Dendritic Spines

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  Subject Areas on Research

  • 7, 8-Dihydroxyflavone induces synapse expression of AMPA GluA1 and ameliorates cognitive and spine abnormalities in a mouse model of fragile X syndrome. 
  • A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. 
  • ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. 
  • Acute and Long-Term Effects of Brief Sevoflurane Anesthesia During the Early Postnatal Period in Rats. 
  • Adeno-associated virus-mediated ILK gene silencing in the rat NAc core. 
  • Adolescent intermittent alcohol exposure: persistence of structural and functional hippocampal abnormalities into adulthood. 
  • Altered morphology of hippocampal dentate granule cell presynaptic and postsynaptic terminals following conditional deletion of TrkB. 
  • Astrocytes refine cortical connectivity at dendritic spines. 
  • Autocrine BDNF-TrkB signalling within a single dendritic spine. 
  • Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain. 
  • Calmodulin activation by calcium transients in the postsynaptic density of dendritic spines. 
  • Cell adhesion: separation of p120's powers? 
  • Changes in Neuroimmune and Neuronal Death Markers after Adolescent Alcohol Exposure in Rats are Reversed by Donepezil. 
  • Deafening drives cell-type-specific changes to dendritic spines in a sensorimotor nucleus important to learned vocalizations. 
  • Dendritic spine geometry can localize GTPase signaling in neurons. 
  • Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities. 
  • Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization. 
  • Donepezil Reverses Dendritic Spine Morphology Adaptations and Fmr1 Epigenetic Modifications in Hippocampus of Adult Rats After Adolescent Alcohol Exposure. 
  • Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. 
  • General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity. 
  • Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner. 
  • In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation. 
  • Inhibition of the dopamine D1 receptor signaling by PSD-95. 
  • Localization of brain-derived neurotrophic factor to distinct terminals of mossy fiber axons implies regulation of both excitation and feedforward inhibition of CA3 pyramidal cells. 
  • Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall. 
  • Maternal Loss of Ube3a Impairs Experience-Driven Dendritic Spine Maintenance in the Developing Visual Cortex. 
  • MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. 
  • Multiscale imaging characterization of dopamine transporter knockout mice reveals regional alterations in spine density of medium spiny neurons. 
  • Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation. 
  • Rapid Golgi analysis method for efficient and unbiased classification of dendritic spines. 
  • Regional-specific effects of ovarian hormone loss on synaptic plasticity in adult human APOE targeted replacement mice. 
  • Regulation of spine structural plasticity by Arc/Arg3.1. 
  • Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders. 
  • Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice. 
  • Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity. 
  • Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells. 
  • Sparing of Descending Axons Rescues Interneuron Plasticity in the Lumbar Cord to Allow Adaptive Learning After Thoracic Spinal Cord Injury. 
  • Spine microdomains for postsynaptic signaling and plasticity. 
  • Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine. 
  • Studying signal transduction in single dendritic spines. 
  • Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging. 
  • Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders? 
  • Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. 
  • The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing. 
  • The mechanisms underlying the spatial spreading of signaling activity. 
  • The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density. 
  • Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1. 
  • Unmasking Proteolytic Activity for Adult Visual Cortex Plasticity by the Removal of Lynx1. 
  • WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory. 
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  Keywords of People

  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology