TRPC Cation Channels
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Subject Areas on Research
- 2007 Young Investigator Award: TRP'ing into a new era for glomerular disease.
- A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion.
- A TRPA1-dependent mechanism for the pungent sensation of weak acids.
- A comparison of the genes coding for canonical TRP channels and their M, V and P relatives.
- A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis.
- Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.
- Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice.
- Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways.
- Cytoskeletal regulation of TRPC channels in the cardiorenal system.
- Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder.
- Focal and segmental glomerulosclerosis: varying biologic mechanisms underlie a final histopathologic end point.
- Gq signaling causes glomerular injury by activating TRPC6.
- Gustatory receptor neurons in Manduca sexta contain a TrpA1-dependent signaling pathway that integrates taste and temperature.
- H2O2-Sensitive Isoforms of Drosophila melanogaster TRPA1 Act in Bitter-Sensing Gustatory Neurons to Promote Avoidance of UV During Egg-Laying.
- In vivo vomeronasal stimulation reveals sensory encoding of conspecific and allospecific cues by the mouse accessory olfactory bulb.
- Increased vascular smooth muscle contractility in TRPC6-/- mice.
- Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure.
- Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice.
- Loss of cell surface TFII-I promotes apoptosis in prostate cancer cells stimulated with activated α₂ -macroglobulin.
- Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity.
- Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel.
- Molecules and mechanisms of mechanotransduction.
- Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1.
- Orai proteins interact with TRPC channels and confer responsiveness to store depletion.
- Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.
- Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity.
- Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice.
- TRPC1 channels are critical for hypertrophic signaling in the heart.
- TRPC2: molecular biology and functional importance.
- TRPC3 channels confer cellular memory of recent neuromuscular activity.
- TRPC6 and FSGS: the latest TRP channelopathy.
- TRPC6 enhances angiotensin II-induced albuminuria.
- TRPV4 channels augment macrophage activation and ventilator-induced lung injury.
- The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus.
- The role of store-operated calcium influx in skeletal muscle signaling.
- Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel.
- Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia.
- Unexpected role of TRPC6 channel in familial nephrotic syndrome: does it have clinical implications?
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Keywords of People
- Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology