Oncolytic Viruses

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  Subject Areas on Research

  • Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs. 
  • Cytotoxic and immunogenic mechanisms of recombinant oncolytic poliovirus. 
  • Engineered Oncolytic Poliovirus PVSRIPO Subverts MDA5-Dependent Innate Immune Responses in Cancer Cells. 
  • Gene Therapy 2017: Progress and Future Directions. 
  • Human Trial of a Genetically Modified Herpes Simplex Virus for Rapid Detection of Positive Peritoneal Cytology in the Staging of Pancreatic Cancer. 
  • Immunotherapy Gone Viral: Bortezomib and oHSV Enhance Antitumor NK-Cell Activity. 
  • Immunotherapy approaches in the treatment of malignant brain tumors. 
  • Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis. 
  • Oncolytic Viral Therapy for Malignant Glioma and Their Application in Clinical Practice. 
  • Oncolytic immunotherapy through tumor-specific translation and cytotoxicity of poliovirus. 
  • Oncolytic polio virotherapy of cancer. 
  • Oncolytic virus-derived type I interferon restricts CAR T cell therapy. 
  • Oncolytic viruses in melanoma. 
  • Phase I trial of intratumoral PVSRIPO in patients with unresectable, treatment-refractory melanoma. 
  • Preparing an oncolytic poliovirus recombinant for clinical application against glioblastoma multiforme. 
  • Recombinant oncolytic poliovirus eliminates glioma in vivo without genetic adaptation to a pathogenic phenotype. 
  • Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models. 
  • Using oncolytic viruses to ignite the tumour immune microenvironment in bladder cancer. 
  • Vaccine Therapy, Oncolytic Viruses, and Gliomas. 
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  Keywords of People

  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering