic progenitor cells in vitro and in vivo. 
  • Antisense to transforming growth factor-beta(1) facilitates the apoptosis of macrophages in rat vein grafts. 
  • Antitumor Activity of BRAF Inhibitor and IFNα Combination in BRAF-Mutant Melanoma. 
  • Antitumor activity of epidermal growth factor receptor-related protein is mediated by inactivation of ErbB receptors and nuclear factor-kappaB in pancreatic cancer. 
  • Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer. 
  • ApoA-I induced CD31 in bone marrow-derived vascular progenitor cells increases adhesion: implications for vascular repair. 
  • Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. 
  • Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration. 
  • Aptamer-mediated delivery of chemotherapy to pancreatic cancer cells. 
  • Arabidopsis lox3 lox4 double mutants are male sterile and defective in global proliferative arrest. 
  • Arterial gene transfer of the TGF-beta signalling protein Smad3 induces adaptive remodelling following angioplasty: a role for CTGF. 
  • Ataxia-telangiectasia group D complementing gene (ATDC) promotes lung cancer cell proliferation by activating NF-κB pathway. 
  • Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis. 
  • Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium. 
  • Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. 
  • Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6. 
  • Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway. 
  • Autoantibodies against cell surface GRP78 promote tumor growth in a murine model of melanoma. 
  • Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor. 
  • Autophagic protein ULK1 regulates FOXM1 signalling in human hepatoma cells. 
  • Autophagy and lymphocyte homeostasis. 
  • Autophagy and mitophagy participate in ocular lens organelle degradation. 
  • Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes. 
  • Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1. 
  • Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. 
  • B cell depletion reduces the development of atherosclerosis in mice. 
  • B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody. 
  • B-cell homeostasis requires complementary CD22 and BLyS/BR3 survival signals. 
  • B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. 
  • BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors. 
  • BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. 
  • BILATERAL DIFFUSE UVEAL MELANOCYTIC PROLIFERATION: A CASE REPORT. 
  • BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway. 
  • BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis. 
  • BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors. 
  • BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. 
  • BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation. 
  • BMP-2 inhibits tumor-initiating ability in human renal cancer stem cells and induces bone formation. 
  • Basal cells as stem cells of the mouse trachea and human airway epithelium. 
  • Basal-like cells constitute the proliferating cell population in cystic fibrosis airways. 
  • Bayesian analysis of signaling networks governing embryonic stem cell fate decisions. 
  • Bcl-xL is an oncogenic driver in colorectal cancer. 
  • Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia. 
  • Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. 
  • Beta-caryophyllene enhances wound healing through multiple routes. 
  • Beta-catenin is a mediator of the response of fibroblasts to irradiation. 
  • Beta-catenin mediates soft tissue contracture in clubfoot. 
  • Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. 
  • Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis. 
  • Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK. 
  • Binding of tissue-type plasminogen activator to the glucose-regulated protein 78 (GRP78) modulates plasminogen activation and promotes human neuroblastoma cell proliferation in vitro. 
  • Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin. 
  • Biocompatibility studies of functionalized regioregular poly(3-hexylthiophene) layers for sensing applications. 
  • Biocompatible hydrogels by oxime Click chemistry. 
  • Biologic effects of platelet-derived growth factor receptor α blockade in uterine cancer. 
  • Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells. 
  • Blocking Cyclin-Dependent Kinase 4/6 During Single Dose Versus Fractionated Radiation Therapy Leads to Opposite Effects on Acute Gastrointestinal Toxicity in Mice. 
  • Bmp7 regulates germ cell proliferation in mouse fetal gonads. 
  • Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice. 
  • Brain cancer stem cells display preferential sensitivity to Akt inhibition. 
  • Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells. 
  • Building and re-building the heart by cardiomyocyte proliferation. 
  • C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway. 
  • CD19 expression in B cells is important for suppression of contact hypersensitivity. 
  • CD19 expression in B cells regulates atopic dermatitis in a mouse model. 
  • CD22-Binding Synthetic Sialosides Regulate B Lymphocyte Proliferation Through CD22 Ligand-Dependent and Independent Pathways, and Enhance Antibody Production in Mice. 
  • CD4 T follicular helper cell dynamics during SIV infection. 
  • CD4+CD8+ T cells represent a significant portion of the anti-HIV T cell response to acute HIV infection. 
  • CD62L- memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice. 
  • CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia. 
  • CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development. 
  • CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control. 
  • CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. 
  • CK1epsilon is required for breast cancers dependent on beta-catenin activity. 
  • CLN3p impacts galactosylceramide transport, raft morphology, and lipid content. 
  • CSPG4 protein as a new target for the antibody-based immunotherapy of triple-negative breast cancer. 
  • CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways. 
  • Ca(v)3.1 splice variant expression during neuronal differentiation of Y-79 retinoblastoma cells. 
  • CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer. 
  • Calcific Aortic Valve Disease: Part 2-Morphomechanical Abnormalities, Gene Reexpression, and Gender Effects on Ventricular Hypertrophy and Its Reversibility. 
  • Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance. 
  • Calories, carbohydrates, and cancer therapy with radiation: exploiting the five R's through dietary manipulation. 
  • Camptothecin analogs with enhanced activity against human breast cancer cells. I. Correlation of potency with lipophilicity and persistence in the cleavage complex. 
  • Can proliferation biomarkers reliably predict recurrence in World Health Organization 2003 defined endometrial stromal sarcoma, low grade? 
  • Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. 
  • Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways. 
  • Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer. 
  • Carbon monoxide reversibly alters iron homeostasis and respiratory epithelial cell function. 
  • Carbonic anhydrase IX in early-stage non-small cell lung cancer. 
  • Cardiac cell therapy in vitro: reproducible assays for comparing the efficacy of different donor cells. 
  • Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes. 
  • Cardiac progenitors and the embryonic cell cycle. 
  • Cardiac regeneration strategies: Staying young at heart. 
  • Cardiac regenerative capacity and mechanisms. 
  • Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development. 
  • Caspase 3 in dying tumor cells mediates post-irradiation angiogenesis. 
  • Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy. 
  • Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. 
  • Cell metabolism: an essential link between cell growth and apoptosis. 
  • Cell population dynamics model for deconvolution of murine embryonic stem cell self-renewal and differentiation responses to cytokines and extracellular matrix. 
  • Change in surface roughness by dynamic shape-memory acrylate networks enhances osteoblast differentiation. 
  • Changes in oligosaccharide chains of autoantibodies to GRP78 expressed during progression of malignant melanoma stimulate melanoma cell growth and survival. 
  • Characterization and optimization of RGD-containing silk blends to support osteoblastic differentiation. 
  • Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models. 
  • Characterization of dendritic-like cells derived from t(9;22) acute lymphoblastic leukemia blasts. 
  • Characterization of the EBV-Induced Persistent DNA Damage Response. 
  • Characterization of umbilical cord blood-derived late outgrowth endothelial progenitor cells exposed to laminar shear stress. 
  • Characterizing the Potency and Impact of Carbon Ion Therapy in a Primary Mouse Model of Soft Tissue Sarcoma. 
  • Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis. 
  • Chemotherapy and the bone marrow stroma. 
  • Chondrogenic differentiation of human embryonic germ cell derived cells in hydrogels. 
  • Chondroitin Sulfate Glycosaminoglycan Hydrogels Create Endogenous Niches for Neural Stem Cells. 
  • Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas. 
  • Chronic fluoxetine increases extra-hippocampal neurogenesis in adult mice. 
  • Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation. 
  • CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis. 
  • Clinicopathologic findings in high-grade B-cell lymphomas with typical Burkitt morphologic features but lacking the MYC translocation. 
  • Clipping of arginine-methylated histone tails by JMJD5 and JMJD7. 
  • Clonal Analysis of the Neonatal Mouse Heart using Nearest Neighbor Modeling. 
  • Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor. 
  • Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance. 
  • Collapsing glomerulopathy: an inflammatory podocytopathy? 
  • Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. 
  • Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma. 
  • Combined PI3K/Akt and Smad2 Activation Promotes Corneal Endothelial Cell Proliferation. 
  • Combined deletion of Id2 and Id3 genes reveals multiple roles for E proteins in invariant NKT cell development and expansion. 
  • Combined inhibition of RNA polymerase I and mTORC1/2 synergize to combat oral squamous cell carcinoma. 
  • Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer. 
  • Combining topographical and genetic cues to promote neuronal fate specification in stem cells. 
  • Coming of age: molecular drivers of aging and therapeutic opportunities. 
  • Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells. 
  • Comparison of endothelial cell phenotypic markers of late-outgrowth endothelial progenitor cells isolated from patients with coronary artery disease and healthy volunteers. 
  • Comparisons of CD8+ T cells specific for human immunodeficiency virus, hepatitis C virus, and cytomegalovirus reveal differences in frequency, immunodominance, phenotype, and interleukin-2 responsiveness. 
  • Complementation of SOD-deficient Escherichia coli by manganese porphyrin mimics of superoxide dismutase activity. 
  • Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis. 
  • Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia. 
  • Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer. 
  • Conditional stabilization of beta-catenin expands the pool of lung stem cells. 
  • Conditional telomerase induction causes proliferation of hair follicle stem cells. 
  • Conditions that promote primary human skeletal myoblast culture and muscle differentiation in vitro. 
  • Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence. 
  • Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation. 
  • Constitutively active erythropoietin receptor expression in breast cancer cells promotes cellular proliferation and migration through a MAP-kinase dependent pathway. 
  • Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: a cautionary note. 
  • Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies. 
  • Contribution of Polycomb group proteins to olfactory basal stem cell self-renewal in a novel c-KIT+ culture model and in vivo. 
  • Control of Arabidopsis lateral root primordium boundaries by MYB36. 
  • Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. 
  • Control of mesenchymal stem cell phenotype and differentiation depending on cell adhesion mechanism. 
  • Controlled release of simvastatin from in situ forming hydrogel triggers bone formation in MC3T3-E1 cells. 
  • Cooperative nutrient accumulation sustains growth of mammalian cells. 
  • Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. 
  • Corneal Endothelial Cell Migration and Proliferation Enhanced by Rho Kinase (ROCK) Inhibitors in In Vitro and In Vivo Models. 
  • Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation. 
  • Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration. 
  • Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression. 
  • Crosslinked hyaluronic acid hydrogels: a strategy to functionalize and pattern. 
  • Crosstalk Between T and B Cells in the Germinal Center After Transplantation. 
  • Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNγ Licensing. 
  • Cryptococcal cell morphology affects host cell interactions and pathogenicity. 
  • Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth. 
  • Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182. 
  • Cutaneous wound healing: recruiting developmental pathways for regeneration. 
  • Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. 
  • Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model. 
  • Cycling in the Cell Fate Landscape. 
  • Cystic pancreatic neuroendocrine tumors: a clinicopathologic study. 
  • Dasatinib (BMS-35482) interacts synergistically with docetaxel, gemcitabine, topotecan, and doxorubicin in ovarian cancer cells with high SRC pathway activation and protein expression. 
  • Death-associated protein kinase 1 promotes growth of p53-mutant cancers. 
  • Decellularized tissue-engineered blood vessel as an arterial conduit. 
  • Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells. 
  • Decreased S100A9 Expression Promoted Rat Airway Smooth Muscle Cell Proliferation by Stimulating ROS Generation and Inhibiting p38 MAPK. 
  • Dedifferentiation of committed epithelial cells into stem cells in vivo. 
  • Defective T cell development and function in the absence of Abelson kinases. 
  • Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells. 
  • Delaying a treatment switch in antiretroviral-treated HIV type 1-infected patients with detectable drug-resistant viremia does not have a profound effect on immune parameters: AIDS Clinical Trials Group Study A5115. 
  • Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma. 
  • Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass. 
  • Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration. 
  • Deletion of the p16INK4a tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse prostate. 
  • Deletion or epigenetic silencing of AJAP1 on 1p36 in glioblastoma. 
  • Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer. 
  • Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells. 
  • Dendritic cells/natural killer cross-talk: a novel target for human immunodeficiency virus type-1 protease inhibitors. 
  • Derivation of chondrogenically-committed cells from human embryonic cells for cartilage tissue regeneration. 
  • Derlin-1 is overexpressed in non-small cell lung cancer and promotes cancer cell invasion via EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9. 
  • Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors. 
  • Detailed analysis of cytomegalovirus (CMV)-specific T cells expanded for adoptive immunotherapy of CMV infection following allogeneic stem cell transplantation for malignant disease. 
  • Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination. 
  • Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells. 
  • Development of a novel method for measuring in vivo breast epithelial cell proliferation in humans. 
  • Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance. 
  • Developmental neurotoxicity of perfluorinated chemicals modeled in vitro. 
  • Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs. 
  • Dexamethasone suppresses DU145 cell proliferation and cell cycle through inhibition of the extracellular signal-regulated kinase 1/2 pathway and cyclin D1 expression. 
  • Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells. 
  • Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses. 
  • Diamagnetic levitation changes growth, cell cycle, and gene expression of Saccharomyces cerevisiae. 
  • Dichotomous roles of TGF-β in human cancer. 
  • Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα. 
  • Differential effect of nitric oxide on thrombospondin-1-, PDGF- and fibronectin-induced migration of vascular smooth muscle cells. 
  • Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines. 
  • Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas. 
  • Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes. 
  • Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis. 
  • Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands. 
  • Differential requirement of RasGRP1 for γδ T cell development and activation. 
  • Differential uptake of DNA-poly(ethylenimine) polyplexes in cells cultured on collagen and fibronectin surfaces. 
  • Dimethylfumarate effectively inhibits lymphangiogenesis via p21 induction and G1 cell cycle arrest. 
  • Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer. 
  • Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells. 
  • Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells. 
  • Direct-contact co-culture between smooth muscle and endothelial cells inhibits TNF-alpha-mediated endothelial cell activation. 
  • Directed intermixing in multicomponent self-assembling biomaterials. 
  • Discovery and characterization of small molecules that target the GTPase Ral. 
  • Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer. 
  • Discovery of thiophene inhibitors of polo-like kinase. 
  • Disparate results between proliferation rates of surgically excised prostate tumors and an in vitro bioassay using sera from a positive randomized controlled trial. 
  • Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. 
  • Dissecting the roles of E1A and E1B in adenoviral replication and RCAd-enhanced RDAd transduction efficacy on tumor cells. 
  • Distinct CD4+ helper T cells involved in primary and secondary responses to infection. 
  • Distinct Responses of Stem Cells to Telomere Uncapping-A Potential Strategy to Improve the Safety of Cell Therapy. 
  • Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia. 
  • Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways. 
  • Distinctions in the specificity of E2F function revealed by gene expression signatures. 
  • Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth. 
  • Do Surface Porosity and Pore Size Influence Mechanical Properties and Cellular Response to PEEK? 
  • Dosage-dependent requirements of Magoh for cortical interneuron generation and survival. 
  • Down-regulation of microRNAs controlling tumourigenic factors in follicular thyroid carcinoma. 
  • Down-regulation of platelet-derived growth factor-D inhibits cell growth and angiogenesis through inactivation of Notch-1 and nuclear factor-kappaB signaling. 
  • Doxorubicin-loaded protease-activated near-infrared fluorescent polymeric nanoparticles for imaging and therapy of cancer. 
  • Drebrin regulates angiotensin II-induced aortic remodelling. 
  • Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biology. 
  • Dual Metronomic Chemotherapy with Nab-Paclitaxel and Topotecan Has Potent Antiangiogenic Activity in Ovarian Cancer. 
  • Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. 
  • Dual action of TGF-beta1 on nasal-polyp derived fibroblasts. 
  • Dual inhibition of αV integrins and Src kinase activity as a combination therapy strategy for colorectal cancer. 
  • Dual-targeted hybrid nanoparticles of synergistic drugs for treating lung metastases of triple negative breast cancer in mice. 
  • Ductular and proliferative response of esophageal submucosal glands in a porcine model of esophageal injury and repair. 
  • Durable HIV-1 antibody and T-cell responses elicited by an adjuvanted multi-protein recombinant vaccine in uninfected human volunteers. 
  • Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma. 
  • Dynamic culture yields engineered myocardium with near-adult functional output. 
  • Dynamic topographical control of mesenchymal stem cells by culture on responsive poly(ε-caprolactone) surfaces. 
  • Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma. 
  • Dysregulated metabolism contributes to oncogenesis. 
  • E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms. 
  • E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression. 
  • EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity. 
  • EGF promotes mammalian cell growth by suppressing cellular senescence. 
  • ER stress modulates cellular metabolism. 
  • ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation. 
  • EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development. 
  • Early KLRG1+ but Not CD57+CD8+ T Cells in Primary Cytomegalovirus Infection Predict Effector Function and Viral Control. 
  • Early fetal hypoxia leads to growth restriction and myocardial thinning. 
  • Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells. 
  • Effect of microRNA modulation on bioartificial muscle function. 
  • Effect of modulating macrophage phenotype on peripheral nerve repair. 
  • Effect of molecular characteristics on cellular uptake, subcellular localization, and phototoxicity of Zn(II) N-alkylpyridylporphyrins. 
  • Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer. 
  • Effect of scaffold microarchitecture on osteogenic differentiation of human mesenchymal stem cells. 
  • Effects of Y27632 on keratinocyte procurement and wound healing. 
  • Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage. 
  • Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells. 
  • Effects of glutamine, glucose, and oxygen concentration on the metabolism and proliferation of rabbit adipose-derived stem cells. 
  • Effects of in vitro brevetoxin exposure on apoptosis and cellular metabolism in a leukemic T cell line (Jurkat). 
  • Effects of myocardial infarction on the distribution and transport of nutrients and oxygen in porcine myocardium. 
  • Effects of plasminogen activator inhibitor-1-specific RNA aptamers on cell adhesion, motility, and tube formation. 
  • Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. 
  • Effects of titanium particle size on osteoblast functions in vitro and in vivo. 
  • Efficient Culture of Human Naive and Memory B Cells for Use as APCs. 
  • Elaboration of tubules with active hedgehog drives parenchymal fibrogenesis in gestational alloimmune liver disease. 
  • Elastic hydrogel as a sensor for detection of mechanical stress generated by single cells grown in three-dimensional environment. 
  • Electron transport complex I is required for CD8+ T cell function. 
  • Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer. 
  • Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae. 
  • Endothelial Bmp4 is induced during arterial remodeling: effects on smooth muscle cell migration and proliferation. 
  • Endothelial Cell-Derived Extracellular Vesicles Mitigate Radiation-Induced Hematopoietic Injury. 
  • Endothelial colony forming cells (ECFCs) as a model for studying effects of low-dose ionizing radiation: growth inhibition by a single dose. 
  • Endothelial progenitor cells: markers of vascular reparative capacity. 
  • Engineered microenvironments for self-renewal and musculoskeletal differentiation of stem cells. 
  • Engineering cell-material interfaces for long-term expansion of human pluripotent stem cells. 
  • Enhanced chondrogenic differentiation of murine embryonic stem cells in hydrogels with glucosamine. 
  • Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation. 
  • Enhanced osteogenic potential of mesenchymal stem cells from cortical bone: a comparative analysis. 
  • Enhancement of dopaminergic properties and protection mediated by neuronal activation of Ras in mouse ventral mesencephalic neurones. 
  • Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice. 
  • Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades. 
  • Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling. 
  • Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6. 
  • Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis. 
  • Epigenetics and cancer metabolism. 
  • Epithelial progenitor cells of the embryonic lung and the role of microRNAs in their proliferation. 
  • Epithelial stem/progenitor cells in lung postnatal growth, maintenance, and repair. 
  • ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure. 
  • Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression. 
  • Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain. 
  • Erythropoietin receptor contributes to melanoma cell survival in vivo. 
  • Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages. 
  • Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes. 
  • Estrogen-independent proliferation is present in estrogen-receptor HER2-positive primary breast cancer after neoadjuvant letrozole. 
  • Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer. 
  • Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. 
  • Evaluation of IRES-mediated, cell-type-specific cytotoxicity of poliovirus using a colorimetric cell proliferation assay. 
  • Evaluation of late outgrowth endothelial progenitor cell and umbilical vein endothelial cell responses to thromboresistant collagen-mimetic hydrogels. 
  • Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader. 
  • Evidence for Feedback Regulation Following Cholesterol Lowering Therapy in a Prostate Cancer Xenograft Model. 
  • Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways. 
  • Evidence for an alternative glycolytic pathway in rapidly proliferating cells. 
  • Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma. 
  • Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells. 
  • Evolutionarily conserved epitopes on human immunodeficiency virus type 1 (HIV-1) and feline immunodeficiency virus reverse transcriptases detected by HIV-1-infected subjects. 
  • Ex vivo expanded human CD4+ regulatory NKT cells suppress expansion of tumor antigen-specific CTLs. 
  • Exemestane's 17-hydroxylated metabolite exerts biological effects as an androgen. 
  • Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas. 
  • Exosomes in Pancreatic Cancer: from Early Detection to Treatment. 
  • Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis. 
  • Explant culture of adult zebrafish hearts for epicardial regeneration studies. 
  • Expression and possible function of fibroblast growth factor 9 (FGF9) and its cognate receptors FGFR2 and FGFR3 in postnatal and adult retina. 
  • Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer. 
  • Expression of ezrin correlates with malignant phenotype of lung cancer, and in vitro knockdown of ezrin reverses the aggressive biological behavior of lung cancer cells. 
  • Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype. 
  • FGF signaling regulates rod photoreceptor cell maintenance and regeneration in zebrafish. 
  • FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma. 
  • FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate. 
  • FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function. 
  • FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and c-Jun dependent mechanisms. 
  • FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway. 
  • Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer. 
  • Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafish. 
  • Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination. 
  • Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis. 
  • Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration. 
  • First in human dose calculation of a single-chain bispecific antibody targeting glioma using the MABEL approach. 
  • First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass. 
  • First somatic mutation of E2F1 in a critical DNA binding residue discovered in well-differentiated papillary mesothelioma of the peritoneum. 
  • Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer. 
  • Flt3 is dispensable to the Hoxa9/Meis1 leukemogenic cooperation. 
  • Fluvastatin reduces proliferation and increases apoptosis in women with high grade breast cancer. 
  • Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. 
  • Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma. 
  • Functional complementation between FADD and RIP1 in embryos and lymphocytes. 
  • Functional genetic variants of RUVBL1 predict overall survival of Chinese patients with epithelial ovarian cancer. 
  • Fusion of the CRM1 nuclear export receptor to AF10 causes leukemia and transcriptional activation of HOXA genes. 
  • G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors. 
  • G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer. 
  • GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers. 
  • GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome. 
  • Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain. 
  • Gene expression and cell growth are modified by silencing SUMO2 and SUMO3 expression. 
  • Generation and analysis of partially haploid cells with Cre-mediated chromosome deletion in the lymphoid system. 
  • Genes restoring redox balance in fermentation-deficient E. coli NZN111. 
  • Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library. 
  • Genetic induction of tumorigenesis in swine. 
  • Genetics of cerebral cavernous malformations. 
  • Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D. 
  • Genomic and Functional Approaches to Understanding Cancer Aneuploidy. 
  • Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells. 
  • Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer. 
  • Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-beta signaling at the bipotent erythro-megakaryocytic progenitor stage. 
  • Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors. 
  • Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. 
  • Global re-wiring of p53 transcription regulation by the hepatitis B virus X protein. 
  • Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression. 
  • Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis. 
  • Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells. 
  • Glutamine prevents apoptosis in intestinal epithelial cells and induces differential protective pathways in heat and oxidant injury models. 
  • Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia. 
  • Glutathione peroxidase-deficient smooth muscle cells cause paracrine activation of normal smooth muscle cells via cyclophilin A. 
  • Glycogen-branching enzyme deficiency leads to abnormal cardiac development: novel insights into glycogen storage disease IV. 
  • Glycosaminoglycan-binding hydrogels enable mechanical control of human pluripotent stem cell self-renewal. 
  • Grading of well-differentiated pancreatic neuroendocrine tumors is improved by the inclusion of both Ki67 proliferative index and mitotic rate. 
  • Gremlin is overexpressed in lung adenocarcinoma and increases cell growth and proliferation in normal lung cells. 
  • Growth signaling at the nexus of stem cell life and death. 
  • Gut immune maturation depends on colonization with a host-specific microbiota. 
  • Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion. 
  • HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor. 
  • HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection. 
  • HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration. 
  • HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. 
  • HER2 dendritic cell vaccines. 
  • HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development. 
  • HIV-1 activates macrophages independent of Toll-like receptors. 
  • HIV-1 neutralization profile and plant-based recombinant expression of actinohivin, an Env glycan-specific lectin devoid of T-cell mitogenic activity. 
  • HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells. 
  • HIV-1-specific CD4+ T lymphocyte turnover and activation increase upon viral rebound. 
  • HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect. 
  • HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer. 
  • Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration. 
  • Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells. 
  • Hedgehog and Notch signaling regulate self-renewal of undifferentiated pleomorphic sarcomas. 
  • Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. 
  • Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth. 
  • Hedgehog regulates yes-associated protein 1 in regenerating mouse liver. 
  • Hedgehog signaling in human medullary thyroid carcinoma: a novel signaling pathway. 
  • Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells. 
  • Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function. 
  • Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation. 
  • Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma. 
  • Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu+ tumors. 
  • High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins. 
  • High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins. 
  • High-LET Radiation Increases Tumor Progression in a K-Ras-Driven Model of Lung Adenocarcinoma. 
  • High-throughput discovery of synthetic surfaces that support proliferation of pluripotent cells. 
  • Highlights from the 46 th annual meeting of the American Society of Hematology. 
  • Histochemical analyses of altered fetal lung development following single vs multiple courses of antenatal steroids. 
  • Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species-Dependent Targeting of Specificity Protein Transcription Factors. 
  • Homeostatic proliferation plus regulatory T-cell depletion promotes potent rejection of B16 melanoma. 
  • Homoserine toxicity in Saccharomyces cerevisiae and Candida albicans homoserine kinase (thr1Delta) mutants. 
  • Human lung stem cells: has the future arrived? 
  • Human neural progenitors express functional lysophospholipid receptors that regulate cell growth and morphology. 
  • Human recombinant erythropoietin (rEpo) has no effect on tumour growth or angiogenesis. 
  • Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse. 
  • Human umbilical cord blood endothelial progenitor cells decrease vein graft neointimal hyperplasia in SCID mice. 
  • Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells. 
  • Hyperoxia impairs postnatal alveolar epithelial development via NADPH oxidase in newborn mice. 
  • Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis. 
  • Hypoexpression and epigenetic regulation of candidate tumor suppressor gene CADM-2 in human prostate cancer. 
  • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. 
  • ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer. 
  • IFN-{beta} signaling positively regulates tumorigenesis in aggressive fibromatosis, potentially by modulating mesenchymal progenitors. 
  • IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma. 
  • IL-1 and TNFα Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration. 
  • IL-10 stimulatory effects on human NK cells explored by gene profile analysis. 
  • IL-12-Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control. 
  • IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia. 
  • IL-27 Facilitates Skin Wound Healing through Induction of Epidermal Proliferation and Host Defense. 
  • IL-7 receptor heterogeneity as a mechanism for repertoire change during postdepletional homeostatic proliferation and its relation to costimulation blockade-resistant rejection. 
  • IRF-1 inhibits NF-κB activity, suppresses TRAF2 and cIAP1 and induces breast cancer cell specific growth inhibition. 
  • IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria. 
  • Iatrogenic lesions of soft tissue and bone. 
  • Identification and Functional Validation of Reciprocal microRNA-mRNA Pairings in African American Prostate Cancer Disparities. 
  • Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation. 
  • Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus. 
  • Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling. 
  • Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells. 
  • Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. 
  • Identification of distinct ChAT⁺ neurons and activity-dependent control of postnatal SVZ neurogenesis. 
  • Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries. 
  • Identification of repurposed small molecule drugs for chordoma therapy. 
  • Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine. 
  • Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development. 
  • Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas. 
  • Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. 
  • Immunodominant liver-specific expression suppresses transgene-directed immune responses in murine pompe disease. 
  • Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer. 
  • Impact of carbohydrate restriction in the context of obesity on prostate tumor growth in the Hi-Myc transgenic mouse model. 
  • Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination. 
  • Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors. 
  • Improving sensitivity and specificity of capturing and detecting targeted cancer cells with anti-biofouling polymer coated magnetic iron oxide nanoparticles. 
  • Improving the outcome of umbilical cord blood transplantation through ex vivo expansion or graft manipulation. 
  • In Vitro Pre-Clinical Validation of Suicide Gene Modified Anti-CD33 Redirected Chimeric Antigen Receptor T-Cells for Acute Myeloid Leukemia. 
  • In utero priming of highly functional effector T cell responses to human malaria. 
  • In vitro assay of immunostimulatory activities of plasmid vectors. 
  • In vitro characteristics of Tenon's fibroblast lines derived from pediatric and adult eyes do not fully explain pediatric glaucoma surgery failure: a preliminary report. 
  • In vitro cytotoxicity of silver nanoparticles in primary rat hepatic stellate cells. 
  • In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. 
  • Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation. 
  • Increased BCR responsiveness in B cells from patients with chronic GVHD. 
  • Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss. 
  • Increased HMGB1 and cleaved caspase-3 stimulate the proliferation of tumor cells and are correlated with the poor prognosis in colorectal cancer. 
  • Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha. 
  • Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. 
  • Inducible and conditional deletion of extracellular signal-regulated kinase 5 disrupts adult hippocampal neurogenesis. 
  • Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro. 
  • Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice. 
  • Induction of hair follicle neogenesis with cultured mouse dermal papilla cells in de novo regenerated skin tissues. 
  • Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation. 
  • Induction of the human heat shock promoter HSP70B by nutritional stress: implications for cancer gene therapy. 
  • Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity. 
  • Influence of physical properties of biomaterials on cellular behavior. 
  • Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer. 
  • Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness. 
  • Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer. 
  • Inhibition of NF-kappaB1 and NF-kappaB2 activation in prostate cancer cells treated with antibody against the carboxyl terminal domain of GRP78: effect of p53 upregulation. 
  • Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways. 
  • Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity. 
  • Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer. 
  • Inhibition of integrative repair of the meniscus following acute exposure to interleukin-1 in vitro. 
  • Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth. 
  • Inhibition of notch signaling induces neural differentiation in Ewing sarcoma. 
  • Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance. 
  • Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists. 
  • Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors. 
  • Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma. 
  • Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis. 
  • Inhibition of the androgen receptor induces a novel tumor promoter, ZBTB46, for prostate cancer metastasis. 
  • Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal. 
  • Initial testing (stage 1) of SGI-1776, a PIM1 kinase inhibitor, by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the curaxin CBL0137 by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ-26481585), by the Pediatric Preclinical Testing Program. 
  • Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the mTOR kinase inhibitor AZD8055 by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the phosphatidylinositol 3' kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program. 
  • Initial testing of JNJ-26854165 (Serdemetan) by the pediatric preclinical testing program. 
  • Initial testing of VS-4718, a novel inhibitor of focal adhesion kinase (FAK), against pediatric tumor models by the Pediatric Preclinical Testing Program. 
  • Initial testing of dasatinib by the pediatric preclinical testing program. 
  • Initial testing of lenalidomide by the pediatric preclinical testing program. 
  • Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP). 
  • Initial testing of the hypoxia-activated prodrug PR-104 by the pediatric preclinical testing program. 
  • Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the pediatric preclinical testing program. 
  • Innate and adaptive receptors interact to balance humoral immunity. 
  • Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response. 
  • Inorganic nitrite attenuates NADPH oxidase-derived superoxide generation in activated macrophages via a nitric oxide-dependent mechanism. 
  • Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila. 
  • Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas. 
  • Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. 
  • Integrin alpha 6 regulates glioblastoma stem cells. 
  • Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration. 
  • Interleukin-15 increases hepatic regenerative activity. 
  • Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone. 
  • Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis. 
  • Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation. 
  • Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents posttraumatic arthritis. 
  • Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation. 
  • Intraductal Oncocytic Papillary Neoplasms: Clinical-Pathologic Characterization of 24 Cases, With An Emphasis on Associated Invasive Carcinomas. 
  • Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche. 
  • Intrinsic and cyclin-dependent kinase-dependent control of spindle pole body duplication in budding yeast. 
  • Investigating Conservation of the Cell-Cycle-Regulated Transcriptional Program in the Fungal Pathogen, Cryptococcus neoformans. 
  • Investigation of HIFU-induced anti-tumor immunity in a murine tumor model. 
  • Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma. 
  • In vitro and in vivo evaluation of resveratrol and 3,5-dihydroxy-4'-acetoxy-trans-stilbene in the treatment of human prostate carcinoma and melanoma. 
  • Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. 
  • Iron deprivation in cancer--potential therapeutic implications. 
  • Isolation and generation of human dendritic cells. 
  • Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism. 
  • JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats. 
  • Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma. 
  • KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage. 
  • Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells. 
  • Key roles of necroptotic factors in promoting tumor growth. 
  • Knockdown of mouse VCAM-1 by vector-based siRNA. 
  • Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells. 
  • LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function. 
  • LGR5 is associated with tumor aggressiveness in papillary thyroid cancer. 
  • LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells. 
  • Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates inflammatory response and homeostasis of spleen and colon in experimental model of Pseudomonas aeruginosa pneumonia. 
  • Laminating the mammalian cortex during development: cell polarity protein function and Hippo signaling. 
  • Late outgrowth endothelial progenitor cells in patients with age-related macular degeneration. 
  • Late-outgrowth endothelial progenitors from patients with coronary artery disease: endothelialization of confluent stromal cell layers. 
  • Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites. 
  • Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution. 
  • Life, death, and the metabolically controlled protein acetylome. 
  • Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis. 
  • Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis. 
  • Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. 
  • Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes. 
  • Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy. 
  • Lonafarnib for cancer and progeria. 
  • Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis. 
  • Long-term efficacy of enzyme replacement therapy for adenosine deaminase (ADA)-deficient severe combined immunodeficiency (SCID). 
  • Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. 
  • Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance. 
  • Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression. 
  • Loss of BMI1 in mature olfactory sensory neurons leads to increased olfactory basal cell proliferation. 
  • Loss of Lrig1 leads to expansion of Brunner glands followed by duodenal adenomas with gastric metaplasia. 
  • Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis. 
  • Loss of PTPRM associates with the pathogenic development of colorectal adenoma-carcinoma sequence. 
  • Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. 
  • Loss of epithelial oestrogen receptor α inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models. 
  • Loss of pericyte smoothened activity in mice with genetic deficiency of leptin. 
  • Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells. 
  • Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment. 
  • Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2. 
  • Low-Dose Histone Deacetylase Inhibitor Treatment Leads to Tumor Growth Arrest and Multi-Lineage Differentiation of Malignant Rhabdoid Tumors. 
  • Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation. 
  • Lung inflammation, injury, and proliferative response after repetitive particulate hexavalent chromium exposure. 
  • Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners. 
  • Lysophosphatidic acid stimulates cell growth by different mechanisms in SKOV-3 and Caov-3 ovarian cancer cells: distinct roles for Gi- and Rho-dependent pathways. 
  • M-HIFU inhibits tumor growth, suppresses STAT3 activity and enhances tumor specific immunity in a transplant tumor model of prostate cancer. 
  • MEKK3 is essential for lymphopenia-induced T cell proliferation and survival. 
  • MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression. 
  • MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation. 
  • MYB36 regulates the transition from proliferation to differentiation in the Arabidopsis root. 
  • Macrophages Facilitate Resistance to Anti-VEGF Therapy by Altered VEGFR Expression. 
  • Maintaining T lymphocyte homeostasis: another duty of autophagy. 
  • Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. 
  • Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam. 
  • Mathematical modeling of the Phoenix Rising pathway. 
  • Maximizing the retention of antigen specific lymphocyte function after cryopreservation. 
  • Mechanical and cytotoxicity testing of acrylic bone cement embedded with microencapsulated 2-octyl cyanoacrylate. 
  • Mechanism of the Antitumor and Radiosensitizing Effects of a Manganese Porphyrin, MnHex-2-PyP. 
  • Mechanisms of action of rapamycin in gliomas. 
  • Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells. 
  • Mechanistic insights of rapid liver regeneration after associating liver partition and portal vein ligation for stage hepatectomy. 
  • Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function. 
  • Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells. 
  • Melanoma, a tumor based on a mutant stem cell? 
  • Meniscus-Derived Matrix Bioscaffolds: Effects of Concentration and Cross-Linking on Meniscus Cellular Responses and Tissue Repair. 
  • Metabolic flux and the regulation of mammalian cell growth. 
  • Metabolic pathway alterations that support cell proliferation. 
  • Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. 
  • Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization. 
  • Metabolism: A new layer of glycolysis. 
  • Methylation subtypes and large-scale epigenetic alterations in gastric cancer. 
  • MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer. 
  • MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex. 
  • Micro-scale and meso-scale architectural cues cooperate and compete to direct aligned tissue formation. 
  • MicroRNA miR-590-5p inhibits breast cancer cell stemness and metastasis by targeting SOX2. 
  • MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways. 
  • MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells. 
  • MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar Carcinoma. 
  • MicroRNAs associated to single drug components of R-CHOP identifies diffuse large B-cell lymphoma patients with poor outcome and adds prognostic value to the international prognostic index. 
  • MicroRNAs in skin tissue engineering. 
  • Microporous annealed particle hydrogel stiffness, void space size, and adhesion properties impact cell proliferation, cell spreading, and gene transfer. 
  • Mineralized gelatin methacrylate-based matrices induce osteogenic differentiation of human induced pluripotent stem cells. 
  • Mineralized synthetic matrices as an instructive microenvironment for osteogenic differentiation of human mesenchymal stem cells. 
  • Minimal barriers to invasion during human colorectal tumor growth. 
  • Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression. 
  • Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest. 
  • Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells. 
  • Model of tumor dormancy/recurrence after short-term chemotherapy. 
  • Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts. 
  • Modeling early stage atherosclerosis in a primary human vascular microphysiological system. 
  • Modeling the developmental neurotoxicity of nicotine in vitro: cell acquisition, growth and viability in PC12 cells. 
  • Modulating the mechanical properties of self-assembled peptide hydrogels via native chemical ligation. 
  • Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. 
  • Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer. 
  • Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise. 
  • Modulation of nonneutralizing HIV-1 gp41 responses by an MHC-restricted TH epitope overlapping those of membrane proximal external region broadly neutralizing antibodies. 
  • Modulation of tissue repair by regeneration enhancer elements. 
  • Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma. 
  • Molecular determinants for enzalutamide-induced transcription in prostate cancer. 
  • Molecular profile and partial functional analysis of novel endothelial cell-derived growth factors that regulate hematopoiesis. 
  • Molecular signatures of thyroid follicular neoplasia. 
  • Morphogenetic signals from chondrocytes promote chondrogenic and osteogenic differentiation of mesenchymal stem cells. 
  • Mucosally-administered human-simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIVSF162P3. 
  • Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium. 
  • Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices. 
  • Multiple roles for Sox2 in the developing and adult mouse trachea. 
  • Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. 
  • Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeleton. 
  • Murine bone marrow stromal cells pulsed with homologous tumor-derived exosomes inhibit proliferation of liver cancer cells. 
  • Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression. 
  • Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression. 
  • Mutant IDH1 is required for IDH1 mutated tumor cell growth. 
  • Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells. 
  • Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting. 
  • Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries. 
  • Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury. 
  • N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway. 
  • N-cadherin functions as a growth suppressor in a model of K-ras-induced PanIN. 
  • N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma. 
  • NDRG4 is required for cell cycle progression and survival in glioblastoma cells. 
  • NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition. 
  • NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis. 
  • NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma. 
  • NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells. 
  • Naive human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin. 
  • Nasal immunization with a recombinant HIV gp120 and nanoemulsion adjuvant produces Th1 polarized responses and neutralizing antibodies to primary HIV type 1 isolates. 
  • Naïve T cells are maintained in the periphery during the first 3 months of acute HIV-1 infection: implications for analysis of thymus function. 
  • Neisseria gonorrhoeae suppresses dendritic cell-induced, antigen-dependent CD4 T cell proliferation. 
  • Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems. 
  • Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration. 
  • Network growth models and genetic regulatory networks. 
  • Neurofibromatosis Type 1 and tumorigenesis: molecular mechanisms and therapeutic implications. 
  • Neuronal Activity-Dependent Control of Postnatal Neurogenesis and Gliogenesis. 
  • Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury. 
  • New drug development in metastatic prostate cancer. 
  • New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. 
  • NgBR is essential for endothelial cell glycosylation and vascular development. 
  • Niche-mediated BMP/SMAD signaling regulates lung alveolar stem cell proliferation and differentiation. 
  • Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth. 
  • Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP. 
  • Nitric oxide-generating hydrogels inhibit neointima formation. 
  • Nitric oxide-producing polyurethanes. 
  • Nitric oxide-releasing polyurethane-PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion. 
  • Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA Metabolism and Proliferation. 
  • Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. 
  • Non-alcoholic steatohepatitis pathogenesis: role of repair in regulating the disease progression. 
  • Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis. 
  • Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesis. 
  • Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. 
  • Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells. 
  • Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells. 
  • Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells. 
  • Notch promotes radioresistance of glioma stem cells. 
  • Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest. 
  • Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies. 
  • Notch signaling maintains Leydig progenitor cells in the mouse testis. 
  • Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting. 
  • Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans. 
  • Novel nanostructured scaffolds as therapeutic replacement options for rotator cuff disease. 
  • Novel role for surfactant protein A in gastrointestinal graft-versus-host disease. 
  • Novel roles of apoptotic caspases in tumor repopulation, epigenetic reprogramming, carcinogenesis, and beyond. 
  • Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma. 
  • Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia. 
  • Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish. 
  • Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. 
  • Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses. 
  • Ocular allergy modulation to hi-dose antigen sensitization is a Treg-dependent process. 
  • Oncogene pathway activation in mammary tumors dictates FDG-PET uptake. 
  • Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway. 
  • Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. 
  • Ontogeny of the eotaxins in human lung. 
  • Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors. 
  • Optical Imaging of Glucose Uptake and Mitochondrial Membrane Potential to Characterize Her2 Breast Tumor Metabolic Phenotypes. 
  • Optimization of a highly standardized carboxyfluorescein succinimidyl ester flow cytometry panel and gating strategy design using discriminative information measure evaluation. 
  • Optimizing PLG nanoparticle-peptide delivery platforms for transplantation tolerance using an allogeneic skin transplant model. 
  • Origin of bistability underlying mammalian cell cycle entry. 
  • Osteopontin has a protective role in prostate tumor development in mice. 
  • Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation. 
  • Overexpression of CRKL correlates with poor prognosis and cell proliferation in non-small cell lung cancer. 
  • Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function. 
  • Overlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development. 
  • Oxidative stress impact on barrier function of porcine angular aqueous plexus cell monolayers. 
  • P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively. 
  • PAK1 mediates resistance to PI3K inhibition in lymphomas. 
  • PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-oesophageal epithelium. 
  • PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma. 
  • PDGFRα + pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo. 
  • PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity. 
  • PI3K stimulates DNA synthesis and cell-cycle progression via its p55PIK regulatory subunit interaction with PCNA. 
  • PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers. 
  • PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation. 
  • PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population. 
  • PTEN Expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer. 
  • PTEN reconstitution alters glioma responses to c-Met pathway inhibition. 
  • PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression. 
  • PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms. 
  • Packed red blood cells suppress T-cell proliferation through a process involving cell-cell contact. 
  • Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model. 
  • Pan-cancer analysis of whole genomes. 
  • Pancreatic intraepithelial neoplasia and histological changes in non-neoplastic pancreas associated with neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma. 
  • Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice. 
  • Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults. 
  • Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism. 
  • Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2. 
  • Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth. 
  • Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth. 
  • Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age. 
  • Persistent neurobehavioral effects of early postnatal domoic acid exposure in rats. 
  • Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ. 
  • Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. 
  • Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. 
  • Phase I study of immunization with dendritic cells modified with fowlpox encoding carcinoembryonic antigen and costimulatory molecules. 
  • Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas. 
  • Phenotypic and functional characterization of cytotoxic T lymphocytes by flow cytometry. 
  • Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. 
  • Phosphorylated Histone H3 (PHH3) Is a Superior Proliferation Marker for Prognosis of Pancreatic Neuroendocrine Tumors. 
  • Photosensitizing action of isomeric zinc N-methylpyridylporphyrins in human carcinoma cells. 
  • Physiologic pulsatile flow bioreactor conditioning of poly(ethylene glycol)-based tissue engineered vascular grafts. 
  • Plasminogen structural domains exhibit different functions when associated with cell surface GRP78 or the voltage-dependent anion channel. 
  • Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. 
  • Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. 
  • Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. 
  • Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue. 
  • Poly(ethylene glycol) hydrogel system supports preadipocyte viability, adhesion, and proliferation. 
  • Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells. 
  • Polycythemia vera erythroid precursors exhibit increased proliferation and apoptosis resistance associated with abnormal RAS and PI3K pathway activation. 
  • Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers. 
  • Porous biocompatible three-dimensional scaffolds of cellulose microfiber/gelatin composites for cell culture. 
  • Post-prenylation-processing enzymes as new targets in oncogenesis. 
  • Post-transcriptional RNA regulons affecting cell cycle and proliferation. 
  • Post-transcriptional regulation of MTA family by microRNAs in the context of cancer. 
  • Precision cancer immunotherapy: optimizing dendritic cell-based strategies to induce tumor antigen-specific T-cell responses against individual patient tumors. 
  • Preclinical Study of AUY922, a Novel Hsp90 Inhibitor, in the Treatment of Esophageal Adenocarcinoma. 
  • Preclinical characterization of DUOC-01, a cell therapy product derived from banked umbilical cord blood for use as an adjuvant to umbilical cord blood transplantation for treatment of inherited metabolic diseases. 
  • Preclinical efficacy of MEK inhibition in Nras-mutant AML. 
  • Preclinical testing of a peptide-based, HER2/neu vaccine for prostate cancer. 
  • Preliminary observations using optical coherence tomography to assess neointimal coverage of a metal stent in a porcine model. 
  • Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis. 
  • Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes. 
  • Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. 
  • Prime-boost regimens with adjuvanted synthetic long peptides elicit T cells and antibodies to conserved regions of HIV-1 in macaques. 
  • Probiotic administration reduces mortality and improves intestinal epithelial homeostasis in experimental sepsis. 
  • Profiling Hsp90 differential expression and the molecular effects of the Hsp90 inhibitor IPI-504 in high-grade glioma models. 
  • Progesterone receptor membrane component 1: is metabolism integral to its function and what other steroids are involved? 
  • Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer. 
  • Progression of intermediate age-related macular degeneration with proliferation and inner retinal migration of hyperreflective foci. 
  • Proliferation behavior of E. coli in a three-dimensional in vitro tumor model. 
  • Proliferation indices correlate with diagnosis and metastasis in diagnostically challenging melanocytic tumors. 
  • Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2. 
  • Proliferation of HIV-infected renal epithelial cells following virus acquisition from infected macrophages. 
  • Proliferative potential and resistance to immune checkpoint blockade in lung cancer patients. 
  • Prolonged beta-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds. 
  • Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer. 
  • Properly folded and functional PorB from Neisseria gonorrhoeae inhibits dendritic cell stimulation of CD4+ T cell proliferation. 
  • Prospective of Ras signaling in stem cells. 
  • Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum. 
  • Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. 
  • Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. 
  • Purine synthesis promotes maintenance of brain tumor initiating cells in glioma. 
  • Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration. 
  • Quantitative high-throughput efficacy profiling of approved oncology drugs in inflammatory breast cancer models of acquired drug resistance and re-sensitization. 
  • RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. 
  • RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. 
  • RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression. 
  • RNA-Seq and ChIP-Seq reveal SQSTM1/p62 as a key mediator of JunB suppression of NF-κB-dependent inflammation. 
  • RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression. 
  • Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study. 
  • Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate. 
  • Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis. 
  • Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation. 
  • Rare codons capacitate Kras-driven de novo tumorigenesis. 
  • Ras controls melanocyte expansion during zebrafish fin stripe regeneration. 
  • RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer. 
  • Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. 
  • Re: KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancer (Int J Cancer 123: 2239-2246, 2008). 
  • Recipient Myd88 Deficiency Promotes Spontaneous Resolution of Kidney Allograft Rejection. 
  • Reconstruction of cell population dynamics using CFSE. 
  • Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance. 
  • Reduction of Stat3 activity attenuates HIV-induced kidney injury. 
  • Regenerative hepatic pseudotumor: a new pseudotumor of the liver. 
  • Regionally-specified second trimester fetal neural stem cells reveals differential neurogenic programming. 
  • Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin. 
  • Regulated spindle orientation buffers tissue growth in the epidermis. 
  • Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection. 
  • Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1. 
  • Regulation of nuclear Prointerleukin-16 and p27(Kip1) in primary human T lymphocytes. 
  • Regulation of plant stem cell quiescence by a brassinosteroid signaling module. 
  • Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2. 
  • Regulation of zebrafish heart regeneration by miR-133. 
  • Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis. 
  • Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. 
  • Regulatory T cells exhibit decreased proliferation but enhanced suppression after pulsing with sirolimus. 
  • Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. 
  • Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma. 
  • Relationship of blood monocytes with chronic lymphocytic leukemia aggressiveness and outcomes: a multi-institutional study. 
  • Rendering the leukemia cell susceptible to attack. 
  • Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo. 
  • Reprogramming of cellular metabolic pathways by human oncogenic viruses. 
  • Requirement of estrogen receptor alpha DNA-binding domain for HPV oncogene-induced cervical carcinogenesis in mice. 
  • Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts. 
  • Resistance to apoptosis, increased growth potential, and altered gene expression in cells that survived genotoxic hexavalent chromium [Cr(VI)] exposure. 
  • Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR. 
  • Resorbable, amino acid-based poly(ester urea)s crosslinked with osteogenic growth peptide with enhanced mechanical properties and bioactivity. 
  • Respiratory Capacity and Reserve Predict Cell Sensitivity to Mitochondria Inhibitors: Mechanism-Based Markers to Identify Metformin-Responsive Cancers. 
  • Response of zonal chondrocytes to extracellular matrix-hydrogels. 
  • Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-β. 
  • Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. 
  • Reversing the Warburg effect as a treatment for glioblastoma. 
  • Role for Nox1 NADPH oxidase in atherosclerosis. 
  • Role for hedgehog pathway in regulating growth and function of invariant NKT cells. 
  • Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling. 
  • Role of Fn14 in acute alcoholic steatohepatitis in mice. 
  • Role of Increased n-acetylaspartate Levels in Cancer. 
  • Role of TGF-β receptor III localization in polarity and breast cancer progression. 
  • Role of YAP1 as a Marker of Sensitivity to Dual AKT and P70S6K Inhibition in Ovarian and Uterine Malignancies. 
  • Role of eotaxin-1 signaling in ovarian cancer. 
  • Role of germinal centers for the induction of broadly-reactive memory B cells. 
  • Role of repulsive factors in vascularization dynamics. 
  • Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma. 
  • Role of transforming growth factor-beta in hematologic malignancies. 
  • Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro. 
  • SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility. 
  • SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway. 
  • SHP-2 is required for the maintenance of cardiac progenitors. 
  • SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression. 
  • SRC family kinase inhibition as a novel strategy to augment melphalan-based regional chemotherapy of advanced extremity melanoma. 
  • STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration. 
  • STAT3-mediated coincidence detection regulates noncanonical immediate early gene induction. 
  • STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice. 
  • SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. 
  • Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component. 
  • Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni. 
  • Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel. 
  • Screening of hyaluronic acid-poly(ethylene glycol) composite hydrogels to support intervertebral disc cell biosynthesis using artificial neural network analysis. 
  • Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma. 
  • Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway. 
  • Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. 
  • Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance. 
  • Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation. 
  • Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model. 
  • Self-assembling peptide-polymer hydrogels designed from the coiled coil region of fibrin. 
  • Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses. 
  • Sequential roles of Hedgehog and Wnt signaling in osteoblast development. 
  • Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism. 
  • Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement. 
  • Serum cholesterol levels and tumor growth in a PTEN-null transgenic mouse model of prostate cancer. 
  • Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats. 
  • ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis. 
  • Side population cells isolated from mesenchymal neoplasms have tumor initiating potential. 
  • Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta. 
  • Silver nanoparticles compromise neurodevelopment in PC12 cells: critical contributions of silver ion, particle size, coating, and composition. 
  • Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors. 
  • Simultaneous proteomic profiling of four different growth states of human fibroblasts, using amine-reactive isobaric tagging reagents and tandem mass spectrometry. 
  • Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. 
  • Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function. 
  • Site-specific polyubiquitination differentially regulates parathyroid hormone receptor-initiated MAPK signaling and cell proliferation. 
  • Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin. 
  • Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells. 
  • Small neuroendocrine lesions in intrathoracic lymph nodes of patients with primary lung adenocarcinoma: real metastasis? 
  • Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging. 
  • Smooth Muscle Cell-targeted RNA Aptamer Inhibits Neointimal Formation. 
  • Smoothened inhibition leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells. 
  • Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer. 
  • Somatostatin receptor 2 signaling promotes growth and tumor survival in small-cell lung cancer. 
  • Sonic Hedgehog-induced proliferation requires specific Gα inhibitory proteins. 
  • Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation. 
  • Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. 
  • Sonic hedgehog is required for cardiac outflow tract and neural crest cell development. 
  • Sonic hedgehog signaling pathway supports cancer cell growth during cancer radiotherapy. 
  • Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base. 
  • Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model. 
  • Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve. 
  • Sox6 as a new modulator of renin expression in the kidney. 
  • Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent. 
  • Spatial memory and hippocampal plasticity are differentially sensitive to the availability of choline in adulthood as a function of choline supply in utero. 
  • Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury. 
  • Stem cells for the ischaemic heart. 
  • Steroid hormones drive cancer development. 
  • Steroid induction of therapy-resistant cytokeratin-5-positive cells in estrogen receptor-positive breast cancer through a BCL6-dependent mechanism. 
  • Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells. 
  • Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. 
  • Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension. 
  • Streptozotocin induces G2 arrest in skeletal muscle myoblasts and impairs muscle growth in vivo. 
  • Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. 
  • Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones. 
  • Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure. 
  • Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli. 
  • Sugar-coating wound repair: a review of FGF-10 and dermatan sulfate in wound healing and their potential application in burn wounds. 
  • Sulforaphane induces inhibition of human umbilical vein endothelial cells proliferation by apoptosis. 
  • Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer. 
  • Suppressing autoimmunity by TGF-β: not just through T(reg) cells. 
  • Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids. 
  • Surfactant protein A integrates activation signal strength to differentially modulate T cell proliferation. 
  • Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis. 
  • Symmetrically dividing cells of the fission yeast schizosaccharomyces pombe do age. 
  • Synephrine Hydrochloride Suppresses Esophageal Cancer Tumor Growth and Metastatic Potential through Inhibition of Galectin-3-AKT/ERK Signaling. 
  • Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma. 
  • Synergism from combined immunologic and pharmacologic inhibition of HER2 in vivo. 
  • Synergistic enhancement of human bone marrow stromal cell proliferation and osteogenic differentiation on BMP-2-derived and RGD peptide concentration gradients. 
  • Synthesis and activity of largazole analogues with linker and macrocycle modification. 
  • Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives. 
  • Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells. 
  • Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers. 
  • T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. 
  • T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation. 
  • T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10. 
  • T-bet:Eomes balance, effector function, and proliferation of cytomegalovirus-specific CD8+ T cells during primary infection differentiates the capacity for durable immune control. 
  • T-lymphocyte alloresponses of Campath-1H-treated kidney transplant patients. 
  • TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein. 
  • TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. 
  • TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways. 
  • TCDD disrupts hypural skeletogenesis during medaka embryonic development. 
  • TCR stimulation without co-stimulatory signals induces expression of "tolerogenic" genes in memory CD4 T cells but does not compromise cell proliferation. 
  • TET2 binds the androgen receptor and loss is associated with prostate cancer. 
  • TGF-β Family Signaling in the Control of Cell Proliferation and Survival. 
  • TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch. 
  • TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk. 
  • TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α. 
  • TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep). 
  • TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice. 
  • Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease. 
  • Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response. 
  • Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth. 
  • Targeted inhibition of alphavbeta3 integrin with an RNA aptamer impairs endothelial cell growth and survival. 
  • Targeted suppression of beta-catenin blocks intestinal adenoma formation in APC Min mice. 
  • Targeting Akt3 signaling in malignant melanoma using isoselenocyanates. 
  • Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer. 
  • Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth. 
  • Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer. 
  • Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy. 
  • Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration. 
  • Targeting cell surface GRP78 enhances pancreatic cancer radiosensitivity through YAP/TAZ protein signaling. 
  • Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer. 
  • Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. 
  • Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma. 
  • Targeting slow-proliferating ovarian cancer cells. 
  • Targeting stem cell behavior in desmoid tumors (aggressive fibromatosis) by inhibiting hedgehog signaling. 
  • Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields. 
  • Targeting the hexosamine biosynthetic pathway and O-linked N-acetylglucosamine cycling for therapeutic and imaging capabilities in diffuse large B-cell lymphoma. 
  • TbetaRIII suppresses non-small cell lung cancer invasiveness and tumorigenicity. 
  • Technology evaluation: Stem-cell therapy, Aastrom Biosciences Inc. 
  • Telomere dysfunction causes alveolar stem cell failure. 
  • Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection. 
  • Temporal modulation of collective cell behavior controls vascular network topology. 
  • Tenascin-C, over expressed in lung cancer down regulates effector functions of tumor infiltrating lymphocytes. 
  • Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program. 
  • Testosterone regulates cell proliferation in aggressive fibromatosis (desmoid tumour). 
  • The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia. 
  • The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis. 
  • The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-A potential therapeutic target. 
  • The C-terminal domain of A1/Bfl-1 regulates its anti-inflammatory function in human endothelial cells. 
  • The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1. 
  • The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency. 
  • The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage. 
  • The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytes. 
  • The Epstein-Barr virus (EBV)-induced tumor suppressor microRNA MiR-34a is growth promoting in EBV-infected B cells. 
  • The G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures. 
  • The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells. 
  • The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis. 
  • The Molecular Link from Diet to Cancer Cell Metabolism. 
  • The N-terminal Set-β Protein Isoform Induces Neuronal Death. 
  • The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. 
  • The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescence. 
  • The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells. 
  • The PICALM protein plays a key role in iron homeostasis and cell proliferation. 
  • The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma. 
  • The Role of the Immune Cells in Fracture Healing. 
  • The Transcriptional Coactivator TAZ Is a Potent Mediator of Alveolar Rhabdomyosarcoma Tumorigenesis. 
  • The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer. 
  • The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. 
  • The biocompatibility of titanium cardiovascular devices seeded with autologous blood-derived endothelial progenitor cells: EPC-seeded antithrombotic Ti implants. 
  • The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. 
  • The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival. 
  • The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion. 
  • The comprehensive role of E-cadherin in maintaining prostatic epithelial integrity during oncogenic transformation and tumor progression. 
  • The consensus mechanics of cultured mammalian cells 
  • The diversity and plasticity of adult hepatic progenitor cells and their niche. 
  • The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer. 
  • The effect of alpha-v integrin inhibition on the malignant characteristics of medulloblastoma. 
  • The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients. 
  • The effect of darbepoetin alfa on growth, oxygenation and radioresponsiveness of a breast adenocarcinoma. 
  • The effect of hyperbranched polyglycerol coatings on drug delivery using degradable polymer nanoparticles. 
  • The epicardium as a hub for heart regeneration. 
  • The extracellular matrix protein agrin promotes heart regeneration in mice. 
  • The granulin-epithelin precursor is a steroid-regulated growth factor in endometrial cancer. 
  • The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways. 
  • The homeodomain protein HOXB13 regulates the cellular response to androgens. 
  • The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation. 
  • The incretins and beta-cell health: contrasting glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 as a path to understand islet function in diabetes. 
  • The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. 
  • The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms. 
  • The interleukin-2 receptor α chain (CD25) plays an important role in regulating monocyte-derived CD40 expression during anti-porcine cellular responses. 
  • The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. 
  • The long and the short of telomeres in bone marrow recipient SCID patients. 
  • The long isoform of cellular FLIP is essential for T lymphocyte proliferation through an NF-kappaB-independent pathway. 
  • The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation. 
  • The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer. 
  • The modulation of MSC integrin expression by RGD presentation. 
  • The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development. 
  • The natural diterpene tonantzitlolone A and its synthetic enantiomer inhibit cell proliferation and kinesin-5 function. 
  • The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. 
  • The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts. 
  • The pediatric preclinical testing program: description of models and early testing results. 
  • The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF. 
  • The rapamycin analog CCI-779 is a potent inhibitor of pancreatic cancer cell proliferation. 
  • The requirement of reversible cysteine sulfenic acid formation for T cell activation and function. 
  • The role of ACAID and CD4+CD25+FOXP3+ regulatory T cells on CTL function against MHC alloantigens. 
  • The role of platelets on regenerating liver: Thoughts beyond parenchymal proliferation. 
  • The role of thrombin and protease-activated receptors in pain mechanisms. 
  • The role of type 1 angiotensin receptors on T lymphocytes in cardiovascular and renal diseases. 
  • The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome. 
  • The secreted metalloprotease ADAMTS20 is required for melanoblast survival. 
  • The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice. 
  • The spreading, migration and proliferation of mouse mesenchymal stem cells cultured inside hyaluronic acid hydrogels. 
  • The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. 
  • The tetraspanin superfamily member NET-6 is a new tumor suppressor gene. 
  • The type III TGF-beta receptor signals through both Smad3 and the p38 MAP kinase pathways to contribute to inhibition of cell proliferation. 
  • The type III TGF-beta receptor suppresses breast cancer progression through GIPC-mediated inhibition of TGF-beta signaling. 
  • The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells. 
  • The use of immobilized osteogenic growth peptide on gradient substrates synthesized via click chemistry to enhance MC3T3-E1 osteoblast proliferation. 
  • The use of mild trypsinization conditions in the detachment of endothelial cells to promote subsequent endothelialization on synthetic surfaces. 
  • The zinc finger transcription factor ZFX is required for maintaining the tumorigenic potential of glioblastoma stem cells. 
  • Therapeutic applications of NSAIDS in cancer: special emphasis on tolfenamic acid. 
  • Therapeutic potential of ReACp53 targeting mutant p53 protein in CRPC. 
  • Therapeutic targeting of erbB3 with MM-121/SAR256212 enhances antitumor activity of paclitaxel against erbB2-overexpressing breast cancer. 
  • Three linked vasculopathic processes characterize Kawasaki disease: a light and transmission electron microscopic study. 
  • Three-dimensional culture conditions differentially affect astrocyte modulation of brain endothelial barrier function in response to transforming growth factor β1. 
  • TiO₂ Nanoparticle-Induced Oxidation of the Plasma Membrane: Importance of the Protein Corona. 
  • Tissue-specific expression and regulation of the alternatively-spliced forms of lysyl hydroxylase 2 (LH2) in human kidney cells and skin fibroblasts. 
  • To be or not IIb: a multi-step process for Epstein-Barr virus latency establishment and consequences for B cell tumorigenesis. 
  • Tobacco Carcinogen-Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer. 
  • Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation. 
  • Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming. 
  • Tor and cyclic AMP-protein kinase A: two parallel pathways regulating expression of genes required for cell growth. 
  • Toward a blueprint for regeneration. 
  • Toward effective immunotherapy for the treatment of malignant brain tumors. 
  • Tracking proliferative history in lymphocyte development with cre-mediated sister chromatid recombination. 
  • Transcriptional regulation of ROS controls transition from proliferation to differentiation in the root. 
  • Transcriptional regulation of changes in growth, cell cycle, and gene expression of Saccharomyces cerevisiae due to changes in buoyancy. 
  • Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression. 
  • Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. 
  • Transgelin-2: Biochemical and Clinical Implications in Cancer and Asthma. 
  • Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. 
  • Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. 
  • Trastuzumab signaling in ErbB2-overexpressing inflammatory breast cancer correlates with X-linked inhibitor of apoptosis protein expression. 
  • Treatment of Cyclosporin A retains host defense against invasive pulmonary aspergillosis in a non-immunosuppressive murine model by preserving the myeloid cell population. 
  • Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function. 
  • Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide. 
  • Tumor cell sensitivity to vemurafenib can be predicted from protein expression in a BRAF-V600E basket trial setting. 
  • Tumor microenvironment tenascin-C promotes glioblastoma invasion and negatively regulates tumor proliferation. 
  • Tumor necrosis factor receptor-2 signaling attenuates vein graft neointima formation by promoting endothelial recovery. 
  • Type 2 alveolar cells are stem cells in adult lung. 
  • Type I collagen synergistically enhances PDGF-induced smooth muscle cell proliferation through pp60src-dependent crosstalk between the alpha2beta1 integrin and PDGFbeta receptor. 
  • Type III TGF-β receptor enhances colon cancer cell migration and anchorage-independent growth. 
  • U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. 
  • UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling. 
  • Ubiquitylation of p53 by the APC/C inhibitor Trim39. 
  • Ultraviolet photolysis of chlorpyrifos: developmental neurotoxicity modeled in PC12 cells. 
  • Understanding the mechanism of bias signaling of the insulin-like growth factor 1 receptor: Effects of LL37 and HASF. 
  • Unusual clinical and immunologic manifestations of transplacentally acquired maternal T cells in severe combined immunodeficiency. 
  • Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells. 
  • Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation. 
  • Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma. 
  • Uterine leiomyomata in relation to insulin-like growth factor-I, insulin, and diabetes. 
  • Utilization of genomic signatures to identify high-efficacy candidate drugs for chemorefractory endometrial cancers. 
  • Utilizing cell-matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels. 
  • VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting. 
  • Vaccination with vif-deleted feline immunodeficiency virus provirus, GM-CSF, and TNF-alpha plasmids preserves global CD4 T lymphocyte function after challenge with FIV. 
  • Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study. 
  • Vaccine-induced boosting of influenza virus-specific CD4 T cells in younger and aged humans. 
  • Validation of histone deacetylase 3 as a therapeutic target in castration-resistant prostate cancer. 
  • Vertebrate Reproduction. 
  • Vitamin B5 Reduces Bacterial Growth via Regulating Innate Immunity and Adaptive Immunity in Mice Infected with Mycobacterium tuberculosis. 
  • Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish. 
  • Vitamin E succinate decreases lung cancer tumor growth in mice. 
  • WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment. 
  • Wild-Type Hras Suppresses the Earliest Stages of Tumorigenesis in a Genetically Engineered Mouse Model of Pancreatic Cancer. 
  • Wild-type p53: tumors can't stand it. 
  • Wnt signaling suppresses MAPK-driven proliferation of intestinal stem cells. 
  • X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model. 
  • Yin yang 1 modulates taxane response in epithelial ovarian cancer. 
  • ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors. 
  • beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium. 
  • c-MYC antisense phosphosphorodiamidate morpholino oligomer inhibits lung metastasis in a murine tumor model. 
  • c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts. 
  • c-Myc is required for maintenance of glioma cancer stem cells. 
  • eIF4E-phosphorylation-mediated Sox2 upregulation promotes pancreatic tumor cell repopulation after irradiation. 
  • iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors. 
  • mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium. 
  • miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. 
  • miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β. 
  • p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway. 
  • xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression. 
  • zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish. 
  • {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. 
  • β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration. 
  • β-Arrestin2 mediates progression of murine primary myelofibrosis. 
  • β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium. 
• 

  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Buckley, Anne Frances, Assistant Professor of Pathology, Pathology
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
  • Juvvadi, Praveen Rao, Associate Professor in Pediatrics, Pediatrics, Infectious Diseases
  • Lagoo, Anand Shreeram, Professor of Pathology, Pathology
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Pharmacology & Cancer Biology
  • Luftig, Micah Alan, Associate Professor of Molecular Genetics and Microbiology, Immunology
  • McCall, Shannon Jones, Associate Professor of Pathology, Pathology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Duke Innovation & Entrepreneurship
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Silver, Debra Lynn, Associate Professor of Molecular Genetics and Microbiology, Duke Science & Society
  • Steinbach, William J., Samuel L. Katz Distinguished Professor of Pediatrics, Duke Innovation & Entrepreneurship
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology
  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, in the School of Medicine, Immunology
  • Yan, Hai, Henry S. Friedman Distinguished Professor of Neuro-Oncology in the School of Medicine, Pathology
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology