E2F3 Transcription Factor

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  Subject Areas on Research

  • A role for E2F activities in determining the fate of Myc-induced lymphomagenesis. 
  • Distinctions in the specificity of E2F function revealed by gene expression signatures. 
  • E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. 
  • Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma. 
  • Gene expression phenotypic models that predict the activity of oncogenic pathways. 
  • Myc requires distinct E2F activities to induce S phase and apoptosis. 
  • Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. 
  • The E2F1-3 transcription factors are essential for cellular proliferation. 
  • Transcriptome regulation and chromatin occupancy by E2F3 and MYC in mice.