Podocytes

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  Subject Areas on Research

  • MYH9 E1841K Mutation Augments Proteinuria and Podocyte Injury and Migration. 
  • A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS. 
  • A novel mouse model of podocyte depletion. 
  • A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases. 
  • ACE-inhibition increases podocyte number in experimental glomerular disease independent of proliferation. 
  • APOL1 Nephrotoxicity: What Does Ion Transport Have to Do With It? 
  • APOL1-G0 or APOL1-G2 Transgenic Models Develop Preeclampsia but Not Kidney Disease. 
  • APOL1-G0 protects podocytes in a mouse model of HIV-associated nephropathy. 
  • Activation of Galpha q-coupled signaling pathways in glomerular podocytes promotes renal injury. 
  • Adriamycin-Induced Podocyte Injury Disrupts the YAP-TEAD1 Axis and Downregulates Cyr61 and CTGF Expression. 
  • Advances in the biology and genetics of the podocytopathies: implications for diagnosis and therapy. 
  • Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis. 
  • Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice. 
  • Beneficial effects of the Rho kinase inhibitor Y27632 in murine puromycin aminonucleoside nephrosis. 
  • Blockade of the natriuretic peptide clearance receptor attenuates proteinuria in a mouse model of focal segmental glomerulosclerosis. 
  • COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. 
  • Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo. 
  • Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease. 
  • Collapsing glomerulopathy: an inflammatory podocytopathy? 
  • Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease. 
  • De novo TRIM8 variants impair its protein localization to nuclear bodies and cause developmental delay, epilepsy, and focal segmental glomerulosclerosis. 
  • Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion. 
  • Dysregulation of WTI (-KTS) is Associated with the Kidney-Specific Effects of the LMX1B R246Q Mutation. 
  • From man to fish: What can Zebrafish tell us about ApoL1 nephropathy? 
  • Gq signaling causes glomerular injury by activating TRPC6. 
  • Gq-dependent signaling upregulates COX2 in glomerular podocytes. 
  • Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions. 
  • IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage. 
  • Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis. 
  • Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1. 
  • Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice. 
  • Losing their footing: Rac1 signaling causes podocyte detachment and FSGS. 
  • Mechanisms of the proteinuria induced by Rho GTPases. 
  • Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. 
  • Notch signaling: a common pathway of injury in podocytopathies? 
  • Pathogenesis and therapy of focal segmental glomerulosclerosis: an update. 
  • Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity. 
  • Podocyte biology in segmental sclerosis and progressive glomerular injury. 
  • Podocyte density is reduced in kidney allografts with high-risk APOL1 genotypes at transplantation. 
  • Podocyte effacement closely links to suPAR levels at time of posttransplantation focal segmental glomerulosclerosis occurrence and improves with therapy. 
  • Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease. 
  • RNA sequencing of isolated cell populations expressing human APOL1 G2 risk variant reveals molecular correlates of sickle cell nephropathy in zebrafish podocytes. 
  • Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis. 
  • Reduction of Stat3 activity attenuates HIV-induced kidney injury. 
  • Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1). 
  • Revisiting the determinants of the glomerular filtration barrier: what goes round must come round. 
  • SMPDL3b modulates insulin receptor signaling in diabetic kidney disease. 
  • Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver-derived angiotensinogen. 
  • Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis. 
  • Stressed-out podocytes in diabetes? 
  • TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α. 
  • TRPC6 enhances angiotensin II-induced albuminuria. 
  • The Bowman's shield: a tribute to translational science and Detlef Schlöndorff. 
  • The EP4 receptor for prostaglandin E2 in glomerular disease: a good receptor turned bad? 
  • The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes. 
  • The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy. 
  • The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. 
  • The kd/kd mouse is a model of collapsing glomerulopathy. 
  • Therapeutic targets in focal and segmental glomerulosclerosis. 
  • Transactivation of the epidermal growth factor receptor by angiotensin II in glomerular podocytes. 
  • Translating genetic findings in hereditary nephrotic syndrome: the missing loops. 
  • Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration. 
  • Ultrastructural Characterization of Proteinuric Patients Predicts Clinical Outcomes. 
  • Unexpected role of TRPC6 channel in familial nephrotic syndrome: does it have clinical implications? 
  • Urinary Single-Cell Profiling Captures the Cellular Diversity of the Kidney. 
  • VEGF inhibition and renal thrombotic microangiopathy. 
  • VEGF inhibition and renal thrombotic microangiopathy. 
  • Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. 
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  Keywords of People

  • Sparks, Matthew A., Associate Professor of Medicine, Medicine, Nephrology