Regulatory Elements, Transcriptional
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Subject Areas on Research
- 29 mammalian genomes reveal novel exaptations of mobile elements for likely regulatory functions in the human genome.
- A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes.
- CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome.
- Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation.
- Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma.
- Conservation of dynamic characteristics of transcriptional regulatory elements in periodic biological processes.
- DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin.
- Defining Transcription Regulatory Elements in the Human Frataxin Gene: Implications for Gene Therapy.
- EF1A1-actin interactions alter mRNA stability to determine differential osteopontin expression in HepG2 and Hep3B cells.
- Effects of sequence variation on differential allelic transcription factor occupancy and gene expression.
- Evolution. CNCing is believing.
- Feather development genes and associated regulatory innovation predate the origin of Dinosauria.
- GREAT improves functional interpretation of cis-regulatory regions.
- Genome-wide identification of regulatory elements in Sertoli cells.
- Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS).
- Heritable individual-specific and allele-specific chromatin signatures in humans.
- Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements.
- Human cardiac cis-regulatory elements, their cognate transcription factors, and regulatory DNA sequence variants.
- Human genome-wide measurement of drug-responsive regulatory activity.
- Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome.
- Identifying novel transcriptional components controlling energy metabolism.
- Inferring gene expression from ribosomal promoter sequences, a crowdsourcing approach.
- Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
- Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells.
- Modeling the evolution of regulatory elements by simultaneous detection and alignment with phylogenetic pair HMMs.
- Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli.
- Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements.
- Noise reduction by diffusional dissipation in a minimal quorum sensing motif.
- Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding.
- Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity.
- Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions.
- Population genetics of cis-regulatory sequences that operate during embryonic development in the sea urchin Strongylocentrotus purpuratus.
- Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells.
- Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
- Regulatory network motifs and hotspots of cancer genes in a mammalian cellular signalling network.
- Site-specific silencing of regulatory elements as a mechanism of X inactivation.
- Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53.
- Stringent comparative sequence analysis reveals SOX10 as a putative inhibitor of glial cell differentiation.
- TFBSshape: a motif database for DNA shape features of transcription factor binding sites.
- Three periods of regulatory innovation during vertebrate evolution.
- optix Drives the Repeated Convergent Evolution of Butterfly Wing Pattern Mimicry
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Keywords of People
- Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
- Reddy, Timothy E, Associate Professor of Biostatistics & Bioinformatics,, Molecular Genetics and Microbiology
- Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology