TRPC Cation Channels

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  Subject Areas on Research

  • A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion. 
  • A TRPA1-dependent mechanism for the pungent sensation of weak acids. 
  • A comparison of the genes coding for canonical TRP channels and their M, V and P relatives. 
  • A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. 
  • Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. 
  • Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. 
  • Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways. 
  • Cytoskeletal regulation of TRPC channels in the cardiorenal system. 
  • Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. 
  • Gq signaling causes glomerular injury by activating TRPC6. 
  • H2O2-Sensitive Isoforms of Drosophila melanogaster TRPA1 Act in Bitter-Sensing Gustatory Neurons to Promote Avoidance of UV During Egg-Laying. 
  • In vivo vomeronasal stimulation reveals sensory encoding of conspecific and allospecific cues by the mouse accessory olfactory bulb. 
  • Increased vascular smooth muscle contractility in TRPC6-/- mice. 
  • Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure. 
  • Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice. 
  • Loss of cell surface TFII-I promotes apoptosis in prostate cancer cells stimulated with activated α₂ -macroglobulin. 
  • Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity. 
  • Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel. 
  • Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. 
  • Orai proteins interact with TRPC channels and confer responsiveness to store depletion. 
  • Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2. 
  • Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity. 
  • Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice. 
  • TRPC Channels in Proteinuric Kidney Diseases. 
  • TRPC1 channels are critical for hypertrophic signaling in the heart. 
  • TRPC2: molecular biology and functional importance. 
  • TRPC3 channels confer cellular memory of recent neuromuscular activity. 
  • TRPC6 enhances angiotensin II-induced albuminuria. 
  • TRPC6 expression in neurons is differentially regulated by NR2A- and NR2B-containing NMDA receptors. 
  • TRPV4 channels augment macrophage activation and ventilator-induced lung injury. 
  • The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus. 
  • The role of store-operated calcium influx in skeletal muscle signaling. 
  • The role of π-helices in TRP channel gating. 
  • Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel. 
  • Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia. 
  • Unexpected role of TRPC6 channel in familial nephrotic syndrome: does it have clinical implications? 
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  Keywords of People

  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology