Utrophin
-
Subject Areas on Research
- A 1.3 kb promoter fragment confers spatial and temporal expression of utrophin A mRNA in mouse skeletal muscle fibers.
- Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain.
- Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression.
- Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction.
- Dystrophin and utrophin isoforms are expressed in glia, but not neurons, of the avian parasympathetic ciliary ganglion.
- Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling.
- Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF-AT pathway.
- Increased expression of utrophin in a slow vs. a fast muscle involves posttranscriptional events.
- Modulation of utrophin A mRNA stability in fast versus slow muscles via an AU-rich element and calcineurin signaling.
- Molecular, cellular, and pharmacological therapies for Duchenne/Becker muscular dystrophies.
- Multiple regulatory events controlling the expression and localization of utrophin in skeletal muscle fibers: insights into a therapeutic strategy for Duchenne muscular dystrophy.
- Pharmacological activation of PPARbeta/delta stimulates utrophin A expression in skeletal muscle fibers and restores sarcolemmal integrity in mature mdx mice.
- Progress in therapy for Duchenne muscular dystrophy.
- Regulation of utrophin in transgenic mice.
- Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophin.
- Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice.
- The utrophin A 5'-untranslated region confers internal ribosome entry site-mediated translational control during regeneration of skeletal muscle fibers.