E2F1 Transcription Factor
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Subject Areas on Research
- A functional variant at the miRNA binding site in E2F1 gene is associated with risk and tumor HPV16 status of oropharynx squamous cell carcinoma.
- A role for E2F activities in determining the fate of Myc-induced lymphomagenesis.
- Combined effects of E2F1 and E2F2 polymorphisms on risk and early onset of squamous cell carcinoma of the head and neck.
- Definition of a FoxA1 Cistrome that is crucial for G1 to S-phase cell-cycle transit in castration-resistant prostate cancer.
- Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues.
- Distinctions in the specificity of E2F function revealed by gene expression signatures.
- Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control.
- E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program.
- E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites.
- Expression level is a key determinant of E2F1-mediated cell fate.
- Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression.
- FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function.
- First somatic mutation of E2F1 in a critical DNA binding residue discovered in well-differentiated papillary mesothelioma of the peritoneum.
- Gene expression phenotypic models that predict the activity of oncogenic pathways.
- Gene-environment regulatory circuits of right ventricular pathology in tetralogy of fallot.
- Highly coordinated gene regulation in mouse skeletal muscle regeneration.
- Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells.
- Multimodal regulation of E2F1 gene expression by progestins.
- Myc requires distinct E2F activities to induce S phase and apoptosis.
- Optimizing aptamer activity for gene therapy applications using expression cassette SELEX.
- Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.
- Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis.
- Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis.
- Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity.
- Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells.
- Viral-mediated noisy gene expression reveals biphasic E2f1 response to MYC.
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Keywords of People
- McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology