Utrophin

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  Subject Areas on Research

  • A 1.3 kb promoter fragment confers spatial and temporal expression of utrophin A mRNA in mouse skeletal muscle fibers. 
  • Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain. 
  • Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression. 
  • Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction. 
  • Dystrophin and utrophin isoforms are expressed in glia, but not neurons, of the avian parasympathetic ciliary ganglion. 
  • Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling. 
  • Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF-AT pathway. 
  • Increased expression of utrophin in a slow vs. a fast muscle involves posttranscriptional events. 
  • Modulation of utrophin A mRNA stability in fast versus slow muscles via an AU-rich element and calcineurin signaling. 
  • Molecular, cellular, and pharmacological therapies for Duchenne/Becker muscular dystrophies. 
  • Multiple regulatory events controlling the expression and localization of utrophin in skeletal muscle fibers: insights into a therapeutic strategy for Duchenne muscular dystrophy. 
  • Pharmacological activation of PPARbeta/delta stimulates utrophin A expression in skeletal muscle fibers and restores sarcolemmal integrity in mature mdx mice. 
  • Progress in therapy for Duchenne muscular dystrophy. 
  • Regulation of utrophin in transgenic mice. 
  • Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophin. 
  • Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice. 
  • The utrophin A 5'-untranslated region confers internal ribosome entry site-mediated translational control during regeneration of skeletal muscle fibers.