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Subject Areas on Research
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15N, 13C and 1H backbone resonance assignments of an artificially engineered TEM-1/PSE-4 class A β-lactamase chimera and its deconvoluted mutant.
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A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production.
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A chimeric kinesin-1 head/kinesin-5 tail motor switches between diffusive and processive motility.
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A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation.
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ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes.
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Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis.
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Altered telomeres in tumors with ATRX and DAXX mutations.
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An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme.
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Ankyrin-G Inhibits Endocytosis of Cadherin Dimers.
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Antisense oligonucleotides targeting mutant Ataxin-7 restore visual function in a mouse model of spinocerebellar ataxia type 7.
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Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis.
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Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1: possible role in volume regulation and osmotaxis.
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CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival.
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Calmodulin activation by calcium transients in the postsynaptic density of dendritic spines.
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Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments.
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Development of a high-throughput screening assay for inhibitors of small ubiquitin-like modifier proteases.
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Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.
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Dihydropteroate synthase mutations in Pneumocystis pneumonia: impact of applying different definitions of prophylaxis, mortality endpoints and mutant in a single cohort.
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Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements.
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Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.
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Distinct functions of POT1 at telomeres.
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Distinct sensitivities to phosphate deprivation suggest that RGF peptides play disparate roles in Arabidopsis thaliana root development.
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Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease.
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EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis.
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Endogenous RGS proteins attenuate Galpha(i)-mediated lysophosphatidic acid signaling pathways in ovarian cancer cells.
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Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma.
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FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons.
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FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus.
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Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.
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Functional genome-wide siRNA screen identifies KIAA0586 as mutated in Joubert syndrome.
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Generation and customization of biosynthetic excitable tissues for electrophysiological studies and cell-based therapies.
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Generation of random mutant libraries with multiple primers in a single reaction.
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Genetic organization, length conservation, and evolution of RNA polymerase II carboxyl-terminal domain.
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HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.
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Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells.
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Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide.
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High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast.
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Impact of Sulfadoxine-Pyrimethamine Resistance on Effectiveness of Intermittent Preventive Therapy for Malaria in Pregnancy at Clearing Infections and Preventing Low Birth Weight.
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Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras.
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Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias.
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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.
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Inverted formin 2 mutations with variable expression in patients with sporadic and hereditary focal and segmental glomerulosclerosis.
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Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01.
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Molecular evidence of sequential evolution of DDT- and pyrethroid-resistant sodium channel in Aedes aegypti.
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Multiple Surface Regions on the Niemann-Pick C2 Protein Facilitate Intracellular Cholesterol Transport.
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Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.
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Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS.
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Pain perception is altered by a nucleotide polymorphism in SCN9A.
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Plasticity of lipid-protein interactions in the function and topogenesis of the membrane protein lactose permease from Escherichia coli.
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Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches.
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Regulatory switch at the cytoplasmic interface controls TRPV channel gating.
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Removal of a single N-linked glycan in human immunodeficiency virus type 1 gp120 results in an enhanced ability to induce neutralizing antibody responses.
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Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse.
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Shank3 mutant mice display autistic-like behaviours and striatal dysfunction.
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Structural mechanism of organic hydroperoxide induction of the transcription regulator OhrR.
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Subcellular localization and functional analysis of the Arabidopsis GTPase RabE.
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TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse.
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Targeting mutant estrogen receptors.
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Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain.
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The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.
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The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.
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The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.
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The essential sequence elements required for RNAP II carboxyl-terminal domain function in yeast and their evolutionary conservation.
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The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axis.
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The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth.
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Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe.
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Transgenic mice expressing the myotilin T57I mutation unite the pathology associated with LGMD1A and MFM.
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Uncoupling of nucleotide hydrolysis and polymerization in the ParA protein superfamily disrupts DNA segregation dynamics.
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Unphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsis.
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epitopes immediately below the base of the V3 loop of gp120 as targets for the initial autologous neutralizing antibody response in two HIV-1 subtype B-infected individuals.
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Keywords of People
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Ferreira, Paulo Alexandre,
Associate Professor in Ophthalmology,
Pathology
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Hogan, Brigid L. M.,
George Barth Geller Distinguished Professor for Research in Molecular Biology,
Cell Biology
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology
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Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Immunology
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Sparks, Matthew A.,
Assistant Professor of Medicine,
Medicine, Nephrology
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Yan, Hai,
Henry S. Friedman Distinguished Professor of Neuro-Oncology in the School of Medicine,
Pathology