Indoleamine-Pyrrole 2,3,-Dioxygenase
-
Subject Areas on Research
- A phase 1 study of PF-06840003, an oral indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor in patients with recurrent malignant glioma.
- Altered expression of TIM-3, LAG-3, IDO, PD-L1, and CTLA-4 during nimotuzumab therapy correlates with responses and prognosis of oral squamous cell carcinoma patients.
- Blocking ovarian cancer progression by targeting tumor microenvironmental leukocytes.
- Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma.
- Common genetic variation in the indoleamine-2,3-dioxygenase genes and antidepressant treatment outcome in major depressive disorder.
- FoxP3 and indoleamine 2,3-dioxygenase immunoreactivity in sentinel nodes from melanoma patients.
- Hyperexpression of Foxp3 and IDO during acute rejection of islet allografts.
- Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cells.
- Intragraft CD11b(+) IDO(+) cells mediate cardiac allograft tolerance by ECDI-fixed donor splenocyte infusions.
- Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy.
- Molecular Analyses Reveal Inflammatory Mediators in the Solid Component and Cyst Fluid of Human Adamantinomatous Craniopharyngioma.
- Parallel Expression of Enzyme Inhibitors of CD8T Cell Activity in Tumor Microenvironments and Secretory Endometrium.
- Placental IDO and oxidative damage in pre-eclampsia: fresh chicken or fresh eggs? Preface.
- Regulatory T cells move in when gliomas say "I Do".
- Targetable Immune Regulatory Molecule Expression in High-Grade Serous Ovarian Carcinomas in African American Women: A Study of PD-L1 and IDO in 112 Cases From the African American Cancer Epidemiology Study (AACES).
- The immunomodulatory roles of macrophages at the maternal-fetal interface.
- The inhibition of the kynurenine pathway prevents behavioral disturbances and oxidative stress in the brain of adult rats subjected to an animal model of schizophrenia.
- Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment.
- Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas.
- miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy.
-
Keywords of People
- Hanks, Brent A., Associate Professor of Medicine, Pharmacology & Cancer Biology
- Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering