History, 21st Century

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  Subject Areas on Research

  • "Opinions differ significantly": Early experiences with meta-analysis and the people who made it possible. 
  • "Take your pill": the role and fantasy of pills in modern medicine. 
  • 'One physical system': Tansley's ecosystem as Earth's critical zone. 
  • 100 years of primate paleontology. 
  • 17^th Century Variola Virus Reveals the Recent History of Smallpox. 
  • 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. 
  • 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. 
  • 50 Years Since the First Plastic Surgery Unit Achieved Department Status: Where Do We Stand and How Do We Compare to Our Close Competition? 
  • A Tribute to Ben Barres: Remembrances from Barres Lab Members. 
  • A brief history of G-protein coupled receptors (Nobel Lecture). 
  • A brief history of Wegener's granulomatosis: on limited, localized, and generalized forms of the disease: comment on the article by the Wegener's Granulomatosis Etanercept Trial Research Group. 
  • A chronological history of the International Conference on Cryptococcus and Cryptococcosis (ICCC), an invaluable forum for growth of the cryptococcal research field and clinical practice. 
  • A conversation with Oliver Smithies. 
  • A critical reappraisal of aspirin for secondary prevention in patients with ischemic heart disease. 
  • A historical perspective on clinical trials innovation and leadership: where have the academics gone? 
  • A history of orthotopic heart transplantation. 
  • A kingpin of academic inclusive fitness: the history and contributions of Bruce Grant. 
  • A modern Cosmas and Damian: Sir Roy Calne and Thomas Starzl receive the 2012 Lasker~Debakey Clinical Medical Research Award. 
  • A remarkable career in science-Joseph G. Gall. 
  • A shared vision. 
  • A tale of two callings. 
  • A tribute to Andrew J. Weaver. 
  • A tribute to Jeffery A. Winer. 
  • A tribute to Michael S. Neuberger. 
  • A tribute to Philip Marcus and the development of the clonogenic assay. 
  • ACR Presidential Address: RethinkingRheumatology: A Brave New World. 
  • AMIA President's Awards, 2003. 
  • Acute pain on and off the battlefield: what we do, what we know, and future directions. 
  • Advances in the nontransplant medical and surgical management of intestinal failure. 
  • Advancing biomarker science in the 21st century. 
  • Albert J. ("Mickey") Stunkard, M.D. 
  • Alfred Goodman Gilman (1941-2015). 
  • American Pediatric Society's 2014 John Howland Award acceptance lecture: saving lives through early diagnosis. 
  • An innovator ahead of her time. 
  • An interview with Dr Blanche Capel. 
  • An interview with Robert J. Lefkowitz. 
  • Antithrombotic Therapy in Patients With Atrial Fibrillation Treated With Oral Anticoagulation Undergoing Percutaneous Coronary Intervention: A North American Perspective: 2021 Update. 
  • Anything that involves a photon and an animal. 
  • Are we there yet? Seizing the moment to integrate medicine and public health. 
  • Are we there yet? Seizing the moment to integrate medicine and public health. 
  • Arrestins come of age: a personal historical perspective. 
  • Assessing the Magnitude of a Surgical Career Through His Trainees: The John L. Cameron Legacy Factor. 
  • Association between physician characteristics and the use of 21-gene recurrence score genomic testing among Medicare beneficiaries with early-stage breast cancer, 2008-2011. 
  • Asynchronous carbon sink saturation in African and Amazonian tropical forests. 
  • B lymphocytes: how they develop and function. 
  • Battle of the Bulge: Aortic Aneurysms and their Management from the 18th to the 21st Century 
  • Becoming a surgeon-scientist: my transition from fellowship to faculty. 
  • Bench to Bedside Discovery, Innovation, Global Health Equity, and Security: A Conversation With Victor J. Dzau, MD. 
  • Biomedical Research in Times of Emergency: Lessons From History. 
  • Bispecific antibodies engage T cells for antitumor immunotherapy. 
  • Building Bridges through Science. 
  • Building a Culture of Safety in Ophthalmology. 
  • Burden of nonalcoholic fatty liver disease in Canada, 2019-2030: a modelling study. 
  • Cancer immunotherapy innovator James Allison receives the 2015 Lasker~DeBakey Clinical Medical Research Award. 
  • Cancer incidence and treatment utilization patterns at a regional cancer center in Tanzania from 2008-2016: Initial report of 2,772 cases. 
  • Celebrating the 20th anniversary of the Journal of Genetic Counseling. 
  • Charting the Path Forward: Development, Goals and Initiatives of the 2019 Infectious Diseases Society of America Strategic Plan. 
  • Chemotherapy Costs and 21-Gene Recurrence Score Genomic Testing Among Medicare Beneficiaries With Early-Stage Breast Cancer, 2005 to 2011. 
  • Childhood vaccine development: an overview. 
  • Christian Raetz: scientist and friend extraordinaire. 
  • Classification of Cleft Lip/Palate: Then and Now. 
  • Cochlear implants: a remarkable past and a brilliant future. 
  • Coming to America: Regulatory Oversight of United States Immigration Policies: A Brief History. 
  • Common Genetic Variation and Susceptibility to Ovarian Cancer: Current Insights and Future Directions. 
  • Computed tomography: revolutionizing the practice of medicine for 40 years. 
  • Contrast echocardiography: past, present, and...future? 
  • Cord Blood Connect: The International Congress for Cord Blood and Perinatal Tissue Research 2020. 
  • Correlation of West Nile Virus Incidence in Donated Blood with West Nile Neuroinvasive Disease Rates, United States, 2010-2012. 
  • Current perspectives on Down syndrome: selected medical and social issues. 
  • Current state of psychiatry in Saudi Arabia. 
  • Daniel Amit (1938-2007). 
  • David L. Epstein, MD, MMM (1944-2014). 
  • Dedication of Special Issue on Purinergic Regulation in the Eye to Mortimer M. Civan. 
  • Demonstration of Automated Analysis of Multiple Analytes on an Integrated Digital Microfluidic Platform. 
  • Diabetes summer camps: history, safety, and outcomes. 
  • Diffusion modulation of the fMRI signal: early investigations on the origin of the BOLD signal. 
  • Discovery of the aquaporins and development of the field. 
  • Disparities in place of death for patients with hematological malignancies, 1999 to 2015. 
  • Distinguished contribution to family nursing research award (2007): Catherine "Kit" Chesla, DNSc, RN, FAAN. 
  • Diverse trajectories of cocaine use through early adulthood among rebellious and socially conforming youth. 
  • Diversity and the Duke BME PhD program: then, now and moving forward. 
  • Does Institutional Memory Matter? 
  • Dr Robert Loh Choo Kiat, JP, BBM, PJG (1925 - 2017). 
  • Dr. Galen Wagner (1939-2016) as an Academic Writer: An Overview of his Peer-reviewed Scientific Publications. 
  • Driving forces of global wildfires over the past millennium and the forthcoming century. 
  • Dynamic treatment regimes, past, present, and future: A conversation with experts. 
  • E Pluribus Unum: The Fungal Kingdom as a Rosetta Stone for Biology and Medicine. 
  • Early career investigator highlight-October. 
  • Early history of circular RNAs, children of splicing. 
  • Educational differences in health risks and illness over the life course: a test of cumulative disadvantage theory. 
  • Effects of demographic and retirement-age policies on future pension deficits, with an application to China. 
  • Elizabeth C. Clipp, PhD, RN, FAAN. 
  • Emerging subspecialties in neurology: neurophysiologic intraoperative monitoring. 
  • Endocrine Society 2014 Laureate Awards. 
  • Endpoints in Heart Failure Drug Development: History and Future. 
  • Eric H. Davidson (1937–2015). 
  • Evaluation of Flibanserin: Science and Advocacy at the FDA. 
  • Evelyn Wiener. 
  • Event-related fMRI in cognition. 
  • Evolution of critical care cardiology: transformation of the cardiovascular intensive care unit and the emerging need for new medical staffing and training models: a scientific statement from the American Heart Association. 
  • Fathers of modern coagulation. 
  • Fifty Years of Mechanical Ventilation-1970s to 2020. 
  • First international association of hyperthermic oncology Tsudomu Sugahara award. 
  • Focus on the research journey. An interview with Robert J. Lefkowitz, MD, scientist, mentor, and recipient of the 2007 National Medal of Science by Elaine Musgrave. 
  • From Drosophila to humans: reflections on the roles of the prolyl isomerases and chaperones, cyclophilins, in cell function and disease. 
  • Genetics and women's health issues--the commitment of EMS to women scientists and gender-associated disease topics. 
  • George Niederehe, Ph.D.: Tribute and Thanks. 
  • Getting a decent (but sparse) signal to the brain for users of cochlear implants. 
  • Global and regional drivers of land-use emissions in 1961-2017. 
  • Global nitrogen budgets in cereals: A 50-year assessment for maize, rice, and wheat production systems. 
  • Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016: A Systematic Analysis for the Global Burden of Disease Study. 
  • Group B Streptococcus (GBS) Colonization and Disease among Pregnant Women: A Historical Cohort Study. 
  • HIV-1 and HIV-Associated Nephropathy 25 Years Later. 
  • Happy 50th Birthday, Cardiac Transplantation: Happy 5th Birthday, JACC: Heart Failure. 
  • HeartMate® II continuous-flow left ventricular assist system. 
  • Helmut Drexler, MD, 1951-2009. 
  • Heterogeneity of Second-Line Treatment for Patients With Multiple Myeloma in the Connect MM Registry (2010-2016). 
  • Historical Evolution and Provider Awareness of Inactive Ingredients in Oral Medications. 
  • Historical perspectives of The American Association for Thoracic Surgery: Dr David B. Skinner (1935-2003)--a surgeon and something more. 
  • Historical perspectives of The American Association for Thoracic Surgery: Henry T. Bahnson (1920-2003). 
  • Historical perspectives of The American Association for Thoracic Surgery: Paul A. Ebert (1932-2009). 
  • History of antibiotics. From salvarsan to cephalosporins. 
  • History of orthopaedic education. 
  • I Lost a Friend From HFpEF: William Anlyan, MD, Chancellor Emeritus and Duke University Trustee. 
  • Implementation of health risk assessments with family health history: barriers and benefits. 
  • In memoriam. D. Bernard Amos April 16, 1923-May 15, 2003. 
  • In memoriam: Edward L Gillette (1932-2006). 
  • In memoriam: J. Edwin Seegmiller, M.D. (1920-2006). 
  • In memory of Professor Galen S. Wagner M.D., Ph.D. (1939-2016): our mentor, colleague and friend. 
  • Increased dry-season length over southern Amazonia in recent decades and its implication for future climate projection 
  • Integrative biomechanics: A paradigm for clinical applications of fundamental mechanics 
  • Intensity and frequency of extreme novel epidemics. 
  • Introducing the New Editor of Arthritis & Rheumatology, Richard J. Bucala, MD, PhD. 
  • Introduction of Robert J. Lefkowitz. 
  • Introduction to Gedenkschrift for David L. Epstein, MD. 
  • Irwin Freedberg: "grandpa" to generations of dermatologists. 
  • JVIR Celebrates 25 Years of Innovation.: Part 4: 2006-2010. 
  • John F. Enders and measles virus vaccine--a reminiscence. 
  • Lack of consensus identifies important areas for future clinical research: Advanced Prostate Cancer Consensus Conference (APCCC) 2019 findings. 
  • Late life depression: a historical perspective upon a maturing field of inquiry. 
  • Leadership case study: Joyce Ann Clayton Thorpe Nichols, PA-C. 
  • Legends in urology. 
  • Linking the history of radiation biology to the hallmarks of cancer. 
  • Living donor liver transplantation: the historical and cultural basis of policy decisions and ongoing ethical questions. 
  • Marijuana Use in the Anesthetized Patient: History, Pharmacology, and Anesthetic Considerations. 
  • Mark D. Rausher. 
  • Melanoma trials that defined surgical management: Overview of trials that established NCCN margin guidelines. 
  • Mercury, vaccines, and autism: one controversy, three histories. 
  • Michael Tomasello: Award for Distinguished Scientific Contributions. 
  • Milestones in thoracic surgery. 
  • Military service, deployments, and exposures in relation to amyotrophic lateral sclerosis survival. 
  • Minimally Invasive Thoracic Surgery 3.0: Lessons Learned From the History of Lung Cancer Surgery. 
  • Missions, Humanitarianism, and the Evolution of Modern Global Surgery. 
  • Mitochondrial Toxicity. 
  • Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age. 
  • Modern cataract surgery: unfinished business and unanswered questions. Foreword. 
  • Myopia - A 21st Century Public Health Issue. 
  • NCCN Guidelines Insights: Head and Neck Cancers, Version 1.2018. 
  • Neuroendocrine biomarkers of prolonged exposure treatment response in military-related PTSD. 
  • Neuroscience and the fallacies of functionalism. 
  • Olevi Kull's lifetime contribution to ecology. 
  • Oliver Smithies: A Remembrance. 
  • Otolaryngology-head and neck surgery at Johns Hopkins: The first 100 years (1914-2014). 
  • Overview of the state of the art of Rh disease: history, current clinical management, and recent progress. 
  • Overview of the state of the art of Rh disease: history, current clinical management, and recent progress. 
  • Patterns of efavirenz use as first-line antiretroviral therapy in the United States: 1999-2015. 
  • Pioneering geneticist Mary-Claire King receives the 2014 Lasker~Koshland Special Achievement Award in Medical Science. 
  • Pioneering paradigms and magnificent manifestos--Leigh Van Valen's priceless contributions to evolutionary biology. 
  • Pioneers in biomedical optics: special section honoring professor Frans F. Jobsis of Duke University. 
  • Psychologic factors in the development of complex regional pain syndrome: history, myth, and evidence. 
  • Q Fever, Scrub Typhus, and Rickettsial Diseases in Children, Kenya, 2011-2012. 
  • Q-Probes studies in anatomic pathology: quality improvement through targeted benchmarking. 
  • Quality improvement in pediatrics: past, present, and future. 
  • R. Edward Coleman, MD, 1943-2012. 
  • Rapid degradation of Deepwater Horizon spilled oil by indigenous microbial communities in Louisiana saltmarsh sediments. 
  • Recipient of the 2014 molecular ecology prize: Johanna Schmitt. 
  • Redefining the Gold Standard of Myocardial Infarction Using Troponin T. 
  • Reduction in Mortality after Umbilical Cord Blood Transplantation in Children Over a 20-Year Period (1995-2014). 
  • Religiosity, psychological resources, and physical health. 
  • Research Update in Neuroscience for Neurosurgeons: a historical perspective. 
  • Research in action: from AIDS to global health to impact. A symposium in recognition of the scientific contributions of Professor Joep Lange. 
  • Research published in 2003 by U.S. family medicine authors. 
  • Retrospective. Anne McLaren (1927-2007). 
  • Retrospective. Norman L. Letvin (1949-2012). 
  • Review and Analysis of Publication Trends over Three Decades in Three High Impact Medicine Journals. 
  • Rheumatology Research Foundation Clinician Scholar Educator Award: Fifteen Years Promoting Rheumatology Educators and Education. 
  • Ru-Rong Ji, Ph.D., Recipient of the 2020 Excellence in Research Award. 
  • Rudolf A. Raff (1941-2019). 
  • Sally Kornbluth: Nature's incredible contraptions. 
  • Sarnoff A. Mednick (1928-2015). 
  • Seeing the PDB. 
  • Serafino Zappacosta: An Enlightened Mentor and Educator. 
  • Society of Thoracic Radiology: grown and growing. 
  • Speciation genetics: evolving approaches. 
  • Speculation on the naming of Moyamoya disease. 
  • Staphylococcus aureus bacteremia at 5 US academic medical centers, 2008-2011: significant geographic variation in community-onset infections. 
  • Stroke: working toward a prioritized world agenda. 
  • Surgeons, plague, and leadership: A historical mantle to carry forward. 
  • Susan Nolen-Hoeksema (1959-2013). 
  • Synopsis of history of American Society for Therapeutic Radiology and Oncology 1958-2008. 
  • Tea with Dr Oliver Smithies, 2007 Nobel laureate in physiology and medicine. Interview by Dr. Anthony Viera. 
  • Technological Improvements in Three-Piece Inflatable Penile Prosthesis Design over the Past 40 Years. 
  • Telemedicine: recent developments and future applications. 
  • Ten-Year Differences in Women's Awareness Related to Coronary Heart Disease: Results of the 2019 American Heart Association National Survey: A Special Report From the American Heart Association. 
  • The 2013 Novitski Prize: Jonathan Pritchard. 
  • The 2013 Thomas Hunt Morgan Medal: Thomas Douglas Petes. 
  • The Challenge of Bipolar Depression in the 21st Century. 
  • The Duke Center for the Study of Aging: one of our earliest roots. 
  • The Education of American Surgeons and the Rise of Surgical Residencies, 1930-1960. 
  • The Evolution of the Inflatable Penile Prosthesis Reservoir and Surgical Placement. 
  • The Evolution of the Journal Club: From Osler to Twitter. 
  • The FDA in the 21st Century: How Is the FDA Responding to the New World? A Focus on Heart Failure Devices. 
  • The HIV-AIDS pandemic at 25--the global response. 
  • The History of Duke Thoracic Surgery. 
  • The James A. Rand Young Investigator's Award: Battling the Opioid Epidemic with Prospective Pain Threshold Measurement. 
  • The Physician as Dictator 
  • The Public Health Burden of Lymphatic Malformations in Children: National Estimates in the United States, 2000-2009. 
  • The Research Practicum and International Research Interdisciplinary School (IRIS) initiatives: In memory of Professor Galen S. Wagner M.D., PhD. 
  • The Snail's Charm. 
  • The Three Cs of a Scientific Autobiography: Curiosity, Circumstance, and Colleagues. 
  • The Wesselhoefts: A medical dynasty from the age of Goethe to the era of nuclear medicine. 
  • The annual ASCI meeting: does nostalgia have a future? 
  • The effects of China's universal two-child policy. 
  • The evolution of platelet-directed pharmacotherapy. 
  • The evolution of speed, size and shape in modern athletics. 
  • The history of human composite tissue allotransplantation. 
  • The history of the University of Wisconsin transplant program. 
  • The history of the combined supra- and infratentorial approach to the petroclival region. 
  • The history, evolution, and clinical use of dendritic cell-based immunization strategies in the therapy of brain tumors. 
  • The human pain genetics database: an interview with Luda Diatchenko. 
  • The jensen symposium; a tribute to a pioneer in the field of nuclear receptor biology. 
  • The lemur revolution starts now: the genomic coming of age for a non-model organism. 
  • The more the merrier? 
  • The new "new racism" thesis: limited government values and race-conscious policy attitudes. 
  • The politics of assessment: water and sanitation MDGs in the Middle East. 
  • The population ecology and social behaviour of taxonomists. 
  • The role of external beam radiotherapy in the treatment of hepatocellular cancer. 
  • The state of infectious diseases clinical trials: a systematic review of ClinicalTrials.gov. 
  • Thirty years of JOPT. 
  • Thoracolumbar spinal deformity. 
  • Toward an Emerging Era of Optimization Research for Acupuncture. 
  • Traditional engineering in the biological century: the biotraditional engineer 
  • Transforming epidemiology for 21st century medicine and public health. 
  • Transfusion medicine as a profession: evolution over the past 50 years. 
  • Trauma laparoscopy from 1925 to 2017: Publication history and study demographics of an evolving modality. 
  • Traumatic childhood experiences in the 21st century: broadening and building on the ACE studies with data from the National Child Traumatic Stress Network. 
  • Trends in Insurance Status Among Patients Diagnosed With Cancer Before and After Implementation of the Affordable Care Act. 
  • Unlocking mechanisms of development through advances in tools. 
  • Unsung hero Robert C. Gallo. 
  • Updates in advanced prostate cancer 2018. 
  • Use of extracorporeal life support in adults with severe acute respiratory failure. 
  • Vagus nerve stimulation (VNS): utility in neuropsychiatric disorders. 
  • Vein Graft Tympanoplasty: How a Transiently Used Graft Material Transformed Middle Ear Surgery. 
  • WOMEN IN REPRODUCTIVE SCIENCE: To be or not to be a testis. 
  • War and pandemics: Catalysts for medical advancement. 
  • What I Know for Sure About the 40 Years of ONS. 
  • What Is a Life Worth?: A Tribute to Dr. William Little, a Pioneer in the Understanding of Heart Failure With Preserved Ejection Fraction. 
  • Whipple disease research accelerates. 
  • William Campbell Little, M.D. In Memoriam. 
  • William Kaelin, Peter Ratcliffe, and Gregg Semenza receive the 2016 Albert Lasker Basic Medical Research Award. 
  • Windows into development: historic, current, and future perspectives on transgenic zebrafish. 
  • Zebrafish: as an integrative model for twenty-first century toxicity testing. 
  • Zika virus: History, emergence, biology, and prospects for control. 
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  Keywords of People

  • Carbrey, Jennifer Mehlman, Assistant Research Professor of Cell Biology, Cell Biology
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Turner, David Ashley, Consulting Professor in the Department of Pediatrics, Pediatrics, Critical Care Medicine
  • Yancy Jr., William Samuel, Professor of Medicine, Medicine, General Internal Medicine