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Subject Areas on Research
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'Chimeric' grafts assembled from multiple allodisparate donors enjoy enhanced transplant survival.
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18F-EF5 PET imaging as an early response biomarker for the hypoxia-activated prodrug SN30000 combined with radiation treatment in a non-small cell lung cancer xenograft model.
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27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6-JAK-STAT3 Signaling in Prostate Cancer Cells.
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27-hydroxycholesterol is an endogenous selective estrogen receptor modulator.
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3'UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension.
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3D printing of high-strength, porous, elastomeric structures to promote tissue integration of implants.
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A Cautionary Tale: Florid Splenic γδ T-cell Proliferation and False-Positive T-cell Clonality by PCR Leads to a Grave Misdiagnosis.
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A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect.
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A Genetic Cardiomyocyte Ablation Model for the Study of Heart Regeneration in Zebrafish.
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A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma.
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A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation.
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A Roadmap to Heart Regeneration Through Conserved Mechanisms in Zebrafish and Mammals.
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A Therapeutic Antibody for Cancer, Derived from Single Human B Cells.
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A bioactive titanium foam scaffold for bone repair.
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A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion.
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A comparison of antiangiogenic therapies for the prevention of liver metastases.
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A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation.
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A critical role for the autophagy gene Atg5 in T cell survival and proliferation.
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A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation.
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A cytokine cocktail directly modulates the phenotype of DC-enriched anti-tumor T cells to convey potent anti-tumor activities in a murine model.
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A dual role for ErbB2 signaling in cardiac trabeculation.
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A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders.
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A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling.
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A high-throughput histoarray for quantitative molecular profiling of multiple, uniformly oriented medaka (Oryzias latipes) embryos.
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A joint analysis of metabolomics and genetics of breast cancer.
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A loss-of-function RNA interference screen for molecular targets in cancer.
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A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and Notch signaling.
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A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor.
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A novel classification of lung cancer into molecular subtypes.
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A novel conditionally replicating "armed" adenovirus selectively targeting gastrointestinal tumors with aberrant wnt signaling.
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A novel fibrotic disorder associated with increased dermal fibroblast proliferation and downregulation of genes of the microfibrillar network.
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A novel monoclonal antibody to secreted frizzled-related protein 2 inhibits tumor growth.
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A novel ribosomopathy caused by dysfunction of RPL10 disrupts neurodevelopment and causes X-linked microcephaly in humans.
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A novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycle.
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A polycyclic aromatic hydrocarbon-enriched environmental chemical mixture enhances AhR, antiapoptotic signaling and a proliferative phenotype in breast cancer cells.
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A role for Pin1 in mammalian germ cell development and spermatogenesis.
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A role for cFLIP in B cell proliferation and stress MAPK regulation.
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A small-molecule antagonist of the hedgehog signaling pathway.
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A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells.
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A statin-regulated microRNA represses human c-Myc expression and function.
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A switch in the control of growth of the wing imaginal disks of Manduca sexta.
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A system for the direct co-culture of endothelium on smooth muscle cells.
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A20 modulates lipid metabolism and energy production to promote liver regeneration.
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A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism.
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ABCB5 is a limbal stem cell gene required for corneal development and repair.
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ACE-inhibition increases podocyte number in experimental glomerular disease independent of proliferation.
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ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis.
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ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis.
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ADAM12: a genetic modifier of preclinical peripheral arterial disease.
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AKT Hyperactivation and the Potential of AKT-Targeted Therapy in Diffuse Large B-Cell Lymphoma.
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ARID1A-mutated ovarian cancers depend on HDAC6 activity.
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ASO Visual Abstract: Patterns and Impact of Fragmented Care in Stages II and III Gastric Cancer.
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ATM deficiency promotes progression of CRPC by enhancing Warburg effect.
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ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation.
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Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells.
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Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors.
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Aberrant methylation and loss of CADM2 tumor suppressor expression is associated with human renal cell carcinoma tumor progression.
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Abi3bp regulates cardiac progenitor cell proliferation and differentiation.
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Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling.
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Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema.
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Abundance and Localization of Progesterone Receptor Isoforms in Endometrium in Women With and Without Endometriosis and in Peritoneal and Ovarian Endometriotic Implants.
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Abundant copy-number loss of CYCLOPS and STOP genes in gastric adenocarcinoma.
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Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks
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Accurate identification of proliferative index in melanocytic neoplasms with Melan-A/Ki-67 double stain.
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Acoustic separation of circulating tumor cells.
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Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses.
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Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells.
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Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation.
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Activation of RalA is critical for Ras-induced tumorigenesis of human cells.
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Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer.
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Activation of the PKB/Akt pathway in histological benign prostatic tissue adjacent to the primary malignant lesions.
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Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism.
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Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response.
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Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice.
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Acute graft-versus-host disease: are we close to bringing the bench to the bedside?
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Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance.
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Adipose stem cell crosstalk with chemo-residual breast cancer cells: implications for tumor recurrence.
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Advances in the biology and genetics of the podocytopathies: implications for diagnosis and therapy.
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Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells.
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Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats.
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Age-related effects on thymic output and homeostatic T cell expansion following depletional induction in renal transplant recipients.
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Aging reduces liver resiliency by dysregulating Hedgehog signaling.
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Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer.
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Akt is required for Stat5 activation and mammary differentiation.
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Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer.
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Altered expression of microRNA-451 in eutopic endometrium of baboons (Papio anubis) with endometriosis.
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Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal Cancer.
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Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression.
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Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells.
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Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors.
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Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells.
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Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase.
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An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells.
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An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis.
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An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis.
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An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.
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An animal model of MYC-driven medulloblastoma.
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An early study on the mechanisms that allow tissue-engineered vascular grafts to resist intimal hyperplasia.
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An engineered vascular endothelial growth factor-activating transcription factor induces therapeutic angiogenesis in ApoE knockout mice with hindlimb ischemia.
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An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.
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An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo.
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An integrative approach identified genes associated with drug response in gastric cancer.
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An oxidized extracellular oxidation-reduction state increases Nox1 expression and proliferation in vascular smooth muscle cells via epidermal growth factor receptor activation.
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Analysis of Epstein-Barr virus-regulated host gene expression changes through primary B-cell outgrowth reveals delayed kinetics of latent membrane protein 1-mediated NF-κB activation.
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Analysis of neuronal proliferation, migration and differentiation in the postnatal brain using equine infectious anemia virus-based lentiviral vectors.
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Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion.
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Analysis of renal cell transformation following exposure to trichloroethene in vivo and its metabolite S-(dichlorovinyl)-L-cysteine in vitro.
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Analysis of the immune responses in chimpanzees infected with HIV type 1 isolates.
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Anchorage-independent cell growth signature identifies tumors with metastatic potential.
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Androgen and estrogen treatment, alone or in combination, differentially influences bone maturation and hypothalamic mechanisms that time puberty in the male rhesus monkey (Macaca mulatta).
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Androgen receptor antagonism drives cytochrome P450 17A1 inhibitor efficacy in prostate cancer.
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Androgen receptor with short polyglutamine tract preferably enhances Wnt/β-catenin-mediated prostatic tumorigenesis.
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Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1.
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Androgens promote prostate cancer cell growth through induction of autophagy.
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Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch.
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Angiogenesis-like activity of endothelial cells co-cultured with VEGF-producing smooth muscle cells.
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Angiotensin-II mediates nonmuscle myosin II activation and expression and contributes to human keloid disease progression.
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Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia.
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Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma.
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Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor.
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Antiangiogenic treatment with the three thrombospondin-1 type 1 repeats recombinant protein in an orthotopic human pancreatic cancer model.
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Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model.
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Antiapoptotic Bcl-2 family proteins BCL-xL and MCL-1 integrate neural progenitor survival and proliferation during postnatal cerebellar neurogenesis.
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Anticancer therapeutic potential of Mn porphyrin/ascorbate system.
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Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.
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Antiproliferative effects of interferon alpha on hepatic progenitor cells in vitro and in vivo.
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Antisense to transforming growth factor-beta(1) facilitates the apoptosis of macrophages in rat vein grafts.
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Antitumor activity of epidermal growth factor receptor-related protein is mediated by inactivation of ErbB receptors and nuclear factor-kappaB in pancreatic cancer.
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Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer.
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Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis.
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Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration.
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Aptamer-mediated delivery of chemotherapy to pancreatic cancer cells.
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Arabidopsis Small Rubber Particle Protein Homolog SRPs Play Dual Roles as Positive Factors for Tissue Growth and Development and in Drought Stress Responses.
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Arabidopsis lox3 lox4 double mutants are male sterile and defective in global proliferative arrest.
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Ataxia-telangiectasia group D complementing gene (ATDC) promotes lung cancer cell proliferation by activating NF-κB pathway.
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Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis.
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Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium.
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Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice.
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Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6.
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Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway.
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Aurora-A kinase is essential for bipolar spindle formation and early development.
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Autoantibodies against cell surface GRP78 promote tumor growth in a murine model of melanoma.
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Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor.
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Autophagic protein ULK1 regulates FOXM1 signalling in human hepatoma cells.
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Autophagy and lymphocyte homeostasis.
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Autophagy and mitophagy participate in ocular lens organelle degradation.
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Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes.
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Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1.
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Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.
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B cell depletion reduces the development of atherosclerosis in mice.
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B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody.
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B-cell homeostasis requires complementary CD22 and BLyS/BR3 survival signals.
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B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study.
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BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors.
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BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV.
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BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia.
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BILATERAL DIFFUSE UVEAL MELANOCYTIC PROLIFERATION: A CASE REPORT.
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BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway.
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BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis.
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BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors.
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BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary.
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BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation.
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BMP-2 inhibits tumor-initiating ability in human renal cancer stem cells and induces bone formation.
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BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis.
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BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes.
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Balancing the decision of cell proliferation and cell fate.
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Basal cells as stem cells of the mouse trachea and human airway epithelium.
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Basal-like cells constitute the proliferating cell population in cystic fibrosis airways.
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Basic mechanisms of therapeutic resistance to radiation and chemotherapy in lung cancer.
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Bayesian analysis of signaling networks governing embryonic stem cell fate decisions.
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Bcl-xL is an oncogenic driver in colorectal cancer.
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Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia.
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Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration.
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Beta-caryophyllene enhances wound healing through multiple routes.
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Beta-catenin is a mediator of the response of fibroblasts to irradiation.
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Beta-catenin mediates soft tissue contracture in clubfoot.
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Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing.
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Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis.
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Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK.
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Binding of tissue-type plasminogen activator to the glucose-regulated protein 78 (GRP78) modulates plasminogen activation and promotes human neuroblastoma cell proliferation in vitro.
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Bioactive surface modification of metal oxides via catechol-bearing modular peptides: multivalent-binding, surface retention, and peptide bioactivity.
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Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin.
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Biocompatibility studies of functionalized regioregular poly(3-hexylthiophene) layers for sensing applications.
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Biocompatible hydrogels by oxime Click chemistry
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Biodegradable and photocrosslinkable polyphosphoester hydrogel.
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Biologic effects of platelet-derived growth factor receptor α blockade in uterine cancer.
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Biological function and mechanism of miR-33a in prostate cancer survival and metastasis: via downregulating Engrailed-2.
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Biomanufacturing organized collagen-based microfibers as a Tissue ENgineered Device (TEND) for tendon regeneration.
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Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells.
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Blocking Cyclin-Dependent Kinase 4/6 During Single Dose Versus Fractionated Radiation Therapy Leads to Opposite Effects on Acute Gastrointestinal Toxicity in Mice.
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Bmp7 regulates germ cell proliferation in mouse fetal gonads.
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Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice.
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Bone marrow-derived AXL tyrosine kinase promotes mitogenic crosstalk and cardiac allograft vasculopathy.
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Brain cancer stem cells display preferential sensitivity to Akt inhibition.
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Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells.
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Building and re-building the heart by cardiomyocyte proliferation.
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C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling.
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C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates.
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C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway.
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CBX3/HP1γ promotes tumor proliferation and predicts poor survival in hepatocellular carcinoma.
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CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts.
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CD19 expression in B cells is important for suppression of contact hypersensitivity.
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CD19 expression in B cells regulates atopic dermatitis in a mouse model.
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CD22-Binding Synthetic Sialosides Regulate B Lymphocyte Proliferation Through CD22 Ligand-Dependent and Independent Pathways, and Enhance Antibody Production in Mice.
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CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells.
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CD4 T follicular helper cell dynamics during SIV infection.
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CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation.
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CD4+CD8+ T cells represent a significant portion of the anti-HIV T cell response to acute HIV infection.
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CD44-SLC1A2 gene fusions in gastric cancer.
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CD62L- memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice.
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CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development.
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CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control.
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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity.
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CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment.
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CK1epsilon is required for breast cancers dependent on beta-catenin activity.
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CLN3p impacts galactosylceramide transport, raft morphology, and lipid content.
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CSPG4 protein as a new target for the antibody-based immunotherapy of triple-negative breast cancer.
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CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways.
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Ca(v)3.1 splice variant expression during neuronal differentiation of Y-79 retinoblastoma cells.
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CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer.
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Caffeine prevents restenosis and inhibits vascular smooth muscle cell proliferation through the induction of autophagy.
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Calcific Aortic Valve Disease: Part 2-Morphomechanical Abnormalities, Gene Reexpression, and Gender Effects on Ventricular Hypertrophy and Its Reversibility.
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Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance.
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Camptothecin analogs with enhanced activity against human breast cancer cells. I. Correlation of potency with lipophilicity and persistence in the cleavage complex.
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Can proliferation biomarkers reliably predict recurrence in World Health Organization 2003 defined endometrial stromal sarcoma, low grade?
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Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression.
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Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells.
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Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways.
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Carbamate derivatives of colchicine show potent activity towards primary acute lymphoblastic leukemia and primary breast cancer cells-in vitro and ex vivo study.
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Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer.
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Carbon monoxide reversibly alters iron homeostasis and respiratory epithelial cell function.
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Carbonic anhydrase IX in early-stage non-small cell lung cancer.
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Cardiac Troponin I-Interacting Kinase Affects Cardiomyocyte S-Phase Activity but Not Cardiomyocyte Proliferation.
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Cardiac cell therapy in vitro: reproducible assays for comparing the efficacy of different donor cells.
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Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes.
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Cardiac progenitors and the embryonic cell cycle.
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Cardiac regeneration strategies: Staying young at heart.
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Cardiac regenerative capacity and mechanisms.
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Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development.
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Caspase 3 in dying tumor cells mediates post-irradiation angiogenesis.
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Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy.
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Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy.
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Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo.
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Cav1.3 channel α1D protein is overexpressed and modulates androgen receptor transactivation in prostate cancers.
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Ccn2a is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish.
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Cell and extracellular matrix growth theory and its implications for tumorigenesis.
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Cell metabolism: an essential link between cell growth and apoptosis.
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Cell population dynamics model for deconvolution of murine embryonic stem cell self-renewal and differentiation responses to cytokines and extracellular matrix.
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Cellular senescence: from anti-cancer weapon to anti-aging target.
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Change in surface roughness by dynamic shape-memory acrylate networks enhances osteoblast differentiation.
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Changes in oligosaccharide chains of autoantibodies to GRP78 expressed during progression of malignant melanoma stimulate melanoma cell growth and survival.
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Characterization and optimization of RGD-containing silk blends to support osteoblastic differentiation.
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Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models.
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Characterization of dendritic-like cells derived from t(9;22) acute lymphoblastic leukemia blasts.
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Characterization of the EBV-Induced Persistent DNA Damage Response.
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Characterization of umbilical cord blood-derived late outgrowth endothelial progenitor cells exposed to laminar shear stress.
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Characterizing human mesenchymal stromal cells' immune-modulatory potency using targeted lipidomic profiling of sphingolipids.
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Characterizing the Potency and Impact of Carbon Ion Therapy in a Primary Mouse Model of Soft Tissue Sarcoma.
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Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis.
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Chemotherapy and the bone marrow stroma.
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Chondrogenic differentiation of human embryonic germ cell derived cells in hydrogels.
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Chondroitin Sulfate Glycosaminoglycan Hydrogels Create Endogenous Niches for Neural Stem Cells.
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Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas.
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Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation.
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CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis.
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Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation.
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Clinicopathologic findings in high-grade B-cell lymphomas with typical Burkitt morphologic features but lacking the MYC translocation.
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Clipping of arginine-methylated histone tails by JMJD5 and JMJD7.
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Clonal Analysis of the Neonatal Mouse Heart using Nearest Neighbor Modeling.
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Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor.
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Coculture of mesenchymal stem cells and respiratory epithelial cells to engineer a human composite respiratory mucosa.
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Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance.
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Collapsing glomerulopathy: an inflammatory podocytopathy?
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Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.
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Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma.
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Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.
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Combined PI3K/Akt and Smad2 Activation Promotes Corneal Endothelial Cell Proliferation.
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Combined deletion of Id2 and Id3 genes reveals multiple roles for E proteins in invariant NKT cell development and expansion.
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Combined inhibition of RNA polymerase I and mTORC1/2 synergize to combat oral squamous cell carcinoma.
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Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer.
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Combining Nelfinavir With Chloroquine Inhibits In Vivo Growth of Human Lung Cancer Xenograft Tumors.
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Combining topographical and genetic cues to promote neuronal fate specification in stem cells.
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Coming of age: molecular drivers of aging and therapeutic opportunities.
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Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.
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Comparison of endothelial cell phenotypic markers of late-outgrowth endothelial progenitor cells isolated from patients with coronary artery disease and healthy volunteers.
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Comparisons of CD8+ T cells specific for human immunodeficiency virus, hepatitis C virus, and cytomegalovirus reveal differences in frequency, immunodominance, phenotype, and interleukin-2 responsiveness.
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Complementation of SOD-deficient Escherichia coli by manganese porphyrin mimics of superoxide dismutase activity.
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Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis.
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Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia.
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Concentration-Dependent hMSC Differentiation on Orthogonal Concentration Gradients of GRGDS and BMP-2 Peptides.
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Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.
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Conditional telomerase induction causes proliferation of hair follicle stem cells.
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Conditions that promote primary human skeletal myoblast culture and muscle differentiation in vitro.
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Connecting copper and cancer: from transition metal signalling to metalloplasia.
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Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence.
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Constitutive expression of CaPLA1 conferred enhanced growth and grain yield in transgenic rice plants.
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Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation.
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Constitutively active erythropoietin receptor expression in breast cancer cells promotes cellular proliferation and migration through a MAP-kinase dependent pathway.
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Construction and preclinical characterization of Fc-mGITRL for the immunotherapy of cancer.
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Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: a cautionary note.
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Context-dependent effects of whole-genome duplication during mammary tumor recurrence.
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Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies.
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Contribution of Polycomb group proteins to olfactory basal stem cell self-renewal in a novel c-KIT+ culture model and in vivo.
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Control of Arabidopsis lateral root primordium boundaries by MYB36.
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Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension.
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Control of mesenchymal stem cell phenotype and differentiation depending on cell adhesion mechanism.
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Controlled release of heparin from poly(epsilon-caprolactone) electrospun fibers.
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Controlled release of simvastatin from in situ forming hydrogel triggers bone formation in MC3T3-E1 cells.
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Cooperative nutrient accumulation sustains growth of mammalian cells.
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Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
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Corneal Endothelial Cell Migration and Proliferation Enhanced by Rho Kinase (ROCK) Inhibitors in In Vitro and In Vivo Models.
-
Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation.
-
Coupled myovascular expansion directs cardiac growth and regeneration.
-
Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration.
-
Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression.
-
Cross-talk between endothelial and breast cancer cells regulates reciprocal expression of angiogenic factors in vitro.
-
Crosslinked hyaluronic acid hydrogels: a strategy to functionalize and pattern
-
Crosstalk Between T and B Cells in the Germinal Center After Transplantation.
-
Cryopreservation of neurospheres derived from human glioblastoma multiforme.
-
Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNγ Licensing.
-
Cryptococcal cell morphology affects host cell interactions and pathogenicity.
-
Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth.
-
Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182.
-
Cutaneous wound healing: recruiting developmental pathways for regeneration.
-
Cyclic regulation of transcription factor C/EBP beta in human endometrium.
-
Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment.
-
Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model.
-
Cycling in the Cell Fate Landscape.
-
Cystic pancreatic neuroendocrine tumors: a clinicopathologic study.
-
DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence.
-
DEK regulates hematopoietic stem engraftment and progenitor cell proliferation.
-
Dasatinib (BMS-35482) interacts synergistically with docetaxel, gemcitabine, topotecan, and doxorubicin in ovarian cancer cells with high SRC pathway activation and protein expression.
-
Death-associated protein kinase 1 promotes growth of p53-mutant cancers.
-
Decellularized tissue-engineered blood vessel as an arterial conduit.
-
Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells.
-
Decreased S100A9 Expression Promoted Rat Airway Smooth Muscle Cell Proliferation by Stimulating ROS Generation and Inhibiting p38 MAPK.
-
Dedifferentiation of committed epithelial cells into stem cells in vivo.
-
Defective T cell development and function in the absence of Abelson kinases.
-
Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells.
-
Delaying a treatment switch in antiretroviral-treated HIV type 1-infected patients with detectable drug-resistant viremia does not have a profound effect on immune parameters: AIDS Clinical Trials Group Study A5115.
-
Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma.
-
Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass.
-
Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration.
-
Deletion of the p16INK4a tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse prostate.
-
Deletion or epigenetic silencing of AJAP1 on 1p36 in glioblastoma.
-
Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer.
-
Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells.
-
Dendritic cells/natural killer cross-talk: a novel target for human immunodeficiency virus type-1 protease inhibitors.
-
Derivation of chondrogenically-committed cells from human embryonic cells for cartilage tissue regeneration.
-
Derlin-1 is overexpressed in non-small cell lung cancer and promotes cancer cell invasion via EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9.
-
Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors.
-
Designing zonal organization into tissue-engineered cartilage.
-
Detailed analysis of cytomegalovirus (CMV)-specific T cells expanded for adoptive immunotherapy of CMV infection following allogeneic stem cell transplantation for malignant disease.
-
Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination.
-
Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells.
-
Development of a novel method for measuring in vivo breast epithelial cell proliferation in humans.
-
Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance.
-
Developmental neurotoxicity of perfluorinated chemicals modeled in vitro.
-
Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs.
-
Dexamethasone suppresses DU145 cell proliferation and cell cycle through inhibition of the extracellular signal-regulated kinase 1/2 pathway and cyclin D1 expression.
-
Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells.
-
Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses.
-
Diamagnetic levitation changes growth, cell cycle, and gene expression of Saccharomyces cerevisiae.
-
Dichotomous roles of TGF-β in human cancer.
-
Dietary flavonoid naringenin induces regulatory T cells via an aryl hydrocarbon receptor mediated pathway.
-
Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα.
-
Differential effect of nitric oxide on thrombospondin-1-, PDGF- and fibronectin-induced migration of vascular smooth muscle cells.
-
Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines.
-
Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas.
-
Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes.
-
Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis.
-
Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands.
-
Differential requirement of RasGRP1 for γδ T cell development and activation.
-
Differential uptake of DNA–poly (ethylenimine) polyplexes in cells cultured on collagen and fibronectin surfaces
-
Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension.
-
Dimethylfumarate effectively inhibits lymphangiogenesis via p21 induction and G1 cell cycle arrest.
-
Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer.
-
Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells.
-
Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells.
-
Direct-contact co-culture between smooth muscle and endothelial cells inhibits TNF-alpha-mediated endothelial cell activation.
-
Directed intermixing in multicomponent self-assembling biomaterials.
-
Discovery and characterization of small molecules that target the GTPase Ral.
-
Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer.
-
Discovery of thiophene inhibitors of polo-like kinase.
-
Disparate results between proliferation rates of surgically excised prostate tumors and an in vitro bioassay using sera from a positive randomized controlled trial.
-
Disrupting Inflammation-Associated CXCL8-CXCR1 Signaling Inhibits Tumorigenicity Initiated by Sporadic- and Colitis-Colon Cancer Stem Cells.
-
Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors.
-
Dissecting the roles of E1A and E1B in adenoviral replication and RCAd-enhanced RDAd transduction efficacy on tumor cells.
-
Distinct CD4+ helper T cells involved in primary and secondary responses to infection.
-
Distinct Responses of Stem Cells to Telomere Uncapping-A Potential Strategy to Improve the Safety of Cell Therapy.
-
Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia.
-
Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.
-
Distinctions in the specificity of E2F function revealed by gene expression signatures.
-
Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth.
-
Do Surface Porosity and Pore Size Influence Mechanical Properties and Cellular Response to PEEK?
-
Dominant-negative androgen receptor inhibition of intracrine androgen-dependent growth of castration-recurrent prostate cancer.
-
Dosage-dependent requirements of Magoh for cortical interneuron generation and survival.
-
Down-regulation of microRNAs controlling tumourigenic factors in follicular thyroid carcinoma.
-
Down-regulation of platelet-derived growth factor-D inhibits cell growth and angiogenesis through inactivation of Notch-1 and nuclear factor-kappaB signaling.
-
Doxorubicin-loaded protease-activated near-infrared fluorescent polymeric nanoparticles for imaging and therapy of cancer.
-
Drebrin regulates angiotensin II-induced aortic remodelling.
-
Dual Metronomic Chemotherapy with Nab-Paclitaxel and Topotecan Has Potent Antiangiogenic Activity in Ovarian Cancer.
-
Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells.
-
Dual action of TGF-beta1 on nasal-polyp derived fibroblasts.
-
Dual inhibition of αV integrins and Src kinase activity as a combination therapy strategy for colorectal cancer.
-
Dual-targeted hybrid nanoparticles of synergistic drugs for treating lung metastases of triple negative breast cancer in mice.
-
Ductular and proliferative response of esophageal submucosal glands in a porcine model of esophageal injury and repair.
-
Durable HIV-1 antibody and T-cell responses elicited by an adjuvanted multi-protein recombinant vaccine in uninfected human volunteers.
-
Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma.
-
Dynamic culture yields engineered myocardium with near-adult functional output.
-
Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma.
-
Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer.
-
Dysregulated metabolism contributes to oncogenesis.
-
E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms.
-
E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression.
-
EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity.
-
EGF promotes mammalian cell growth by suppressing cellular senescence.
-
ER stress modulates cellular metabolism.
-
ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation.
-
EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development.
-
EZH2 expression is associated with inferior overall survival in mantle cell lymphoma.
-
Early KLRG1+ but Not CD57+CD8+ T Cells in Primary Cytomegalovirus Infection Predict Effector Function and Viral Control.
-
Early fetal hypoxia leads to growth restriction and myocardial thinning.
-
Early forming label-retaining muscle stem cells require p27kip1 for maintenance of the primitive state.
-
Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells.
-
Effect of intermittent fasting on prostate cancer tumor growth in a mouse model.
-
Effect of microRNA modulation on bioartificial muscle function.
-
Effect of modulating macrophage phenotype on peripheral nerve repair
-
Effect of molecular characteristics on cellular uptake, subcellular localization, and phototoxicity of Zn(II) N-alkylpyridylporphyrins.
-
Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer.
-
Effect of scaffold microarchitecture on osteogenic differentiation of human mesenchymal stem cells.
-
Effects of Y27632 on keratinocyte procurement and wound healing.
-
Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production.
-
Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage.
-
Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells.
-
Effects of glutamine, glucose, and oxygen concentration on the metabolism and proliferation of rabbit adipose-derived stem cells.
-
Effects of histone methyltransferase inhibition in endometriosis.
-
Effects of in vitro brevetoxin exposure on apoptosis and cellular metabolism in a leukemic T cell line (Jurkat).
-
Effects of myocardial infarction on the distribution and transport of nutrients and oxygen in porcine myocardium.
-
Effects of plasminogen activator inhibitor-1-specific RNA aptamers on cell adhesion, motility, and tube formation.
-
Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival.
-
Effects of titanium particle size on osteoblast functions in vitro and in vivo.
-
Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer.
-
Efficient Culture of Human Naive and Memory B Cells for Use as APCs.
-
Elaboration of tubules with active hedgehog drives parenchymal fibrogenesis in gestational alloimmune liver disease.
-
Elastic hydrogel as a sensor for detection of mechanical stress generated by single cells grown in three-dimensional environment.
-
Electron transport complex I is required for CD8+ T cell function.
-
Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer.
-
Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia.
-
Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae.
-
Endometrial CXCL13 expression is cycle regulated in humans and aberrantly expressed in humans and Rhesus macaques with endometriosis.
-
Endothelial Bmp4 is induced during arterial remodeling: effects on smooth muscle cell migration and proliferation.
-
Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury.
-
Endothelial Cell-Derived Extracellular Vesicles Mitigate Radiation-Induced Hematopoietic Injury.
-
Endothelial colony forming cells (ECFCs) as a model for studying effects of low-dose ionizing radiation: growth inhibition by a single dose.
-
Endothelial progenitor cells: markers of vascular reparative capacity.
-
Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain.
-
Engineered microenvironments for self-renewal and musculoskeletal differentiation of stem cells.
-
Engineering cell-material interfaces for long-term expansion of human pluripotent stem cells.
-
Enhanced Schwann cell attachment and alignment using one-pot "dual click" GRGDS and YIGSR derivatized nanofibers.
-
Enhanced Th17-cell responses render CCR2-deficient mice more susceptible for autoimmune arthritis.
-
Enhanced chondrogenic differentiation of murine embryonic stem cells in hydrogels with glucosamine.
-
Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation.
-
Enhanced osteogenic potential of mesenchymal stem cells from cortical bone: a comparative analysis.
-
Entrectinib is a potent inhibitor of Trk-driven neuroblastomas in a xenograft mouse model.
-
Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice.
-
Environmental oxygen regulates astrocyte proliferation to guide angiogenesis during retinal development.
-
Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis.
-
Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.
-
Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling.
-
Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6.
-
Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity.
-
Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis.
-
Epigenetic regulator BMI1 promotes alveolar rhabdomyosarcoma proliferation and constitutes a novel therapeutic target.
-
Epigenetics and cancer metabolism.
-
Epithelial progenitor cells of the embryonic lung and the role of microRNAs in their proliferation.
-
Epithelial stem/progenitor cells in lung postnatal growth, maintenance, and repair.
-
ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure.
-
Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression.
-
Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain.
-
Erythropoietin receptor contributes to melanoma cell survival in vivo.
-
Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages.
-
Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes.
-
Estrogen-independent proliferation is present in estrogen-receptor HER2-positive primary breast cancer after neoadjuvant letrozole.
-
Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer.
-
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation.
-
Evaluation of IRES-mediated, cell-type-specific cytotoxicity of poliovirus using a colorimetric cell proliferation assay.
-
Evaluation of late outgrowth endothelial progenitor cell and umbilical vein endothelial cell responses to thromboresistant collagen-mimetic hydrogels.
-
Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader.
-
Evidence for Feedback Regulation Following Cholesterol Lowering Therapy in a Prostate Cancer Xenograft Model.
-
Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways.
-
Evidence for an alternative glycolytic pathway in rapidly proliferating cells.
-
Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma.
-
Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells.
-
Evolutionarily conserved epitopes on human immunodeficiency virus type 1 (HIV-1) and feline immunodeficiency virus reverse transcriptases detected by HIV-1-infected subjects.
-
Ex vivo expanded human CD4+ regulatory NKT cells suppress expansion of tumor antigen-specific CTLs.
-
Exemestane's 17-hydroxylated metabolite exerts biological effects as an androgen.
-
Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.
-
Exosomes in Pancreatic Cancer: from Early Detection to Treatment.
-
Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha.
-
Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis.
-
Explant culture of adult zebrafish hearts for epicardial regeneration studies.
-
Expression and possible function of fibroblast growth factor 9 (FGF9) and its cognate receptors FGFR2 and FGFR3 in postnatal and adult retina.
-
Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer.
-
Expression of Toll-like receptors in human endometrial epithelial cells and cell lines.
-
Expression of ezrin correlates with malignant phenotype of lung cancer, and in vitro knockdown of ezrin reverses the aggressive biological behavior of lung cancer cells.
-
Expression of oncogenic HRAS in human Rh28 and RMS-YM rhabdomyosarcoma cells leads to oncogene-induced senescence.
-
Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype.
-
Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids.
-
Extracellular vesicles from endometriosis patients are characterized by a unique miRNA-lncRNA signature.
-
FGF signaling regulates rod photoreceptor cell maintenance and regeneration in zebrafish.
-
FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma.
-
FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate.
-
FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function.
-
FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and c-Jun dependent mechanisms.
-
FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway.
-
Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer.
-
Fatty acid metabolites in rapidly proliferating breast cancer.
-
Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafish.
-
Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells.
-
Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination.
-
Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.
-
Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration.
-
Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma.
-
First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway.
-
First in human dose calculation of a single-chain bispecific antibody targeting glioma using the MABEL approach.
-
First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass.
-
First somatic mutation of E2F1 in a critical DNA binding residue discovered in well-differentiated papillary mesothelioma of the peritoneum.
-
Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer.
-
Fluvastatin reduces proliferation and increases apoptosis in women with high grade breast cancer.
-
Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma.
-
Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.
-
Functional complementation between FADD and RIP1 in embryos and lymphocytes.
-
Functional genetic variants of RUVBL1 predict overall survival of Chinese patients with epithelial ovarian cancer.
-
G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation.
-
G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors.
-
G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer.
-
GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy.
-
GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers.
-
GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome.
-
Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain.
-
Gene expression and cell growth are modified by silencing SUMO2 and SUMO3 expression.
-
Generation and analysis of partially haploid cells with Cre-mediated chromosome deletion in the lymphoid system.
-
Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis.
-
Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library.
-
Genetic induction of tumorigenesis in swine.
-
Genetics of cerebral cavernous malformations.
-
Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.
-
Genomic and Functional Approaches to Understanding Cancer Aneuploidy.
-
Genomic loss of miR-486 regulates tumor progression and the OLFM4 antiapoptotic factor in gastric cancer.
-
Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells.
-
Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.
-
Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-beta signaling at the bipotent erythro-megakaryocytic progenitor stage.
-
Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors.
-
Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2.
-
Global re-wiring of p53 transcription regulation by the hepatitis B virus X protein.
-
Global transcriptome profile of Cryptococcus neoformans during exposure to hydrogen peroxide induced oxidative stress.
-
Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer.
-
Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression.
-
Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.
-
Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma.
-
Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells.
-
Glutamine prevents apoptosis in intestinal epithelial cells and induces differential protective pathways in heat and oxidant injury models.
-
Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia.
-
Glutathione peroxidase-deficient smooth muscle cells cause paracrine activation of normal smooth muscle cells via cyclophilin A.
-
Glycogen-branching enzyme deficiency leads to abnormal cardiac development: novel insights into glycogen storage disease IV.
-
Gradient hydrogels for screening stiffness effects on patient-derived glioblastoma xenograft cellfates in 3D.
-
Grading of well-differentiated pancreatic neuroendocrine tumors is improved by the inclusion of both Ki67 proliferative index and mitotic rate.
-
Gremlin is overexpressed in lung adenocarcinoma and increases cell growth and proliferation in normal lung cells.
-
Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death.
-
Growth of mesenchymal stem cells on electrospun type I collagen nanofibers.
-
Growth signaling at the nexus of stem cell life and death.
-
Gut immune maturation depends on colonization with a host-specific microbiota.
-
Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway.
-
Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion.
-
HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor.
-
HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection.
-
HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration.
-
HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization.
-
HER2 dendritic cell vaccines.
-
HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development.
-
HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly.
-
HIV-1 activates macrophages independent of Toll-like receptors.
-
HIV-1 neutralization profile and plant-based recombinant expression of actinohivin, an Env glycan-specific lectin devoid of T-cell mitogenic activity.
-
HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells.
-
HIV-1-specific CD4+ T lymphocyte turnover and activation increase upon viral rebound.
-
HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect.
-
HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer.
-
Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration.
-
Harnessing the effect of adoptively transferred tumor-reactive T cells on endogenous (host-derived) antitumor immunity.
-
Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells.
-
Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages.
-
Hedgehog and Notch signaling regulate self-renewal of undifferentiated pleomorphic sarcomas.
-
Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis.
-
Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth.
-
Hedgehog regulates yes-associated protein 1 in regenerating mouse liver.
-
Hedgehog signaling in human medullary thyroid carcinoma: a novel signaling pathway.
-
Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.
-
Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function.
-
Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation.
-
Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma.
-
Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu+ tumors.
-
Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction.
-
High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins.
-
High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins.
-
High-LET Radiation Increases Tumor Progression in a K-Ras-Driven Model of Lung Adenocarcinoma.
-
Highlights from the 46 th annual meeting of the American Society of Hematology.
-
Hippo pathway effectors YAP and TAZ and their association with skeletal muscle ageing.
-
Histochemical analyses of altered fetal lung development following single vs multiple courses of antenatal steroids.
-
Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species-Dependent Targeting of Specificity Protein Transcription Factors.
-
Homeostatic proliferation plus regulatory T-cell depletion promotes potent rejection of B16 melanoma.
-
Homoserine toxicity in Saccharomyces cerevisiae and Candida albicans homoserine kinase (thr1Delta) mutants.
-
Human Erbb2-induced Erk activity robustly stimulates cycling and functional remodeling of rat and human cardiomyocytes.
-
Human lung stem cells: has the future arrived?
-
Human neural progenitors express functional lysophospholipid receptors that regulate cell growth and morphology.
-
Human recombinant erythropoietin (rEpo) has no effect on tumour growth or angiogenesis.
-
Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse.
-
Human umbilical cord blood endothelial progenitor cells decrease vein graft neointimal hyperplasia in SCID mice.
-
Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells.
-
Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis.
-
Hypoexpression and epigenetic regulation of candidate tumor suppressor gene CADM-2 in human prostate cancer.
-
Hypoxia promotes proliferation and osteogenic differentiation potentials of human mesenchymal stem cells.
-
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells.
-
ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer.
-
IFN-{beta} signaling positively regulates tumorigenesis in aggressive fibromatosis, potentially by modulating mesenchymal progenitors.
-
IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma.
-
IL-1 and TNFα Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration.
-
IL-10 stimulatory effects on human NK cells explored by gene profile analysis.
-
IL-12-Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control.
-
IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension.
-
IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia.
-
IL-27 Facilitates Skin Wound Healing through Induction of Epidermal Proliferation and Host Defense.
-
IL-7 receptor heterogeneity as a mechanism for repertoire change during postdepletional homeostatic proliferation and its relation to costimulation blockade-resistant rejection.
-
IRF-1 inhibits NF-κB activity, suppresses TRAF2 and cIAP1 and induces breast cancer cell specific growth inhibition.
-
IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria.
-
Iatrogenic lesions of soft tissue and bone.
-
Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity.
-
Identification and Functional Validation of Reciprocal microRNA-mRNA Pairings in African American Prostate Cancer Disparities.
-
Identification and targeting of a HES1-YAP1-CDKN1C functional interaction in fusion-negative rhabdomyosarcoma.
-
Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer.
-
Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation.
-
Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus.
-
Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells.
-
Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.
-
Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells.
-
Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.
-
Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries.
-
Identification of repurposed small molecule drugs for chordoma therapy.
-
Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine.
-
Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development.
-
Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas.
-
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.
-
Immunodominant liver-specific expression suppresses transgene-directed immune responses in murine pompe disease.
-
Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer.
-
Impact of Th1/Th2 cytokine polarity induced by invariant NKT cells on the incidence of pregnancy loss in mice.
-
Impact of a recombinant fowlpox vaccine on the efficacy of adoptive cell therapy with tumor infiltrating lymphocytes in a patient with metastatic melanoma.
-
Impact of carbohydrate restriction in the context of obesity on prostate tumor growth in the Hi-Myc transgenic mouse model.
-
Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells.
-
Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors.
-
Improving sensitivity and specificity of capturing and detecting targeted cancer cells with anti-biofouling polymer coated magnetic iron oxide nanoparticles.
-
Improving the outcome of umbilical cord blood transplantation through ex vivo expansion or graft manipulation.
-
In Vitro Pre-Clinical Validation of Suicide Gene Modified Anti-CD33 Redirected Chimeric Antigen Receptor T-Cells for Acute Myeloid Leukemia.
-
In utero priming of highly functional effector T cell responses to human malaria.
-
In vitro assay of immunostimulatory activities of plasmid vectors.
-
In vitro characteristics of Tenon's fibroblast lines derived from pediatric and adult eyes do not fully explain pediatric glaucoma surgery failure: a preliminary report.
-
In vitro cytotoxicity of silver nanoparticles in primary rat hepatic stellate cells.
-
In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration.
-
Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation.
-
Increased BCR responsiveness in B cells from patients with chronic GVHD.
-
Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss.
-
Increased HMGB1 and cleaved caspase-3 stimulate the proliferation of tumor cells and are correlated with the poor prognosis in colorectal cancer.
-
Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.
-
Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor.
-
Indolent T-lymphoblastic proliferation associated with low grade follicular dendritic cell sarcoma and Castleman disease.
-
Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro.
-
Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration.
-
Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice.
-
Induction of hair follicle neogenesis with cultured mouse dermal papilla cells in de novo regenerated skin tissues.
-
Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation.
-
Induction of the human heat shock promoter HSP70B by nutritional stress: implications for cancer gene therapy.
-
Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity.
-
Influence of physical properties of biomaterials on cellular behavior.
-
Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer.
-
Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness.
-
Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer.
-
Inhibition of NF-kappaB1 and NF-kappaB2 activation in prostate cancer cells treated with antibody against the carboxyl terminal domain of GRP78: effect of p53 upregulation.
-
Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways.
-
Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity.
-
Inhibition of calcium-independent phospholipase A2 suppresses proliferation and tumorigenicity of ovarian carcinoma cells.
-
Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer.
-
Inhibition of integrative repair of the meniscus following acute exposure to interleukin-1 in vitro.
-
Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth.
-
Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension.
-
Inhibition of notch signaling induces neural differentiation in Ewing sarcoma.
-
Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance.
-
Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists.
-
Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors.
-
Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.
-
Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis.
-
Inhibition of the androgen receptor induces a novel tumor promoter, ZBTB46, for prostate cancer metastasis.
-
Initial testing (stage 1) of SGI-1776, a PIM1 kinase inhibitor, by the pediatric preclinical testing program.
-
Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program.
-
Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program.
-
Initial testing (stage 1) of the curaxin CBL0137 by the pediatric preclinical testing program.
-
Initial testing (stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ-26481585), by the Pediatric Preclinical Testing Program.
-
Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program.
-
Initial testing (stage 1) of the mTOR kinase inhibitor AZD8055 by the pediatric preclinical testing program.
-
Initial testing (stage 1) of the phosphatidylinositol 3' kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program.
-
Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program.
-
Initial testing of JNJ-26854165 (Serdemetan) by the pediatric preclinical testing program.
-
Initial testing of VS-4718, a novel inhibitor of focal adhesion kinase (FAK), against pediatric tumor models by the Pediatric Preclinical Testing Program.
-
Initial testing of dasatinib by the pediatric preclinical testing program.
-
Initial testing of lenalidomide by the pediatric preclinical testing program.
-
Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP).
-
Initial testing of the hypoxia-activated prodrug PR-104 by the pediatric preclinical testing program.
-
Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the pediatric preclinical testing program.
-
Innate and adaptive receptors interact to balance humoral immunity.
-
Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response.
-
Inorganic nitrite attenuates NADPH oxidase-derived superoxide generation in activated macrophages via a nitric oxide-dependent mechanism.
-
Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila.
-
Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.
-
Instant Ultrasound-Evoked Precise Nanobubble Explosion and Deep Photodynamic Therapy for Tumors Guided by Molecular Imaging.
-
Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers.
-
Integrin alpha 6 regulates glioblastoma stem cells.
-
Integrin-Targeting Knottin Peptide-Drug Conjugates Are Potent Inhibitors of Tumor Cell Proliferation.
-
Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration.
-
Interleukin-15 increases hepatic regenerative activity.
-
Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone.
-
Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis.
-
Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.
-
Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents posttraumatic arthritis.
-
Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation.
-
Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity.
-
Intraductal Oncocytic Papillary Neoplasms: Clinical-Pathologic Characterization of 24 Cases, With An Emphasis on Associated Invasive Carcinomas.
-
Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche.
-
Intrinsic and cyclin-dependent kinase-dependent control of spindle pole body duplication in budding yeast.
-
Investigating Conservation of the Cell-Cycle-Regulated Transcriptional Program in the Fungal Pathogen, Cryptococcus neoformans.
-
Investigation of HIFU-induced anti-tumor immunity in a murine tumor model.
-
Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma.
-
In vitro and in vivo evaluation of resveratrol and 3,5-dihydroxy-4'-acetoxy-trans-stilbene in the treatment of human prostate carcinoma and melanoma.
-
Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling.
-
Isolation and characterization of stem cells from the human parathyroid gland.
-
Isolation and generation of human dendritic cells.
-
Isolation and optimization of murine IL-10 receptor blocking oligonucleotide aptamers using high-throughput sequencing.
-
Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism.
-
Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.
-
JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats.
-
Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma.
-
KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage.
-
Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells.
-
Key roles of necroptotic factors in promoting tumor growth.
-
Knockdown of mouse VCAM-1 by vector-based siRNA.
-
Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells.
-
LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function.
-
LGR5 is associated with tumor aggressiveness in papillary thyroid cancer.
-
LINC00675 activates androgen receptor axis signaling pathway to promote castration-resistant prostate cancer progression.
-
LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells.
-
Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates inflammatory response and homeostasis of spleen and colon in experimental model of Pseudomonas aeruginosa pneumonia.
-
Large granular lymphocytic leukemia coexists with myeloid clones and myelodysplastic syndrome.
-
Late outgrowth endothelial progenitor cells in patients with age-related macular degeneration.
-
Late-outgrowth endothelial progenitors from patients with coronary artery disease: endothelialization of confluent stromal cell layers.
-
Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites.
-
Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy.
-
Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3.
-
Life, death, and the metabolically controlled protein acetylome.
-
Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer.
-
Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis.
-
Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis.
-
Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis.
-
Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes.
-
Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy.
-
LncRNA PSR Regulates Vascular Remodeling Through Encoding a Novel Protein Arteridin.
-
Lonafarnib for cancer and progeria.
-
Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis.
-
Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation.
-
Long-term efficacy of enzyme replacement therapy for adenosine deaminase (ADA)-deficient severe combined immunodeficiency (SCID).
-
Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces.
-
Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance.
-
Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression.
-
Loss of BMI1 in mature olfactory sensory neurons leads to increased olfactory basal cell proliferation.
-
Loss of Lrig1 leads to expansion of Brunner glands followed by duodenal adenomas with gastric metaplasia.
-
Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis.
-
Loss of PTPRM associates with the pathogenic development of colorectal adenoma-carcinoma sequence.
-
Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo.
-
Loss of epithelial oestrogen receptor α inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models.
-
Loss of microRNA-21 leads to profound stromal remodeling and short survival in K-Ras-driven mouse models of pancreatic cancer.
-
Loss of pericyte smoothened activity in mice with genetic deficiency of leptin.
-
Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells.
-
Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment.
-
Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2.
-
Low-Dose Histone Deacetylase Inhibitor Treatment Leads to Tumor Growth Arrest and Multi-Lineage Differentiation of Malignant Rhabdoid Tumors.
-
Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation.
-
Lung inflammation, injury, and proliferative response after repetitive particulate hexavalent chromium exposure.
-
Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners.
-
Lysophosphatidic acid stimulates cell growth by different mechanisms in SKOV-3 and Caov-3 ovarian cancer cells: distinct roles for Gi- and Rho-dependent pathways.
-
M-HIFU inhibits tumor growth, suppresses STAT3 activity and enhances tumor specific immunity in a transplant tumor model of prostate cancer.
-
MEKK3 is essential for lymphopenia-induced T cell proliferation and survival.
-
MESH1 knockdown triggers proliferation arrest through TAZ repression.
-
MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression.
-
MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation.
-
MYB36 regulates the transition from proliferation to differentiation in the Arabidopsis root.
-
MYC/BCL2 double-hit high-grade B-cell lymphoma.
-
Macrophages Facilitate Resistance to Anti-VEGF Therapy by Altered VEGFR Expression.
-
Maintaining T lymphocyte homeostasis: another duty of autophagy.
-
Malignant proliferating trichilemmal cyst: a case report with review of literature.
-
Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species.
-
Manganese Porphyrin and Radiotherapy Improves Local Tumor Response and Overall Survival in Orthotopic Murine Mammary Carcinoma Models.
-
Mantle Cell Lymphoma Involving Skin: A Clinicopathologic Study of 37 Cases.
-
Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam.
-
Mathematical modeling of the Phoenix Rising pathway.
-
Matrix Stiffness Modulates Patient-Derived Glioblastoma Cell Fates in Three-Dimensional Hydrogels.
-
Maximizing the retention of antigen specific lymphocyte function after cryopreservation.
-
Mechanical and cytotoxicity testing of acrylic bone cement embedded with microencapsulated 2-octyl cyanoacrylate.
-
Mechanism of the Antitumor and Radiosensitizing Effects of a Manganese Porphyrin, MnHex-2-PyP.
-
Mechanisms of action of rapamycin in gliomas.
-
Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells.
-
Mechanistic insights of rapid liver regeneration after associating liver partition and portal vein ligation for stage hepatectomy.
-
Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function.
-
Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells.
-
Melanoma proliferation and chemoresistance controlled by the DEK oncogene.
-
Melanoma, a tumor based on a mutant stem cell?
-
Meniscus-Derived Matrix Bioscaffolds: Effects of Concentration and Cross-Linking on Meniscus Cellular Responses and Tissue Repair.
-
Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure.
-
Metabolic flux and the regulation of mammalian cell growth.
-
Metabolic pathway alterations that support cell proliferation.
-
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.
-
Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization.
-
Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line.
-
Metabolism: A new layer of glycolysis.
-
Methylation subtypes and large-scale epigenetic alterations in gastric cancer.
-
MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer.
-
MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex.
-
Micro-scale and meso-scale architectural cues cooperate and compete to direct aligned tissue formation.
-
MicroRNA miR-590-5p inhibits breast cancer cell stemness and metastasis by targeting SOX2.
-
MicroRNA-146a-5p Attenuates Fibrosis-related Molecules in Irradiated and TGF-beta1-Treated Human Hepatic Stellate Cells by Regulating PTPRA-SRC Signaling.
-
MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways.
-
MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells.
-
MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar Carcinoma.
-
MicroRNAs associated to single drug components of R-CHOP identifies diffuse large B-cell lymphoma patients with poor outcome and adds prognostic value to the international prognostic index.
-
MicroRNAs in skin tissue engineering.
-
Microporous annealed particle hydrogel stiffness, void space size, and adhesion properties impact cell proliferation, cell spreading, and gene transfer.
-
Mimicking brain tumor-vasculature microanatomical architecture via co-culture of brain tumor and endothelial cells in 3D hydrogels.
-
Mineralized gelatin methacrylate-based matrices induce osteogenic differentiation of human induced pluripotent stem cells.
-
Mineralized synthetic matrices as an instructive microenvironment for osteogenic differentiation of human mesenchymal stem cells.
-
Minimal barriers to invasion during human colorectal tumor growth.
-
Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression.
-
Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest.
-
Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells.
-
Model of tumor dormancy/recurrence after short-term chemotherapy.
-
Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts.
-
Modeling early stage atherosclerosis in a primary human vascular microphysiological system.
-
Modeling the developmental neurotoxicity of nicotine in vitro: cell acquisition, growth and viability in PC12 cells.
-
Modification of Poly(propylene fumarate)-Bioglass Composites with Peptide Conjugates to Enhance Bioactivity.
-
Modulating the mechanical properties of self-assembled peptide hydrogels via native chemical ligation.
-
Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis.
-
Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer.
-
Modulation of Xenogeneic T-cell Proliferation by B7 and mTOR Blockade of T Cells and Porcine Endothelial Cells.
-
Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise.
-
Modulation of nonneutralizing HIV-1 gp41 responses by an MHC-restricted TH epitope overlapping those of membrane proximal external region broadly neutralizing antibodies.
-
Modulation of tissue repair by regeneration enhancer elements.
-
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.
-
Molecular determinants for enzalutamide-induced transcription in prostate cancer.
-
Molecular profile and partial functional analysis of novel endothelial cell-derived growth factors that regulate hematopoiesis.
-
Molecular signatures of thyroid follicular neoplasia.
-
Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas.
-
Morphogenetic signals from chondrocytes promote chondrogenic and osteogenic differentiation of mesenchymal stem cells.
-
Mucosally-administered human-simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIVSF162P3.
-
Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium.
-
Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices.
-
Multiple roles for Sox2 in the developing and adult mouse trachea.
-
Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition.
-
Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeleton.
-
Murine bone marrow stromal cells pulsed with homologous tumor-derived exosomes inhibit proliferation of liver cancer cells.
-
Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
-
Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression.
-
Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression.
-
Mutant IDH1 is required for IDH1 mutated tumor cell growth.
-
Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells.
-
Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting.
-
Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice.
-
Mycobacterium tuberculosis whole cell lysate enhances proliferation of CD8 positive lymphocytes and nitric oxide secretion in the lungs of live porcine respiratory and reproductive syndrome virus vaccinated pigs.
-
Myoblast deactivation within engineered human skeletal muscle creates a transcriptionally heterogeneous population of quiescent satellite-like cells.
-
Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries.
-
Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury.
-
N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway.
-
N-cadherin functions as a growth suppressor in a model of K-ras-induced PanIN.
-
N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.
-
NCKAP1 improves patient outcome and inhibits cell growth by enhancing Rb1/p53 activation in hepatocellular carcinoma.
-
NDRG4 is required for cell cycle progression and survival in glioblastoma cells.
-
NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition.
-
NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis.
-
NO inhibits hyperoxia-induced NF-κB activation in neonatal pulmonary microvascular endothelial cells.
-
Naive human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin.
-
Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy.
-
Nasal immunization with a recombinant HIV gp120 and nanoemulsion adjuvant produces Th1 polarized responses and neutralizing antibodies to primary HIV type 1 isolates.
-
Naïve T cells are maintained in the periphery during the first 3 months of acute HIV-1 infection: implications for analysis of thymus function.
-
Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging.
-
Nelfinavir Inhibits the Growth of Small-cell Lung Cancer Cells and Patient-derived Xenograft Tumors.
-
Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo.
-
Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems.
-
Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration.
-
Network growth models and genetic regulatory networks.
-
Neurofibromatosis Type 1 and tumorigenesis: molecular mechanisms and therapeutic implications.
-
Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision.
-
Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury.
-
New drug development in metastatic prostate cancer.
-
New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate.
-
NgBR is essential for endothelial cell glycosylation and vascular development.
-
Niche-mediated BMP/SMAD signaling regulates lung alveolar stem cell proliferation and differentiation.
-
Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth.
-
Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP.
-
Nitric oxide-generating hydrogels inhibit neointima formation.
-
Nitric oxide-producing polyurethanes.
-
Nitric oxide-releasing polyurethane-PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion.
-
Nitric oxide-releasing silica nanoparticle inhibition of ovarian cancer cell growth.
-
Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA Metabolism and Proliferation.
-
Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors.
-
Non-alcoholic steatohepatitis pathogenesis: role of repair in regulating the disease progression.
-
Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis.
-
Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesis.
-
Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.
-
Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells.
-
Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells.
-
Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.
-
Notch promotes radioresistance of glioma stem cells.
-
Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest.
-
Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies.
-
Notch signaling maintains Leydig progenitor cells in the mouse testis.
-
Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting.
-
Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans.
-
Novel functional variants in the Notch pathway and survival of Chinese colorectal cancer.
-
Novel nanostructured scaffolds as therapeutic replacement options for rotator cuff disease.
-
Novel role for surfactant protein A in gastrointestinal graft-versus-host disease.
-
Novel roles of apoptotic caspases in tumor repopulation, epigenetic reprogramming, carcinogenesis, and beyond.
-
Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma.
-
Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia.
-
Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish.
-
Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis.
-
Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses.
-
OGP functionalized phenylalanine-based poly(ester urea) for enhancing osteoinductive potential of human mesenchymal stem cells.
-
Ocular allergy modulation to hi-dose antigen sensitization is a Treg-dependent process.
-
Oncogene pathway activation in mammary tumors dictates FDG-PET uptake.
-
Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway.
-
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.
-
Ontogeny of the eotaxins in human lung.
-
Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.
-
Optical Imaging of Glucose Uptake and Mitochondrial Membrane Potential to Characterize Her2 Breast Tumor Metabolic Phenotypes.
-
Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia.
-
Optimization of a highly standardized carboxyfluorescein succinimidyl ester flow cytometry panel and gating strategy design using discriminative information measure evaluation.
-
Optimizing PLG nanoparticle-peptide delivery platforms for transplantation tolerance using an allogeneic skin transplant model.
-
Origin of bistability underlying mammalian cell cycle entry.
-
Origins and Proliferative States of Human Oligodendrocyte Precursor Cells.
-
Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation.
-
Osteopontin has a protective role in prostate tumor development in mice.
-
Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation.
-
Overexpression of CRKL correlates with poor prognosis and cell proliferation in non-small cell lung cancer.
-
Overexpression of a Brassica rapa NGATHA gene in Arabidopsis thaliana negatively affects cell proliferation during lateral organ and root growth.
-
Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function.
-
Oxidative DNA base damage in MCF-10A breast epithelial cells at clinically achievable concentrations of doxorubicin.
-
Oxidative stress impact on barrier function of porcine angular aqueous plexus cell monolayers.
-
P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively.
-
PAK1 mediates resistance to PI3K inhibition in lymphomas.
-
PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-oesophageal epithelium.
-
PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer.
-
PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma.
-
PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo.
-
PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity.
-
PI3K stimulates DNA synthesis and cell-cycle progression via its p55PIK regulatory subunit interaction with PCNA.
-
PILAR is a novel modulator of human T-cell expansion.
-
PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers.
-
PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation.
-
PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population.
-
PTEN Expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer.
-
PTEN hamartoma tumor syndromes.
-
PTEN reconstitution alters glioma responses to c-Met pathway inhibition.
-
PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression.
-
PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms.
-
PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy.
-
Packed red blood cells suppress T-cell proliferation through a process involving cell-cell contact.
-
Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model.
-
Pan-cancer analysis of whole genomes.
-
Pancreatic intraepithelial neoplasia and histological changes in non-neoplastic pancreas associated with neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma.
-
Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice.
-
Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults.
-
Parallel Expression of Enzyme Inhibitors of CD8T Cell Activity in Tumor Microenvironments and Secretory Endometrium.
-
Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism.
-
Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.
-
Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes.
-
Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.
-
Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth.
-
Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age.
-
Persistent neurobehavioral effects of early postnatal domoic acid exposure in rats.
-
Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ.
-
Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.
-
Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.
-
Phase I study of immunization with dendritic cells modified with fowlpox encoding carcinoembryonic antigen and costimulatory molecules.
-
Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas.
-
Phenotypic and functional characterization of cytotoxic T lymphocytes by flow cytometry.
-
Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth.
-
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.
-
Photosensitizing action of isomeric zinc N-methylpyridylporphyrins in human carcinoma cells.
-
Physiologic pulsatile flow bioreactor conditioning of poly(ethylene glycol)-based tissue engineered vascular grafts.
-
Plasminogen structural domains exhibit different functions when associated with cell surface GRP78 or the voltage-dependent anion channel.
-
Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung.
-
Platelet-rich plasma enhances mechanical strength of strattice in rat model of ventral hernia repair.
-
Plectin is a regulator of prostate cancer growth and metastasis.
-
Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells.
-
Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity.
-
Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue.
-
Poly(ethylene glycol) hydrogel system supports preadipocyte viability, adhesion, and proliferation.
-
Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells.
-
Polycythemia vera erythroid precursors exhibit increased proliferation and apoptosis resistance associated with abnormal RAS and PI3K pathway activation.
-
Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers.
-
Polymer-assisted intratumoral delivery of ethanol: Preclinical investigation of safety and efficacy in a murine breast cancer model.
-
Poor Endometrial Proliferation After Clomiphene is Associated With Altered Estrogen Action.
-
Porous biocompatible three-dimensional scaffolds of cellulose microfiber/gelatin composites for cell culture.
-
Post-prenylation-processing enzymes as new targets in oncogenesis.
-
Post-transcriptional RNA regulons affecting cell cycle and proliferation.
-
Post-transcriptional regulation of MTA family by microRNAs in the context of cancer.
-
Precision cancer immunotherapy: optimizing dendritic cell-based strategies to induce tumor antigen-specific T-cell responses against individual patient tumors.
-
Preclinical Study of AUY922, a Novel Hsp90 Inhibitor, in the Treatment of Esophageal Adenocarcinoma.
-
Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma.
-
Preclinical characterization of DUOC-01, a cell therapy product derived from banked umbilical cord blood for use as an adjuvant to umbilical cord blood transplantation for treatment of inherited metabolic diseases.
-
Preclinical efficacy of MEK inhibition in Nras-mutant AML.
-
Preclinical evaluation of a regimen combining chidamide and ABT-199 in acute myeloid leukemia.
-
Preclinical testing of a peptide-based, HER2/neu vaccine for prostate cancer.
-
Preliminary observations using optical coherence tomography to assess neointimal coverage of a metal stent in a porcine model.
-
Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis.
-
Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes.
-
Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes.
-
Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells.
-
Prime-boost regimens with adjuvanted synthetic long peptides elicit T cells and antibodies to conserved regions of HIV-1 in macaques.
-
Probiotic administration reduces mortality and improves intestinal epithelial homeostasis in experimental sepsis.
-
Profiling Hsp90 differential expression and the molecular effects of the Hsp90 inhibitor IPI-504 in high-grade glioma models.
-
Progesterone receptor membrane component 1: is metabolism integral to its function and what other steroids are involved?
-
Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer.
-
Proliferation and differentiation of human embryonic germ cell derivatives in bioactive polymeric fibrous scaffold.
-
Proliferation behavior of E. coli in a three-dimensional in vitro tumor model.
-
Proliferation indices correlate with diagnosis and metastasis in diagnostically challenging melanocytic tumors.
-
Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2.
-
Proliferation of HIV-infected renal epithelial cells following virus acquisition from infected macrophages.
-
Proliferative potential and resistance to immune checkpoint blockade in lung cancer patients.
-
Prolonged beta-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds.
-
Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer.
-
Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum.
-
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.
-
Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.
-
Proteomic dissection of LPS-inducible, PHF8-dependent secretome reveals novel roles of PHF8 in TLR4-induced acute inflammation and T cell proliferation.
-
Purine synthesis promotes maintenance of brain tumor initiating cells in glioma.
-
Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration.
-
Quantitative assessment of new cell proliferation in the dentate gyrus and learning after isoflurane or propofol anesthesia in young and aged rats.
-
RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development.
-
RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation.
-
RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence.
-
RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression.
-
RNA-Seq and ChIP-Seq reveal SQSTM1/p62 as a key mediator of JunB suppression of NF-κB-dependent inflammation.
-
RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression.
-
Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study.
-
Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate.
-
Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation.
-
Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer.
-
Rare codons capacitate Kras-driven de novo tumorigenesis.
-
Ras controls melanocyte expansion during zebrafish fin stripe regeneration.
-
RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer.
-
Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.
-
Re: KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancer (Int J Cancer 123: 2239-2246, 2008).
-
Recipient Myd88 Deficiency Promotes Spontaneous Resolution of Kidney Allograft Rejection.
-
Reconstruction of cell population dynamics using CFSE.
-
Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.
-
Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance.
-
Reduction of Stat3 activity attenuates HIV-induced kidney injury.
-
Reduction of oxidative stress attenuates lipoapoptosis exacerbated by hypoxia in human hepatocytes.
-
Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer.
-
Regenerative hepatic pseudotumor: a new pseudotumor of the liver.
-
Regionally-specified second trimester fetal neural stem cells reveals differential neurogenic programming.
-
Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin.
-
Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling.
-
Regulated spindle orientation buffers tissue growth in the epidermis.
-
Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection.
-
Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1.
-
Regulation of nuclear Prointerleukin-16 and p27(Kip1) in primary human T lymphocytes.
-
Regulation of plant stem cell quiescence by a brassinosteroid signaling module.
-
Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2.
-
Regulation of zebrafish heart regeneration by miR-133.
-
Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis.
-
Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression.
-
Regulatory T cells exhibit decreased proliferation but enhanced suppression after pulsing with sirolimus.
-
Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development.
-
Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma.
-
Relationship of blood monocytes with chronic lymphocytic leukemia aggressiveness and outcomes: a multi-institutional study.
-
Rendering the leukemia cell susceptible to attack.
-
Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo.
-
Reproducibility of adipogenic responses to metabolism disrupting chemicals in the 3T3-L1 pre-adipocyte model system: An interlaboratory study.
-
Reprogramming of cellular metabolic pathways by human oncogenic viruses.
-
Repulsive expansion dynamics in colony growth and gene expression.
-
Requirement of estrogen receptor alpha DNA-binding domain for HPV oncogene-induced cervical carcinogenesis in mice.
-
Resistance to apoptosis, increased growth potential, and altered gene expression in cells that survived genotoxic hexavalent chromium [Cr(VI)] exposure.
-
Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.
-
Resorbable, amino acid-based poly(ester urea)s crosslinked with osteogenic growth peptide with enhanced mechanical properties and bioactivity.
-
Respiratory Capacity and Reserve Predict Cell Sensitivity to Mitochondria Inhibitors: Mechanism-Based Markers to Identify Metformin-Responsive Cancers.
-
Response of zonal chondrocytes to extracellular matrix-hydrogels.
-
Resveratrol and endometrium: a closer look at an active ingredient of red wine using in vivo and in vitro models.
-
Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-β.
-
Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration.
-
Reversing the Warburg effect as a treatment for glioblastoma.
-
Role for Nox1 NADPH oxidase in atherosclerosis.
-
Role for hedgehog pathway in regulating growth and function of invariant NKT cells.
-
Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling.
-
Role of Fn14 in acute alcoholic steatohepatitis in mice.
-
Role of Increased n-acetylaspartate Levels in Cancer.
-
Role of TGF-β receptor III localization in polarity and breast cancer progression.
-
Role of YAP1 as a Marker of Sensitivity to Dual AKT and P70S6K Inhibition in Ovarian and Uterine Malignancies.
-
Role of eotaxin-1 signaling in ovarian cancer.
-
Role of germinal centers for the induction of broadly-reactive memory B cells.
-
Role of repulsive factors in vascularization dynamics.
-
Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma.
-
Role of transforming growth factor-beta in hematologic malignancies.
-
Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro.
-
SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility.
-
SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway.
-
SFPQ promotes an oncogenic transcriptomic state in melanoma.
-
SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells.
-
SHP-2 is required for the maintenance of cardiac progenitors.
-
SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines.
-
SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression.
-
SRC family kinase inhibition as a novel strategy to augment melphalan-based regional chemotherapy of advanced extremity melanoma.
-
STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration.
-
STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation.
-
STAT3-mediated coincidence detection regulates noncanonical immediate early gene induction.
-
STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice.
-
SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.
-
Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells.
-
Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component.
-
Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni.
-
Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel.
-
Screening of hyaluronic acid-poly(ethylene glycol) composite hydrogels to support intervertebral disc cell biosynthesis using artificial neural network analysis.
-
Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma.
-
Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway.
-
Seeing stars: Development and function of retinal astrocytes.
-
Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival.
-
Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature.
-
Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance.
-
Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.
-
Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model.
-
Self-assembling peptide-polymer hydrogels designed from the coiled coil region of fibrin.
-
Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses.
-
Sequential roles of Hedgehog and Wnt signaling in osteoblast development.
-
Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism.
-
Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement.
-
Serum cholesterol levels and tumor growth in a PTEN-null transgenic mouse model of prostate cancer.
-
Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats.
-
ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.
-
Side population cells isolated from mesenchymal neoplasms have tumor initiating potential.
-
Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.
-
Silver nanoparticles compromise neurodevelopment in PC12 cells: critical contributions of silver ion, particle size, coating, and composition.
-
Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors.
-
Simulated microgravity-mediated reversion of murine lymphoma immune evasion.
-
Simultaneous proteomic profiling of four different growth states of human fibroblasts, using amine-reactive isobaric tagging reagents and tandem mass spectrometry.
-
Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain.
-
Single-cell RNA-seq of out-of-thaw mesenchymal stromal cells shows tissue-of-origin differences and inter-donor cell-cycle variations.
-
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma.
-
Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response.
-
Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart.
-
Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration.
-
Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.
-
Site-specific polyubiquitination differentially regulates parathyroid hormone receptor-initiated MAPK signaling and cell proliferation.
-
Size scaling in collective cell growth.
-
Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin.
-
Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells.
-
Smad4 restricts differentiation to promote expansion of satellite cell derived progenitors during skeletal muscle regeneration.
-
Small neuroendocrine lesions in intrathoracic lymph nodes of patients with primary lung adenocarcinoma: real metastasis?
-
Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging.
-
Smooth Muscle Cell-targeted RNA Aptamer Inhibits Neointimal Formation.
-
Smoothened inhibition leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells.
-
Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer.
-
Somatostatin receptor 2 signaling promotes growth and tumor survival in small-cell lung cancer.
-
Sonic Hedgehog-induced proliferation requires specific Gα inhibitory proteins.
-
Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation.
-
Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells.
-
Sonic hedgehog is required for cardiac outflow tract and neural crest cell development.
-
Sonic hedgehog signaling pathway supports cancer cell growth during cancer radiotherapy.
-
Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base.
-
Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model.
-
Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve.
-
Sox6 as a new modulator of renin expression in the kidney.
-
Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent.
-
Spatial memory and hippocampal plasticity are differentially sensitive to the availability of choline in adulthood as a function of choline supply in utero.
-
Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt.
-
Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury.
-
Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells.
-
Stem cells for the ischaemic heart.
-
Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation.
-
Steroid hormones drive cancer development.
-
Steroid induction of therapy-resistant cytokeratin-5-positive cells in estrogen receptor-positive breast cancer through a BCL6-dependent mechanism.
-
Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells.
-
Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.
-
Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension.
-
Strategic Therapeutic Targeting to Overcome Venetoclax Resistance in Aggressive B-cell Lymphomas.
-
Streptozotocin induces G2 arrest in skeletal muscle myoblasts and impairs muscle growth in vivo.
-
Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts.
-
Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones.
-
Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure.
-
Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli.
-
Sugar-coating wound repair: a review of FGF-10 and dermatan sulfate in wound healing and their potential application in burn wounds.
-
Sulforaphane induces inhibition of human umbilical vein endothelial cells proliferation by apoptosis.
-
Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer.
-
Suppressing autoimmunity by TGF-β: not just through T(reg) cells.
-
Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids.
-
Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repair.
-
Surfactant protein A integrates activation signal strength to differentially modulate T cell proliferation.
-
Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma.
-
Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis.
-
Synephrine Hydrochloride Suppresses Esophageal Cancer Tumor Growth and Metastatic Potential through Inhibition of Galectin-3-AKT/ERK Signaling.
-
Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma.
-
Synergic effect of OP449 and FTY720 on oral squamous cell carcinoma.
-
Synergism from combined immunologic and pharmacologic inhibition of HER2 in vivo.
-
Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells.
-
Synergistic enhancement of human bone marrow stromal cell proliferation and osteogenic differentiation on BMP-2-derived and RGD peptide concentration gradients.
-
Synthesis and Anticancer Activity of Tertiary Amides of Salinomycin and Their C20-oxo Analogues.
-
Synthesis and activity of largazole analogues with linker and macrocycle modification
-
Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives.
-
Synthesis of IR-780 dye-conjugated abiraterone for prostate cancer imaging and therapy.
-
Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells.
-
Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.
-
Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.
-
T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis.
-
T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation.
-
T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10.
-
T-bet:Eomes balance, effector function, and proliferation of cytomegalovirus-specific CD8+ T cells during primary infection differentiates the capacity for durable immune control.
-
T-lymphocyte alloresponses of Campath-1H-treated kidney transplant patients.
-
TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein.
-
TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages.
-
TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways.
-
TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice.
-
TCDD disrupts hypural skeletogenesis during medaka embryonic development.
-
TET2 binds the androgen receptor and loss is associated with prostate cancer.
-
TGF-β Family Signaling in the Control of Cell Proliferation and Survival.
-
TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.
-
TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch.
-
THZ531 Induces a State of BRCAness in Multiple Myeloma Cells: Synthetic Lethality with Combination Treatment of THZ 531 with DNA Repair Inhibitors.
-
TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk.
-
TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α.
-
TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep).
-
TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist.
-
TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice.
-
Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease.
-
Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response.
-
Targeted disruption of Mapk14 (p38MAPKalpha) in granulosa cells and cumulus cells causes cell-specific changes in gene expression profiles that rescue COC expansion and maintain fertility.
-
Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth.
-
Targeted inhibition of alphavbeta3 integrin with an RNA aptamer impairs endothelial cell growth and survival.
-
Targeted suppression of beta-catenin blocks intestinal adenoma formation in APC Min mice.
-
Targeting Akt3 signaling in malignant melanoma using isoselenocyanates.
-
Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer.
-
Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance.
-
Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth.
-
Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer.
-
Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib.
-
Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy.
-
Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration.
-
Targeting cell surface GRP78 enhances pancreatic cancer radiosensitivity through YAP/TAZ protein signaling.
-
Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer.
-
Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth.
-
Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma.
-
Targeting slow-proliferating ovarian cancer cells.
-
Targeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases.
-
Targeting stem cell behavior in desmoid tumors (aggressive fibromatosis) by inhibiting hedgehog signaling.
-
Targeting the MEK1 cascade in lung epithelium inhibits proliferation and fibrogenesis by asbestos.
-
Targeting the hexosamine biosynthetic pathway and O-linked N-acetylglucosamine cycling for therapeutic and imaging capabilities in diffuse large B-cell lymphoma.
-
TbetaRIII suppresses non-small cell lung cancer invasiveness and tumorigenicity.
-
Technology evaluation: Stem-cell therapy, Aastrom Biosciences Inc.
-
Telomere dysfunction causes alveolar stem cell failure.
-
Temperature-responsive hydroxybutyl chitosan for the culture of mesenchymal stem cells and intervertebral disk cells.
-
Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection.
-
Temporal modulation of collective cell behavior controls vascular network topology.
-
Tenascin-C, over expressed in lung cancer down regulates effector functions of tumor infiltrating lymphocytes.
-
Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program.
-
Testosterone regulates cell proliferation in aggressive fibromatosis (desmoid tumour).
-
The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia.
-
The Amino Acid Sensor Eif2ak4/GCN2 Is Required for Proliferation of Osteoblast Progenitors in Mice.
-
The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-A potential therapeutic target.
-
The C-terminal domain of A1/Bfl-1 regulates its anti-inflammatory function in human endothelial cells.
-
The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.
-
The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.
-
The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage.
-
The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytes.
-
The Epstein-Barr virus (EBV)-induced tumor suppressor microRNA MiR-34a is growth promoting in EBV-infected B cells.
-
The G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures.
-
The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells.
-
The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity.
-
The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.
-
The Molecular Link from Diet to Cancer Cell Metabolism.
-
The N-terminal Set-β Protein Isoform Induces Neuronal Death.
-
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.
-
The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescence.
-
The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells.
-
The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma.
-
The Role of Opioids and Their Receptors in Urological Malignancy: A Review.
-
The Role of the Immune Cells in Fracture Healing.
-
The Transcriptional Coactivator TAZ Is a Potent Mediator of Alveolar Rhabdomyosarcoma Tumorigenesis.
-
The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets.
-
The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer.
-
The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target.
-
The biocompatibility of titanium cardiovascular devices seeded with autologous blood-derived endothelial progenitor cells: EPC-seeded antithrombotic Ti implants.
-
The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis.
-
The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.
-
The chemopreventive agent myoinositol inhibits Akt and extracellular signal-regulated kinase in bronchial lesions from heavy smokers.
-
The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion.
-
The comprehensive role of E-cadherin in maintaining prostatic epithelial integrity during oncogenic transformation and tumor progression.
-
The consensus mechanics of cultured mammalian cells
-
The diversity and plasticity of adult hepatic progenitor cells and their niche.
-
The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.
-
The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients.
-
The effect of darbepoetin alfa on growth, oxygenation and radioresponsiveness of a breast adenocarcinoma.
-
The effect of hyperbranched polyglycerol coatings on drug delivery using degradable polymer nanoparticles.
-
The epicardium as a hub for heart regeneration.
-
The extracellular matrix protein agrin promotes heart regeneration in mice.
-
The granulin-epithelin precursor is a steroid-regulated growth factor in endometrial cancer.
-
The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways.
-
The homeodomain protein HOXB13 regulates the cellular response to androgens.
-
The human oncoprotein and chromatin architectural factor DEK counteracts DNA replication stress.
-
The importance of LAT in the activation, homeostasis, and regulatory function of T cells.
-
The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation.
-
The incretins and beta-cell health: contrasting glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 as a path to understand islet function in diabetes.
-
The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy.
-
The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms.
-
The interleukin-2 receptor α chain (CD25) plays an important role in regulating monocyte-derived CD40 expression during anti-porcine cellular responses.
-
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism.
-
The long and the short of telomeres in bone marrow recipient SCID patients.
-
The long isoform of cellular FLIP is essential for T lymphocyte proliferation through an NF-kappaB-independent pathway.
-
The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans.
-
The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation.
-
The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer.
-
The modulation of MSC integrin expression by RGD presentation
-
The molecular mechanism of LncRNA34a-mediated regulation of bone metastasis in hepatocellular carcinoma.
-
The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development.
-
The natural diterpene tonantzitlolone A and its synthetic enantiomer inhibit cell proliferation and kinesin-5 function.
-
The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.
-
The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts.
-
The pediatric preclinical testing program: description of models and early testing results.
-
The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF
-
The rapamycin analog CCI-779 is a potent inhibitor of pancreatic cancer cell proliferation.
-
The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.
-
The role of ACAID and CD4+CD25+FOXP3+ regulatory T cells on CTL function against MHC alloantigens.
-
The role of CAF derived exosomal microRNAs in the tumour microenvironment of melanoma.
-
The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.
-
The role of WNT10B in normal prostate gland development and prostate cancer.
-
The role of platelets on regenerating liver: Thoughts beyond parenchymal proliferation.
-
The role of thrombin and protease-activated receptors in pain mechanisms.
-
The role of type 1 angiotensin receptors on T lymphocytes in cardiovascular and renal diseases.
-
The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome.
-
The secreted metalloprotease ADAMTS20 is required for melanoblast survival.
-
The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice.
-
The spreading, migration and proliferation of mouse mesenchymal stem cells cultured inside hyaluronic acid hydrogels
-
The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse.
-
The tetraspanin superfamily member NET-6 is a new tumor suppressor gene.
-
The transcriptional response of the islet to pregnancy in mice.
-
The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.
-
The type III TGF-beta receptor signals through both Smad3 and the p38 MAP kinase pathways to contribute to inhibition of cell proliferation.
-
The type III TGF-beta receptor suppresses breast cancer progression through GIPC-mediated inhibition of TGF-beta signaling.
-
The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells.
-
The use of immobilized osteogenic growth peptide on gradient substrates synthesized via click chemistry to enhance MC3T3-E1 osteoblast proliferation.
-
The use of mild trypsinization conditions in the detachment of endothelial cells to promote subsequent endothelialization on synthetic surfaces.
-
The zinc finger transcription factor ZFX is required for maintaining the tumorigenic potential of glioblastoma stem cells.
-
Therapeutic applications of NSAIDS in cancer: special emphasis on tolfenamic acid.
-
Therapeutic potential of ReACp53 targeting mutant p53 protein in CRPC.
-
Therapeutic targeting of erbB3 with MM-121/SAR256212 enhances antitumor activity of paclitaxel against erbB2-overexpressing breast cancer.
-
Three linked vasculopathic processes characterize Kawasaki disease: a light and transmission electron microscopic study.
-
Three-Dimensional Printing of Nano Hydroxyapatite/Poly(ester urea) Composite Scaffolds with Enhanced Bioactivity.
-
Three-dimensional co-culture of rat hepatocyte spheroids and NIH/3T3 fibroblasts enhances hepatocyte functional maintenance.
-
Three-dimensional culture conditions differentially affect astrocyte modulation of brain endothelial barrier function in response to transforming growth factor β1.
-
TiO2
Nanoparticle-Induced Oxidation of the Plasma Membrane: Importance of the Protein Corona.
-
Tissue-specific expression and regulation of the alternatively-spliced forms of lysyl hydroxylase 2 (LH2) in human kidney cells and skin fibroblasts.
-
To be or not IIb: a multi-step process for Epstein-Barr virus latency establishment and consequences for B cell tumorigenesis.
-
Tobacco Carcinogen-Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer.
-
Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells.
-
Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation.
-
Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.
-
Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming.
-
Tor and cyclic AMP-protein kinase A: two parallel pathways regulating expression of genes required for cell growth.
-
Toward a blueprint for regeneration.
-
Toward effective immunotherapy for the treatment of malignant brain tumors.
-
Tp53 Suppression Promotes Cardiomyocyte Proliferation during Zebrafish Heart Regeneration.
-
Tracking proliferative history in lymphocyte development with cre-mediated sister chromatid recombination.
-
Transcriptional regulation of ROS controls transition from proliferation to differentiation in the root.
-
Transcriptional regulation of changes in growth, cell cycle, and gene expression of Saccharomyces cerevisiae due to changes in buoyancy.
-
Transcriptome regulation and chromatin occupancy by E2F3 and MYC in mice.
-
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
-
Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.
-
Transgelin-2: Biochemical and Clinical Implications in Cancer and Asthma.
-
Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells.
-
Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration.
-
Trastuzumab signaling in ErbB2-overexpressing inflammatory breast cancer correlates with X-linked inhibitor of apoptosis protein expression.
-
Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function.
-
Triple-hit B-cell Lymphoma With MYC, BCL2, and BCL6 Translocations/Rearrangements: Clinicopathologic Features of 11 Cases.
-
Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.
-
Tumor cell sensitivity to vemurafenib can be predicted from protein expression in a BRAF-V600E basket trial setting.
-
Tumor infiltrating lymphocyte therapy for metastatic melanoma: analysis of tumors resected for TIL.
-
Tumor microenvironment tenascin-C promotes glioblastoma invasion and negatively regulates tumor proliferation.
-
Tumor necrosis factor receptor-2 signaling attenuates vein graft neointima formation by promoting endothelial recovery.
-
Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma.
-
Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer.
-
Type 2 alveolar cells are stem cells in adult lung.
-
Type III TGF-β receptor enhances colon cancer cell migration and anchorage-independent growth.
-
U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia.
-
UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling.
-
Ubiquitylation of p53 by the APC/C inhibitor Trim39.
-
Ultraviolet photolysis of chlorpyrifos: developmental neurotoxicity modeled in PC12 cells.
-
Understanding the mechanism of bias signaling of the insulin-like growth factor 1 receptor: Effects of LL37 and HASF.
-
Unusual clinical and immunologic manifestations of transplacentally acquired maternal T cells in severe combined immunodeficiency.
-
Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells.
-
Ursodeoxycholic acid-induced inhibition of DLC1 protein degradation leads to suppression of hepatocellular carcinoma cell growth.
-
Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation.
-
Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma.
-
Uterine leiomyomata in relation to insulin-like growth factor-I, insulin, and diabetes.
-
Utilization of genomic signatures to identify high-efficacy candidate drugs for chemorefractory endometrial cancers.
-
Utilizing cell–matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels
-
VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting.
-
Vaccination with vif-deleted feline immunodeficiency virus provirus, GM-CSF, and TNF-alpha plasmids preserves global CD4 T lymphocyte function after challenge with FIV.
-
Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study.
-
Vaccine-induced boosting of influenza virus-specific CD4 T cells in younger and aged humans.
-
Validation of histone deacetylase 3 as a therapeutic target in castration-resistant prostate cancer.
-
Vertebrate Reproduction.
-
Vertical Inhibition of the RAF-MEK-ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in H/NRASQ61X Mutant Rhabdomyosarcoma.
-
Vitamin B5 Reduces Bacterial Growth via Regulating Innate Immunity and Adaptive Immunity in Mice Infected with Mycobacterium tuberculosis.
-
Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish.
-
Vitamin D receptor and retinoid X receptor α status and vitamin D insufficiency in models of murine colitis.
-
Vitamin E succinate decreases lung cancer tumor growth in mice.
-
WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment.
-
When Friends Bring You Down: Peer Stress Proliferation and Suicidality.
-
Widespread Repression of Gene Expression in Cancer by a Wnt/β-Catenin/MAPK Pathway.
-
Wild-Type Hras Suppresses the Earliest Stages of Tumorigenesis in a Genetically Engineered Mouse Model of Pancreatic Cancer.
-
Wild-type p53: tumors can't stand it.
-
Wnt signaling suppresses MAPK-driven proliferation of intestinal stem cells.
-
Wnt11 regulates cardiac chamber development and disease during perinatal maturation.
-
X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model.
-
Xist exerts gene-specific silencing during XCI maintenance and impacts lineage-specific cell differentiation and proliferation during hematopoiesis.
-
Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27.
-
Yin yang 1 modulates taxane response in epithelial ovarian cancer.
-
ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors.
-
c-MYC antisense phosphosphorodiamidate morpholino oligomer inhibits lung metastasis in a murine tumor model.
-
c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts.
-
c-Myc is required for maintenance of glioma cancer stem cells.
-
eIF4E-phosphorylation-mediated Sox2 upregulation promotes pancreatic tumor cell repopulation after irradiation.
-
hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration.
-
iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.
-
mTOR Activation Initiates Renal Cell Carcinoma Development by Coordinating ERK and p38MAPK.
-
mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium.
-
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
-
miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β.
-
p38 MAP kinases in the heart.
-
p38 Mitogen-activated protein kinase regulates chamber-specific perinatal growth in heart.
-
p38α MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions.
-
p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner.
-
p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway.
-
xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression.
-
zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish.
-
{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.
-
β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration.
-
β-Arrestin2 mediates progression of murine primary myelofibrosis.
-
β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium.
-
Keywords of People
-
-
-
Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
-
Buckley, Anne Frances,
Assistant Professor of Pathology,
Pathology
-
Choi, Steven Sok,
Associate Professor of Medicine,
Medicine, Gastroenterology
-
Ferrari, Guido,
Professor in Surgery,
Molecular Genetics and Microbiology
-
Gunn, Michael Dee,
Professor of Medicine,
Immunology
-
Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
-
Lagoo, Anand Shreeram,
Professor of Pathology,
Pathology
-
Linardic, Corinne Mary,
Associate Professor of Pediatrics,
Cell Biology
-
Luftig, Micah Alan,
Associate Professor of Molecular Genetics and Microbiology,
Cell Biology
-
McCall, Shannon Jones,
Associate Professor of Pathology,
Pathology
-
McDonnell, Donald Patrick,
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine,
Cell Biology
-
McLendon, Roger Edwin,
Professor of Pathology,
Pathology
-
Milano, Carmelo Alessio,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery,
Surgery, Cardiovascular and Thoracic Surgery
-
Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Biomedical Engineering
-
Shinohara, Mari L.,
Associate Professor of Immunology,
Cell Biology
-
Silver, Debra Lynn,
Associate Professor of Molecular Genetics and Microbiology,
Duke Science & Society
-
Sunday, Mary Elizabeth Anne,
Professor of Pathology,
Cell Biology
-
Velkey, John Matthew,
Assistant Professor of the Practice of Medical Education in the Department of Cell Biology,
Cell Biology
-
Weinhold, Kent James,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery,
Immunology
-
Yan, Hai,
Adjunct Professor of Pathology,
Pathology
-
Zhong, Xiaoping,
Professor of Pediatrics,
Immunology