Subject Areas on Research
- PHGDH amplification and altered glucose metabolism in human melanoma.
- Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.
- Prenatal genetic diagnosis of Neu-Laxova syndrome.
- Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.
- Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism.